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Very limited long-term follow-up data indicate no adverse developmental effects when haloperidol is used alone. However, use with other antipsychotic drugs occasionally might negatively affect the infant. One expert guideline recommends against using haloperidol during breastfeeding,[1] but a safety scoring system finds haloperidol possible to use cautiously during breastfeeding.[2] Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently." /><meta name="og:title" content="Haloperidol" /><meta name="og:type" content="book" /><meta name="og:description" content="Limited information indicates that maternal doses of haloperidol up to 10 mg daily produce low levels in milk and usually do not affect the breastfed infant. Very limited long-term follow-up data indicate no adverse developmental effects when haloperidol is used alone. However, use with other antipsychotic drugs occasionally might negatively affect the infant. One expert guideline recommends against using haloperidol during breastfeeding,[1] but a safety scoring system finds haloperidol possible to use cautiously during breastfeeding.[2] Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK500910/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM132/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK500910/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK500910_"><span class="title" itemprop="name">Haloperidol</span></h1><p class="small">Last Revision: <span itemprop="dateModified">August 15, 2023</span>.</p><p><em>Estimated reading time: 5 minutes</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 52-86-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134970855" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134970855" alt="image 134970855 in the ncbi pubchem database" /></a><div id="LM132.Drug_Levels_and_Effects"><h2 id="_LM132_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM132.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that maternal doses of haloperidol up to 10 mg daily produce low levels in milk and usually do not affect the breastfed infant. Very limited long-term follow-up data indicate no adverse developmental effects when haloperidol is used alone. However, use with other antipsychotic drugs occasionally might negatively affect the infant. One expert guideline recommends against using haloperidol during breastfeeding,[<a class="bk_pop" href="#LM132.REF.1">1</a>] but a safety scoring system finds haloperidol possible to use cautiously during breastfeeding.[<a class="bk_pop" href="#LM132.REF.2">2</a>] Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.</p></div><div id="LM132.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> In one woman, a milk level of 5 mcg/L was detected 11 hours after a dose during therapy with an average dose of 29.2 mg daily. Another level of 2 mcg/L was measured 9 hours after a 12 mg oral dose. Haloperidol was not detectable in milk 3 days after the last 7 mg dose.[<a class="bk_pop" href="#LM132.REF.3">3</a>]</p><p>During a regimen of haloperidol 5 mg orally twice daily in one woman, random milk levels were 18 and 23.5 mcg/L. On day 21 of therapy, the mother's milk level was 4 mcg/L.[<a class="bk_pop" href="#LM132.REF.4">4</a>]</p><p>A woman had been taking haloperidol for 29 days before and after delivery. Although she was not breastfeeding, a breastmilk sample was obtained 12 days postpartum when the dose had been 6 mg orally for 7 days. The milk haloperidol level 3 hours after the last dose was 1.7 mcg/L.[<a class="bk_pop" href="#LM132.REF.5">5</a>]</p><p>Three patients taking haloperidol 3, 4 and 6 mg daily had random milk levels of 32, 17 and 4.7 mcg/L at unspecified times after a dose, although the latter patient was reportedly nonadherent to the drug regimen.[<a class="bk_pop" href="#LM132.REF.6">6</a>,<a class="bk_pop" href="#LM132.REF.7">7</a>]</p><p>Nine patients who were taking haloperidol had foremilk and/or hindmilk samples collected on 1 to 3 occasions 12 to 15 hours after the previous dose of haloperidol. HPLC assay found that foremilk haloperidol levels ranged from undetectable (<1 mcg/L) to 24.9 mcg/L, with no correlation to the maternal doses of 1 to 40 mg daily. Foremilk haloperidol concentrations correlated better with maternal plasma levels. Hindmilk concentrations were slightly higher than foremilk concentrations when both samples were collected. Measurement of the same samples with an enzyme immunoassay found higher levels, ranging from undetectable (<10 mcg/L) to 988 mcg/L, again correlated better with maternal serum concentrations than maternal dosage. The authors considered the higher values to represent the contribution of undetermined metabolites that were unmeasured by HPLC.[<a class="bk_pop" href="#LM132.REF.8">8</a>]</p><p><i>Infant Levels.</i> A nursing mother took haloperidol 5 mg orally twice daily. On day 21 of therapy, the infant's urine contained 1.5 mcg/L of haloperidol.[<a class="bk_pop" href="#LM132.REF.4">4</a>]</p><p>Four breastfed infants whose mothers were taking haloperidol in doses of 5 to 20 mg daily had serum concentrations measured by enzyme immunoassay. Serum concentrations ranged from 0.8 to 2.1 mcg/L. Neither the extent of nursing, the exact age at the time of sample collection, nor the time of sampling were stated.[<a class="bk_pop" href="#LM132.REF.8">8</a>]</p></div><div id="LM132.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>In one breast-fed infant, there were no sedative effects and the baby fed well during maternal intake of 5 mg orally twice daily. The mother took haloperidol during six weeks of breast feeding and at 6 and 12 months of age, the baby had achieved all milestones of growth and development.[<a class="bk_pop" href="#LM132.REF.4">4</a>]</p><p>One infant was breastfed for 5 weeks beginning at 2 weeks of age during maternal haloperidol (dose not stated) and imipramine (150 mg daily) therapy. The infant showed normal development when tested once between 1 and 4 months and once between 12 and 18 months of age.[<a class="bk_pop" href="#LM132.REF.9">9</a>]</p><p>In a small prospective study on the long-term effects of antipsychotics in breastfed infants, a decline in developmental scores was found at 12 to 18 months of age in 2 of the 4 the infants of mothers taking both chlorpromazine and haloperidol. The other 2 infants and all infants exposed to either drug alone developed normally.[<a class="bk_pop" href="#LM132.REF.8">8</a>]</p><p>One woman with schizophrenia took haloperidol and trihexyphenidyl during 3 pregnancies and postpartum. Haloperidol doses were 7.5 to 10 mg daily in the first 2 pregnancies and 15 mg daily in the third. She breastfed (extent not stated) all 3 children for 6 to 8 months using the same doses. Development was age-appropriate in all children aged 16 months at 8 years of age at the time of assessment.[<a class="bk_pop" href="#LM132.REF.10">10</a>]</p><p>Two women, one with bipolar disorder and the other with long-standing schizophrenia, were treated with haloperidol 5 mg daily during pregnancy and breastfeeding (extent not stated). One mother also received olanzapine 10 mg daily and the other received amisulpride 400 mg daily. Follow-up of the breastfed infants for 11 to 13 months found no adverse effects and normal development of the infants.[<a class="bk_pop" href="#LM132.REF.11">11</a>]</p><p>A woman diagnosed with schizophrenia was taking risperidone 1.5 mg daily during late pregnancy and postpartum while nursing (extent not stated) her full-term infant. At 2 weeks postpartum, haloperidol 0.8 mg daily was added because of a recurrence of symptoms. At these dosages, no adverse effects were seen in the infant. However, because of recurring symptoms, the dosage of haloperidol was increased to 1.5 mg daily. Three days later, the infant had excessive sedation, poor feeding, and slowing in motor movements. Pediatric assessment found no medical reason for these effects. Breastfeeding was discontinued and the infant's symptoms resolved completely in 5 days. The infant's symptoms were probably caused by the drug combination.[<a class="bk_pop" href="#LM132.REF.12">12</a>]</p></div><div id="LM132.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Galactorrhea caused by hyperprolactinemia has been reported with haloperidol [<a class="bk_pop" href="#LM132.REF.13">13</a>-<a class="bk_pop" href="#LM132.REF.20">20</a>] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[<a class="bk_pop" href="#LM132.REF.21">21</a>] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.</p></div><div id="LM132.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM205/">Olanzapine</a>, <a href="/books/n/lactmed/LM233/">Quetiapine</a>, <a href="/books/n/lactmed/LM240/">Risperidone</a></p></div><div id="LM132.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM132.REF.1">Larsen
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ER, Damkier
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P, Pedersen
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LH, et al.
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Use of psychotropic drugs during pregnancy and breast-feeding.
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Acta Psychiatr Scand Suppl
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2015;445:1-28. [<a href="https://pubmed.ncbi.nlm.nih.gov/26344706" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26344706</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM132.REF.2">Uguz
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F.
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A new safety scoring system for the use of psychotropic drugs during lactation.
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Am J Ther
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2021;28:e118-e126. [<a href="https://pubmed.ncbi.nlm.nih.gov/30601177" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30601177</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM132.REF.3">Stewart
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RB, Karas
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PK. Haloperidol excretion in human milk.
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Am J Psychiatry
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1980;137:849-50. [<a href="https://pubmed.ncbi.nlm.nih.gov/7386670" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7386670</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM132.REF.4">Whalley
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LJ, Blain
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PG, Prime
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JK. Haloperidol secreted in breast milk.
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Br Med J (Clin Res Ed)
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1981;282:1746-7. [<a href="/pmc/articles/PMC1505716/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1505716</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/6786603" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6786603</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM132.REF.5">Kuniyoshi
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M, Inanaga
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K. Haloperidol and biperiden plasma levels in a pregnant atypical psychotic woman and a neonate--a case report.
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Kurume Med J
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1985;32:199-202. [<a href="https://pubmed.ncbi.nlm.nih.gov/3835398" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3835398</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="LM132.REF.6">Ohkubo
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T, Shimoyama
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R, Sugawara
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K. Measurement of haloperidol in human breast milk by high-performance liquid chromatography.
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J Pharm Sci
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1992;81:947-9. [<a href="https://pubmed.ncbi.nlm.nih.gov/1432646" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 1432646</span></a>]</div></dd><dt>7.</dt><dd><div class="bk_ref" id="LM132.REF.7">Sugawara
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K, Shimoyama
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R, Ohkubo
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T. Determinations of psychotropic drugs and antiepileptic drugs by high-performance liquid chromatography and its monitoring in human breast milk.
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Hirosaki Med J
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1999;51 (Suppl):S81-6.</div></dd><dt>8.</dt><dd><div class="bk_ref" id="LM132.REF.8">Yoshida
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K, Smith
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Neuroleptic drugs in breast-milk: A study of pharmacokinetics and of possible adverse effects in breast-fed infants.
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Psychol Med
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1998;28:81-91. [<a href="https://pubmed.ncbi.nlm.nih.gov/9483685" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9483685</span></a>]</div></dd><dt>9.</dt><dd><div class="bk_ref" id="LM132.REF.9">Yoshida
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K, Smith
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Investigation of pharmacokinetics and possible adverse effects in infants exposed to tricyclic antidepressants in breast-milk.
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J Affect Disord
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1997;43:225-37. [<a href="https://pubmed.ncbi.nlm.nih.gov/9186793" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9186793</span></a>]</div></dd><dt>10.</dt><dd><div class="bk_ref" id="LM132.REF.10">Mendhekar
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DN, Andrade
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C. Uneventful use of haloperidol and trihehexyphenidyl during three consecutive pregnancies.
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Arch Womens Ment Health
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2011;14:83-4. [<a href="https://pubmed.ncbi.nlm.nih.gov/21116668" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21116668</span></a>]</div></dd><dt>11.</dt><dd><div class="bk_ref" id="LM132.REF.11">Uguz
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Breastfed infants exposed to combined antipsychotics: Two case reports.
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Am J Ther
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2016;23:e1962-e1964. [<a href="https://pubmed.ncbi.nlm.nih.gov/26539905" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26539905</span></a>]</div></dd><dt>12.</dt><dd><div class="bk_ref" id="LM132.REF.12">Uguz
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Adverse events in a breastfed infant exposed to risperidone and haloperidol.
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Breastfeed Med
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2019;14:683-4. [<a href="https://pubmed.ncbi.nlm.nih.gov/31135176" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 31135176</span></a>]</div></dd><dt>13.</dt><dd><div class="bk_ref" id="LM132.REF.13">Turkington
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RW. Prolactin secretion in patients treated with various drugs: Phenothiazines, tricyclic antidepressants, reserpine, and methyldopa.
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Arch Intern Med
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1972;130:349-54. [<a href="https://pubmed.ncbi.nlm.nih.gov/4560178" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4560178</span></a>]</div></dd><dt>14.</dt><dd><div class="bk_ref" id="LM132.REF.14">Turkington
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RW. Serum prolactin levels in patients with gynecomastia.
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J Clin Endocrinol Metab
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1972;34:62-6. [<a href="https://pubmed.ncbi.nlm.nih.gov/5061776" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 5061776</span></a>]</div></dd><dt>15.</dt><dd><div class="bk_ref" id="LM132.REF.15">Beumont
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PJ, Gelder
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MG, Friesen
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HG, et al.
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The effects of phenothiazine on endrocrine function: I Patients with inappropriate lactation and amenorrhoea.
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Br J Psychiatry
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1974;124:413-9. [<a href="https://pubmed.ncbi.nlm.nih.gov/4151788" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 4151788</span></a>]</div></dd><dt>16.</dt><dd><div class="bk_ref" id="LM132.REF.16">Langer
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G, Puhringer
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W. Haloperidol and droperidol treatment in schizophrenics. Clinical application of the "prolactin-model".
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Acta Psychiatr Belg
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1980;80:574-83. [<a href="https://pubmed.ncbi.nlm.nih.gov/7234451" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7234451</span></a>]</div></dd><dt>17.</dt><dd><div class="bk_ref" id="LM132.REF.17">Crawford
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AM, Beasley
|
|
CM, Jr, Tollefson
|
|
GD. The acute and long-term effect of olanzapine compared with placebo and haloperidol on serum prolactin concentrations.
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Schizophr Res
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1997;26:41-54. [<a href="https://pubmed.ncbi.nlm.nih.gov/9376336" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9376336</span></a>]</div></dd><dt>18.</dt><dd><div class="bk_ref" id="LM132.REF.18">Atmaca
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M, Kuloglu
|
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M, Tezcan
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E, et al.
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Quetiapine is not associated with increase in prolactin secretion in contrast to haloperidol.
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Arch Med Res
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2002;33:562-5. [<a href="https://pubmed.ncbi.nlm.nih.gov/12505103" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12505103</span></a>]</div></dd><dt>19.</dt><dd><div class="bk_ref" id="LM132.REF.19">Fiore
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L, Scapagnini
|
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U, Canonico
|
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PL. Effect of dihydroergocryptine and dihydroergocristine on cyclic AMP accumulation and prolactin release in vitro: Evidence for a dopaminomimetic action.
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Horm Res
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1987;25:171-7. [<a href="https://pubmed.ncbi.nlm.nih.gov/3032757" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3032757</span></a>]</div></dd><dt>20.</dt><dd><div class="bk_ref" id="LM132.REF.20">Shim
|
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JC, Shin
|
|
JG, Kelly
|
|
DL, et al.
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Adjunctive treatment with a dopamine partial agonist, aripiprazole, for antipsychotic-induced hyperprolactinemia: a placebo-controlled trial.
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Am J Psychiatry
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2007;164:1404-10. [<a href="https://pubmed.ncbi.nlm.nih.gov/17728426" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17728426</span></a>]</div></dd><dt>21.</dt><dd><div class="bk_ref" id="LM132.REF.21">Maguire
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GA. Prolactin elevation with antipsychotic medications: Mechanisms of action and clinical consequences.
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J Clin Psychiatry
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2002;63 (Suppl 4):56-62. [<a href="https://pubmed.ncbi.nlm.nih.gov/11913677" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11913677</span></a>]</div></dd></dl></div></div><div id="LM132.Substance_Identification"><h2 id="_LM132_Substance_Identification_">Substance Identification</h2><div id="LM132.Substance_Name"><h3>Substance Name</h3><p>Haloperidol</p></div><div id="LM132.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>52-86-8</p></div><div id="LM132.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antipsychotic Agents</p><p>Butyrophenones</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK500910</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29999969" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">29999969</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM795/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM613/" title="Next page in this title">Next ></a></div></div></div></div>
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