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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Auranofin" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/07/15" /><meta name="citation_pmid" content="30000086" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501027/" /><meta name="citation_keywords" content="Auranofina" /><meta name="citation_keywords" content="Auranofine" /><meta name="citation_keywords" content="Auranofinum" /><meta name="citation_keywords" content="Ridaura" /><meta name="citation_keywords" content="AURANOFIN" /><meta name="citation_keywords" content="Triethylphosphine gold" /><meta name="citation_keywords" content="Auranofine [INN-French]" /><meta name="citation_keywords" content="Auranofinum [INN-Latin]" /><meta name="citation_keywords" content="Auranofina [INN-Spanish]" /><meta name="citation_keywords" content="SKF-39162d" /><meta name="citation_keywords" content="UNII-3H04W2810V" /><meta name="citation_keywords" content="HSDB 7172" /><meta name="citation_keywords" content="Auranofin [USAN:INN:BAN:JAN]" /><meta name="citation_keywords" content="SK&F 39162D" /><meta name="citation_keywords" content="EINECS 251-801-9" /><meta name="citation_keywords" content="SK&F D-39162" /><meta name="citation_keywords" content="3H04W2810V" /><meta name="citation_keywords" content="SK&F 39162" /><meta name="citation_keywords" content="(1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate" /><meta name="citation_keywords" content="2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold" /><meta name="citation_keywords" content="Gold, (1-thio-beta-D-glucopyranosato-S)(triethylphosphine)-, 2,3,4,6-tetraacetate" /><meta name="citation_keywords" content="Gold, (1-thio-beta-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)- (9CI)" /><meta name="citation_keywords" content="Gold, (2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S)(triethylphosphine)-" /><meta name="citation_keywords" content="34031-32-8" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Auranofin" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/07/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501027/" /><meta name="description" content="Excretion of gold into milk after auranofin has not been studied. Case reports with other gold salts indicate that gold appears in milk in small quantities and at least a little of it is absorbed because it is detectable in the infant's urine. No convincing cases of toxicity have been reported. Opinions of authors of review articles vary from recommending avoidance to allowing use.[1-5] Monitoring for possible adverse effects in the breastfed infant would seem prudent." /><meta name="og:title" content="Auranofin" /><meta name="og:type" content="book" /><meta name="og:description" content="Excretion of gold into milk after auranofin has not been studied. Case reports with other gold salts indicate that gold appears in milk in small quantities and at least a little of it is absorbed because it is detectable in the infant's urine. No convincing cases of toxicity have been reported. Opinions of authors of review articles vary from recommending avoidance to allowing use.[1-5] Monitoring for possible adverse effects in the breastfed infant would seem prudent." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501027/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM18/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501027/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501027_"><span class="title" itemprop="name">Auranofin</span></h1><p class="small">Last Revision: <span itemprop="dateModified">July 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 34031-32-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134999267" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134999267" alt="image 134999267 in the ncbi pubchem database" /></a><div id="LM18.Drug_Levels_and_Effects"><h2 id="_LM18_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM18.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Excretion of gold into milk after auranofin has not been studied. Case reports with other gold salts indicate that gold appears in milk in small quantities and at least a little of it is absorbed because it is detectable in the infant's urine. No convincing cases of toxicity have been reported. Opinions of authors of review articles vary from recommending avoidance to allowing use.[<a class="bk_pop" href="#LM18.REF.1">1</a>-<a class="bk_pop" href="#LM18.REF.5">5</a>] Monitoring for possible adverse effects in the breastfed infant would seem prudent.</p></div><div id="LM18.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM18.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Four infants reportedly have been breastfed during maternal gold therapy (including gold sodium thiomalate and gold aurothioglucose).[<a class="bk_pop" href="#LM18.REF.6">6</a>-<a class="bk_pop" href="#LM18.REF.9">9</a>] Transient facial edema occurred in an 18-month-old infant, 3 months after the mother's treatment stopped.[<a class="bk_pop" href="#LM18.REF.6">6</a>] The reaction was possibly due to gold in the mother's milk ingested by the infant.</p></div><div id="LM18.Effects_on_Lactation_and_Breastmilk"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM18.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Rheumatoid Arthritis) <a href="/books/n/lactmed/LM105/">Etanercept</a>, <a href="/books/n/lactmed/LM129/">Gold Sodium Thiomalate</a>, <a href="/books/n/lactmed/LM290/">Hydroxychloroquine</a>, <a href="/books/n/lactmed/LM476/">Infliximab</a>, <a href="/books/n/lactmed/LM466/">Methotrexate</a>, <a href="/books/n/lactmed/LM208/">Penicillamine</a>, <a href="/books/n/lactmed/LM442/">Sulfasalazine</a></p></div><div id="LM18.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM18.REF.1">Østensen
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M.
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Treatment with immunosuppressive and disease modifying drugs during pregnancy and lactation.
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Am J Reprod Immunol
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1992;28:148-52
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[<a href="https://pubmed.ncbi.nlm.nih.gov/1285866" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1285866</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM18.REF.2">Rayburn
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WF. Connective tissue disorders and pregnancy. Recommendations for prescribing.
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J Reprod Med
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1998;43:341-9
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[<a href="https://pubmed.ncbi.nlm.nih.gov/9583066" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9583066</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM18.REF.3">Janssen
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NM, Genta
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MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy and lactation.
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Arch Intern Med
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2000;160:610-9
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[<a href="https://pubmed.ncbi.nlm.nih.gov/10724046" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10724046</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM18.REF.4">Ramsey-Goldman
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R, Schilling
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E. Optimum use of disease-modifying and immunosuppressive antirheumatic agents during pregnancy and lactation.
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Clin Immunother
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1996;5:40-58.doi:10.1007/BF03259314 [<a href="http://dx.crossref.org/10.1007/BF03259314" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM18.REF.5">Brooks
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PM, Needs
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CJ. Antirheumatic drugs in pregnancy and lactation.
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Baillieres Clin Rheumatol
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1990;4:157-71
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[<a href="https://pubmed.ncbi.nlm.nih.gov/2282661" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2282661</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="LM18.REF.6">Bell
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RA, Dale
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IM. Gold secretion in maternal milk.
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Arthritis Rheum
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1976;19:1374
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[<a href="https://pubmed.ncbi.nlm.nih.gov/826260" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 826260</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="LM18.REF.7">Sørensen
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SS. Pharmacodynamic examination of patients treated with gold preparations.
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Nord Med
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1970;84:1508
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[<a href="https://pubmed.ncbi.nlm.nih.gov/5494985" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 5494985</span></a>]</div></dd><dt>8.</dt><dd><div class="bk_ref" id="LM18.REF.8">Blau
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SP. Metabolism of gold during lactation.
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Arthritis Rheum
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1973;16:777-8
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[<a href="https://pubmed.ncbi.nlm.nih.gov/4757877" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4757877</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="LM18.REF.9">Bennett
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PN, Humphries
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SJ, Osborne
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JP, et al.
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Use of sodium aurothiomalate during lactation.
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Br J Clin Pharmacol
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1990;29:777-9
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[<a href="/pmc/articles/PMC1380184/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1380184</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/2116162" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2116162</span></a>]</div></dd></dl></div></div><div id="LM18.Substance_Identification"><h2 id="_LM18_Substance_Identification_">Substance Identification</h2><div id="LM18.Substance_Name"><h3>Substance Name</h3><p>Auranofin</p></div><div id="LM18.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>34031-32-8</p></div><div id="LM18.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antirheumatic Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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