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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">&lt; Prev</span><a class="active page_link next" href="/books/n/op0525ppadd/ch1/" title="Next page in this title">Next &gt;</a></div></div></div>
<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="http://www.cadth.ca/" title="Canadian Agency for Drugs and Technologies in Health" class="img_link icnblk_img" ref="pagearea=logo&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-op0525ppadd-lrg.png" alt="Cover of Addendum to Interventions for the Treatment of Obstructive Sleep Apnea in Adults: A Health Technology Assessment &#x02013; Project Protocol" /></a><div class="icnblk_cntnt"><h1 id="_NBK487883_"><span itemprop="name">Addendum to Interventions for the Treatment of Obstructive Sleep Apnea in
Adults: A Health Technology Assessment &#x02013; Project Protocol</span></h1><p><i>CADTH Optimal Use Report, No. 6.1a</i></p><p class="contrib-group"><span itemprop="author">Khai Tran</span>, <span itemprop="author">Joanne Kim</span>, <span itemprop="author">Bernice Tsoi</span>, <span itemprop="author">Tamara Rader</span>, <span itemprop="author">Sarah Garland</span>, <span itemprop="author">Katherine Duthie</span>, <span itemprop="author">Ken Bond</span>, <span itemprop="author">Kelsey Seal</span>, <span itemprop="author">David Kaunelis</span>, <span itemprop="author">Dr. Fernanda Almeida</span>, <span itemprop="author">Lt. Col. Glenda Ross</span>, and <span itemprop="author">Major Roch Messier</span>.</p><a data-jig="ncbitoggler" href="#__NBK487883_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK487883_ai__"><p class="contrib-group"><h4>Authors</h4><span itemprop="author">Khai Tran</span>,<sup>1</sup> <span itemprop="author">Joanne Kim</span>,<sup>1</sup> <span itemprop="author">Bernice Tsoi</span>,<sup>1</sup> <span itemprop="author">Tamara Rader</span>,<sup>1</sup> <span itemprop="author">Sarah Garland</span>,<sup>1</sup> <span itemprop="author">Katherine Duthie</span>,<sup>2</sup> <span itemprop="author">Ken Bond</span>,<sup>1</sup> <span itemprop="author">Kelsey Seal</span>,<sup>1</sup> <span itemprop="author">David Kaunelis</span>,<sup>1</sup> <span itemprop="author">Dr. Fernanda Almeida</span>,<sup>3</sup> <span itemprop="author">Lt. Col. Glenda Ross</span>,<sup>4</sup> and <span itemprop="author">Major Roch Messier</span><sup>4</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup> CADTH, Ottawa, Ontario</div><div class="affiliation"><sup>2</sup> Alberta Health Services, Edmonton, Alberta</div><div class="affiliation"><sup>3</sup> University of British Columbia, Vancouver, British
Columbia</div><div class="affiliation"><sup>4</sup> Canadian Armed Forces</div></div><div class="half_rhythm">Ottawa (ON): <a href="http://www.cadth.ca/" ref="pagearea=meta&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher"><span itemprop="publisher">Canadian Agency for Drugs and Technologies in Health</span></a>; <span itemprop="datePublished">2016 Jun</span>.</div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK487883" data-jigconfig="modal:true">Copyright and
Permissions</a></span></li></ul></div><div id="_ncbi_dlg_cpyrght_NBK487883" style="display:none" title="Copyright and&#10; Permissions"><div><div>Copyright &#x000a9; 2016 CADTH.</div><div class="half_rhythm"><div>Except where otherwise noted, this work is distributed under the terms of
a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
licence (CC BY-NC-ND), a copy of which is available at <a href="http://creativecommons.org/licenses/by-nc-nd/4.0/" ref="pagearea=meta&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">http://creativecommons.org/licenses/by-nc-nd/4.0/</a></div></div></div></div><div class="bk_noprnt"><form method="get" action="/books/n/op0525ppadd/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div itemprop="description"><p>As a follow-up to the overview of reviews conducted for Research Questions 1a and 1b
in the main health technology assessment (HTA) protocol, and to address gaps within
the published systematic review (SR) literature, an SR of relevant published primary
studies on the clinical effectiveness, comparative clinical effectiveness, and
safety of interventions for the treatment of obstructive sleep apnea (OSA) in adults
will be conducted. Specifically, this SR will focus on addressing Research Questions
1a and 1b, in relation to certain combinations of interventions, comparators, and
outcomes that are missing in the overview of reviews, as listed in Table 1.</p></div><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK487883_toc_ch1" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK487883_toc_ch1"><a class="toc-item" href="/books/n/op0525ppadd/ch1/">CLINICAL REVIEW</a><ul id="toc_lst_NBK487883_toc_ch1" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK487883_toc_op0525pp_add_Study_Design"><a class="toc-item" href="/books/n/op0525ppadd/ch1/#op0525pp_add.Study_Design">Study Design</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_op0525pp_add_Literature_Search"><a class="toc-item" href="/books/n/op0525ppadd/ch1/#op0525pp_add.Literature_Search">Literature Search</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_op0525pp_add_Selection_Criteria"><a class="toc-item" href="/books/n/op0525ppadd/ch1/#op0525pp_add.Selection_Criteria">Selection Criteria</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_op0525pp_add_Exclusion_Criteria"><a class="toc-item" href="/books/n/op0525ppadd/ch1/#op0525pp_add.Exclusion_Criteria">Exclusion Criteria</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_op0525pp_add_Screening_and_Selecting_Stu"><a class="toc-item" href="/books/n/op0525ppadd/ch1/#op0525pp_add.Screening_and_Selecting_Stu">Screening and Selecting Studies for Inclusion</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_op0525pp_add_Data_Extraction"><a class="toc-item" href="/books/n/op0525ppadd/ch1/#op0525pp_add.Data_Extraction">Data Extraction</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_op0525pp_add_Risk_of_Bias_Assessments"><a class="toc-item" href="/books/n/op0525ppadd/ch1/#op0525pp_add.Risk_of_Bias_Assessments">Risk of Bias Assessments</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_op0525pp_add_Summary_of_Evidence"><a class="toc-item" href="/books/n/op0525ppadd/ch1/#op0525pp_add.Summary_of_Evidence">Summary of Evidence</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_RL1"><a class="toc-item" href="/books/n/op0525ppadd/RL1/">REFERENCES</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_app1"><a class="toc-item" href="/books/n/op0525ppadd/app1/">APPENDIX 1. LITERATURE SEARCH STRATEGY</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_app2"><a class="toc-item" href="/books/n/op0525ppadd/app2/">APPENDIX 2. FULL-TEXT SCREENING CHECKLIST</a></li><li class="half_rhythm" id="toc_itm_NBK487883_toc_app3"><a class="toc-item" href="/books/n/op0525ppadd/app3/">APPENDIX 3. DATA EXTRACTION FORM</a></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div class="pmc_boxed-text-box fm-sec whole_rhythm"><h3>About the Series</h3><div class="half_rhythm"><div>CADTH Optimal Use Report</div></div><div class="half_rhythm"><div>ISSN: 2369-7385</div></div></div><div><h4 class="inline">Suggested citation:</h4><p>Addendum to
Interventions for the treatment of obstructive sleep apnea in adults: a health
technology assessment &#x02014; project protocol. Ottawa: CADTH; 2016 June.
(CADTH optimal use report; vol.6, no.1a).</p></div><div><p id="P3">This report is prepared by the Canadian Agency for Drugs and Technologies in
Health (CADTH). This report contains a comprehensive review of existing public
literature, studies, materials, and other information and documentation
(collectively the &#x0201c;source documentation&#x0201d;) available to CADTH at the
time it was prepared, and it was guided by expert input and advice throughout its
preparation.</p><p id="P4">The information in this report is intended to help health care
decision-makers, patients, health care professionals, health systems leaders, and
policy-makers make well-informed decisions and thereby improve the quality of health
care services. The information in this report should not be used as a substitute for
the application of clinical judgment in respect to the care of a particular patient
or other professional judgment in any decision-making process, nor is it intended to
replace professional medical advice. While CADTH has taken care in the preparation
of this report to ensure that its contents are accurate, complete, and up-to-date,
CADTH does not make any guarantee to that effect. CADTH is not responsible for any
errors or omissions or injury, loss, or damage arising from or as a result of the
use (or misuse) of any information contained in or implied by the information in
this report.</p><p id="P5">CADTH takes sole responsibility for the final form and content of this
report. The statements, conclusions, and views expressed herein do not necessarily
represent the view of Health Canada or any provincial or territorial government.</p><p id="P6">Production of this report is made possible through a financial contribution
from Health Canada.</p></div><div><p>PROSPERO Registration Number: CRD42016036348</p></div></div></div>
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<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK487883/?report=reader">PubReader</a></li><li><a href="/books/NBK487883/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK487883" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK487883" style="display:none" title="Cite this Page"><div class="bk_tt">Tran K, Kim J, Tsoi B, et al. Addendum to Interventions for the Treatment of Obstructive Sleep Apnea in Adults: A Health Technology Assessment Project Protocol [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Jun. (CADTH Optimal Use Report, No. 6.1a.)<span class="bk_cite_avail"></span></div></div></li><li><a href="/books/n/op0525ppadd/pdf/">PDF version of this title</a> (400K)</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Other titles in this collection</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="source-links" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/n/cadthopcollect/">CADTH Optimal Use Reports</a></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related publications</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="document-links" 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