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<title>[Box], Clinical Case 5.6 - Endocrinology - NCBI Bookshelf</title>
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<meta name="robots" content="NOINDEX,NOFOLLOW,NOARCHIVE,NOIMAGEINDEX" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="[Box], Clinical Case 5.6" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="BIOS Scientific Publishers" /><meta name="DC.Contributor" content="Stephen Nussey" /><meta name="DC.Contributor" content="Saffron Whitehead" /><meta name="DC.Date" content="2001" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK24/" /><meta name="description" content="A 26-year-old man had been under long-term follow up for hypopituitarism as a result of the treatment of a very large 3rd ventricular brain tumor presenting at the age of 15 years. He had been treated by the insertion of a ventricular—peritoneal shunt to reduce hydrocephalus and 5500 cGy of craniospinal irradiation. Over the course of his 26th year, it was noted that his standing height decreased by 6 cm. His serum biochemistry was normal. In particular, the serum calcium was 2.45 mmol/l (NR 2.2–2.6 mmol/l), the Pi 1.1 mmol/l (NR 0.8–1.4 mmol/l) and the albumin 38 g/l (NR 38–48 g/l) and his replacement endocrine medication of hydrocortisone, thyroxine and mixed testosterone esters was unchanged. X-rays of his spine reveal marked osteoporosis (Box 5.34) that was confirmed on bone biopsy. Bone mineral density by dual X-ray absorptiometry was markedly reduced." /><meta name="bk-non-canon-loc" content="/books/n/endocrin/A742/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK24/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="main-content lit-style"><div class="body-content whole_rhythm"><div id="ch5cc6" class="box"><h3><span class="title">Clinical Case 5.6</span></h3><p>A 26-year-old man had been under long-term follow up for hypopituitarism as a result of the treatment of a very large 3rd ventricular brain tumor presenting at the age of 15 years. He had been treated by the insertion of a ventricular—peritoneal shunt to reduce hydrocephalus and 5500 cGy of craniospinal irradiation. Over the course of his 26th year, it was noted that his standing height decreased by 6 cm. His serum biochemistry was normal. In particular, the serum calcium was 2.45 mmol/l (NR 2.2–2.6 mmol/l), the P<sub>i</sub> 1.1 mmol/l (NR 0.8–1.4 mmol/l) and the albumin 38 g/l (NR 38–48 g/l) and his replacement endocrine medication of hydrocortisone, thyroxine and mixed testosterone esters was unchanged. X-rays of his spine reveal marked osteoporosis (Box 5.34) that was confirmed on bone biopsy. Bone mineral density by dual X-ray absorptiometry was markedly reduced.</p></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><p>From: <a href="/books/NBK24/" target="mainwindow">Chapter 5, The parathyroid glands and vitamin D</a></p><div class="iconblock clearfix ten_col"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/endocrin/" target="mainwindow"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-endocrin-lrg.png" alt="Cover of Endocrinology" height="100px" width="80px" /></a><div class="icnblk_cntnt"><div><div>Endocrinology: An Integrated Approach.</div><div>Nussey S, Whitehead S.</div><div>Oxford: <a href="http://www.garlandscience.com/about.asp" target="mainwindow" ref="pagearea=content-footer&targetsite=external&targetcat=link&targettype=publisher">BIOS Scientific Publishers</a>; 2001.</div></div></div></div><div class="half_rhythm"><a href="/books/about/copyright/" target="mainwindow">Copyright</a> © 2001, BIOS Scientific Publishers Limited.</div><p>NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div>
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