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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Xenon - Drugs and Lactation Database (LactMed®) - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]">
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<meta name="citation_title" content="Xenon">
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<meta name="citation_publisher" content="National Institute of Child Health and Human Development">
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<meta name="citation_date" content="2021/06/21">
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<meta name="citation_keywords" content="XENON">
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<meta name="citation_keywords" content="Xenon, compressed">
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<meta name="citation_keywords" content="EINECS 231-172-7">
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<meta name="citation_keywords" content="UN2036">
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<meta name="citation_keywords" content="UN2591">
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<meta name="citation_keywords" content="7440-63-3">
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<meta name="citation_keywords" content="3H3U766W84">
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<meta name="citation_keywords" content="Xenon, refrigerated liquid (cryogenic liquids)">
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<meta name="citation_keywords" content="Xenon, compressed [UN2036] [Nonflammable gas]">
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<meta name="citation_keywords" content="Xenon, refrigerated liquid (cryogenic liquids) [UN2591] [Nonflammable gas]">
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<meta name="description" content="Xenon is an inert gas that has been used for general anesthesia. It was undetectable in breastmilk after extubation of the mothers. Breastfeeding can be resumed as soon as the mother has recovered sufficiently from general anesthesia to nurse.[1] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure.">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK500678_"><span class="title" itemprop="name">Xenon</span></h1><p class="fm-aai"><a href="#_NBK500678_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 1 minute</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><p>CASRN: 7440-63-3</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/134988675" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=134988675" alt="image 134988675 in the ncbi pubchem database" /></a><div id="LM1110.Drug_Levels_and_Effects"><h2 id="_LM1110_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1110.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Xenon is an inert gas that has been used for general anesthesia. It was undetectable in breastmilk after extubation of the mothers. Breastfeeding can be resumed as soon as the mother has recovered sufficiently from general anesthesia to nurse.[<a class="bibr" href="#LM1110.REF.1" rid="LM1110.REF.1">1</a>] When a combination of anesthetic agents is used for a procedure, follow the recommendations for the most problematic medication used during the procedure.</p></div><div id="LM1110.Drug_Levels"><h3>Drug Levels</h3><p><i>Maternal Levels.</i> Two mothers who underwent general anesthesia were given propofol and remifentanil as induction agents and rocuronium for intubation. After induction, propofol was stopped and xenon inhalation was used to maintain anesthesia for 57 and 59 minutes, respectively. Xenon was undetectable in breastmilk at 0 and 300 minutes after extubation in both mothers.[<a class="bibr" href="#LM1110.REF.2" rid="LM1110.REF.2">2</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1110.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Four mothers who underwent general anesthesia were given propofol and remifentanil as induction agents and rocuronium for intubation. After induction, propofol was stopped and xenon inhalation was used to maintain anesthesia for between 57 and 70 minutes. Infants resumed breastfeeding from 1.5 to 5 hours after the end of surgery. None of the infants had noticeable symptoms of dizziness or drowsiness. All infants fared well at home after their mothers were discharged.[<a class="bibr" href="#LM1110.REF.2" rid="LM1110.REF.2">2</a>]</p></div><div id="LM1110.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1110.References"><h3>References</h3><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="LM1110.REF.1">Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. <span><span class="ref-journal">Paediatr Anaesth. </span>2014;<span class="ref-vol">24</span>:359–71.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/24372776" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24372776</span></a>]</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="LM1110.REF.2">Stuttmann R, Schafer C, Hilbert P, et al. The breast feeding mother and xenon anaesthesia: Four case reports. Breast feeding and xenon anaesthesia. <span><span class="ref-journal">BMC Anesthesiol. </span>2010;<span class="ref-vol">10</span>:1.</span> [<a href="/pmc/articles/PMC2837001/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2837001</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/20167123" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 20167123</span></a>]</div></dd></dl></dl></div></div><div id="LM1110.Substance_Identification"><h2 id="_LM1110_Substance_Identification_">Substance Identification</h2><div id="LM1110.Substance_Name"><h3>Substance Name</h3><p>Xenon</p></div><div id="LM1110.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>7440-63-3</p></div><div id="LM1110.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Anesthetics, Inhalation</p><p>Elements</p><p>Gases</p></div></div><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK500678_pubdet_">Publication Details</h2><h3>Publication History</h3><p class="small">Last Revision: <span itemprop="dateModified">June 21, 2021</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div></div><h3>Publisher</h3><p><a href="https://www.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Institute of Child Health and Human Development</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Xenon. [Updated 2021 Jun 21].<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/lactmed/xanomeline/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/lactmed/LM814/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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