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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Lisinopril" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2025/02/15" /><meta name="citation_pmid" content="30000065" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK501006/" /><meta name="citation_keywords" content="Lisinopril dihydrate" /><meta name="citation_keywords" content="Renacor" /><meta name="citation_keywords" content="Prinivil" /><meta name="citation_keywords" content="Zestril" /><meta name="citation_keywords" content="Prinzide" /><meta name="citation_keywords" content="Ranolip" /><meta name="citation_keywords" content="Qbrelis" /><meta name="citation_keywords" content="Zestoretic" /><meta name="citation_keywords" content="UNII-E7199S1YWR" /><meta name="citation_keywords" content="E7199S1YWR" /><meta name="citation_keywords" content="MK-521" /><meta name="citation_keywords" content="(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Lisinopril" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2025/02/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK501006/" /><meta name="description" content="Because of the low levels of lisinopril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants." /><meta name="og:title" content="Lisinopril" /><meta name="og:type" content="book" /><meta name="og:description" content="Because of the low levels of lisinopril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK501006/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM160/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK501006/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK501006_"><span class="title" itemprop="name">Lisinopril</span></h1><p class="small">Last Revision: <span itemprop="dateModified">February 15, 2025</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 83915-83-7</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135013705" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135013705" alt="image 135013705 in the ncbi pubchem database" /></a><div id="LM160.Drug_Levels_and_Effects"><h2 id="_LM160_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM160.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Because of the low levels of lisinopril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.</p></div><div id="LM160.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Five women who were taking lisinopril and had donated milk samples to a breastmilk repository had their milk analyzed for lisinopril. Milk samples were collected under steady-state conditions at time intervals of 0, 1, 2, 4, 6, 8, 10, 12, and 24 hours after a dose. One woman was taking 5 mg daily, and two each were taking 10 and 20 mg daily. Milk lisinopril measurements were adjusted (doubled or halved) to a standard 10 mg daily dosage. The peak concentration of lisinopril was 0.63 mcg/L and occurred at an average of 4 hours after the dose. The average lisinopril concentration was 0.49 mcg/L, which corresponds to an infant daily dose of 0.073 mcg/kg daily and a relative infant dose of 0.06%.[<a class="bk_pop" href="#LM160.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM160.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Five women who were taking lisinopril reported any perceived adverse effects in their infants. Four taking doses of 5, 10 and 20 mg daily reported no adverse effects in their infants. One had taken 5 mg of lisinopril daily and breastfed her 1-year-old since birth, exclusive probably through 6 months and extensively thereafter. The fifth women reported that her infant’s “poop smelled unpleasant and was often green”, but she continued breastfeeding and taking lisinopril.[<a class="bk_pop" href="#LM160.REF.1">1</a>] It is not clear if the infant’s condition was related to lisinopril.</p></div><div id="LM160.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM160.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM26/">Benazepril</a>, <a href="/books/n/lactmed/LM38/">Captopril</a>, <a href="/books/n/lactmed/LM102/">Enalapril</a>, <a href="/books/n/lactmed/LM234/">Quinapril</a></p></div><div id="LM160.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM160.REF.1">Chugh
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J, Dai
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J, Datta
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P, et al.
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Investigating the transfer of lisinopril into human milk: A quantitative analysis.
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J Cardiovasc Pharmacol
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2025;85:84-7.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/39405564" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 39405564</span></a>]</div></dd></dl></div></div><div id="LM160.Substance_Identification"><h2 id="_LM160_Substance_Identification_">Substance Identification</h2><div id="LM160.Substance_Name"><h3>Substance Name</h3><p>Lisinopril</p></div><div id="LM160.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>83915-83-7</p></div><div id="LM160.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antihypertensive Agents</p><p>Angiotensin-Converting Enzyme Inhibitors</p><p>ACE Inhibitors</p><p>ACEIs</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK501006</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/30000065" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">30000065</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM834/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM1224/" title="Next page in this title">Next ></a></div></div></div></div>
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