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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Samarium Sm 153 Lexidronam Pentasodium - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_title" content="Samarium Sm 153 Lexidronam Pentasodium">
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<meta name="citation_keywords" content="Quadramet">
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<meta name="citation_keywords" content="Samarium-153 EDTMP">
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<meta name="citation_keywords" content="Samarium-153-ethylene diamine tetramethylene phosphonate">
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<meta name="citation_keywords" content="Samarium Sm-153 Lexidronam Pentasodium">
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<meta name="citation_keywords" content="DB09509">
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<meta name="citation_keywords" content="Samarium (153 Sm) lexidronam pentasodium">
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<meta name="description" content="Information in this record refers to the use of samarium Sm 153 lexidronam pentasodium as a therapeutic agent. No information is available on the use of samarium Sm 153 lexidronam pentasodium during breastfeeding. Most conditions treated with samarium Sm 153 would not occur in mothers wishing to nurse. However, the manufacturer recommends not administering the drug in women who wish to continue breastfeeding. Because of the relatively long half-life of samarium 153, the standard waiting period of 10 half-lives would be close to 3 weeks which might be impractical for resuming breastfeeding. The manufacturer and expert opinion recommend discontinuing breastfeeding if the agent is administered.[1]">
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<meta name="og:description" content="Information in this record refers to the use of samarium Sm 153 lexidronam pentasodium as a therapeutic agent. No information is available on the use of samarium Sm 153 lexidronam pentasodium during breastfeeding. Most conditions treated with samarium Sm 153 would not occur in mothers wishing to nurse. However, the manufacturer recommends not administering the drug in women who wish to continue breastfeeding. Because of the relatively long half-life of samarium 153, the standard waiting period of 10 half-lives would be close to 3 weeks which might be impractical for resuming breastfeeding. The manufacturer and expert opinion recommend discontinuing breastfeeding if the agent is administered.[1]">
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id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK500700_"><span class="title" itemprop="name">Samarium Sm 153 Lexidronam Pentasodium</span></h1><p class="fm-aai"><a href="#_NBK500700_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 160369-78-8</p><div id="LM1130.Drug_Levels_and_Effects"><h2 id="_LM1130_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1130.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Information in this record refers to the use of samarium Sm 153 lexidronam pentasodium as a therapeutic agent. No information is available on the use of samarium Sm 153 lexidronam pentasodium during breastfeeding. Most conditions treated with samarium Sm 153 would not occur in mothers wishing to nurse. However, the manufacturer recommends not administering the drug in women who wish to continue breastfeeding. Because of the relatively long half-life of samarium 153, the standard waiting period of 10 half-lives would be close to 3 weeks which might be impractical for resuming breastfeeding. The manufacturer and expert opinion recommend discontinuing breastfeeding if the agent is administered.[<a class="bibr" href="#LM1130.REF.1" rid="LM1130.REF.1">1</a>]</p><p>Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at background levels they may safely resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[<a class="bibr" href="#LM1130.REF.2" rid="LM1130.REF.2">2</a>]</p></div><div id="LM1130.Drug_Levels"><h3>Drug Levels</h3><p>Samarium Sm 153 emits both medium-energy beta particles and a gamma photon, and has a physical half-life of 1.93 days.</p></div><div id="LM1130.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1130.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1130.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM1130.REF.1">Bodei L, Lam M, Chiesa C, et al. EANM procedure guideline for treatment of refractory metastatic bone pain. <span><span class="ref-journal">Eur J Nucl Med Mol Imaging. </span>2008;<span class="ref-vol">35</span>:1934–40.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18649080" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18649080</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM1130.REF.2">Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: Mechanisms, findings, and radiation dosimetry. <span><span class="ref-journal">J Nucl Med. </span>2000;<span class="ref-vol">41</span>:863–73.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10809203" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10809203</span></a>]</div></dd></dl></dl></div></div><div id="LM1130.Substance_Identification"><h2 id="_LM1130_Substance_Identification_">Substance Identification</h2><div id="LM1130.Substance_Name"><h3>Substance Name</h3><p>Samarium Sm 153 Lexidronam Pentasodium</p></div><div id="LM1130.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>160369-78-8</p></div><div id="LM1130.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Radiopharmaceuticals</p><p>Samarium Radioisotopes</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK500700_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">August 17, 2020</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Samarium Sm 153 Lexidronam Pentasodium. 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