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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Deferasirox - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Deferasirox">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2024/06/15">
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<meta name="citation_keywords" content="Deferasirox">
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<meta name="citation_keywords" content="Exjade">
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<meta name="citation_keywords" content="Deferasiroxum">
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<meta name="citation_keywords" content="Jadenu">
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<meta name="citation_keywords" content="Jadenu Sprinkle">
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<meta name="citation_keywords" content="ICL670A">
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<meta name="citation_keywords" content="Deferasiroxum [INN-Latin]">
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<meta name="citation_keywords" content="ICL 670A">
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<meta name="citation_keywords" content="4-(3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid">
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<meta name="citation_keywords" content="Benzoic acid, 4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)-">
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<meta name="DC.Title" content="Deferasirox">
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<meta name="description" content="Deferasirox appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during deferasirox treatment,[1] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving deferasirox and finding of no drug in breastmilk.[2] However, since little published information is available on the use of deferasirox during breastfeeding, monitoring of the infant's serum iron is recommended.">
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<meta name="og:description" content="Deferasirox appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during deferasirox treatment,[1] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving deferasirox and finding of no drug in breastmilk.[2] However, since little published information is available on the use of deferasirox during breastfeeding, monitoring of the infant's serum iron is recommended.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK500812_"><span class="title" itemprop="name">Deferasirox</span></h1><p class="fm-aai"><a href="#_NBK500812_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 201530-41-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135129477" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135129477" alt="image 135129477 in the ncbi pubchem database" /></a><div id="LM1231.Drug_Levels_and_Effects"><h2 id="_LM1231_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1231.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Deferasirox appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during deferasirox treatment,[<a class="bibr" href="#LM1231.REF.1" rid="LM1231.REF.1">1</a>] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving deferasirox and finding of no drug in breastmilk.[<a class="bibr" href="#LM1231.REF.2" rid="LM1231.REF.2">2</a>] However, since little published information is available on the use of deferasirox during breastfeeding, monitoring of the infant's serum iron is recommended.</p></div><div id="LM1231.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A woman with beta-thalassemia was started on deferasirox 2250 mg (35 mg/kg) daily immediately postpartum. The drug was undetectable (<0.1 mcg/L) in a milk sample taken 2 hours after a dose.[<a class="bibr" href="#LM1231.REF.2" rid="LM1231.REF.2">2</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1231.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>A woman with beta-thalassemia was started on deferasirox 2250 mg (35 mg/kg) daily immediately postpartum and exclusively breastfed her infant. Blood samples were taken from the infant at 1, 10 and 30 days postpartum. Serum ferritin levels were 190, 218, and 96 mcg/L, respectively (normal range 22 to 275 mcg/L). Serum iron levels were 101, 77 and 71 mcg/dL, respectively (normal range 60 to 170 mcg/dL). The infant's growth was normal during the first month at the 41st percentile.[<a class="bibr" href="#LM1231.REF.2" rid="LM1231.REF.2">2</a>]</p></div><div id="LM1231.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1231.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>
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<a href="/books/n/lactmed/LM1230/?report=reader">Deferoxamine</a>
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</p></div><div id="LM1231.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM1231.REF.1">Ho
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PJ, Tay
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L, Lindeman
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R, et al.
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Australian guidelines for the assessment of iron overload and iron chelation in transfusion-dependent thalassaemia major, sickle cell disease and other congenital anaemias.
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Intern Med J
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2011;41:516-24.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/21615659" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21615659</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM1231.REF.2">Giampreti
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A, Mattioli
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F, Faraoni
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L, et al.
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Lactation in beta-thalassemia major: Is deferasirox compatible? The first case with clinical data and breastmilk concentrations.
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Clin Toxicol
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2018;56:539. doi:10.1080/15563650.2018.1457818 [<a href="http://dx.crossref.org/10.1080/15563650.2018.1457818" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl></dl></div></div><div id="LM1231.Substance_Identification"><h2 id="_LM1231_Substance_Identification_">Substance Identification</h2><div id="LM1231.Substance_Name"><h3>Substance Name</h3><p>Deferasirox</p></div><div id="LM1231.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>201530-41-8</p></div><div id="LM1231.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Chelating Agents</p><p>Iron Chelating Agents</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK500812_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">June 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Deferasirox. [Updated 2024 Jun 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM1227/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1232/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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