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<meta name="citation_keywords" content="Adiab">
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<meta name="citation_keywords" content="Melix">
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<meta name="citation_keywords" content="Glybenzcyclamide">
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<meta name="citation_keywords" content="Pira">
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<meta name="citation_keywords" content="Glibenclamidum">
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<meta name="citation_keywords" content="1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea">
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<meta name="citation_keywords" content="5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide">
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<meta name="og:description" content="Limited data indicate that the levels of glyburide in milk are negligible. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1,2]">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK500865_"><span class="title" itemprop="name">Glyburide</span></h1><p class="fm-aai"><a href="#_NBK500865_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 10238-21-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134991406" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134991406" alt="image 134991406 in the ncbi pubchem database" /></a><div id="LM128.Drug_Levels_and_Effects"><h2 id="_LM128_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM128.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited data indicate that the levels of glyburide in milk are negligible. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[<a class="bibr" href="#LM128.REF.1" rid="LM128.REF.1">1</a>,<a class="bibr" href="#LM128.REF.2" rid="LM128.REF.2">2</a>]</p></div><div id="LM128.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Eight women who had recently delivered were given a single dose of glyburide 5 mg (n = 6) or 10 mg (n = 2) orally. Glyburide was undetectable (<5 mcg/L) in milk at 2, 4, 6 and 8 hours after the dose. The authors estimated that the maximum dosages that a fully breastfed infant would receive with the 5 and 10 mg doses are <1.5% and <0.7% of the maternal weight-adjusted dosage, respectively.[<a class="bibr" href="#LM128.REF.3" rid="LM128.REF.3">3</a>,<a class="bibr" href="#LM128.REF.4" rid="LM128.REF.4">4</a>]</p><p>In a separate study reported in the same paper, 3 women who had delivered via cesarean section and were receiving glyburide 5 mg daily in the immediate postoperative period had milk glyburide levels measured. Trough glyburide milk levels were undetectable (<80 mcg/L).[<a class="bibr" href="#LM128.REF.3" rid="LM128.REF.3">3</a>]</p><p>A mother with diabetes caused by a genetic mutation required a very high dose of 85 mg daily of glyburide, which was increased to 90 mg daily during pregnancy. Her milk glyburide levels were 7.3 mcg/L on day 3 postpartum and 3.1 mcg/L on day 6, although the times with respect to the dosage were not reported. The authors estimated that the breastfed infant would receive a daily dosage of less than 0.01 mg daily.[<a class="bibr" href="#LM128.REF.5" rid="LM128.REF.5">5</a>]</p><p><i>Infant Levels.</i> A preterm infant whose mother was taking a high dose of glyburide of 90 mg daily at delivery was hypoglycemic at birth and required high doses of intravenous glucose for 8 days after birth. The infant was breastfed (extent not stated) and had glyburide serum levels of 9 mcg/L on day 3 postpartum and 9.8 mcg/L on day 19. The authors speculated that breastfeeding might have prolonged the infant's high serum glyburide levels, although they calculated that the infant would have received less than 0.01 mg of the drug daily via breastmilk.[<a class="bibr" href="#LM128.REF.5" rid="LM128.REF.5">5</a>]</p></div><div id="LM128.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>The blood glucose level was normal in one breastfed infant whose mothers was taking oral glyburide 5 mg daily.[<a class="bibr" href="#LM128.REF.3" rid="LM128.REF.3">3</a>]</p></div><div id="LM128.Effects_on_Lactation_and_Breastmil"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM128.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM1/?report=reader">Acarbose</a>, <a href="/books/n/lactmed/LM127/?report=reader">Glipizide</a>, <a href="/books/n/lactmed/LM147/?report=reader">Insulin</a>, <a href="/books/n/lactmed/LM173/?report=reader">Metformin</a>, <a href="/books/n/lactmed/LM407/?report=reader">Miglitol</a></p></div><div id="LM128.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM128.REF.1">Everett
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JA. Use of oral antidiabetic agents during breastfeeding.
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J Hum Lact
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1997;13:319-21.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/9429368" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 9429368</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM128.REF.2">Berlin
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CM, Briggs
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GG. Drugs and chemicals in human milk.
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Semin Fetal Neonatal Med
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2005;10:149-59.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/15701580" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15701580</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM128.REF.3">Feig
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DS, Briggs
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GG, Kraemer
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JM, et al.
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Transfer of glyburide and glipizide into breast milk.
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Diabetes Care
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2005;28:1851-5.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/16043722" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16043722</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM128.REF.4">Feig
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DS, Kraemer
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JM, Moskovitz
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DN, et al.
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The transfer of glyburide into breast milk.
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Clin Pharmacol Ther
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2004;75:P24. doi:10.1016/j.clpt.2003.11.089 [<a href="http://dx.crossref.org/10.1016/j.clpt.2003.11.089" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM128.REF.5">Myngheer
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N, Allegaert
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K, Hattersley
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A, et al.
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Fetal macrosomia and neonatal hyperinsulinemic hypoglycemia associated with transplacental transfer of sulfonylurea in a mother with KCNJ11-related neonatal diabetes.
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Diabetes Care
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2014;37:3333-5.
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[<a href="/pmc/articles/PMC5894804/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5894804</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25231897" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25231897</span></a>]</div></dd></dl></dl></div></div><div id="LM128.Substance_Identification"><h2 id="_LM128_Substance_Identification_">Substance Identification</h2><div id="LM128.Substance_Name"><h3>Substance Name</h3><p>Glyburide</p></div><div id="LM128.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>10238-21-8</p></div><div id="LM128.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Hypoglycemic Agents</p><p>Sulfonylurea Compounds</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK500865_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">June 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Glyburide. [Updated 2024 Jun 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM950/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1321/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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