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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Technetium Tc 99m Gluconate - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_keywords" content="Technetium Tc-99m gluconate">
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<meta name="citation_keywords" content="Technetium (99mtc) gluconate">
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<meta name="citation_keywords" content="Technetium Tc 99m gluconate">
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<meta name="citation_keywords" content="D-Gluconic acid, technetium-99Tc salt">
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<meta name="citation_keywords" content="D-Gluconic acid, technetium-99Tc(5+) salt">
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<meta name="description" content='Information in this record refers to the use of technetium Tc 99m gluconate as a diagnostic agent. A US Nuclear Regulatory Commission subcommittee has recommended that nursing be discontinued for 24 hours after administration of all technetium Tc 99m diagnostic products to simplify guidance recommendations, although this time interval may be longer than necessary.[1] Other experts state that breastfeeding need not be interrupted after administration of Tc 99m gluconate.[2] However, to follow the principle of keeping exposure "as low as reasonably achievable", some experts recommend nursing the infant just before administration of the radiopharmaceutical and interrupting breastfeeding for 3 to 6 hours after the dose, then expressing the milk completely once and discarding it. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[3-5]'>
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<meta name="og:description" content='Information in this record refers to the use of technetium Tc 99m gluconate as a diagnostic agent. A US Nuclear Regulatory Commission subcommittee has recommended that nursing be discontinued for 24 hours after administration of all technetium Tc 99m diagnostic products to simplify guidance recommendations, although this time interval may be longer than necessary.[1] Other experts state that breastfeeding need not be interrupted after administration of Tc 99m gluconate.[2] However, to follow the principle of keeping exposure "as low as reasonably achievable", some experts recommend nursing the infant just before administration of the radiopharmaceutical and interrupting breastfeeding for 3 to 6 hours after the dose, then expressing the milk completely once and discarding it. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[3-5]'>
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK500787_"><span class="title" itemprop="name">Technetium Tc 99m Gluconate</span></h1><p class="fm-aai"><a href="#_NBK500787_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 2 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 78812-55-2</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/249819665" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=249819665" alt="image 249819665 in the ncbi pubchem database" /></a><div id="LM1209.Drug_Levels_and_Effects"><h2 id="_LM1209_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1209.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Information in this record refers to the use of technetium Tc 99m gluconate as a diagnostic agent. A US Nuclear Regulatory Commission subcommittee has recommended that nursing be discontinued for 24 hours after administration of all technetium Tc 99m diagnostic products to simplify guidance recommendations, although this time interval may be longer than necessary.[<a class="bibr" href="#LM1209.REF.1" rid="LM1209.REF.1">1</a>] Other experts state that breastfeeding need not be interrupted after administration of Tc 99m gluconate.[<a class="bibr" href="#LM1209.REF.2" rid="LM1209.REF.2">2</a>] However, to follow the principle of keeping exposure "as low as reasonably achievable", some experts recommend nursing the infant just before administration of the radiopharmaceutical and interrupting breastfeeding for 3 to 6 hours after the dose, then expressing the milk completely once and discarding it. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[<a class="bibr" href="#LM1209.REF.3" rid="LM1209.REF.3">3</a>-<a class="bibr" href="#LM1209.REF.5" rid="LM1209.REF.5">5</a>]</p><p>Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level, she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[<a class="bibr" href="#LM1209.REF.6" rid="LM1209.REF.6">6</a>]</p><p>For nursing mothers who work with Tc 99m substances in their workplace, there is no need to take any precautions other than those appropriate for general radiation protection.[<a class="bibr" href="#LM1209.REF.7" rid="LM1209.REF.7">7</a>]</p></div><div id="LM1209.Drug_Levels"><h3>Drug Levels</h3><p>Tc 99m is a gamma emitter with a principal photon energy of 140 keV and a physical half-life of 6.04 hours.[<a class="bibr" href="#LM1209.REF.1" rid="LM1209.REF.1">1</a>]</p></div><div id="LM1209.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1209.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1209.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM1209.REF.1">Dilsizian V, Metter D, Palestro C, Zanzonico P. Advisory Committee on Medical Uses of Isotopes (ACMUI) Sub-Committee on Nursing Mother Guidelines for the Medical Administration of Radioactive Material. Final report submitted: January 31, 2019. 2019. <a href="https://www.nrc.gov/docs/ML1903/ML19038A498.pdf" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.nrc.gov/docs<wbr style="display:inline-block"></wbr>​/ML1903/ML19038A498.pdf</a></div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM1209.REF.2">Mattsson
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S, Johansson
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L, Leide Svegborn
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S, et al.
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Radiation dose to patients from radiopharmaceuticals: A compendium of current information related to frequently used substances. ICRP Publication 128. Annex D. Recommendations on breast-feeding interruptions.
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Ann ICRP
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2015;44:319-21. [<a href="https://pubmed.ncbi.nlm.nih.gov/26069086" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26069086</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="LM1209.REF.3">Mountford
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PJ, Coakley
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AJ. A review of the secretion of radioactivity in human breast milk: Data, quantitative analysis and recommendations.
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Nucl Med Commun
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1989;10:15-27.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/2645546" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 2645546</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="LM1209.REF.4">Early PJ, Sodee DB. Principles and practice of nuclear medicine. 2nd ed. St Louis Mosby-Year Book, Inc 1995:1380-1.</div></dd></dl><dl class="bkr_refwrap"><dt>5.</dt><dd><div class="bk_ref" id="LM1209.REF.5">ARSAC notes for guidance: Good clinical practice in nuclear medicine. Notes for guidance on the clinical administration of radiopharmaceuticals and use of sealed radioactive sources. 2020. <a href="https://www.gov.uk/government/publications/arsac-notes-for-guidance" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">https://www<wbr style="display:inline-block"></wbr>​.gov.uk/government<wbr style="display:inline-block"></wbr>​/publications<wbr style="display:inline-block"></wbr>​/arsac-notes-for-guidance</a> [<a href="https://pubmed.ncbi.nlm.nih.gov/10732169" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10732169</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>6.</dt><dd><div class="bk_ref" id="LM1209.REF.6">Stabin
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MG, Breitz
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HB. Breast milk excretion of radiopharmaceuticals: Mechanisms, findings, and radiation dosimetry.
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J Nucl Med
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2000;41:863-73.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/10809203" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10809203</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>7.</dt><dd><div class="bk_ref" id="LM1209.REF.7">Almén
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A, Mattsson
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S. Radiological protection of foetuses and breast-fed children of occupationally exposed women in nuclear medicine - Challenges for hospitals.
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Phys Med
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2017;43:172-7.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/28882410" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28882410</span></a>]</div></dd></dl></dl></div></div><div id="LM1209.Substance_Identification"><h2 id="_LM1209_Substance_Identification_">Substance Identification</h2><div id="LM1209.Substance_Name"><h3>Substance Name</h3><p>Technetium Tc 99m Gluconate</p></div><div id="LM1209.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>78812-55-2</p></div><div id="LM1209.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Radiopharmaceuticals</p><p>Technetium Compounds</p><p>Diagnostic Agents</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK500787_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">June 15, 2024</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Technetium Tc 99m Gluconate. [Updated 2024 Jun 15].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/LM679/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM1146/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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