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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Genomics: From Phage to Human - Sequence - Evolution - Function - NCBI Bookshelf</title>
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<meta name="citation_inbook_title" content="Sequence - Evolution - Function: Computational Approaches in Comparative Genomics">
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<meta name="citation_title" content="Genomics: From Phage to Human">
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<meta name="citation_publisher" content="Kluwer Academic">
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<meta name="citation_date" content="2003">
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<meta name="citation_author" content="Eugene V Koonin">
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<meta name="citation_author" content="Michael Y Galperin">
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<meta name="DC.Title" content="Genomics: From Phage to Human">
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<meta name="DC.Contributor" content="Eugene V Koonin">
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<meta name="DC.Contributor" content="Michael Y Galperin">
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<meta name="DC.Date" content="2003">
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<meta name="description" content="The first genome, that of RNA bacteriophage MS2, was sequenced in 1976, in a truly heroic feat of direct determination of an RNA sequence [225]. This was followed by the genome of bacteriophage ϕX174, the first triumph of the new, rapid sequencing methods developed in the laboratories of Walter Gilbert and Fred Sanger [553,743]. These are some of the smallest known genomes with only four and ten genes, respectively. Then, in 1982, the last paper published by Sanger before he retired, announced the first relatively large genome to be sequenced, that of bacteriophage λ, probably the most famous model system of classic molecular biology [742]. Phage λ has 48,502 bases of genomic DNA and ~70 known and predicted protein-coding genes and 23 RNA-coding genes. At 70 characters per line and 43 lines per page, this sequence alone would take over 16 pages of this book. However, the listing of the λ protein-coding genes (Table 1.1) fits into just two pages and definitely conveys more information. These days, it may be hard to imagine all the excitement felt by molecular biologists 20 years ago when the λ genome was finally finished. Nevertheless, even in this era of high-throughput methods, it could be instructive to look back and address several questions: (i) is λ genome a good model of the subsequently sequenced prokaryotic and eukaryotic genomes? (ii) how accurate was the sequence itself and the original gene assignment? and (iii) how much more have we learned about functions of λ genes in the past 20 years?">
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<meta name="og:description" content="The first genome, that of RNA bacteriophage MS2, was sequenced in 1976, in a truly heroic feat of direct determination of an RNA sequence [225]. This was followed by the genome of bacteriophage ϕX174, the first triumph of the new, rapid sequencing methods developed in the laboratories of Walter Gilbert and Fred Sanger [553,743]. These are some of the smallest known genomes with only four and ten genes, respectively. Then, in 1982, the last paper published by Sanger before he retired, announced the first relatively large genome to be sequenced, that of bacteriophage λ, probably the most famous model system of classic molecular biology [742]. Phage λ has 48,502 bases of genomic DNA and ~70 known and predicted protein-coding genes and 23 RNA-coding genes. At 70 characters per line and 43 lines per page, this sequence alone would take over 16 pages of this book. However, the listing of the λ protein-coding genes (Table 1.1) fits into just two pages and definitely conveys more information. These days, it may be hard to imagine all the excitement felt by molecular biologists 20 years ago when the λ genome was finally finished. Nevertheless, even in this era of high-throughput methods, it could be instructive to look back and address several questions: (i) is λ genome a good model of the subsequently sequenced prokaryotic and eukaryotic genomes? (ii) how accurate was the sequence itself and the original gene assignment? and (iii) how much more have we learned about functions of λ genes in the past 20 years?">
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class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK20263_"><span class="label">Chapter 1</span><span class="title" itemprop="name">Genomics: From Phage to Human</span></h1><p class="fm-aai"><a href="#_NBK20263_pubdet_">Publication Details</a></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="A5"><h2 id="_A5_">1.1. The Humble Beginnings …</h2><p>The first genome, that of RNA bacteriophage MS2, was sequenced in 1976, in a truly
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heroic feat of direct determination of an RNA sequence [<a href="/books/n/sef/A727/?report=reader#A953">225</a>]. This was followed by the genome of bacteriophage
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ϕX174, the first triumph of the new, rapid sequencing methods developed in
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the laboratories of Walter Gilbert and Fred Sanger [<a href="/books/n/sef/A727/?report=reader#A1281">553</a>,<a href="/books/n/sef/A727/?report=reader#A1471">743</a>]. These are
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some of the smallest known genomes with only four and ten genes, respectively. Then,
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in 1982, the last paper published by Sanger before he retired, announced the first
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relatively large genome to be sequenced, that of bacteriophage λ,
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probably the most famous model system of classic molecular biology [<a href="/books/n/sef/A727/?report=reader#A1470">742</a>]. Phage λ has 48,502 bases of
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genomic DNA and ~70 known and predicted protein-coding genes and 23 RNA-coding
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genes. At 70 characters per line and 43 lines per page, this sequence alone would
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take over 16 pages of this book. However, the listing of the λ
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protein-coding genes (<a class="figpopup" href="/books/NBK20263/table/A6/?report=objectonly" target="object" rid-figpopup="figA6" rid-ob="figobA6">Table 1.1</a>) fits into
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just two pages and definitely conveys more information. These days, it may be hard
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to imagine all the excitement felt by molecular biologists 20 years ago when the
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λ genome was finally finished. Nevertheless, even in this era of
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high-throughput methods, it could be instructive to look back and address several
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questions: (i) is λ genome a good model of the subsequently sequenced
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prokaryotic and eukaryotic genomes? (ii) how accurate was the sequence itself and
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the original gene assignment? and (iii) how much more have we learned about
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functions of λ genes in the past 20 years?</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figA6"><a href="/books/NBK20263/table/A6/?report=objectonly" target="object" title="Table 1.1" class="img_link icnblk_img figpopup" rid-figpopup="figA6" rid-ob="figobA6"><img class="small-thumb" src="/books/NBK20263/table/A6/?report=thumb" src-large="/books/NBK20263/table/A6/?report=previmg" alt="Table 1.1. Protein-coding genes of bacteriophage λ." /></a><div class="icnblk_cntnt"><h4 id="A6"><a href="/books/NBK20263/table/A6/?report=objectonly" target="object" rid-ob="figobA6">Table 1.1</a></h4><p class="float-caption no_bottom_margin">Protein-coding genes of bacteriophage λ. </p></div></div><p>The answer to the first question is definitely yes: λ genome has many
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features common to the genomes of cellular life forms, particularly prokaryotes.
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Most of the genome consists of protein-coding genes. Adjacent genes are often
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transcribed in the same direction and encode proteins that have similar functions
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and/or interact with each other (e.g. cell lysis proteins, tail components).
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Adjacent genes either slightly overlap or are separated by intergenic regions of
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varying length, typically much shorter than the genes themselves.</p><p>To answer the second question, both the sequence and gene assignments turned out to
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be essentially correct. The latter may not be surprising since the λ
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genome was annotated by researchers who had studied the phage for years, on the
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basis of the entire body of knowledge amassed by that time. In contemporary genome
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sequencing projects, such detailed analysis by highly qualified biologists with
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intimate knowledge of the biology of the given organism is more an exception, rather
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than the norm, partly because biological information on many of the sequenced
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organisms is simply too scarce.</p><p>A comparison of <a class="figpopup" href="/books/NBK20263/table/A6/?report=objectonly" target="object" rid-figpopup="figA6" rid-ob="figobA6">Table 1.1</a> with the original
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paper by Sanger et al. [<a href="/books/n/sef/A727/?report=reader#A1470">742</a>] shows that
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there is actually not much to add to the gene annotations. The use of recently
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developed sophisticated gene prediction programs, such as Glimmer (see <a href="/books/n/sef/A166/?report=reader#A168">4.1</a>), coupled with the analysis of the regions
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that are conserved between lambda and related bacteriophages, led to the conclusion
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that certain intergenic regions might contain additional protein-coding genes
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(marked by asterisks in the <a class="figpopup" href="/books/NBK20263/table/A6/?report=objectonly" target="object" rid-figpopup="figA6" rid-ob="figobA6">Table 1.1</a>).
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Unfortunately, most of these genes remain uncharacterized, and it is not even known
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whether they are ever expressed. It is worth noting that exactly the same doubts
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exist about the possible functions and/or expression of a large number of so-called
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“hypothetical” genes, identified in the genomes of cellular life
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forms by essentially the same two principal approaches (see <a href="/books/n/sef/A166/?report=reader#A168">4.1</a>).</p><p>When reading the Sanger paper now, 20 years after it appeared, one is struck by the
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absence of any analysis of protein sequences in this detailed, thorough work.
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Although the authors have done careful computational analysis of open reading
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frames, particularly the likely translation starts and codon usage, the very word
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“homolog” is not used in the article, and there is no mention of
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|
any search of protein sequence databases, something that these days is, by default,
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|
an integral part of any genomic study. Not that protein sequence databases did not
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|
exist at the time: the first one, the Protein Identification Resource, was launched
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by Margaret Dayhoff, one of the great pioneers of computational biology, in 1965,
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|
long before genomics had even become conceivable [<a href="/books/n/sef/A727/?report=reader#A900">172</a>,<a href="/books/n/sef/A727/?report=reader#A901">173</a>]. However, reliable and
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rapid methods for searching this database still have not been developed, and more
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generally, database search was not a part of the culture in molecular biology at the
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time. And for a good reason, too. Had Sanger and his coworkers performed a PIR
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search, even using the methods available in 2002, they would not have found anything
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|
of interest because the sequences available at that time were few and far apart, and
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there were no homologs of phage λ proteins among them. Clearly, the time
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|
was not ripe for comparative genomics and, in a sense, for genomics itself because,
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as we will see throughout this book, the comparative approach is truly central to
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the genomic enterprise.</p><p>Revisiting phage λ genome after 20 years, we see a completely different
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“genomescape”. Using the PSI-BLAST program (see <a href="/books/n/sef/A166/?report=reader#A199">4.3</a>), the search of the complete non-redundant
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|
protein sequence database maintained at the NCBI (National Center for Biotechnology
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Information, a division of the National Institutes of Health in Bethesda, Maryland,
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USA) for homologs of the 73 proteins listed as gene products of phage λ
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takes about an hour on a moderate power computer. Another hour was spent running
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selected proteins through the conserved domain search using the CDD option of the
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NCBI’s BLAST server (see <a href="/books/n/sef/A166/?report=reader#A213">4.4</a>). Of
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course, we could have scoured the literature for descriptions of computational
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analyses of λ proteins instead. However, extracting the relevant
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information from databases, such as PubMed (see <a href="/books/n/sef/A55/?report=reader#A149">3.7</a>), is far from trivial because, in most cases, the papers including
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this information dealt with more general issues and would not have λ, let
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|
alone a particular gene, mentioned in the title or abstract. Running the searches
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anew was much faster and easier. Besides, sequence databases are growing daily,
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which may substantially affect the results of searches and might even lead to new
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discoveries. Perusing the results, we should note that, with a few exceptions, there
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are now homologs readily detectable for the phage proteins. In the majority of
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cases, these are proteins from other related phages (sometimes integrated as
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prophages into the bacterial chromosome). However, 12 λ proteins show
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conservation in bacteria, archaea, and eukaryotes (<a class="figpopup" href="/books/NBK20263/table/A7/?report=objectonly" target="object" rid-figpopup="figA7" rid-ob="figobA7">Table 1.2</a>). For several of these proteins whose functions have not been
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studied experimentally, non-trivial functional predictions become possible.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figA7"><a href="/books/NBK20263/table/A7/?report=objectonly" target="object" title="Table 1.2" class="img_link icnblk_img figpopup" rid-figpopup="figA7" rid-ob="figobA7"><img class="small-thumb" src="/books/NBK20263/table/A7/?report=thumb" src-large="/books/NBK20263/table/A7/?report=previmg" alt="Table 1.2. Non-trivial evolutionary connections and functional predictions for bacteriophage λ proteins." /></a><div class="icnblk_cntnt"><h4 id="A7"><a href="/books/NBK20263/table/A7/?report=objectonly" target="object" rid-ob="figobA7">Table 1.2</a></h4><p class="float-caption no_bottom_margin">Non-trivial evolutionary connections and functional predictions for
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bacteriophage λ proteins. </p></div></div><p>It is remarkable that some of the more interesting computational predictions remain
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without experimental test. Admittedly, the visibility of molecular biology of
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bacteriophages as a research field has not increased since the 1970’s, and
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the funds have pretty much tapered off. Good examples are the Ea59 and K genes that
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are predicted to encode an ATPase and a metal-dependent protease, respectively. Both
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are clear and readily testable predictions that have been described in print, even
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if briefly [<a href="/books/n/sef/A727/?report=reader#A1024">296</a>,<a href="/books/n/sef/A727/?report=reader#A1407">679</a>]. However, to our knowledge, no experimental tests of
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these predictions have been reported so far. Interestingly, an observation has been
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made during these searches that actually seems to have a novel aspect to it. The
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Ea31 protein was shown to contain a metal-dependent nuclease domain [<a href="/books/n/sef/A727/?report=reader#A778">50</a>]. The stop codon of the Ea31 gene overlaps
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the start codon of Ea59, leading to the intriguing hypothesis that the two proteins
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interact and form an ATP-dependent nuclease complex. We discuss sequence analysis of
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Ea31 in greater detail in <a href="/books/n/sef/A166/?report=reader">Chapter 4</a> to
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illustrate the process of discovery in database searches. Furthermore, this is a
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little example of context analysis, an increasingly important direction in genome
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annotation, which is covered in <a href="/books/n/sef/A264/?report=reader">Chapter
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5</a>. This situation is not uncommon: computational analysis of genomes
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|
keeps yielding interesting functional predictions, even years after the publication
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of the sequence; what is most often lacking is systematic experimental testing of
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|
these predictions.</p><p>We will come back to this dramatic rift between computational and experimental
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|
analysis of most, if not all, genomes with more numbers, but first let us step back
|
|
and have a quick look into the history of genomics, which is short, but dynamic
|
|
(<a class="figpopup" href="/books/NBK20263/table/A8/?report=objectonly" target="object" rid-figpopup="figA8" rid-ob="figobA8">Table 1.3</a>). By definition, genomics
|
|
requires genome sequences, and to engage in comparative genomics, one needs at least
|
|
two genomes to compare. In a close analogy to the history of molecular genetics,
|
|
which owes most of its early progress to bacteriophages used as model systems,
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|
comparative genomics was first practiced with the genomes of viruses. These are
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|
several orders of magnitude smaller than even the tiniest bacterial genomes and, in
|
|
case a virus grows well, sequencing of viral genomes became a relatively
|
|
straightforward enterprise in the early 1980’s. By 1983, six years after
|
|
the beginning of the sequencing era, a considerable number of complete genomes of
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diverse small viruses of plants, animals, and bacteria (bacteriophages) had been
|
|
amassed, and the time was ripe for the birth of comparative genomics.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figA8"><a href="/books/NBK20263/table/A8/?report=objectonly" target="object" title="Table 1.3" class="img_link icnblk_img figpopup" rid-figpopup="figA8" rid-ob="figobA8"><img class="small-thumb" src="/books/NBK20263/table/A8/?report=thumb" src-large="/books/NBK20263/table/A8/?report=previmg" alt="Table 1.3. A brief timeline of genomics." /></a><div class="icnblk_cntnt"><h4 id="A8"><a href="/books/NBK20263/table/A8/?report=objectonly" target="object" rid-ob="figobA8">Table 1.3</a></h4><p class="float-caption no_bottom_margin">A brief timeline of genomics. </p></div></div><p>Pinpointing the exact beginning of comparative genomics may be difficult. In a sense,
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one may say that it was born as soon as there were two genomes to compare, i.e. in
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1977 when the genome of phage ϕX174 was sequenced and could be compared with
|
|
the already available sequence of the RNA phage MS2. However, this was a vacuous
|
|
start because the two phages had virtually nothing in common (<i>a
|
|
propos</i>, this has not changed in 20 years: for all we know, these phage
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|
families are truly unrelated). It seems that comparative genomics had a real head
|
|
start with two astonishing discoveries that caught most, if not all, virologists
|
|
utterly by surprise. First, it has been shown that RNA-containing retroviruses
|
|
(causative agents of certain leucoses in animals and humans and, as shown later, of
|
|
AIDS) shared a conserved replicative enzyme, the reverse transcriptase, with two
|
|
groups of DNA viruses, the hepadnaviruses (including the medically important
|
|
hepatitis B virus) and caulimoviruses, infecting plants [<a href="/books/n/sef/A727/?report=reader#A1575">847</a>]. Second, it turned out that small RNA viruses infecting
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|
animals (picornaviruses, such as polio and foot-and-mouth disease) and those
|
|
infecting plants (cowpea mosaic virus) shared not only significant sequence
|
|
similarity that allowed the identification of homologous (orthologous) genes, but
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|
also, in part, the order of these genes in their genomes [<a href="/books/n/sef/A727/?report=reader#A735">7</a>,<a href="/books/n/sef/A727/?report=reader#A784">56</a>,<a href="/books/n/sef/A727/?report=reader#A1063">335</a>]. Subsequent systematic studies have
|
|
revealed a complex network of homologous relationships within the vast classes of
|
|
positive-strand RNA viruses and negative-strand RNA viruses. Although still
|
|
disputed, the concept emerged that each of these classes was monophyletic, that is,
|
|
probably evolved from a common ancestral virus [<a href="/books/n/sef/A727/?report=reader#A1188">460</a>]. These studies combined two elements that were crucial in defining
|
|
the identity of the emerging discipline of comparative and evolutionary
|
|
genomics.</p><p>Firstly, the objects of analysis were complete genomes, however small, rather than
|
|
individual genes, and accordingly, the notions of conservation of gene order and
|
|
gene shuffling became important. Secondly, the discoveries made through these genome
|
|
comparisons were completely unexpected; there was no experimental data that would
|
|
prepare researchers for the startling unity of superficially unrelated viruses.</p><p>In retrospect, it is somewhat ironic that comparative genomics had to start with
|
|
virus genomes (due to the experimental contingency) because viral proteins tend to
|
|
evolve extremely fast, and detection of conservation between distant viruses may be
|
|
a non-trivial task, even with advanced methods of computational sequence analysis,
|
|
let alone with those available in the early 1980’s. This was a challenge
|
|
and perhaps a blessing in disguise. The difficulty of detecting sequence
|
|
conservation among viral proteins prompted those who ventured into this area to
|
|
employ approaches that later proved invaluable in comparative genomics and
|
|
computational biology in general: (i) compare protein sequences, rather than
|
|
nucleotide sequences directly, whenever distant relationships are involved and
|
|
sensitivity is an issue; (ii) rely on multiple, rather than pairwise, comparisons;
|
|
(iii) search for conserved patterns or motifs in multiple sequences; and, above all
|
|
(iv) actually look at sequences (and structures whenever these are available) and
|
|
think about the potential relationships in an effort to synthesize all relevant
|
|
shreds of information. This practice has been dubbed, more or less pejoratively,
|
|
“sequence gazing” [<a href="/books/n/sef/A727/?report=reader#A1069">341</a>]. Sure enough, sequence and structure comparisons are prone to error
|
|
and, worse, to fantasy, and these dangers had been particularly grave in the early
|
|
days, before the statistical foundations of computational biology had been worked
|
|
out and the rules of thumb had been established through accumulated practices. There
|
|
is no doubt, however, that success stories of computational prediction of gene
|
|
functions have been of much greater import and have, to a large extent, determined
|
|
the very feasibility of the further progress of genomics.</p><p>The first comparative-genomic study of a larger scale, investigating the
|
|
relationships between genomes that contained >100 genes each, came in 1986
|
|
[<a href="/books/n/sef/A727/?report=reader#A1286">558</a>]. The newly sequenced genome of
|
|
varicella zoster virus was carefully compared to the previously sequenced
|
|
Epstein-Barr virus genome (the original Epstein-Barr genome paper [<a href="/books/n/sef/A727/?report=reader#A796">68</a>] resembled the λ work in that no
|
|
homologs were reported for any of the viral proteins because, indeed, none were to
|
|
be easily identified among the sequences then available). This work, though little
|
|
noticed outside virology, already included the principal elements of the
|
|
comparative-genomic approach, if not the actual methods.</p></div><div id="A9"><h2 id="_A9_">1.2. … and the Astonishing Progress of Genome Sequencing</h2><p>Comparative genomics of cellular life forms is in a way a
|
|
“by-product” of the Human Genome Project. Probably the greatest
|
|
insight of the leaders of the early stages of this project was the realization that,
|
|
in isolation, the human genome would be a costly but uninterpretable string of three
|
|
billion or so of A’s, T’s, G’s and C’s. Only
|
|
through systematic comparisons to other genomes may we hope to make sense of the
|
|
text of this “Book of Life”. As far as genomics is concerned,
|
|
Theodosius Dobzhansky’s famous dictum “Nothing in biology makes
|
|
sense except in the light of evolution” is not some kind of evolutionist
|
|
propaganda, but an entirely literal and more or less routine description of the
|
|
situation. And so, in the last decade of the second millennium, the genome sequences
|
|
started pouring in. Yeast chromosome III, the first respectable chunk of contiguous
|
|
genome sequence [<a href="/books/n/sef/A727/?report=reader#A1357">629</a>] that became available
|
|
in 1992 (quite modest, by today’s standards, just ~320,000 base pairs),
|
|
generated major excitement epitomized in the title of a <i>Nature</i> note
|
|
describing a re-analysis of the ORFs from this chromosome:
|
|
“What’s in the genome?” [<a href="/books/n/sef/A727/?report=reader#A833">105</a>]. From the analysis of this sequence and other large
|
|
genome segments that started to appear in the next months, at least two notions were
|
|
derived that became critical for the subsequent evolution of comparative genomics:
|
|
(i) there were many more genes in the genome than anyone suspected previously on the
|
|
basis of genetic or biochemical experiments; and (ii) methods of computational
|
|
analysis matter—careful analysis employing multiple complementary
|
|
approaches yields incomparably more information on gene functions and evolutionary
|
|
relationships than any single automatic procedure.</p><p>The appearance in August 1995 of the complete genome sequence of the parasitic
|
|
bacterium <i>Haemophilus influenzae</i> [<a href="/books/n/sef/A727/?report=reader#A960">232</a>] ushered in the era of “real” genomics, the
|
|
study of complete genomes of cellular organisms. The acceleration of genome
|
|
sequencing required for this to happen was greatly facilitated by the whole-genome
|
|
shotgun approach pioneered by Craig Venter, Hamilton Smith, and Leroy Hood [<a href="/books/n/sef/A727/?report=reader#A1599">871</a>]. Systematic comparative approaches were
|
|
tried immediately, even before the second genome came, by using the largely finished
|
|
genome of <i>Escherichia coli</i> [<a href="/books/n/sef/A727/?report=reader#A1557">829</a>]. Since that point, complete genomes of bacteria and archaea have
|
|
been arriving at a steady rate, which seems to be accelerating in the 3<sup>rd</sup>
|
|
millennium (<a class="figpopup" href="/books/NBK20263/figure/A10/?report=objectonly" target="object" rid-figpopup="figA10" rid-ob="figobA10">Figure 1.1</a>). Starting with the
|
|
second genome sequencing paper [<a href="/books/n/sef/A727/?report=reader#A970">242</a>],
|
|
reports on new genomes inevitably became comparative-genomic studies because, as we
|
|
have already mentioned, that is the only way to even start understanding
|
|
“what’s in the genome”.
|
|
|
|
</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figA10" co-legend-rid="figlgndA10"><a href="/books/NBK20263/figure/A10/?report=objectonly" target="object" title="Figure 1.1" class="img_link icnblk_img figpopup" rid-figpopup="figA10" rid-ob="figobA10"><img class="small-thumb" src="/books/NBK20263/bin/ch1f1.gif" src-large="/books/NBK20263/bin/ch1f1.jpg" alt="Figure 1.1. Growth of the number of completely sequenced genomes." /></a><div class="icnblk_cntnt" id="figlgndA10"><h4 id="A10"><a href="/books/NBK20263/figure/A10/?report=objectonly" target="object" rid-ob="figobA10">Figure 1.1</a></h4><p class="float-caption no_bottom_margin">Growth of the number of completely sequenced genomes. The data are from Table 1.4. The
|
|
2002 figure is extrapolated from the 5-month results. </p></div></div><p>By June 1, 2002, genomes of 73 species of unicellular organisms (55 bacterial
|
|
species, 16 archaea, and 2 eukaryotes) were completely sequenced and available in
|
|
public databases. In the three parts of <a class="figpopup" href="/books/NBK20263/table/A11/?report=objectonly" target="object" rid-figpopup="figA11" rid-ob="figobA11">Table
|
|
1.4</a>, the completely sequenced bacterial, archaeal, and eukaryotic genomes
|
|
are listed in the order of decreasing size. The largest prokaryotic genomes
|
|
(<i>Streptomyces coelicolor</i> among bacteria, <i>Methanosarcina
|
|
acetivorans</i> among the archaea) have been sequenced only recently, which
|
|
promises many interesting discoveries yet to come.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figA11"><a href="/books/NBK20263/table/A11/?report=objectonly" target="object" title="Table 1.4" class="img_link icnblk_img figpopup" rid-figpopup="figA11" rid-ob="figobA11"><img class="small-thumb" src="/books/NBK20263/table/A11/?report=thumb" src-large="/books/NBK20263/table/A11/?report=previmg" alt="Table 1.4. Completely sequenced genomes (as of June 1, 2002)." /></a><div class="icnblk_cntnt"><h4 id="A11"><a href="/books/NBK20263/table/A11/?report=objectonly" target="object" rid-ob="figobA11">Table 1.4</a></h4><p class="float-caption no_bottom_margin">Completely sequenced genomes (as of June 1, 2002). </p></div></div><p>By the time of this writing (August 2002), the first genomes of multicellular
|
|
eukaryotes, the nematode worm <i>Caenorhabditis elegans</i>, the fruit fly
|
|
<i>Drosophila melanogaster</i>, the thale cress <i>Arabidopsis
|
|
thaliana</i>, the pufferfish <i>Fugu rubripes</i>, and
|
|
<i>Homo sapiens</i> have been nearly completed (let us note that the
|
|
very concept of a complete genome sequence for these organisms differs from that for
|
|
prokaryotes and unicellular eukaryotes). At least 100 more prokaryotic genomes and
|
|
many eukaryotic genomes, including those of mouse and rat, were at different stages
|
|
of completion. Beyond doubt, many more finished or nearly finished genome sequences
|
|
exist in proprietary databases maintained by biotech companies, but since these
|
|
cannot be freely analyzed, they do not count inasmuch as comparative genomics is
|
|
discussed.</p><p>Any list of completed genomes rapidly becomes outdated and so will <a class="figpopup" href="/books/NBK20263/table/A11/?report=objectonly" target="object" rid-figpopup="figA11" rid-ob="figobA11">Table 1.4</a>, even as this book appears in print.
|
|
Periodically updated listings of both finished and unfinished publicly funded genome
|
|
sequencing projects are available at the web sites maintained at the Institute for
|
|
Genomic Research (TIGR, <a href="http://www.tigr.org/tdb/mdb/mdb.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.tigr.org/tdb/mdb/mdb.html</a>) and at the NCBI (<a href="/PMGifs/Genomes/micr.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.ncbi.nlm.nih.gov/PMGifs/Genomes/micr.html</a>). The
|
|
Chicago-based Integrated Genomics Inc. maintains Genomes OnLine Database (<a href="http://wit.genomesonline.org" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://wit.genomesonline.org</a>), which lists most public as well as
|
|
some private projects. In addition, web sites of the genome sequencing centers list
|
|
the projects run or planned in those particular institutions (see <a href="/books/n/sef/A607/?report=reader">Appendix 2</a>).</p><p>The relative ease of 6- to 8-fold coverage sequencing as compared to finishing and
|
|
genome annotation resulted in the availability of a number of incomplete genomes,
|
|
which are not going to be finalized any time soon (see, for example, the web site of
|
|
the Department of Energy Joint Genome Institute, <a href="http://www.jgi.doe.gov/JGI_microbial/html/index.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.jgi.doe.gov/JGI_microbial/html/index.html</a>). These
|
|
sequences are a treasure trove for someone who knows what to look for. Most of the
|
|
data are available for searching through the NCBI BLAST page at <a href="/cgi-bin/Entrez/genom_table_cgi" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/genom_table_cgi</a> or
|
|
through the web sites of the respective sequencing centers. A partial list of the
|
|
major genome sequencing centers is available in <a href="/books/n/sef/A607/?report=reader">Appendix 2</a>. Of course, as new genome sequencing centers appear on the
|
|
map, this listing is going to become obsolete, too. For updated listings of such
|
|
centers, one could look at the web sites of NCBI (<a href="/PMGifs/Genomes/links.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.ncbi.nlm.nih.gov/PMGifs/Genomes/links.html</a>) or the
|
|
National Human Genome Research Institute (<a href="http://www.genome.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.genome.gov</a>).</p><p>In addition to the whole-genome sequencing projects, there are many large-scale
|
|
expressed sequence tags (EST) sequencing projects, aimed at collecting partial mRNA
|
|
sequence data from eukaryotic organisms that have not yet made it to the list of
|
|
priority targets for complete sequencing.</p></div><div id="A12"><h2 id="_A12_">1.3. Basic Questions of Comparative Genomics</h2><p>In the subsequent chapters of this book, we address many specific problems in
|
|
comparative and evolutionary genomics. Right now, however, it makes sense to address
|
|
some basic questions, the answers to which, as we believe, define the status of this
|
|
research area.</p><p>
|
|
<b>
|
|
<i>How good is our current collection of genome sequences?</i>
|
|
</b> Or, more precisely, how representative is it of the actual diversity of life
|
|
forms? To address this issue, one has to superimpose the sequenced genomes over the
|
|
taxonomy tree and see how densely populated the main branches are. When this is done
|
|
with the prokaryotic part of the taxonomy, the result seems to be rather
|
|
encouraging: the main bacterial and archaeal lineages are already represented by
|
|
either a complete genome sequence or a genome project that is nearing completion
|
|
(<a class="figpopup" href="/books/NBK20263/table/A13/?report=objectonly" target="object" rid-figpopup="figA13" rid-ob="figobA13">Table 1.5</a>). However, this needs to be
|
|
taken with a grain of salt because our knowledge of prokaryotic diversity is itself
|
|
quite incomplete. Environmental molecular evolutionary studies indicate that the
|
|
great majority of bacterial and archaeal species is uncultivable with the current
|
|
methods [<a href="/books/n/sef/A727/?report=reader#A1372">644</a>]. Recent techniques aimed at
|
|
growing these organisms [<a href="/books/n/sef/A727/?report=reader#A1139">411</a>] might
|
|
eventually result in a real revolution in microbial genomics, but it will take years
|
|
to unfold. Most of those species whose rRNA sequences are produced by environmental
|
|
cloning fall within known bacterial and archaeal lineages, suggesting that we have
|
|
already sampled most of the prokaryotic diversity. However, this argument is
|
|
somewhat circular because we have no idea how many prokaryotes might be not only
|
|
uncultivable but also unclonable, even with the most non-specific set of PCR primers
|
|
that have been tried. A case in point is the recent report of a new archaeal phylum,
|
|
the Nanoarchaea [<a href="/books/n/sef/A727/?report=reader#A1090">362</a>]. With these caveats,
|
|
it is fair to say that, to the best of our knowledge, the diversity of prokaryotes
|
|
is reasonably well covered by genome sequences, and hence, the stage is set for
|
|
prokaryotic evolutionary genomics.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figA13"><a href="/books/NBK20263/table/A13/?report=objectonly" target="object" title="Table 1.5" class="img_link icnblk_img figpopup" rid-figpopup="figA13" rid-ob="figobA13"><img class="small-thumb" src="/books/NBK20263/table/A13/?report=thumb" src-large="/books/NBK20263/table/A13/?report=previmg" alt="Table 1.5. Coverage of the main prokaryotic phyla by genome projects." /></a><div class="icnblk_cntnt"><h4 id="A13"><a href="/books/NBK20263/table/A13/?report=objectonly" target="object" rid-ob="figobA13">Table 1.5</a></h4><p class="float-caption no_bottom_margin">Coverage of the main prokaryotic phyla by genome projects. </p></div></div><p>The situation with eukaryotes is different in that we seem to have a better grasp of
|
|
the true eukaryotic diversity and realize that the available set of genome sequences
|
|
is by no means representative (<a class="figpopup" href="/books/NBK20263/table/A14/?report=objectonly" target="object" rid-figpopup="figA14" rid-ob="figobA14">Table 1.6</a>).
|
|
While certain groups (ascomycetes, nematodes, insects, mammals) are being tackled by
|
|
multiple genome projects, most of the early branching eukaryotic lineages are not
|
|
represented among the sequenced genomes, and neither are most of the animal and
|
|
plant phyla, including such important groups as sponges, coelencerates, and
|
|
segmented (annelid) worms. Certainly, this is no reason to postpone detailed
|
|
comparative-genomic analysis, but this insufficiency of genomic data needs to be
|
|
taken into account when conclusions are made on eukaryotic evolution.</p><div class="iconblock whole_rhythm clearfix ten_col table-wrap" id="figA14"><a href="/books/NBK20263/table/A14/?report=objectonly" target="object" title="Table 1.6" class="img_link icnblk_img figpopup" rid-figpopup="figA14" rid-ob="figobA14"><img class="small-thumb" src="/books/NBK20263/table/A14/?report=thumb" src-large="/books/NBK20263/table/A14/?report=previmg" alt="Table 1.6. Status of the eukaryotic genome projects." /></a><div class="icnblk_cntnt"><h4 id="A14"><a href="/books/NBK20263/table/A14/?report=objectonly" target="object" rid-ob="figobA14">Table 1.6</a></h4><p class="float-caption no_bottom_margin">Status of the eukaryotic genome projects. </p></div></div><p>The next question that we have to address is: <b>
|
|
<i>Why does comparative genomics work to give us information on gene
|
|
functions and evolution?</i>
|
|
</b> The general answer is provided by the neutral theory of molecular evolution
|
|
[<a href="/books/n/sef/A727/?report=reader#A1168">440</a>]. Neutral evolution is fast, as
|
|
convincingly demonstrated, for example, by the rapid deterioration of pseudogene
|
|
sequences. Therefore, whenever we detect sequence conservation among proteins or
|
|
nucleic acids from species separated by a long span of evolution (and this, in
|
|
practical terms, involves any comparison between two species because these are
|
|
typically separated by millions of years, time more than sufficient for a pseudogene
|
|
to change beyond recognition), we can be sure that this conservation is due to the
|
|
pressure of purifying selection driven by functional constraints. To put it in even
|
|
simpler terms, <b>
|
|
<i>what is conserved in a sequence is functionally important</i>
|
|
</b>. Furthermore, and less trivially, the conserved amino acids and nucleotides
|
|
almost always perform the same or similar functions, at least in structural and
|
|
biochemical terms, in homologous protein, RNA, or DNA molecules.</p><p>These general concepts of molecular evolution indicate that comparative genomics is
|
|
likely to be informative in principle, but they tell us nothing about the
|
|
evolutionary distances at which it is expected to work. The theory would not have
|
|
been violated in any way if only homologs from closely related species showed
|
|
significant sequence similarity. However, it had been known already in the
|
|
pre-genomic era that certain proteins are highly conserved even between vertebrates
|
|
and bacteria, and the very first genome comparisons revealed deep evolutionary
|
|
conservation for the majority of proteins. When state of the art methods for
|
|
sequence comparison are applied, homologs from more than one distantly related
|
|
species are detectable for 70-80% of the proteins encoded in any
|
|
prokaryotic genome [<a href="/books/n/sef/A727/?report=reader#A1555">827</a>]. At present this
|
|
fraction seems to be somewhat lower for some of the eukaryotes, but only because the
|
|
taxonomic density of genome sequencing so far has been insufficient. Indeed, in the
|
|
genomes of humans and mice, species that diverged from their common ancestor 80-100
|
|
million years ago, nearly all genes are conserved. These crucial facts show that <b>
|
|
<i>genome comparisons are likely to reveal important information on the
|
|
functions and evolutionary relationships of the great majority of genes in
|
|
any genome.</i>
|
|
</b>
|
|
</p><p>We have already stated that genomics would not make any sense at all without the
|
|
possibility of informative genome comparison. <b>
|
|
<i>Why is this so?</i>
|
|
</b> In principle, one could imagine that a combination of theoretical methods
|
|
for deciphering a protein’s three-dimensional structure from the sequence
|
|
and experimental studies would allow functional identification without recourse to
|
|
evolutionary analysis. However, neither of these approaches is up to the task. Some
|
|
recent progress notwithstanding, there is no hope that, in the foreseeable future,
|
|
<i>ab initio</i> methods become capable of correctly predicting the
|
|
structure of proteins on genome scale (or on any significant scale except, possibly,
|
|
for some small proteins with simple folds), let alone their functions.</p><p>As for genome-wide experimental characterization of protein functions, far-reaching
|
|
studies have been conducted, such as elucidation of the phenotype of all gene
|
|
knockout mutants, massive study of subcellular localization, and identification of
|
|
protein-protein interaction in bulk for yeast <i>S. cerevisiae</i> [<a href="/books/n/sef/A727/?report=reader#A1442">714</a>,<a href="/books/n/sef/A727/?report=reader#A1604">876</a>]. However, actual determination of the biochemical activity and more
|
|
so of the biological function of a protein remains a unique task, and even for model
|
|
organisms such as yeast or <i>E. coli</i>, this goal is not in sight for
|
|
all gene products.</p><p>Indeed, for the great majority of organisms whose genomes have been sequenced, only a
|
|
few genes have been studied experimentally (<a class="figpopup" href="/books/NBK20263/figure/A15/?report=objectonly" target="object" rid-figpopup="figA15" rid-ob="figobA15">Figure
|
|
1.2</a>), and there is no hope for substantial progress in the near
|
|
future.
|
|
|
|
</p><div class="iconblock whole_rhythm clearfix ten_col fig" id="figA15" co-legend-rid="figlgndA15"><a href="/books/NBK20263/figure/A15/?report=objectonly" target="object" title="Figure 1.2" class="img_link icnblk_img figpopup" rid-figpopup="figA15" rid-ob="figobA15"><img class="small-thumb" src="/books/NBK20263/bin/ch1f2.gif" src-large="/books/NBK20263/bin/ch1f2.jpg" alt="Figure 1.2. The current state of annotation of some genomes." /></a><div class="icnblk_cntnt" id="figlgndA15"><h4 id="A15"><a href="/books/NBK20263/figure/A15/?report=objectonly" target="object" rid-ob="figobA15">Figure 1.2</a></h4><p class="float-caption no_bottom_margin">The current state of annotation of some genomes. The data were derived from the original genome sequencing papers [94]. The
|
|
information on experimentally characterized genes of <i>E.
|
|
coli</i> is from the GeneProtEC and <i>E. coli</i>
|
|
Proteome databases, the corresponding <a href="/books/NBK20263/figure/A15/?report=objectonly" target="object" rid-ob="figobA15">(more...)</a></p></div></div><p>Even for <i>E. coli</i>, the workhorse of molecular genetics for the last
|
|
50 years, less than half of the genes have been experimentally characterized. Prior
|
|
to the completion of the genome of the archaeon <i>M. jannaschii</i>, only
|
|
four proteins have been characterized in that organism: two flagellins, RadA
|
|
recombinase and the adenylate kinase (in <a class="figpopup" href="/books/NBK20263/figure/A15/?report=objectonly" target="object" rid-figpopup="figA15" rid-ob="figobA15">Figure
|
|
1.2</a>, this sector is just not visible).</p><p>The availability of the genome sequence spawned efforts to characterize other genes
|
|
in these organisms, but so far these studies made only a limited contribution. The
|
|
level of characterization of eukaryotic genomes is not much higher, although
|
|
post-genomic efforts are improving the understanding of the yeast and nematode
|
|
proteomes (see <a href="/books/n/sef/A55/?report=reader#A121">3.5.2</a>).</p><p>Under these circumstances, the theory of molecular evolution and, in particular, the
|
|
simple connection between evolutionary conservation and function outlined above
|
|
remain the crucial theoretical underpinning and the main methodology of functional
|
|
genomics. The comparative approach allows researchers to predict protein functions
|
|
by transferring information from functionally characterized proteins of model
|
|
organisms to their uncharacterized homologs and to delineate the functionally
|
|
critical parts of protein (and RNA) molecules, such as catalytic or binding sites.
|
|
Naturally, the quality of these inferences depends on the sensitivity and robustness
|
|
of computational methods employed by comparative genomics. These caveats
|
|
notwithstanding, we will argue that comprehensive comparative analysis of genomic
|
|
sequences and the proteins they encode is an absolute prerequisite to further
|
|
advances in our understanding of cell biology. Actually, we tend to believe that
|
|
comparative genomics is up to something grander, namely prioritization of targets
|
|
for systematic experimental studies. This approach has been partially realized in
|
|
structural genomics, and we see no reason why it cannot be profitably applied in
|
|
functional genomics as well. We will be quite satisfied if this book makes just a
|
|
small step in this direction.</p></div><div id="A1678"><h2 id="_A1678_">1.4. Further Reading</h2><dl class="temp-labeled-list"><dl class="bkr_refwrap"><dt>1.</dt><dd><div class="bk_ref" id="A18">Doolittle RF. 1986. <em>Of Urfs and
|
|
Orfs: A primer on how to analyze derived amino acid
|
|
sequences.</em> University Science Books, San Diego.</div></dd></dl><dl class="bkr_refwrap"><dt>2.</dt><dd><div class="bk_ref" id="A19">Cairns J, Stent GS, Watson JD. 1992.
|
|
<em>Phage and the Origins of Molecular Biology.</em> Cold
|
|
Spring Harbor Laboratory Press, Cold Spring Harbor, NY.</div></dd></dl><dl class="bkr_refwrap"><dt>3.</dt><dd><div class="bk_ref" id="A20">Mount DW. 2000. <em>Bioinformatics:
|
|
Sequence and genome analysis.</em> Cold Spring Harbor Laboratory
|
|
Press, Cold Spring Harbor, NY. Chapter 1.</div></dd></dl><dl class="bkr_refwrap"><dt>4.</dt><dd><div class="bk_ref" id="A21">Koonin EV, Dolja VV. Evolution and taxonomy of positive-strand RNA viruses:
|
|
implications of comparative analysis of amino acid
|
|
sequences. <span><span class="ref-journal">Critical Reviews in Biochemistry and Molecular Biology. </span>1993;<span class="ref-vol">28</span>:375–430.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8269709" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8269709</span></a>]</div></dd></dl></dl></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK20263_pubdet_">Publication Details</h2><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> © 2003, Kluwer Academic.</div></div><h3>Publisher</h3><p><a href="http://www.springer.com/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">Kluwer Academic</a>, Boston</p><h3>NLM Citation</h3><p>Koonin EV, Galperin MY. Sequence - Evolution - Function: Computational Approaches in Comparative Genomics. Boston: Kluwer Academic; 2003. Chapter 1, Genomics: From Phage to Human.<span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/sef/A2/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/sef/A22/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article><article data-type="table-wrap" id="figobA6"><div id="A6" class="table"><h3><span class="label">Table 1.1</span><span class="title">Protein-coding genes of bacteriophage λ</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK20263/table/A6/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__A6_lrgtbl__"><table class="no_margin"><thead><tr><th id="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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Chromosomal location, bases
|
|
</th><th id="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
DNA strand
|
|
</th><th id="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
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Length, aa
|
|
</th><th id="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
Gene name
|
|
</th><th id="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
|
|
Gene product
|
|
</th></tr></thead><tbody><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">191..736</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">181</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">nu1</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DNA packaging protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">711..2636</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">641</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">A</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DNA packaging protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2633..2839</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">68</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">W</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Head-tail joining protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2836..4437</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">533</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">B</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Capsid component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4418..5737</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">439</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">C</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Capsid component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5132..5737</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">201</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">nu3</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Capsid assembly</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5747..6079</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">110</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">D</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Head-DNA stabilization</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">6135..7160</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">341</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">E</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Capsid component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">7202..7600</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">132</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Fi</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DNA packaging</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">7612..7965</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">117</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Fii</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Head-tail joining</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">7977..8555</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">192</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Z</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">8552..8947</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">131</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">U</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">8955..9695</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">256</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">V</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">9711..10133</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">140</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">G</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">10115..10549</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">144</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">T</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">10542..13103</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">853</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">H</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">13100..13429</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">109</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">M</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">13429..14127</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">232</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">L</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">14276..14875</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">199</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">K</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">14773..15444</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">223</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">I</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail component</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">15505..18903</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1132</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">L</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail:host specificity</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">18965..19585</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">206</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">lom</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Outer host membrane</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">19650..20855</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">401</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf401</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail fiber protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">20147..20767</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">206</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf206</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypothetical protein*</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">21029..21973</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">314</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf314</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail fiber</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">21973..22557</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">194</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf194</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fiber assembly protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">22686..23918</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">410</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ea47</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">24509..25399</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">296</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ea31</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25396..26973</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">525</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ea59</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">27812..28882</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">356</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">int</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Integration protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28860..29078</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">72</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">xis</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Excisionase</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29118..29285</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">55</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypothetical protein*</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29374..29655</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">93</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ea8.5</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">29847..30395</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">182</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ea22</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">30839..31024</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">61</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf61</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypothetical protein*</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31005..31196</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">63</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf63</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypothetical protein*</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31169..31351</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf60a</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypothetical protein*</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">31348..32028</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">226</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">exo</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exonuclease</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32025..32810</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">261</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">bet</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Recombination protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32816..33232</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">138</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">gam</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Host-nuclease inhibitor protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33187..33330</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">47</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">kil</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Host-killing</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33299..33463</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">54</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">cIII</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antitermination</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">33536..33904</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">122</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ssb</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Single-stranded DNA binding protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34087..34287</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">66</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ral</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Restriction alleviation</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34271..34357</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">28</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf28</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypothetical protein*</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">34482..35036</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">184</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">imm21</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Superinfection exclusion protein B</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35037..35438</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">133</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">N</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Early gene regulator</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">35825..36259</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">144</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">rexB</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusion</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">36275..37114</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">279</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">rexA</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exclusion</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">37227..37940</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">237</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">cI</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Repressor</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">38041..38241</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">67</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">cro</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antirepressor</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">38360..38653</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">97</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">cII</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Antitermination</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">38686..39585</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">299</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">O</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DNA replication</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">39582..40283</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">233</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">P</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DNA replication</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40280..40570</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">96</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">ren</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ren exclusion protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">40644..41084</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">146</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Nin146</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">41081..41953</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">290</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Nin290</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">41950..42123</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">57</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Nin57</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">42090..42272</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">60</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Nin60</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">42269..42439</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">56</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Nin56</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">42429..43043</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">204</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Nin204</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">43040..43246</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">68</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Nin68</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">43224..43889</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">221</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Nin221</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">43886..44509</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">207</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Q</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Late gene regulator</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">44621..44815</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">64</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">orf64</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypothetical protein*</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">45186..45509</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">107</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">S</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cell lysis protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">45493..45969</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">158</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">R</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cell lysis protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">45966..46427</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">153</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">Rz</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cell lysis protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">46459..46752</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">97</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">bor</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bor protein precursor</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">47042..47575</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">−</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">177</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Putative envelope protein</td></tr><tr><td headers="hd_h_A6_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">47738..47944</td><td headers="hd_h_A6_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">+</td><td headers="hd_h_A6_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">68</td><td headers="hd_h_A6_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A6_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hypothetical protein*</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt></dt><dd><div id="N0x1cf9150N0x3675450"><p class="no_margin">Based on the data from the NCBI Entrez Genomes web site, <a href="http://www.ncbi.nih.gov/Genomes/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.ncbi.nih.gov/Genomes/</a>. </p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobA7"><div id="A7" class="table"><h3><span class="label">Table 1.2</span><span class="title">Non-trivial evolutionary connections and functional predictions for
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bacteriophage λ proteins</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK20263/table/A7/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__A7_lrgtbl__"><table class="no_margin"><thead><tr><th id="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Gene product
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</th><th id="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Evolutionary conservation
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</th><th id="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Structure, Domain architecture<sup>a</sup>
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</th><th id="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Predicted function, Reference
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</th></tr></thead><tbody><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A (TerL)</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteriophages, herpesviruses</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A modified P-loop ATPase domain, distantly
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related to a vast class of helicases</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ATPase subunit of the terminase, involved
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in DNA packaging in phage head</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">C</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria and archaea</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">ClpP protease domain</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Minor capsid protein, cleaves the scaffold
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protein during maturation</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">K</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea, and eukaryotes</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Consists of an N-terminal JAB/MPN domain
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(predicted metalloprotease) and a C-terminal CHAP domain
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(Cys,His-dependent DL-glutamate-specific amidohydrolase)</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Tail subunit; predicted protease involved
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in tail assembly (based on the presence of the JAB/MPN domain)
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[<a href="/books/n/sef/A727/?report=reader#A1407">679</a>] and peptidoglycan
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lysis (based on the presence of the peptidoglycan amidohydrolase
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CHAP domain [<a href="/books/n/sef/A727/?report=reader#A1689">948</a>]</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ea31</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Scattered distribution archaea</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Endo VII-colicin domain</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Predicted nuclease of the McrA (HNH)
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family [<a href="/books/n/sef/A727/?report=reader#A778">50</a>]</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ea59</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea, and eukaryotes</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">P-loop ATPase domain of the ABC class</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Predicted ATPase [<a href="/books/n/sef/A727/?report=reader#A1024">296</a>]</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Exo (RedX)</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea, eukaryotes,
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viruses</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">λ exonuclease domain, distantly
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related to a broad variety of nucleases</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">A nuclease involved in phage recombination
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and late rolling-circle replication</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">CI</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">N-terminal helix-turn-helix DNA-binding
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domain fused to a C-terminal serine protease domain of the LexA/UmuD
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family</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Transcription repressor of genes required
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for lytic development</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cro</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Helix-turn-helix DNA-binding domain</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Transcription repressor of early
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genes</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">O</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Helix-turn-helix DNA-binding domain</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">DNA-binding protein involved in the
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initiation of replication</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ren</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Helix-turn-helix DNA-binding domain</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Protein involved in exclusion of
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replication of heterologous genomes in λ-infected
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bacteria</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nin290</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea, eukaryotes</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">PP-loop ATPase domain</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Predicted ATP pyrophosphatase, role in
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phage replication unknown [<a href="/books/n/sef/A727/?report=reader#A830">102</a>]</td></tr><tr><td headers="hd_h_A7_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Nin221</td><td headers="hd_h_A7_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Bacteria, archaea, eukaryotes</td><td headers="hd_h_A7_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Calcineurin-like serine/threonine protein
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phosphatase domain</td><td headers="hd_h_A7_1_1_1_4" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Protein phosphatase, role in phage
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replication unknown [<a href="/books/n/sef/A727/?report=reader#A1178">450</a>]</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="N0x1cf9150N0x3675b58"><p class="no_margin"> Detailed descriptions of these and other domains are available in the
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Pfam, SMART, and CDD protein domain databases (see <a href="/books/n/sef/A55/?report=reader#A70">3.2</a>) and in SCOP and CATH protein structure
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databases (see <a href="/books/n/sef/A55/?report=reader#A95">3.3</a>).</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobA8"><div id="A8" class="table"><h3><span class="label">Table 1.3</span><span class="title">A brief timeline of genomics</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK20263/table/A8/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__A8_lrgtbl__"><table class="no_top_margin"><thead><tr><th id="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">
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Year
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</th><th id="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">
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Event
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</th><th id="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">
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Ref.
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</th></tr></thead><tbody><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1962  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The first theory of molecular evolution;
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the Molecular Clock concept (Linus Pauling and Emile
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Zukerkandl)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1674">946</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1965  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Atlas of Protein Sequences, the first
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protein database (Margaret Dayhoff and coworkers)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A901">173</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1970  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Needleman-Wunsch algorithm for global
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protein sequence alignment</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1334">606</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1977  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">New DNA sequencing methods (Fred Sanger,
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Walter Gilbert and coworkers); bacteriophage ϕX174
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sequence</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1281">553</a>,<a href="/books/n/sef/A727/?report=reader#A1471">743</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1977  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">First software for sequence analysis
|
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(Roger Staden)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1525">797</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1977  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Phylogenetic taxonomy; archaea discovered;
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the notion of the three primary kingdoms of life introduced (Carl
|
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Woese and coworkers)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1633">905</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1981  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Smith-Waterman algorithm for local protein
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sequence alignment</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1512">784</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1981  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Human mitochondrial genome sequenced</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A756">28</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1981  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The concept of a sequence motif (Russell
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Doolittle)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A913">185</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1982  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">GenBank Release 3 made public</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;"></td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1982  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Phage λ genome sequenced (Fred
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Sanger and coworkers)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1470">742</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1983  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">The first practical sequence database
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searching algorithm (John Wilbur and David Lipman)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1620">892</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1985  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">FASTP/FASTN: fast sequence similarity
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searching (William Pearson and David Lipman)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1249">521</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1986  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Introduction of Markov models for DNA
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analysis (Mark Borodovsky and coworkers)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A835">107</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1987  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">First profile search algorithm (Michael
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Gribskov, Andrew McLachlan, David Eisenberg)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1043">315</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1988  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">National Center for Biotechnology
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Information (NCBI) created at NIH/NLM</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;"></td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1988  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EMBnet network for database distribution
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created</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;"></td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1990  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">BLAST: fast sequence similarity searching
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with rigorous statistics (Stephen Altschul, David Lipman and
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coworkers)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A748">20</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1991  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EST: expressed sequence tag sequencing
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(Craig Venter and coworkers)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A732">4</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1994  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Hidden Markov Models of multiple
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alignments (David Haussler and coworkers; Pierre Baldi and
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coworkers)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A799">71</a>,<a href="/books/n/sef/A727/?report=reader#A800">72</a>,<a href="/books/n/sef/A727/?report=reader#A1201">473</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1994  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">SCOP classification of protein structures
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(Alexei Murzin, Cyrus Chothia and coworkers)</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1318">590</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1995  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">First bacterial genomes completely
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sequenced</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A960">232</a>,<a href="/books/n/sef/A727/?report=reader#A970">242</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1996  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">First archaeal genome completely
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sequenced</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A858">130</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1996  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">First eukaryotic genome (yeast) completely
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sequenced</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1018">290</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1997  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Introduction of gapped BLAST and
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PSI-BLAST</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A750">22</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1997  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">COGs: Evolutionary classification of
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proteins from complete genomes</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1556">828</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1998  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Worm genome, the first multicellular
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genome, (nearly) completely sequenced</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1568">840</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1999  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fly genome (nearly) completely
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sequenced</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A731">3</a>]</td></tr><tr><td headers="hd_h_A8_1_1_1_1" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001  </td><td headers="hd_h_A8_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Human genome (nearly) completely
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sequenced</td><td headers="hd_h_A8_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1216">488</a>,<a href="/books/n/sef/A727/?report=reader#A1598">870</a>]</td></tr></tbody></table></div></div></article><article data-type="fig" id="figobA10"><div id="A10" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK20263/bin/ch1f1.jpg" alt="Figure 1.1. Growth of the number of completely sequenced genomes." /></div><h3><span class="label">Figure 1.1</span><span class="title">Growth of the number of completely sequenced genomes</span></h3><div class="caption"><p> The data are from <a class="figpopup" href="/books/NBK20263/table/A11/?report=objectonly" target="object" rid-figpopup="figA11" rid-ob="figobA11">Table 1.4</a>. The
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2002 figure is extrapolated from the 5-month results.</p></div></div></article><article data-type="table-wrap" id="figobA11"><div id="A11" class="table"><h3><span class="label">Table 1.4</span><span class="title">Completely sequenced genomes (as of June 1, 2002)</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK20263/table/A11/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__A11_lrgtbl__"><table class="no_margin"><thead><tr><th id="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:bottom;">
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Species<sup>a</sup>
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</th><th id="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">
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Genome size, kb
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</th><th id="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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Total no. of proteins
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</th><th id="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">
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Year finished
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</th><th id="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">
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Sequencing center<sup>b</sup>
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</th><th id="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:bottom;">
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Ref.
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</th></tr></thead><tbody><tr><td headers="hd_h_A11_1_1_1_1 hd_h_A11_1_1_1_2 hd_h_A11_1_1_1_3 hd_h_A11_1_1_1_4 hd_h_A11_1_1_1_5 hd_h_A11_1_1_1_6" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">
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<b>Bacteria</b>
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</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Streptomyces coelicolor</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">8,668</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">7,567</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sanger Centre</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A813">85</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Mesorhizobium loti</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">7,036</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">6,752</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kazusa Institute</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1143">415</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Sinorhizobium meliloti</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">6,692</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">6,205</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EU Consortium</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A865">137</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Nostoc</i> sp<i>. (Anabaena)</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">6,414</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5,366</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kazusa Institute</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1144">416</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Pseudomonas aeruginosa</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">6,264</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5,565</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Pathogenesis Co.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1535">807</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Agrobacterium tumefaciens</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5,674</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5,419</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">U. Washington, Cereon Inc.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1021">293</a>,<a href="/books/n/sef/A727/?report=reader#A1645">917</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Xanthomonas citri</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5,176</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,312</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">U. Sao Paulo</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A895">167</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Xanthomonas campestris</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5,076</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,181</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">U. Sao Paulo</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A895">167</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Salmonella typhimurium</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,857</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,451</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sidney Kimmel Cancer Center</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1285">557</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Salmonella typhi</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,809</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,600</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sanger Centre</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1382">654</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Yersinia pestis</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,654</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,008</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sanger Centre</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1384">656</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Escherichia coli</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,639</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,289</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1997</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">U. Wisconsin</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A822">94</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Mycobacterium tuberculosis</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">4,412</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">3,918</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1998</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">Sanger
|
|
Centre</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A880">152</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Bacillus subtilis</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,215</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,100</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1997</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Institute Pasteur</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1205">477</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Bacillus halodurans</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,202</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,066</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">JAMST Center</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1548">820</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Vibrio cholerae</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,033</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,827</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TIGR</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1065">337</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Caulobacter crescentus</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,017</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,737</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TIGR</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1346">618</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Clostridium acetobutylicum</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,941</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,672</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Genome Therapeutics</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1350">622</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Ralstonia solanacearum</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">3,716</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">3,442</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2002</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">Genoscope</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1459">731</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Synechocystis</i> sp.</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,573</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,169</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1996</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Kazusa Institute</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1145">417</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Corynebacterium glutamicum</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,309</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,040</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">U. Bielefeld</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1559">831</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Mycobacterium leprae</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">3,268</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,720</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2001</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">Sanger
|
|
Centre</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A881">153</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Clostridium perfringens</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">3,031</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,660</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2002</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">U. Tsukuba</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1495">767</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Listeria innocua</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">3,011</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,981</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2001</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">Institute
|
|
Pasteur</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1014">286</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Listeria monocytogenes</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,945</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,855</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2001</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">Institute
|
|
Pasteur</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1014">286</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Staphylococcus aureus</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,814</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,594</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Juntendo U.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1209">481</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Thermoanaerobacter tengcongensis</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,689</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,588</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Beijing Genomics Inst.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A801">73</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Xylella fastidiosa</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,679</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,766</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2000</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">San Paulo
|
|
State</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1500">772</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Deinococcus radiodurans</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,649</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,580</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1999</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TIGR</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1619">891</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Lactococcus lactis</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,365</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,266</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">INRA</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A825">97</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Pasteurella multocida</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,257</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,014</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2001</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">U.
|
|
Minnesota</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1282">554</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Neisseria meningitidus</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,184</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,121</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2000</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">TIGR,
|
|
Sanger</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1381">653</a>,<a href="/books/n/sef/A727/?report=reader#A1565">837</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Fusobacterium nucleatum</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,174</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,067</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2002</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">Integr.Genomics</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1146">418</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Streptococcus pneumoniae</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,160</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,094</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2001</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">TIGR</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1085">357</a>,<a href="/books/n/sef/A727/?report=reader#A1564">836</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Brucella melitensis</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,117</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2,059</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2002</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">U. Scranton</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A907">179</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Thermotoga maritima</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,861</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,846</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1999</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TIGR</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1338">610</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Streptococcus pyogenes</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,852</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,697</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2001</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">U. Oklahoma</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A951">223</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Haemophilus influenzae</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,830</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,709</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1995</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">TIGR</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A960">232</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Campylobacter jejuni</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,641</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,654</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2000</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">Sanger
|
|
Centre</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1383">655</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Helicobacter pylori</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,668</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,566</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1997</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">TIGR</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1576">848</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Aquifex aeolicus</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,551</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,522</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1998</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Diversa Corp.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A903">175</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Rickettsia conorii</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,269</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,274</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2000</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">U.
|
|
Marseille</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1354">626</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Chlamydia pneumoniae</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,230</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,052</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1999</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">UC Berkeley</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1140">412</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Treponema pallidum</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,138</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,031</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1998</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">TIGR</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A971">243</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Rickettsia prowazekii</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,111</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">834</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1998</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">Uppsala U.</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A758">30</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Chlamydia muridarum</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,069</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">909</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2000</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">TIGR</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1422">694</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Chlamydia trachomatis</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1,042</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">894</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1998</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">UC Berkeley</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1533">805</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Borellia burgdorferi</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">911</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">850</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1997</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">TIGR</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A969">241</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Mycoplasma pneumoniae</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">816</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">677</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1996</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">U.
|
|
Heidelberg</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1075">347</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Ureaplasma urealyticum</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">752</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">611</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2000</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">U. Alabama</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1015">287</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Mycoplasma pulmonis</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">964</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">782</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">2001</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">U. Bordeaux</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A872">144</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Buchnera sp. APS</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">641</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">564</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">U. Tokyo</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1494">766</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">
|
|
<i>Mycoplasma genitalium</i>
|
|
</span>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">580</span>
|
|
</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">467</span>
|
|
</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<span style="color:lightgrey">1995</span>
|
|
</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<span style="color:lightgrey">TIGR</span>
|
|
</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A970">242</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1 hd_h_A11_1_1_1_2 hd_h_A11_1_1_1_3 hd_h_A11_1_1_1_4 hd_h_A11_1_1_1_5 hd_h_A11_1_1_1_6" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>Archaea</b>
|
|
</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Methanosarcina acetivorans</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5,751</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,540</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Whitehead Inst.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A982">254</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Methanosarcina mazei</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,096</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3,371</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">U. Göttingen</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A909">181</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Sulfolobus solfataricus</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,992</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,997</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">EU/Canada</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1492">764</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Sulfolobus tokodaii</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,695</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,826</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NITE</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1154">426</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Halobacterium sp NRC-1</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,380</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,446</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Inst. Syst. Biol.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1344">616</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Pyrobaculum aerophilum</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,222</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,605</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">UCLA</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A959">231</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Archaeoglobus fulgidus</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,178</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,420</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1997</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TIGR</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1172">444</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Pyrococcus furiosus</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,908</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2,065</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">U. Maryland</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1432">704</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Methanobacerium thermoautotrophicum</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,751</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,869</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1997</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Genome Therapeutics</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1509">781</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Pyrococcus abyssi</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,765</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,765</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Genoscope</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1327">599</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Pyrococcus horikoshii</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,739</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~1,750</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1998</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NITE</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1156">428</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Methanopyrus kandleri</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,695</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,691</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Fidelity Sistems</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1507">779</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Aeropyrum pernix</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,670</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~1,720</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1999</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NITE</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1155">427</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Methanococcus jannaschii</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,665</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,715</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1996</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">TIGR</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A858">130</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Thermoplasma volcanuim</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,585</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,499</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">NIBHT</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1158">430</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Thermoplasma acidophilum</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,565</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,478</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">MPI Biochem.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1447">719</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1 hd_h_A11_1_1_1_2 hd_h_A11_1_1_1_3 hd_h_A11_1_1_1_4 hd_h_A11_1_1_1_5 hd_h_A11_1_1_1_6" colspan="6" rowspan="1" style="text-align:left;vertical-align:top;">
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<b>Eukaryotes</b>
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</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Homo sapiens</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~3,100,000</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~40,000</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Human Genome Project, Celera</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1216">488</a>,<a href="/books/n/sef/A727/?report=reader#A1598">870</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Mus musculus</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~3,100,000</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~40,000</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mouse Genome Project, Celera</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Oryza sativa</i>
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~420,000</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">32,277</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Syngenta Corp.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1017">289</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Anopheles gambiae</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~278,000</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Celera, Sanger</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<i>Drosophila melanogaster</i>
|
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</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~137,300</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~13,500</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Celera, UC Berkeley</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A731">3</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<i>Arabidopsis thaliana</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~115,400</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">25,498</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2000</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Arabidopsis Genome Project</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A763">35</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<i>Caenorhabditis elegans</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~96,900</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~19,000</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1999</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sanger Centre, Washington U.</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1568">840</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<i>Saccharomyces cerevisiae</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~11,600</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~6,000</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1996</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">European Consortium</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1018">290</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<i>Schizosaccharomyces pombe</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~12,600</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4,824</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2002</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Sanger Centre</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1646">918</a>]</td></tr><tr><td headers="hd_h_A11_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<i>Encephalitozoon cuniculi</i>
|
|
</td><td headers="hd_h_A11_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">~2,500</td><td headers="hd_h_A11_1_1_1_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1,997</td><td headers="hd_h_A11_1_1_1_4" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2001</td><td headers="hd_h_A11_1_1_1_5" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Genoscope</td><td headers="hd_h_A11_1_1_1_6" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">[<a href="/books/n/sef/A727/?report=reader#A1153">425</a>]</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="N0x1cf9150N0x3717e78"><p class="no_margin"> Further in the book, these names are used mostly in the abbreviated
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form. Shading indicates obligate parasites.</p></div></dd></dl><dl class="bkr_refwrap"><dt>b</dt><dd><div id="N0x1cf9150N0x3717f98"><p class="no_margin"> For the complete names of the sequencing centers, see the NCBI Entrez
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Genomes web site <a href="/entrez/query.fcgi?dbGenome" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=Genome</a>,
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<a href="/books/n/sef/A607/?report=reader">Appendix 2</a>, or the original
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references.</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobA13"><div id="A13" class="table"><h3><span class="label">Table 1.5</span><span class="title">Coverage of the main prokaryotic phyla by genome projects</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK20263/table/A13/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__A13_lrgtbl__"><table class="no_margin"><thead><tr><th id="hd_h_A13_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></th><th id="hd_h_A13_1_1_1_2" colspan="2" content-type="rowsep" rowspan="1" style="text-align:center;vertical-align:top;">
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<b>Genome sequencing</b>
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<span class="hr"></span>
|
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</th></tr><tr><th headers="hd_h_A13_1_1_1_1" id="hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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Major prokaryotic phyla<sup>a</sup>
|
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</th><th headers="hd_h_A13_1_1_1_2" id="hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
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Completed
|
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</th><th headers="hd_h_A13_1_1_1_2" id="hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
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In progress
|
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</th></tr></thead><tbody><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1 hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2 hd_h_A13_1_1_2_3" colspan="3" rowspan="1" style="text-align:left;vertical-align:top;">
|
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<b>Archaea</b>
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</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Crenarchaeota</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Euryarchaeota</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">12</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1 hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2 hd_h_A13_1_1_2_3" colspan="3" rowspan="1" style="text-align:left;vertical-align:top;">
|
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<b>Bacteria</b>
|
|
</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Aquificales</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> CFB/Chlorobium group</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">4</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Chlamydiales/Verrucomicrobia
|
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group</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Chrysiogenetes</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Cyanobacteria</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Deferribacteres</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Dehalococcoides group</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Dictyoglomus group</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Fibrobacter/Acidobacteria
|
|
group</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Bacillus/Clostridium group (low
|
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G+C gram-positive)</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">13</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">20</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Actinobacteria (high
|
|
G+C gram-positive)</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">3</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">8</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Fusobacteria</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Green non-sulfur bacteria</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Planctomycetales</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Proteobacteria</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">23</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">44</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Alpha subdivision</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">7</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">9</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Beta subdivision</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">8</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Gamma subdivision</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">12</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">20</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Delta subdivision</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">5</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Epsilon
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subdivision</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Spirochaetales</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">2</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Thermodesulfobacteria</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Thermomicrobia</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Thermotogales</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A13_1_1_1_1 hd_h_A13_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Thermus/Deinococcus group</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1</td><td headers="hd_h_A13_1_1_1_2 hd_h_A13_1_1_2_3" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">1</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="N0x1cf9150N0x3718f10"><p class="no_margin"> The taxonomy is from the NCBI Taxonomy database (see <a href="/books/n/sef/A55/?report=reader#A129">3.6</a>). The data on the finished and
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ongoing genome sequencing projects are from the Entrez Genomes database
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(<a href="/PMGifs/Genomes/micr.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http://www<wbr style="display:inline-block"></wbr>​.ncbi.nlm.nih<wbr style="display:inline-block"></wbr>​.gov/PMGifs/Genomes/micr.html</a>)
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and the Genomes OnLine Database (<a href="http://genomesonline.org" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">http:<wbr style="display:inline-block"></wbr>​//genomesonline.org</a>).</p></div></dd></dl></dl></div></div></div></article><article data-type="table-wrap" id="figobA14"><div id="A14" class="table"><h3><span class="label">Table 1.6</span><span class="title">Status of the eukaryotic genome projects</span></h3><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK20263/table/A14/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__A14_lrgtbl__"><table class="no_margin"><thead><tr><th id="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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<b>Major eukaryotic phyla</b>
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<sup>a</sup>
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</th><th id="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:middle;">
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Representatives with ongoing sequencing projects
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</th></tr></thead><tbody><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Acanthamoebidae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Acantharea</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Alveolata</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>
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<i>Babesia bovis</i>
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</b>, Cryptosporidium parvum, Eimeria tenella, <b>Plasmodium
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falciparum</b>, <b>
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<i>P. berghei</i>
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</b>, <b>
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<i>P. chabaudi</i>
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</b>, P. vivax, P. yoelii, <b>
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<i>Theileria annulata</i>
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</b>, <b>
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<i>Toxoplasma gondii</i>
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</b>
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</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Apicomplexa</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"></td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Ciliophora</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paramecium tetraurelia, Tetrahymena
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sp.</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Dinophyceae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Haplosporida</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Apusomonadidae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cercozoa</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Chlorarachnion reptans</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Core jakobids</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Reclinomonas americana</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cryptophyta</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Guillardia theta</b> (nucleomorph genome)</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Diplomonadida</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>
|
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<i>Giardia intestinalis</i>
|
|
</b>
|
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</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Entamoebidae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<b>
|
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<i>Entamoeba histolytica</i>
|
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</b>
|
|
</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Euglenozoa</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<b>
|
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<i>Leishmania major</i>
|
|
</b>, <b>
|
|
<i>Trypanosoma brucei</i>
|
|
</b>
|
|
</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Glaucocystophyceae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Granuloreticulosea</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Haptophyceae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Heterolobosea</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Lobosea</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Malawimonadidae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Microsporidia</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Encephalitozoon cuniculi,</b> Spraguea lophii</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Mycetozoa</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
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<b>
|
|
<i>Dictyostelium discoideum</i>
|
|
</b>
|
|
</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Oxymonadida</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Parabasalidea</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Paramyxea</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Pelobiontida</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Plasmodiophorida</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Polycystinea</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Retortamonadidae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Rhodophyta</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Porphyra yezoensis</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Stramenopiles</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Thalassiosira pseudonana</td></tr><tr><td headers="hd_h_A14_1_1_1_1 hd_h_A14_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Viridiplantae</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Chlorophyta</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Chlamydonas reinhardtii</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Streptophyta</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Alfalfa, barley, bean, coffee, corn,
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|
cotton, pine, poplar, potato, rice, sorghum, soybean, sugar cane,
|
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tomato, wheat</td></tr><tr><td headers="hd_h_A14_1_1_1_1 hd_h_A14_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">Fungi/Metazoa group</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Aconchulinia</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<b>-</b>
|
|
</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;"> Choanoflagellida</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">
|
|
<b>-</b>
|
|
</td></tr><tr><td headers="hd_h_A14_1_1_1_1 hd_h_A14_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"> Fungi</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Ascomycota</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
|
<b>Saccharomyces cerevisiae</b>, <b>Schizosaccharomyces
|
|
pombe,</b>
|
|
<b>
|
|
<i>Aspergillus nidulans</i>
|
|
</b>, <b>
|
|
<i>A. fumigatus</i>
|
|
</b>, A. niger, <b>
|
|
<i>Candida albicans</i>
|
|
</b>, Coccidioides immitis, Debaryomyces hansenii, Fusarium
|
|
proliferatum, <b>
|
|
<i>Neurospora crassa</i>
|
|
</b>, Pneumocystis carinii, Trichoderma reesei</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Basidiomycota</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Cryptococcus neoformans, Phanerochaete
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chrysosporium, Ustilago maydis</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Chytridiomycota</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Zygomycota</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1 hd_h_A14_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;"> Metazoa</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Porifera
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(sponges)</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Cnidaria</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Ctenophora</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Platyhelminthes</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Schistosoma mansoni, S. japonicum</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Nematoda</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Caenorhabditis elegans</b>, Ascaris suum, Brugia malayi, C.
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briggsae, Haemonchus contortus</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Annelida</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Mollusca</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">  Arthropoda</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Drosophila melanogaster, Anopheles gambiae</b>, Aedes
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aegypti, A. albopictus, Amblyomma americanum, Glossina
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morsitans</td></tr><tr><td headers="hd_h_A14_1_1_1_1 hd_h_A14_1_1_1_2" colspan="2" rowspan="1" style="text-align:left;vertical-align:top;">  Chordata</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">   Urochordata</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ciona intestinalis (sea squirt), C.
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savignyi</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">   Actinopterygii</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Takifugu rubripes (fugu)</b>, <b>
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<i>Danio rerio (zebrafish)</i>
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</b>, Oreochromis niloticus (tilapia)</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">   Amphibia</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Ambystoma mexicanum (axolotl), Xenopus
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tropicalis (frog), X. laevis</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">   Crocodylidae</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:center;vertical-align:top;">-</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">   Aves
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(birds)</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">Chicken, turkey</td></tr><tr><td headers="hd_h_A14_1_1_1_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">   Mammals</td><td headers="hd_h_A14_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
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<b>Human</b>, <b>mouse</b>, rat, cat, chimpanzee, cow,
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dog</td></tr></tbody></table></div><div class="tblwrap-foot"><div><dl class="temp-labeled-list small"><dl class="bkr_refwrap"><dt>a</dt><dd><div id="N0x1cf9150N0x3743ec0"><p class="no_margin"> The taxonomy is from the NCBI Taxonomy database (see <a href="/books/n/sef/A55/?report=reader#A129">3.6</a>). Organisms with finished or
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almost finished projects are shown in bold; advanced-stage projects are
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shown in bold and italic; not all sequencing projects for each
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phylogenetic lineage are listed. Absence of sequencing projects for any
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representative of a phylogenetic lineage, according to the Entrez
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Genomes and Genomes OnLine databases, is indicated by a dash.</p></div></dd></dl></dl></div></div></div></article><article data-type="fig" id="figobA15"><div id="A15" class="figure bk_fig"><div class="graphic"><img data-src="/books/NBK20263/bin/ch1f2.jpg" alt="Figure 1.2. The current state of annotation of some genomes." /></div><h3><span class="label">Figure 1.2</span><span class="title">The current state of annotation of some genomes</span></h3><div class="caption"><p> The data were derived from the original genome sequencing papers [<a href="/books/n/sef/A727/?report=reader#A822">94</a>,<a href="/books/n/sef/A727/?report=reader#A858">130</a>,<a href="/books/n/sef/A727/?report=reader#A1018">290</a>,<a href="/books/n/sef/A727/?report=reader#A1216">488</a>]. The
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information on experimentally characterized genes of <i>E.
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coli</i> is from the GeneProtEC and <i>E. coli</i>
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Proteome databases, the corresponding data for yeast and human are from
|
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the MIPS and OMIM databases, respectively (see <a href="/books/n/sef/A55/?report=reader#A116">3.5</a>). The numbers of genes characterized by
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similarity only and similar to unknown genes are from the COG database
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(see <a href="/books/n/sef/A55/?report=reader#A103">3.4</a>); these numbers might be
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a slight underestimate because each COG is required to include
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representatives of three sufficiently distant species, and those few
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proteins that have a homolog in only one other species are lost in this
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analysis.</p></div></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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