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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Ceftazidime and Avibactam - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Ceftazidime and Avibactam">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2021/08/16">
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<meta name="citation_pmid" content="30000012">
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<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK500953/">
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<meta name="citation_keywords" content="Avibactam">
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<meta name="citation_keywords" content="NXL104">
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<meta name="citation_keywords" content="Avibactam [USAN:INN]">
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<meta name="citation_keywords" content="NXL 104">
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<meta name="citation_keywords" content="UNII-7352665165">
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<meta name="citation_keywords" content="1192500-31-4">
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<meta name="citation_keywords" content="ceftazidime">
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<meta name="citation_keywords" content="Pentacef">
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<meta name="citation_keywords" content="Tazidime">
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<meta name="citation_keywords" content="Tazicef">
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<meta name="citation_keywords" content="Ceptaz">
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<meta name="citation_keywords" content="Fortaz">
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<meta name="citation_keywords" content="SN 401 pentahydrate">
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<meta name="citation_keywords" content="Ceftazidime pentahydrate">
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<meta name="citation_keywords" content="UNII-9M416Z9QNR">
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<meta name="citation_keywords" content="Tazidime In Plastic Container">
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<meta name="citation_keywords" content="9M416Z9QNR">
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<meta name="citation_keywords" content="Ceftazidime [USAN:USP:INN:BAN:JAN]">
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<meta name="citation_keywords" content="GR 20263">
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<meta name="citation_keywords" content="LY 139381">
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<meta name="citation_keywords" content="1-(((6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)pyridinium hydroxide, inner salt, 7(sup 2)-(Z)-(O-(1-carboxy-1-methylethyl)oxime), pentahydrate">
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<meta name="citation_keywords" content="78439-06-2">
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<meta name="citation_keywords" content="Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, hydroxide, inner salt, (6R-(6-alpha,7-beta(Z)))-, pentahydrate">
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<meta name="citation_keywords" content="Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, hydroxide, inner salt, pentahydrate, (6R-(6alpha,7beta(Z)))-">
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<meta name="citation_keywords" content="Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, inner salt, pentahydrate, (6R-(6alpha,7beta(Z)))-">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK500953_"><span class="title" itemprop="name">Ceftazidime and Avibactam</span></h1><p class="fm-aai"><a href="#_NBK500953_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 1192500-31-4 78439-06-2</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135263398" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135263398" alt="image 135263398 in the ncbi pubchem database" /></a><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135012688" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135012688" alt="image 135012688 in the ncbi pubchem database" /></a><div id="LM1359.Drug_Levels_and_Effects"><h2 id="_LM1359_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1359.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that ceftazidime produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Avibactam has not been studied in nursing mothers. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Ceftazidime-avibactam is acceptable in nursing mothers.</p></div><div id="LM1359.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Ceftazidime 2 grams was given to 11 women intravenously every 8 hours for 5 days. The average trough milk level was 3.8 mg/L before the next dose, 5.2 mg/L 1 hour after the dose and 4.5 mg/L at 3 hours after the dose. These differences were not statistically significant. The average drug concentrations in milk were 3.9 mg/L for samples before the seventh dose and 4.9 mg/L in milk samples after the seventh dose, but this difference was not statistically significant. There was no correlation between the mother's weight and the ceftazidime milk levels.[<a class="bibr" href="#LM1359.REF.1" rid="LM1359.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1359.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1359.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1359.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM1359.REF.1">Blanco JD, Jorgensen JH, Castaneda YS, et al. Ceftazidime levels in human breast milk. <span><span class="ref-journal">Antimicrob Agents Chemother. </span>1983;<span class="ref-vol">23</span>:479–80.</span> [<a href="/pmc/articles/PMC184672/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC184672</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/6342531" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6342531</span></a>]</div></dd></dl></dl></div></div><div id="LM1359.Substance_Identification"><h2 id="_LM1359_Substance_Identification_">Substance Identification</h2><div id="LM1359.Substance_Name"><h3>Substance Name</h3><p>Ceftazidime and Avibactam</p></div><div id="LM1359.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>1192500-31-4 78439-06-2</p></div><div id="LM1359.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Anti-Infective Agents</p><p>Antibacterial Agents</p><p>Cephalosporins</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK500953_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">August 16, 2021</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Ceftazidime and Avibactam. [Updated 2021 Aug 16].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM54/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM55/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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