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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Magnesium Aspartate" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/01/15" /><meta name="citation_pmid" content="29999954" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK500895/" /><meta name="citation_keywords" content="Magnesium aspartate" /><meta name="citation_keywords" content="UNII-R17X820ROL" /><meta name="citation_keywords" content="Magnesium aspartate tetrahydrate" /><meta name="citation_keywords" content="R17X820ROL" /><meta name="citation_keywords" content="7018-07-7" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Magnesium Aspartate" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/01/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK500895/" /><meta name="description" content="No information is available on the excretion of magnesium following magnesium aspartate during breastfeeding. However, other magnesium salts have been studied. Intravenous magnesium sulfate increases milk magnesium concentrations only slightly. Oral absorption of magnesium by the infant is poor, so maternal magnesium aspartate is not expected to affect the breastfed infant's serum magnesium. Magnesium aspartate supplementation during pregnancy might delay the onset of lactation, but it can be taken during breastfeeding and no special precautions are required." /><meta name="og:title" content="Magnesium Aspartate" /><meta name="og:type" content="book" /><meta name="og:description" content="No information is available on the excretion of magnesium following magnesium aspartate during breastfeeding. However, other magnesium salts have been studied. Intravenous magnesium sulfate increases milk magnesium concentrations only slightly. Oral absorption of magnesium by the infant is poor, so maternal magnesium aspartate is not expected to affect the breastfed infant's serum magnesium. Magnesium aspartate supplementation during pregnancy might delay the onset of lactation, but it can be taken during breastfeeding and no special precautions are required." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK500895/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM1306/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK500895/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK500895_"><span class="title" itemprop="name">Magnesium Aspartate</span></h1><p class="small">Last Revision: <span itemprop="dateModified">January 15, 2024</span>.</p><p><em>Estimated reading time: 2 minutes</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 7018-07-7</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135264003" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135264003" alt="image 135264003 in the ncbi pubchem database" /></a><div id="LM1306.Drug_Levels_and_Effects"><h2 id="_LM1306_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1306.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>No information is available on the excretion of magnesium following magnesium aspartate during breastfeeding. However, other magnesium salts have been studied. Intravenous magnesium sulfate increases milk magnesium concentrations only slightly. Oral absorption of magnesium by the infant is poor, so maternal magnesium aspartate is not expected to affect the breastfed infant's serum magnesium. Magnesium aspartate supplementation during pregnancy might delay the onset of lactation, but it can be taken during breastfeeding and no special precautions are required.</p></div><div id="LM1306.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Ten women with pre-eclampsia were given 4 grams of magnesium sulfate intravenously followed by 1 gram per hour until 24 hours after delivery. While the average serum magnesium was 35.5 mg/L in treated women compared to 18.2 mg/L in 5 untreated controls, colostrum magnesium levels at the time of discontinuation of the infusion were 64 mg/L in treated women and 48 mg/L in the controls. By 48 hours after discontinuation, colostrum magnesium levels were only slightly above control values and by 72 hours they were virtually identical to controls.[<a class="bk_pop" href="#LM1306.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1306.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Fifty mothers who were in the first day postpartum received 15 mL of either mineral oil or an emulsion of mineral oil and another magnesium salt, magnesium hydroxide equivalent to 900 mg of magnesium hydroxide, although the exact number who received each product was not stated. Additional doses were given on subsequent days if needed. None of the breastfed infants were noted to have any markedly abnormal stools, but all of the infants also received supplemental feedings.[<a class="bk_pop" href="#LM1306.REF.2">2</a>]</p></div><div id="LM1306.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>One mother who received intravenous magnesium sulfate for 3 days for pregnancy-induced hypertension had lactogenesis II delayed until day 10 postpartum. No other specific cause was found for the delay, although a complete work-up was not done.[<a class="bk_pop" href="#LM1306.REF.3">3</a>] A subsequent controlled clinical trial found no evidence of delayed lactation in mothers who received intravenous magnesium sulfate therapy.[<a class="bk_pop" href="#LM1306.REF.4">4</a>] Some, but not all, studies have found a trend toward increased time to the first feeding or decreased sucking in infants of mothers treated with intravenous magnesium sulfate during labor because of placental transfer of magnesium to the fetus.[<a class="bk_pop" href="#LM1306.REF.4">4</a>,<a class="bk_pop" href="#LM1306.REF.5">5</a>]</p><p>A study in 40 pairs of matched healthy women with vaginally delivered singleton pregnancies, outcome endpoints were compared in those receiving continuous oral magnesium aspartate HCl supplementation mean dose of 459 mg daily (range 365 to 729 mg of magnesium daily) for at least 4 weeks before delivery versus non-supplemented controls. In the magnesium group, significantly fewer women could breastfeed their infants exclusively at discharge (63% vs 80%).[<a class="bk_pop" href="#LM1306.REF.6">6</a>]</p></div><div id="LM1306.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM1306.REF.1">Cruikshank
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DP, Varner
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MW, Pitkin
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RM. Breast milk magnesium and calcium concentrations following magnesium sulfate treatment.
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Am J Obstet Gynecol
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1982;143:685-8.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7091241" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7091241</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM1306.REF.2">Baldwin
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WF. Clinical study of senna administration to nursing mothers: Assessment of effects on infant bowel habits.
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Can Med Assoc J
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1963;89:566-8.
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[<a href="/pmc/articles/PMC1921820/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1921820</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/14045350" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14045350</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM1306.REF.3">Haldeman
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W.
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Can magnesium sulfate therapy impact lactogenesis?
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J Hum Lact
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1993;9:249-52.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/8260059" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8260059</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM1306.REF.4">Riaz
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M, Porat
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R, Brodsky
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NL, Hurt
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H. The effects of maternal magnesium sulfate treatment on newborns: A prospective controlled study.
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J Perinatol
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1998;18:449-54.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/9848759" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9848759</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM1306.REF.5">Rasch
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DK, Huber
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PA, Richardson
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CJ, et al.
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Neurobehavioral effects of neonatal hypermagnesemia.
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J Pediatr
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1982;100:272-6.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/7199083" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 7199083</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="LM1306.REF.6">Meier
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B, Huch
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R, Zimmermann
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R, von Mandach, U. Does continuing oral magnesium supplementation until delivery affect labor and puerperium outcome?
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Eur J Obstet Gynecol Reprod Biol
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2005;123:157-61.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/15899543" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15899543</span></a>]</div></dd></dl></div></div><div id="LM1306.Substance_Identification"><h2 id="_LM1306_Substance_Identification_">Substance Identification</h2><div id="LM1306.Substance_Name"><h3>Substance Name</h3><p>Magnesium Aspartate</p></div><div id="LM1306.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>7018-07-7</p></div><div id="LM1306.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Magnesium Compounds</p><p>Minerals</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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