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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="Drugs and Lactation Database (LactMed®) [Internet]" /><meta name="citation_title" content="Nitazoxanide" /><meta name="citation_publisher" content="National Institute of Child Health and Human Development" /><meta name="citation_date" content="2023/09/15" /><meta name="citation_pmid" content="29999627" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK500567/" /><meta name="citation_keywords" content="NITAZOXANIDE" /><meta name="citation_keywords" content="Alinia" /><meta name="citation_keywords" content="Nitazoxanida" /><meta name="citation_keywords" content="Nitazoxanidum" /><meta name="citation_keywords" content="55981-09-4" /><meta name="citation_keywords" content="Nitazoxanidum [INN-Latin]" /><meta name="citation_keywords" content="Nitazoxanida [INN-Spanish]" /><meta name="citation_keywords" content="UNII-SOA12P041N" /><meta name="citation_keywords" content="SOA12P041N" /><meta name="citation_keywords" content="Nitazoxanide [USAN:INN:BAN]" /><meta name="citation_keywords" content="NSC 697855" /><meta name="citation_keywords" content="EINECS 259-931-8" /><meta name="citation_keywords" content="2-(Acetolyloxy)-N-(5-nitro-2-thiazolyl)benzamide" /><meta name="citation_keywords" content="BRN 1225475" /><meta name="citation_keywords" content="Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-" /><meta name="citation_keywords" content="(2-((5-Nitro-2-thiazolyl)carbamoyl)phenyl)acetat" /><meta name="citation_keywords" content="PH 5776" /><meta name="citation_keywords" content="N-(5-Nitro-2-thiazolyl)salicylamide acetate (ester)" /><meta name="citation_keywords" content="N-(5-Nitrothiazol-2-yl)salicylamide acetate ester" /><meta name="citation_keywords" content="o-(N-(5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate" /><meta name="citation_keywords" content="Salicylamide, N-(5-nitro-2-thiazolyl)-, acetate (ester)" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Nitazoxanide" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Institute of Child Health and Human Development" /><meta name="DC.Date" content="2023/09/15" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK500567/" /><meta name="description" content="Limited information indicates that a maternal dose of 500 mg of nitazoxanide produces low levels of an active metabolite, tizoxanide, in breastmilk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. But until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant." /><meta name="og:title" content="Nitazoxanide" /><meta name="og:type" content="book" /><meta name="og:description" content="Limited information indicates that a maternal dose of 500 mg of nitazoxanide produces low levels of an active metabolite, tizoxanide, in breastmilk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. But until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK500567/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-lactmed-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/lactmed/LM1005/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK500567/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. </p></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK500567_"><span class="title" itemprop="name">Nitazoxanide</span></h1><p class="small">Last Revision: <span itemprop="dateModified">September 15, 2023</span>.</p><p><em>Estimated reading time: 1 minute</em></p></div><div class="body-content whole_rhythm" itemprop="text"><p>CASRN: 55981-09-4</p><a href="https://pubchem.ncbi.nlm.nih.gov/substance/135002935" title="View this structure in PubChem" class="img_link" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=pubchem"><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&sid=135002935" alt="image 135002935 in the ncbi pubchem database" /></a><div id="LM1005.Drug_Levels_and_Effects"><h2 id="_LM1005_Drug_Levels_and_Effects_">Drug Levels and Effects</h2><div id="LM1005.Summary_of_Use_during_Lactation"><h3>Summary of Use during Lactation</h3><p>Limited information indicates that a maternal dose of 500 mg of nitazoxanide produces low levels of an active metabolite, tizoxanide, in breastmilk and would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. But until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.</p></div><div id="LM1005.Drug_Levels"><h3>Drug Levels</h3><p>After oral administration, nitazoxanide is not found in the bloodstream, but is rapidly converted to the active metabolites, tizoxanide and tizoxanide glucuronide, which are detectable in plasma.</p><p><i>Maternal Levels.</i> A volunteer lactating mother took a single 500 mg oral dose of nitazoxanide as a commercial suspension (Nitazode, Al Andalous Medical Co., Cairo, Egypt). The concentration of the active metabolite, tizoxanide, was 1.4 mg/L at 6 hours after the dose. Tizoxanide glucuronide was not measured.[<a class="bk_pop" href="#LM1005.REF.1">1</a>]</p><p><i>Infant Levels.</i> Relevant published information was not found as of the revision date.</p></div><div id="LM1005.Effects_in_Breastfed_Infants"><h3>Effects in Breastfed Infants</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1005.Effects_on_Lactation_and_Breastmi"><h3>Effects on Lactation and Breastmilk</h3><p>Relevant published information was not found as of the revision date.</p></div><div id="LM1005.References"><h3>References</h3><dl class="temp-labeled-list"><dt>1.</dt><dd><div class="bk_ref" id="LM1005.REF.1">Hadad
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GM, Abdel Salam, RA, Emara
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S. Validated and optimized high-performance liquid chromatographic determination of tizoxanide, the main active metabolite of nitazoxanide in human urine, plasma and breast milk.
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J Chromatogr Sci
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2012;50:509-15. [<a href="https://pubmed.ncbi.nlm.nih.gov/22525879" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22525879</span></a>]</div></dd></dl></div></div><div id="LM1005.Substance_Identification"><h2 id="_LM1005_Substance_Identification_">Substance Identification</h2><div id="LM1005.Substance_Name"><h3>Substance Name</h3><p>Nitazoxanide</p></div><div id="LM1005.CAS_Registry_Number"><h3>CAS Registry Number</h3><p>55981-09-4</p></div><div id="LM1005.Drug_Class"><h3>Drug Class</h3><p>Breast Feeding</p><p>Lactation</p><p>Milk, Human</p><p>Anti-Infective Agents</p><p>Antiparasitic Agents</p></div></div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_top_margin"><p><b>Disclaimer: </b>Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.</p></p></div></dd></dl></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a><p class="small"><b>Attribution Statement:</b> LactMed is a registered trademark of the U.S. Department of Health and Human Services.</p></div><div class="small"><span class="label">Bookshelf ID: NBK500567</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/29999627" title="PubMed record of this page" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">29999627</a></span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/lactmed/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/lactmed/LM200/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/lactmed/nitisinone/" title="Next page in this title">Next ></a></div></div></div></div>
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