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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE,NOIMAGEINDEX" /><meta name="citation_inbook_title" content="Essentials of Glycobiology [Internet]. 3rd edition" /><meta name="citation_title" content="Foreword: Propelling a Field Forward" /><meta name="citation_publisher" content="Cold Spring Harbor Laboratory Press" /><meta name="citation_date" content="2017" /><meta name="citation_author" content="Ajit Varki" /><meta name="citation_author" content="Richard D Cummings" /><meta name="citation_author" content="Jeffrey D Esko" /><meta name="citation_author" content="Pamela Stanley" /><meta name="citation_author" content="Gerald W Hart" /><meta name="citation_author" content="Markus Aebi" /><meta name="citation_author" content="Alan G Darvill" /><meta name="citation_author" content="Taroh Kinoshita" /><meta name="citation_author" content="Nicolle H Packer" /><meta name="citation_author" content="James H Prestegard" /><meta name="citation_author" content="Ronald L Schnaar" /><meta name="citation_author" content="Peter H Seeberger" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK453040/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Foreword: Propelling a Field Forward" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="Cold Spring Harbor Laboratory Press" /><meta name="DC.Contributor" content="Ajit Varki" /><meta name="DC.Contributor" content="Richard D Cummings" /><meta name="DC.Contributor" content="Jeffrey D Esko" /><meta name="DC.Contributor" content="Pamela Stanley" /><meta name="DC.Contributor" content="Gerald W Hart" /><meta name="DC.Contributor" content="Markus Aebi" /><meta name="DC.Contributor" content="Alan G Darvill" /><meta name="DC.Contributor" content="Taroh Kinoshita" /><meta name="DC.Contributor" content="Nicolle H Packer" /><meta name="DC.Contributor" content="James H Prestegard" /><meta name="DC.Contributor" content="Ronald L Schnaar" /><meta name="DC.Contributor" content="Peter H Seeberger" /><meta name="DC.Date" content="2017" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK453040/" /><meta name="description" content="Publication of this third edition of Essentials of Glycobiology inspires a look back as well as a look forward. Rarely has a textbook played such a dominant role in defining, reporting, and guiding progress in a field. From a global perspective, the importance of its subject matter is obvious: glycans are the most abundant organic polymers in our biosphere. However, the complexity of these molecules can be intimidating. Glycan biosynthesis occurs in a combinatorial, non-template-driven fashion, in contrast to DNA, RNA, and protein. Glycan biosynthesis and degradation are driven by myriad enzymes, many of whose substrate specificities and kinetic mechanisms remain poorly defined. In addition, glycans perform an immense range of biological functions, serving, for example, as nutrient substrates, as participants in signaling pathways, and as scaffolds for building multicellular “machines.” Considering these realities, and the competing allure of many other scientific fields in this rapidly evolving era of genome-driven fundamental and applied science, it is not hard to understand why “glycobiologists” today have become an endangered species. On the other hand, the importance of their field has never been greater. Glycobiology is inherently interdisciplinary and radiates into, as well as being informed and “fertilized” by, so many other areas of biology." /><meta name="og:title" content="Foreword: Propelling a Field Forward" /><meta name="og:type" content="book" /><meta name="og:description" content="Publication of this third edition of Essentials of Glycobiology inspires a look back as well as a look forward. Rarely has a textbook played such a dominant role in defining, reporting, and guiding progress in a field. From a global perspective, the importance of its subject matter is obvious: glycans are the most abundant organic polymers in our biosphere. However, the complexity of these molecules can be intimidating. Glycan biosynthesis occurs in a combinatorial, non-template-driven fashion, in contrast to DNA, RNA, and protein. Glycan biosynthesis and degradation are driven by myriad enzymes, many of whose substrate specificities and kinetic mechanisms remain poorly defined. In addition, glycans perform an immense range of biological functions, serving, for example, as nutrient substrates, as participants in signaling pathways, and as scaffolds for building multicellular “machines.” Considering these realities, and the competing allure of many other scientific fields in this rapidly evolving era of genome-driven fundamental and applied science, it is not hard to understand why “glycobiologists” today have become an endangered species. On the other hand, the importance of their field has never been greater. Glycobiology is inherently interdisciplinary and radiates into, as well as being informed and “fertilized” by, so many other areas of biology." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK453040/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-glyco3-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/glyco3/foreword/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK579977/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. </p></div><div class="bk_msg_box bk_bttm_mrgn clearfix bk_noprnt"><div class="iconblock clearfix"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/glyco4/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-glyco4-lrg.png" alt="Cover" height="100px" width="80px" /></a><div class="icnblk_cntnt"><ul class="messages"><li class="info icon"><span class="icon"><a href="/books/n/glyco4/">A new version of this title is available</a></span></li><li class="info icon"><span class="icon"><a href="/books/NBK579977/">See the updated version of this chapter</a></span></li></ul></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK453040_"><span class="title" itemprop="name">Foreword: Propelling a Field Forward</span></h1><p class="small">Published online: 2017.</p></div><div class="body-content whole_rhythm" itemprop="text"><p>P<span class="small-caps">ublication of this third edition</span> of <i>Essentials of Glycobiology</i> inspires a look back as well as a look forward. Rarely has a textbook played such a dominant role in defining, reporting, and guiding progress in a field. From a global perspective, the importance of its subject matter is obvious: glycans are the most abundant organic polymers in our biosphere. However, the complexity of these molecules can be intimidating. Glycan biosynthesis occurs in a combinatorial, non-template-driven fashion, in contrast to DNA, RNA, and protein. Glycan biosynthesis and degradation are driven by myriad enzymes, many of whose substrate specificities and kinetic mechanisms remain poorly defined. In addition, glycans perform an immense range of biological functions, serving, for example, as nutrient substrates, as participants in signaling pathways, and as scaffolds for building multicellular “machines.” Considering these realities, and the competing allure of many other scientific fields in this rapidly evolving era of genome-driven fundamental and applied science, it is not hard to understand why “glycobiologists” today have become an endangered species. On the other hand, the importance of their field has never been greater. Glycobiology is inherently interdisciplinary and radiates into, as well as being informed and “fertilized” by, so many other areas of biology.</p><p>We all need mentors, and in many ways this textbook has served that function for both nascent and established glycobiologists; it has provoked thinking and provided stewardship as a cogent, consistent, and accessible source of accrued knowledge over its two- (and now three-) edition life span.</p><p>This knowledge is also timely as we consider the present and the future. Like many fields, glycobiology has benefited from high-throughput genomics, which has allowed rapid identification of potential glycan-modifying enzymes as well as glycan-binding proteins. This explosion of information is illustrated by the outpouring of microbiome sequencing projects, which are emphasizing how richly endowed microbes are with glycoside hydrolases, polysaccharide lyases, and glycosyltransferases not encoded in the genome of their respective hosts. Moving forward, ongoing analyses of microbial community function will undoubtedly provide new insights into how glycans serve as foundations for nutrient-sharing relationships between primary and secondary consumers in the food webs that sustain these communities. These analyses should also continue to reveal new details about how glycans function as microbial “signposts” recognized and accommodated by the host immune system so that mutually beneficial host–microbial relationships can be established and maintained, whereas in other contexts they are attacked by the immune system or function to cloak pathogens from recognition.</p><p>Ongoing improvements in the analytic tools used for characterizing glycan-containing molecules will propel efforts seeking to comprehensively define “glycomes” that comprise all of the glycans that can be made by a cell, tissue, or organism as a function of its differentiation, development, or physiological state. CRISPR-based genome editing tools will provide unprecedented opportunities to precisely manipulate glycan biosynthetic and degradative pathways within cells and thus ascertain the functions of their products. New chemical tools that allow modification of specified glycans in living cells should also facilitate studies of glycan function in different physiological and pathologic contexts. At the same time, improvements in glycan synthetic chemistry are yielding high-diversity libraries that enable the targets of carbohydrate-binding proteins to be determined. These improvements are also allowing specific glycans of interest to be produced in large quantities for a variety of purposes. For these and many other reasons, the readers and editors of this volume face an exciting future for glycobiology and, together, are poised to create that future.</p><div class="half_rhythm">
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Jeffrey I. Gordon<br />
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<i>Washington University School of Medicine</i><br />
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Lora V. Hooper<br />
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<i>University of Texas Southwestern Medical Center</i><br />
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<i>October 2016</i>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> 2015-2017 by The Consortium of Glycobiology Editors, La Jolla, California. All rights reserved.<p class="small">PDF files are not available for download.</p></div><div class="small"><span class="label">Bookshelf ID: NBK453040</span></div><div style="margin-top:2em" class="bk_noprnt"><a class="bk_cntns" href="/books/n/glyco3/">Contents</a><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/glyco3/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/glyco3/preface/" title="Next page in this title">Next ></a></div></div></div></div>
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