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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Methicillin" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/11/15" /><meta name="citation_pmid" content="30000082" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501023/" /><meta name="citation_keywords" content="methicillin" /><meta name="citation_keywords" content="Meticillin" /><meta name="citation_keywords" content="Methycillin" /><meta name="citation_keywords" content="Methicillinum" /><meta name="citation_keywords" content="Meticillinum" /><meta name="citation_keywords" content="Meticilline" /><meta name="citation_keywords" content="Metacillin" /><meta name="citation_keywords" content="Meticilina" /><meta name="citation_keywords" content="Dimocillin" /><meta name="citation_keywords" content="Meticillina" /><meta name="citation_keywords" content="UNII-Q91FH1328A" /><meta name="citation_keywords" content="BRL 1241" /><meta name="citation_keywords" content="HSDB 3121" /><meta name="citation_keywords" content="EINECS 200-505-8" /><meta name="citation_keywords" content="Q91FH1328A" /><meta name="citation_keywords" content="(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Methicillin" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/11/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501023/" /><meta name="description" content="Amounts of methicillin ingested by the infant in breastmilk are small and would not be expected to cause any adverse effects. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Methicillin is acceptable in nursing mothers." /><meta name="og:title" content="Methicillin" /><meta name="og:type" content="book" /><meta name="og:description" content="Amounts of methicillin ingested by the infant in breastmilk are small and would not be expected to cause any adverse effects. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Methicillin is acceptable in nursing mothers." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501023/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM176/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501023/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501023_"><span class="title" itemprop="name">Methicillin</span></h1><p class="small">Last Revision: <span itemprop="dateModified">November 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 61-32-5</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134970879" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134970879" alt="image 134970879 in the ncbi pubchem database" /></a><div id="LM176.Drug_Levels_and_Effects"><h2 id="_LM176_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM176.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Amounts of methicillin ingested by the infant in breastmilk are small and would not be expected to cause any adverse effects. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with penicillins, but these effects have not been adequately evaluated. Methicillin is acceptable in nursing mothers.</p></div><div id="LM176.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Intramuscular injections of methicillin 1 gram every 6 hours for 6 to 9 days in 17 women with monolateral mastitis yielded methicillin levels in milk that reached a peak of 0.31 mg/L at 3 hours after the first dose on the first day in the healthy breast, and much lower levels in the breast with mastitis. After the last dose, peak milk levels of 1.53 mg/L occurred 6 hours after the dose. Methicillin milk levels from both breasts were equal.[<a class="bk_pop" href="#LM176.REF.1">1</a>]</p><p>After a single intramuscular dose of 1 gram of methicillin in 3 women, milk levels ranged from 0.2 to 0.3 mg/L between 1 and 6 hours.[<a class="bk_pop" href="#LM176.REF.2">2</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM176.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM176.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM176.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Methicillin-sensitive <i>Staph. aureus</i>) <a href="/books/n/lactmed/LM43/">Cefazolin</a>, <a href="/books/n/lactmed/LM90/">Cephalexin</a>, <a href="/books/n/lactmed/LM60/">Dicloxacillin</a>, <a href="/books/n/lactmed/LM1083/">Floxacillin</a>, <a href="/books/n/lactmed/LM206/">Oxacillin</a>, <a href="/books/n/lactmed/LM193/">Nafcillin</a>; (Methicillin-resistant <i>Staph. aureus</i>) <a href="/books/n/lactmed/LM100/">Doxycycline</a>, <a href="/books/n/lactmed/LM797/">Linezolid</a>, <a href="/books/n/lactmed/LM183/">Minocycline</a>, <a href="/books/n/lactmed/LM417/">Trimethoprim-Sulfamethoxazole</a>, <a href="/books/n/lactmed/LM394/">Vancomycin</a></p></div><div id="LM176.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM176.REF.1">Kulakov
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VI, Zak
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IR, Kulikova
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NN, et al.
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Body pharmacokinetics of methicillin, oxacillin and cephaloridine in puerperal mastitis.
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Antibiotiki
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1981;26:110-3.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7212690" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7212690</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM176.REF.2">Matsuda
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S.
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Transfer of antibiotics into maternal milk.
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Biol Res Pregnancy Perinatol
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1984;5:57-60.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6743732" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6743732</span></a>]</div></dd></dl></div></div><div id="LM176.Substance_Identification"><h2 id="_LM176_Substance_Identification_">Substance Identification</h2><div id="LM176.Substance_Name"><h3>Substance Name</h3><p>Methicillin</p></div><div id="LM176.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>61-32-5</p></div><div id="LM176.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents</p><p>Antibacterial Agents</p><p>Penicillins</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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