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<title>Box 5.18, Bone resorption and local effects of malignant cells - Endocrinology - NCBI Bookshelf</title>
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<meta name="robots" content="NOINDEX,NOFOLLOW,NOARCHIVE,NOIMAGEINDEX" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Box 5.18, Bone resorption and local effects of malignant cells" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="BIOS Scientific Publishers" /><meta name="DC.Contributor" content="Stephen Nussey" /><meta name="DC.Contributor" content="Saffron Whitehead" /><meta name="DC.Date" content="2001" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK24/" /><meta name="description" content="Osteoclasts arise from hematopoietic precursors of the monocyte lineage. Their differentiation is stimulated by factors such as macrophage colony-stimulating factor (M-CSF), cytokines such as IL-6 and PTH and vitamin D. A sealed space is formed by integrin (I)-mediated binding to bone surfaces, and the elaborately folded ruffled border acts, essentially, as a large lysosome secreting acid and enzymes onto the sealed bone area. This causes both demineralization and break down of the bone matrix protein. Osteoclasts do not have PTH or vitamin D receptors but their activity is regulated by osteoclast activating factors (OAFs) such as arachidonic acid derivatives and cytokines whose production can be stimulated by PTH and vitamin D. Bone metastases can also secrete OAFs and thus cause bone resorption." /><meta name="bk-non-canon-loc" content="/books/n/endocrin/A742/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK24/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script>
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<div class="main-content lit-style"><div class="body-content whole_rhythm"><div id="A821" class="box"><h3><span class="label">Box 5.18</span><span class="title">Bone resorption and local effects of malignant cells</span></h3><div class="graphic"><img src="/books/NBK24/bin/ch5fb18.jpg" alt="Image ch5fb18.jpg" /></div><p>Osteoclasts arise from hematopoietic precursors of the monocyte lineage. Their differentiation is stimulated by factors such as macrophage colony-stimulating factor (M-CSF), cytokines such as IL-6 and PTH and vitamin D. A sealed space is formed by integrin (I)-mediated binding to bone surfaces, and the elaborately folded ruffled border acts, essentially, as a large lysosome secreting acid and enzymes onto the sealed bone area. This causes both demineralization and break down of the bone matrix protein. Osteoclasts do not have PTH or vitamin D receptors but their activity is regulated by osteoclast activating factors (OAFs) such as arachidonic acid derivatives and cytokines whose production can be stimulated by PTH and vitamin D. Bone metastases can also secrete OAFs and thus cause bone resorption.</p></div><div id="bk_toc_contnr"></div></div></div>
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<div class="post-content"><div><p>From: <a href="/books/NBK24/" target="mainwindow">Chapter 5, The parathyroid glands and vitamin D</a></p><div class="iconblock clearfix ten_col"><a class="img_link icnblk_img" title="Table of Contents Page" href="/books/n/endocrin/" target="mainwindow"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-endocrin-lrg.png" alt="Cover of Endocrinology" height="100px" width="80px" /></a><div class="icnblk_cntnt"><div><div>Endocrinology: An Integrated Approach.</div><div>Nussey S, Whitehead S.</div><div>Oxford: <a href="http://www.garlandscience.com/about.asp" target="mainwindow" ref="pagearea=content-footer&targetsite=external&targetcat=link&targettype=publisher">BIOS Scientific Publishers</a>; 2001.</div></div></div></div><div class="half_rhythm"><a href="/books/about/copyright/" target="mainwindow">Copyright</a> © 2001, BIOS Scientific Publishers Limited.</div><p>NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div></div>
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