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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Deferasirox" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/06/15" /><meta name="citation_pmid" content="29999871" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK500812/" /><meta name="citation_keywords" content="Deferasirox" /><meta name="citation_keywords" content="Exjade" /><meta name="citation_keywords" content="Deferasiroxum" /><meta name="citation_keywords" content="Jadenu" /><meta name="citation_keywords" content="Jadenu Sprinkle" /><meta name="citation_keywords" content="ICL670A" /><meta name="citation_keywords" content="Deferasiroxum [INN-Latin]" /><meta name="citation_keywords" content="ICL 670A" /><meta name="citation_keywords" content="ICL 670" /><meta name="citation_keywords" content="UNII-V8G4MOF2V9" /><meta name="citation_keywords" content="ICL670" /><meta name="citation_keywords" content="V8G4MOF2V9" /><meta name="citation_keywords" content="HSDB 7844" /><meta name="citation_keywords" content="4-(3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid" /><meta name="citation_keywords" content="Benzoic acid, 4-(3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)-" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Deferasirox" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/06/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK500812/" /><meta name="description" content="Deferasirox appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during deferasirox treatment,[1] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving deferasirox and finding of no drug in breastmilk.[2] However, since little published information is available on the use of deferasirox during breastfeeding, monitoring of the infant's serum iron is recommended." /><meta name="og:title" content="Deferasirox" /><meta name="og:type" content="book" /><meta name="og:description" content="Deferasirox appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during deferasirox treatment,[1] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving deferasirox and finding of no drug in breastmilk.[2] However, since little published information is available on the use of deferasirox during breastfeeding, monitoring of the infant's serum iron is recommended." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK500812/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM1231/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK500812/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK500812_"><span class="title" itemprop="name">Deferasirox</span></h1><p class="small">Last Revision: <span itemprop="dateModified">June 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 201530-41-8</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135129477" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135129477" alt="image 135129477 in the ncbi pubchem database" /></a><div id="LM1231.Drug_Levels_and_Effects"><h2 id="_LM1231_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1231.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Deferasirox appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during deferasirox treatment,[<a class="bk_pop" href="#LM1231.REF.1">1</a>] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving deferasirox and finding of no drug in breastmilk.[<a class="bk_pop" href="#LM1231.REF.2">2</a>] However, since little published information is available on the use of deferasirox during breastfeeding, monitoring of the infant's serum iron is recommended.</p></div><div id="LM1231.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> A woman with beta-thalassemia was started on deferasirox 2250 mg (35 mg/kg) daily immediately postpartum. The drug was undetectable (<0.1 mcg/L) in a milk sample taken 2 hours after a dose.[<a class="bk_pop" href="#LM1231.REF.2">2</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1231.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>A woman with beta-thalassemia was started on deferasirox 2250 mg (35 mg/kg) daily immediately postpartum and exclusively breastfed her infant. Blood samples were taken from the infant at 1, 10 and 30 days postpartum. Serum ferritin levels were 190, 218, and 96 mcg/L, respectively (normal range 22 to 275 mcg/L). Serum iron levels were 101, 77 and 71 mcg/dL, respectively (normal range 60 to 170 mcg/dL). The infant's growth was normal during the first month at the 41st percentile.[<a class="bk_pop" href="#LM1231.REF.2">2</a>]</p></div><div id="LM1231.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1231.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p>
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<a href="/books/n/lactmed/LM1230/">Deferoxamine</a>
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</p></div><div id="LM1231.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM1231.REF.1">Ho
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PJ, Tay
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L, Lindeman
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R, et al.
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Australian guidelines for the assessment of iron overload and iron chelation in transfusion-dependent thalassaemia major, sickle cell disease and other congenital anaemias.
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Intern Med J
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2011;41:516-24.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/21615659" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21615659</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM1231.REF.2">Giampreti
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A, Mattioli
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F, Faraoni
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L, et al.
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Lactation in beta-thalassemia major: Is deferasirox compatible? The first case with clinical data and breastmilk concentrations.
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Clin Toxicol
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2018;56:539. doi:10.1080/15563650.2018.1457818 [<a href="http://dx.crossref.org/10.1080/15563650.2018.1457818" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></dd></dl></div></div><div id="LM1231.Substance_Identification"><h2 id="_LM1231_Substance_Identification_">Substance Identification</h2><div id="LM1231.Substance_Name"><h3>Substance Name</h3><p>Deferasirox</p></div><div id="LM1231.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>201530-41-8</p></div><div id="LM1231.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Chelating Agents</p><p>Iron Chelating Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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