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<meta name="citation_date" content="1998">
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<meta name="og:description" content="The immune system is a complex and highly developed system, yet its mission is simple: to seek and kill invaders. If a person is born with a severely defective immune system, death from infection by a virus, bacterium, fungus or parasite will occur. In severe combined immunodeficiency, lack of an enzyme means that toxic waste builds up inside immune system cells, killing them and thus devastating the immune system. A lack of immune system cells is also the basis for DiGeorge syndrome: improper development of the thymus gland means that T cell production is diminished.">
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yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK22243_"><span class="title" itemprop="name">Diseases of the Immune System</span></h1><p class="fm-aai"><a href="#_NBK22243_pubdet_">Publication Details</a></p></div></div><div class="body-content whole_rhythm" itemprop="text"><div id="_abs_rndgid_" itemprop="description"><div class="graphic"><img src="/books/NBK22243/bin/immune.jpg" alt="Image immune.jpg" /></div><p>The immune system is a complex and highly developed system, yet its mission is simple: to seek and kill invaders. If a person is born with a severely defective immune system, death from infection by a virus, bacterium, fungus or parasite will occur. In severe combined immunodeficiency, lack of an enzyme means that toxic waste builds up inside immune system cells, killing them and thus devastating the immune system. A lack of immune system cells is also the basis for DiGeorge syndrome: improper development of the thymus gland means that T cell production is diminished.</p><p>Most other immune disorders result from either an excessive immune response or an 'autoimmune attack'. Asthma, familial Mediterranean fever and Crohn's disease (inflammatory bowel disease) all result from an over-reaction of the immune system, while autoimmune polyglandular syndrome and some facets of diabetes are due to the immune system attacking 'self' cells and molecules. A key part of the immune system's role is to differentiate between invaders and the body's own cells - when it fails to make this distinction, a reaction against 'self' cells and molecules causes autoimmune disease. </p></div><div id="A51.diseases"><h2 id="_A51_diseases_">Diseases</h2><ul class="simple-list"><li class="half_rhythm"><div>
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<a href="/books/n/gnd/asthma/?report=reader">Asthma</a>
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</div></li><li class="half_rhythm"><div>
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<a href="/books/n/gnd/ataxiatelangiectasia/?report=reader">Ataxia telangiectasia</a>
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<a href="/books/n/gnd/autoimmunepolyglandularsyndrome/?report=reader">Autoimmune polyglandular syndrome</a>
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<a href="/books/n/gnd/burkittlymphoma/?report=reader">Burkitt lymphoma</a>
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<a href="/books/n/gnd/diabetestype1/?report=reader">Diabetes, type 1</a>
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</div></li><li class="half_rhythm"><div>
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<a href="/books/n/gnd/digeorgesyndrome/?report=reader">DiGeorge syndrome</a>
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</div></li><li class="half_rhythm"><div>
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<a href="/books/n/gnd/familialmediterraneanfever/?report=reader">Familial Mediterranean fever</a>
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</div></li><li class="half_rhythm"><div>
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<a href="/books/n/gnd/immunodeficiencywithhyperigm/?report=reader">Immunodeficiency with hyper-IgM</a>
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<a href="/books/n/gnd/leukemiachronicmyeloid/?report=reader">Leukemia, chronic myeloid</a>
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</div></li><li class="half_rhythm"><div>
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<a href="/books/n/gnd/severecombinedimmunodeficiency/?report=reader">Severe combined immunodeficiency</a>
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</div></li></ul></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK22243_pubdet_">Publication Details</h2><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>National Center for Biotechnology Information (US). Genes and Disease [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 1998-. Diseases of the Immune System.<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/gnd/A46/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/gnd/A56/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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