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<meta name="citation_title" content="Methyldopa">
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<meta name="citation_keywords" content="Alphamethyldopa">
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<meta name="citation_keywords" content="Aldomet">
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<meta name="citation_keywords" content="Alpha medopa">
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<meta name="citation_keywords" content="alpha-Methyl dopa">
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<meta name="citation_keywords" content="Metildopa">
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<meta name="citation_keywords" content="Aldomin">
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<meta name="citation_keywords" content="(S)-(-)-alpha-Methyldopa">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK501026_"><span class="title" itemprop="name">Methyldopa</span></h1><p class="fm-aai"><a href="#_NBK501026_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 555-30-6</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134976346" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134976346" alt="image 134976346 in the ncbi pubchem database" /></a><div id="LM179.Drug_Levels_and_Effects"><h2 id="_LM179_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM179.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because of the low levels of methyldopa in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.</p></div><div id="LM179.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Three women who were 2 to 15 days postpartum were taking 250 mg of methyldopa orally 3 or 4 times daily. Randomly drawn milk samples had levels of drug and conjugate that ranged from < 0.1 to 0.5 mg/L at a dose of 750 mg daily and were 0.8 mg/L at a dose of 1 gram daily.[<a class="bibr" href="#LM179.REF.1" rid="LM179.REF.1">1</a>]</p><p>In 3 women who were 1 to 8 weeks postpartum, peak levels of drug and conjugate occurred between 3 and 6 hours after the dose. Peak levels of drug and conjugate after a dose of 500 mg were 0.2, 0.66 and 1.14 mg/L in 3 mothers' milk. The authors estimated an infant dosage of less than 0.2% of the mother's total dosage.[<a class="bibr" href="#LM179.REF.2" rid="LM179.REF.2">2</a>]</p><p><i>Infant Levels.</i> No methyldopa was detectable (<200 mcg/L) in the serum of an infant whose mother was taking methyldopa 250 mg twice daily. The infant's urine contained a methyldopa concentration of 3.8 mg/L.[<a class="bibr" href="#LM179.REF.3" rid="LM179.REF.3">3</a>]</p><p>In an 8-week-old infant whose mother was receiving 1 gram daily of methyldopa, a serum level of 90 mcg/L was found 10 hours after a 500 mg maternal dose. Another 1-week-old infant whose mother was receiving 500 mg daily had no detectable drug in the serum (<50 mcg/L).[<a class="bibr" href="#LM179.REF.2" rid="LM179.REF.2">2</a>]</p></div><div id="LM179.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>No acute or long-term adverse effects were reported in any 15 infants ranging in age from less than 1 week to 8 weeks of age whose mothers were taking oral methyldopa 0.25 to 1.5 grams daily.[<a class="bibr" href="#LM179.REF.1" rid="LM179.REF.1">1</a>-<a class="bibr" href="#LM179.REF.4" rid="LM179.REF.4">4</a>]</p></div><div id="LM179.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Methyldopa can increase serum prolactin and has caused galactorrhea.[<a class="bibr" href="#LM179.REF.5" rid="LM179.REF.5">5</a>-<a class="bibr" href="#LM179.REF.8" rid="LM179.REF.8">8</a>] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM179.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM727/?report=reader">Candesartan</a>, <a href="/books/n/lactmed/LM26/?report=reader">Benazepril</a>, <a href="/books/n/lactmed/LM38/?report=reader">Captopril</a>, <a href="/books/n/lactmed/LM102/?report=reader">Enalapril</a>, <a href="/books/n/lactmed/LM160/?report=reader">Lisinopril</a>, <a href="/books/n/lactmed/LM234/?report=reader">Quinapril</a>, <a href="/books/n/lactmed/LM137/?report=reader">Hydrochlorothiazide</a>, <a href="/books/NBK501026/?report=reader">Methyldopa</a>, <a href="/books/n/lactmed/LM301/?report=reader">Propranolol</a></p></div><div id="LM179.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM179.REF.1">Jones
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HM, Cummings
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AJ. A study of the transfer of alpha-methyldopa to the human foetus and newborn infant.
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Br J Clin Pharmacol
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1978;6:432-4
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[<a href="/pmc/articles/PMC1429559/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1429559</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/728288" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 728288</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM179.REF.2">White
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WB, Andreoli
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JW, Cohn
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RD. Alpha-methyldopa disposition in mothers with hypertension and in their breast-fed infants.
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Clin Pharmacol Ther
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1985;37:387-90
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3838502" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3838502</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM179.REF.3">Hauser
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GJ, Almog
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S, Tirosh
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M, et al.
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Effect of alpha-methyldopa excreted in human milk on the breast-fed infant.
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Helv Paediatr Acta
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1985;40:83-6
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[<a href="https://pubmed.ncbi.nlm.nih.gov/3843238" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3843238</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM179.REF.4">Hoskins
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JA, Holliday
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SB. Determination of alpha-methyldopa and methyldopate in human breast milk and plasma by ion-exchange chromatography using electrochemical detection.
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J Chromatogr
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1982;230:162-7
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7202013" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7202013</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM179.REF.5">Arze
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RS, Ramos
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JM, Rashid
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HU, et al.
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Amenorrhoea, galactorrhoea, and hyperprolactinaemia induced by methyldopa.
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Br Med J
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1981;283:194
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[<a href="/pmc/articles/PMC1506699/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1506699</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/6789964" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6789964</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM179.REF.6">Turkington
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RW. Prolactin secretion in patients treated with various drugs: Phenothiazines, tricyclic antidepressants, reserpine, and methyldopa.
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Arch Intern Med
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1972;130:349-54
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[<a href="https://pubmed.ncbi.nlm.nih.gov/4560178" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4560178</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM179.REF.7">Vaidya
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RA, Vaidya
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AB, Van Woert
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MH, et al.
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Galactorrhea and Parkinson-like syndrome: An adverse effect of alpha-methyldopa.
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Metabolism
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1970;19:1068-70
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[<a href="https://pubmed.ncbi.nlm.nih.gov/4923681" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4923681</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>8.</dt><dd><div class="bk_ref" id="LM179.REF.8">Cohen MA, Davies PH. Drug therapy and hyperprolactinaemia. Adv Drug React Bull 1998:723-6</div></dd></dl></dl></div></div><div id="LM179.Substance_Identification"><h2 id="_LM179_Substance_Identification_">Substance Identification</h2><div id="LM179.Substance_Name"><h3>Substance Name</h3><p>Methyldopa</p></div><div id="LM179.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>555-30-6</p></div><div id="LM179.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antihypertensive Agents</p><p>Adrenergic alpha-2 Receptor Agonists</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK501026_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Methyldopa. [Updated 2024 Nov 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM178/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM467/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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