144 lines
No EOL
18 KiB
XML
144 lines
No EOL
18 KiB
XML
<?xml version="1.0" encoding="utf-8"?>
|
|
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
|
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
|
|
|
|
<head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
|
<!-- AppResources meta begin -->
|
|
<meta name="paf-app-resources" content="" />
|
|
<script type="text/javascript">var ncbi_startTime = new Date();</script>
|
|
|
|
<!-- AppResources meta end -->
|
|
|
|
<!-- TemplateResources meta begin -->
|
|
<meta name="paf_template" content="" />
|
|
|
|
<!-- TemplateResources meta end -->
|
|
|
|
<!-- Logger begin -->
|
|
<meta name="ncbi_db" content="books" /><meta name="ncbi_pdid" content="book-part" /><meta name="ncbi_acc" content="NBK500824" /><meta name="ncbi_domain" content="lactmed" /><meta name="ncbi_report" content="printable" /><meta name="ncbi_type" content="fulltext" /><meta name="ncbi_objectid" content="" /><meta name="ncbi_pcid" content="/NBK500824/?report=printable" /><meta name="ncbi_app" content="bookshelf" />
|
|
<!-- Logger end -->
|
|
|
|
<title>Sofosbuvir - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
|
|
|
|
<!-- AppResources external_resources begin -->
|
|
<link rel="stylesheet" href="/core/jig/1.15.2/css/jig.min.css" /><script type="text/javascript" src="/core/jig/1.15.2/js/jig.min.js"></script>
|
|
|
|
<!-- AppResources external_resources end -->
|
|
|
|
<!-- Page meta begin -->
|
|
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Sofosbuvir" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2023/09/15" /><meta name="citation_pmid" content="29999883" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK500824/" /><meta name="citation_keywords" content="Sofosbuvir" /><meta name="citation_keywords" content="PSI-7977" /><meta name="citation_keywords" content="Sovaldi" /><meta name="citation_keywords" content="Hepcinat" /><meta name="citation_keywords" content="Hepcvir" /><meta name="citation_keywords" content="Resof" /><meta name="citation_keywords" content="SoviHep" /><meta name="citation_keywords" content="Vosevi" /><meta name="citation_keywords" content="Harvoni" /><meta name="citation_keywords" content="Epclusa" /><meta name="citation_keywords" content="UNII-WJ6CA3ZU8B" /><meta name="citation_keywords" content="PSI 7977" /><meta name="citation_keywords" content="1620486-68-1" /><meta name="citation_keywords" content="WJ6CA3ZU8B" /><meta name="citation_keywords" content="GS-7977" /><meta name="citation_keywords" content="GS 7977" /><meta name="citation_keywords" content="HSDB 8226" /><meta name="citation_keywords" content="2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester" /><meta name="citation_keywords" content="L-Alanine, N-((P(S),2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl)-, 1-methylethyl ester" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Sofosbuvir" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2023/09/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK500824/" /><meta name="description" content="Sofosbuvir has not been well studied in nursing mothers being treated for hepatitis C infection, although one infant was breastfed for 3 weeks and had no developmental abnormalities. If sofosbuvir alone or in combination with ledipasvir (Harvoni) is required by the mother, it is not a reason to discontinue breastfeeding.[1] Some sources recommend against breastfeeding when sofosbuvir is used with ribavirin." /><meta name="og:title" content="Sofosbuvir" /><meta name="og:type" content="book" /><meta name="og:description" content="Sofosbuvir has not been well studied in nursing mothers being treated for hepatitis C infection, although one infant was breastfed for 3 weeks and had no developmental abnormalities. If sofosbuvir alone or in combination with ledipasvir (Harvoni) is required by the mother, it is not a reason to discontinue breastfeeding.[1] Some sources recommend against breastfeeding when sofosbuvir is used with ribavirin." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK500824/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM1242/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK500824/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
|
|
|
|
<!-- Page meta end -->
|
|
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8B49FF7D837251000000000098008B.m_5" />
|
|
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3985586/3808861/4121862/3974050/3917732/251717/4216701/14534/45193/4113719/3849091/3984811/3751656/4033350/3840896/3577051/3852958/3984801/12930/3964959.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3411343/3882866.css" media="print" /></head>
|
|
<body class="book-part">
|
|
<div class="grid no_max_width">
|
|
<div class="col twelve_col nomargin shadow">
|
|
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
|
|
<div class="sysmessages">
|
|
<noscript>
|
|
<p class="nojs">
|
|
<strong>Warning:</strong>
|
|
The NCBI web site requires JavaScript to function.
|
|
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
|
</p>
|
|
</noscript>
|
|
</div>
|
|
<!--/.sysmessage-->
|
|
<div class="wrap">
|
|
<div class="page">
|
|
<div class="top">
|
|
|
|
<div class="header">
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<!--<component id="Page" label="headcontent"/>-->
|
|
|
|
</div>
|
|
<div class="content">
|
|
<!-- site messages -->
|
|
<div class="container content">
|
|
<div class="document">
|
|
<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
|
|
<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK500824_"><span class="title" itemprop="name">Sofosbuvir</span></h1><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2023</span>.</p><p><em>Estimated reading time: 2 minutes</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 1190307-88-0</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135267508" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135267508" alt="image 135267508 in the ncbi pubchem database" /></a><div id="LM1242.Drug_Levels_and_Effects"><h2 id="_LM1242_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1242.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Sofosbuvir has not been well studied in nursing mothers being treated for hepatitis C infection, although one infant was breastfed for 3 weeks and had no developmental abnormalities. If sofosbuvir alone or in combination with ledipasvir (Harvoni) is required by the mother, it is not a reason to discontinue breastfeeding.[<a class="bk_pop" href="#LM1242.REF.1">1</a>] Some sources recommend against breastfeeding when sofosbuvir is used with ribavirin.</p><p>Hepatitis C is not transmitted through breastmilk and breastmilk has been shown to inactivate hepatitis C virus (HCV).[<a class="bk_pop" href="#LM1242.REF.2">2</a>-<a class="bk_pop" href="#LM1242.REF.5">5</a>] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C.</p><p>Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.[<a class="bk_pop" href="#LM1242.REF.2">2</a>,<a class="bk_pop" href="#LM1242.REF.5">5</a>]</p></div><div id="LM1242.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1242.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>An infant was breastfed (extent not stated) for 3 weeks postpartum by a mother who took sofosbuvir 400 mg plus ledipasvir 90 mg daily for 12 weeks beginning at 31 weeks of gestation for her chronic hepatitis C infection. The infant was followed for 1 year and found to have normal growth and development.[<a class="bk_pop" href="#LM1242.REF.6">6</a>]</p></div><div id="LM1242.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1242.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>(Hepatitis C) <a href="/books/n/lactmed/LM148/">Interferon Alfa</a>, <a href="/books/n/lactmed/LM581/">Interferon Alfacon-1</a>, <a href="/books/n/lactmed/LM1082/">Peginterferon Alfa</a></p></div><div id="LM1242.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM1242.REF.1">Spera
|
|
AM, Eldin
|
|
TK, Tosone
|
|
G, Orlando
|
|
R. Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?
|
|
World J Hepatol
|
|
2016;8:557-65. [<a href="/pmc/articles/PMC4840161/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4840161</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27134703" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27134703</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM1242.REF.2">Cottrell
|
|
EB, Chou
|
|
R, Wasson
|
|
N, et al.
|
|
Reducing risk for mother-to-infant transmission of hepatitis C virus: A systematic review for the U.S. Preventive Services Task Force.
|
|
Ann Intern Med
|
|
2013;158:109-13. [<a href="https://pubmed.ncbi.nlm.nih.gov/23437438" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 23437438</span></a>]</div></dd><dt>3.</dt><dd><div class="bk_ref" id="LM1242.REF.3">Pfaender
|
|
S, Heyden
|
|
J, Friesland
|
|
M, et al.
|
|
Inactivation of hepatitis C virus infectivity by human breast milk.
|
|
J Infect Dis
|
|
2013;208:1943-52. [<a href="https://pubmed.ncbi.nlm.nih.gov/24068703" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24068703</span></a>]</div></dd><dt>4.</dt><dd><div class="bk_ref" id="LM1242.REF.4">Tovo
|
|
PA, Calitri
|
|
C, Scolfaro
|
|
C, et al.
|
|
Vertically acquired hepatitis C virus infection: Correlates of transmission and disease progression.
|
|
World J Gastroenterol
|
|
2016;22:1382-92. [<a href="/pmc/articles/PMC4721973/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4721973</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26819507" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26819507</span></a>]</div></dd><dt>5.</dt><dd><div class="bk_ref" id="LM1242.REF.5">Workowski
|
|
KA, Bachmann
|
|
LH, Chan
|
|
PA, et al.
|
|
Sexually transmitted infections treatment guidelines, 2021.
|
|
MMWR Recomm Rep
|
|
2021;70:1-187. [<a href="/pmc/articles/PMC8344968/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC8344968</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/34292926" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 34292926</span></a>]</div></dd><dt>6.</dt><dd><div class="bk_ref" id="LM1242.REF.6">Zeng
|
|
QL, Yu
|
|
ZJ, Lv
|
|
J, et al.
|
|
Sofosbuvir-based therapy for late pregnant women and infant with severe chronic hepatitis C: A case series study.
|
|
J Med Virol
|
|
2022;94:4548-53. [<a href="https://pubmed.ncbi.nlm.nih.gov/35595682" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 35595682</span></a>]</div></dd></dl></div></div><div id="LM1242.Substance_Identification"><h2 id="_LM1242_Substance_Identification_">Substance Identification</h2><div id="LM1242.Substance_Name"><h3>Substance Name</h3><p>Sofosbuvir</p></div><div id="LM1242.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>1190307-88-0</p></div><div id="LM1242.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Antiviral Agents</p><p>Nucleotides</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
|
|
<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK500824</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29999883" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">29999883</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM1453/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/LM767/" title="Next page in this title">Next ></a></div></div></div></div>
|
|
|
|
</div>
|
|
</div>
|
|
</div>
|
|
<div class="bottom">
|
|
|
|
<div id="NCBIFooter_dynamic">
|
|
<!--<component id="Breadcrumbs" label="breadcrumbs"/>
|
|
<component id="Breadcrumbs" label="helpdesk"/>-->
|
|
|
|
</div>
|
|
|
|
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"> </script>
|
|
</div>
|
|
</div>
|
|
<!--/.page-->
|
|
</div>
|
|
<!--/.wrap-->
|
|
</div><!-- /.twelve_col -->
|
|
</div>
|
|
<!-- /.grid -->
|
|
|
|
<span class="PAFAppResources"></span>
|
|
|
|
<!-- BESelector tab -->
|
|
|
|
|
|
|
|
<noscript><img alt="statistics" src="/stat?jsdisabled=true&ncbi_db=books&ncbi_pdid=book-part&ncbi_acc=NBK500824&ncbi_domain=lactmed&ncbi_report=printable&ncbi_type=fulltext&ncbi_objectid=&ncbi_pcid=/NBK500824/?report=printable&ncbi_app=bookshelf" /></noscript>
|
|
|
|
|
|
<!-- usually for JS scripts at page bottom -->
|
|
<!--<component id="PageFixtures" label="styles"></component>-->
|
|
|
|
|
|
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal104 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
|
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
|
|
|
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3879255/4121861/3501987/4008961/3893018/3821238/3400083/3426610.js" snapshot="books"></script></body>
|
|
</html> |