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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Nonoxynol-9" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2024/06/15" /><meta name="citation_pmid" content="29999743" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK500684/" /><meta name="citation_keywords" content="Nonoxynol-9" /><meta name="citation_keywords" content="Nonoxynol 9" /><meta name="citation_keywords" content="Delfen" /><meta name="citation_keywords" content="ToDay" /><meta name="citation_keywords" content="PEG-9 Nonyl phenyl ether" /><meta name="citation_keywords" content="Nonaethylene glycol nonylphenyl ether" /><meta name="citation_keywords" content="Nonylphenol octa(oxyethylene) ethanol" /><meta name="citation_keywords" content="HSDB 8094" /><meta name="citation_keywords" content="EINECS 247-816-5" /><meta name="citation_keywords" content="Nonaethylene glycol mono(nonylphenyl) ether" /><meta name="citation_keywords" content="Polyoxyethylene (9) nonyl phenyl ether" /><meta name="citation_keywords" content="Polyethylene glycol 450 nonyl phenyl ether" /><meta name="citation_keywords" content="26-(Nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol" /><meta name="citation_keywords" content="3,6,9,12,15,18,21,24-Octaoxahexacosan-1-ol, 26-(nonylphenoxy)-" /><meta name="citation_keywords" content="N 9" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Nonoxynol-9" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2024/06/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK500684/" /><meta name="description" content="Nonoxynol-9 is a relatively nontoxic nonionic surfactant and only trivial amounts of the drug have been found in the milk of animals after vaginal administration.[1] Limited information indicates that breastfed infants of mothers using vaginal nonoxynol-9 experienced no adverse effects. Vaginal use of nonoxynol-9 is acceptable in nursing mothers." /><meta name="og:title" content="Nonoxynol-9" /><meta name="og:type" content="book" /><meta name="og:description" content="Nonoxynol-9 is a relatively nontoxic nonionic surfactant and only trivial amounts of the drug have been found in the milk of animals after vaginal administration.[1] Limited information indicates that breastfed infants of mothers using vaginal nonoxynol-9 experienced no adverse effects. Vaginal use of nonoxynol-9 is acceptable in nursing mothers." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK500684/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM1116/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK500684/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK500684_"><span class="title" itemprop="name">Nonoxynol-9</span></h1><p class="small">Last Revision: <span itemprop="dateModified">June 15, 2024</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 26571-11-9</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135030146" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135030146" alt="image 135030146 in the ncbi pubchem database" /></a><div id="LM1116.Drug_Levels_and_Effects"><h2 id="_LM1116_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1116.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Nonoxynol-9 is a relatively nontoxic nonionic surfactant and only trivial amounts of the drug have been found in the milk of animals after vaginal administration.[<a class="bk_pop" href="#LM1116.REF.1">1</a>] Limited information indicates that breastfed infants of mothers using vaginal nonoxynol-9 experienced no adverse effects. Vaginal use of nonoxynol-9 is acceptable in nursing mothers.</p></div><div id="LM1116.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Relevant published information was not found as of the revision date.</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1116.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>In a study comparing various methods of contraception, the breastfed infants of women who used a nonoxynol-9-containing foam had no observable adverse effects.[<a class="bk_pop" href="#LM1116.REF.2">2</a>]</p></div><div id="LM1116.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Compared with a combination contraceptive containing ethinyl estradiol 30 mcg and levonorgestrel 150 mcg, women who used either nonoxynol-9 foam or copper-T IUD had less inhibition of lactation than the combined oral contraceptive.[<a class="bk_pop" href="#LM1116.REF.2">2</a>]</p></div><div id="LM1116.Alternate_Drugs_to_Consider"><h3>Alternate Drugs to Consider</h3><p><a href="/books/n/lactmed/LM622/">Etonogestrel</a>, <a href="/books/n/lactmed/LM1089/">Intrauterine Copper Contraceptive</a>, <a href="/books/n/lactmed/LM421/">Oral Levonorgestrel</a>, <a href="/books/n/lactmed/LM1335/">Intrauterine Levonorgestrel</a>, <a href="/books/n/lactmed/LM1336/">Levonorgestrel Implant</a>, <a href="/books/n/lactmed/LM415/">Medroxyprogesterone Acetate</a>, <a href="/books/n/lactmed/LM419/">Norethindrone</a>, <a href="/books/n/lactmed/LM470/">Progesterone</a></p></div><div id="LM1116.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM1116.REF.1">Johnson
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W, Jr. Final report on the safety assessment of octoxynol-1, octoxynol-3, octoxynol-5, octoxynol-6, octoxynol-7, octoxynol-8, octoxynol-9, octoxynol-10, octoxynol-11, octoxynol-12, octoxynol-13, octoxynol-16, octoxynol-20, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40, octoxynol-70, octoxynol-9 carboxylic acid, octoxynol-20 carboxylic acid, potassium octoxynol-12 phosphate, sodium octoxynol-2 ethane sulfonate, sodium octoxynol-2 sulfate, sodium octoxynol-6 sulfate, and sodium octoxynol-9 sulfate.
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Int J Toxicol
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2004;23
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Suppl 1:59-111.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/15162838" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15162838</span></a>]</div></dd><dt>2.</dt><dd><div class="bk_ref" id="LM1116.REF.2">Peralta
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O, Díaz
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S, Juez
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G, et al.
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Fertility regulation in nursing women: V. Long-term influence of a low-dose combined oral contraceptive initiated at day 90 postpartum on lactation and infant growth.
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Contraception
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1983;27:27-38.
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[<a href="https://pubmed.ncbi.nlm.nih.gov/6404597" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 6404597</span></a>]</div></dd></dl></div></div><div id="LM1116.Substance_Identification"><h2 id="_LM1116_Substance_Identification_">Substance Identification</h2><div id="LM1116.Substance_Name"><h3>Substance Name</h3><p>Nonoxynol-9</p></div><div id="LM1116.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>26571-11-9</p></div><div id="LM1116.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Contraceptive Agents</p><p>Spermatocidal Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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