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<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Adverse Effects of Vaccines - NCBI Bookshelf</title>
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<meta name="author" content="Kathleen Stratton, Andrew Ford, Erin Rusch, Ellen Wright Clayton, Committee to Review Adverse Effects of Vaccines; Institute of Medicine">
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<meta name="citation_title" content="Adverse Effects of Vaccines">
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<meta name="citation_publisher" content="National Academies Press (US)">
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<meta name="citation_date" content="2011/08/25">
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<meta name="citation_author" content="Kathleen Stratton">
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<meta name="citation_author" content="Andrew Ford">
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<meta name="citation_author" content="Erin Rusch">
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<meta name="citation_author" content="Ellen Wright Clayton">
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<meta name="citation_author" content="Committee to Review Adverse Effects of Vaccines">
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<meta name="citation_author" content="Institute of Medicine">
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<meta name="citation_pmid" content="24624471">
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<meta name="citation_doi" content="10.17226/13164">
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<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK190024/">
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<meta name="DC.Title" content="Adverse Effects of Vaccines">
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<meta name="DC.Publisher" content="National Academies Press (US)">
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<meta name="DC.Contributor" content="Kathleen Stratton">
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<meta name="DC.Contributor" content="Andrew Ford">
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<meta name="DC.Contributor" content="Erin Rusch">
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<meta name="DC.Contributor" content="Ellen Wright Clayton">
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<meta name="DC.Contributor" content="Committee to Review Adverse Effects of Vaccines">
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<meta name="DC.Contributor" content="Institute of Medicine">
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<meta name="DC.Date" content="2011/08/25">
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<meta name="description" content="In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma.">
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<meta name="og:title" content="Adverse Effects of Vaccines">
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<meta name="og:description" content="In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma.">
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style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><div class="main-content lit-style"><div class="fm-sec bkr_bottom_sep"><div class="bkr_thumb"><a href="http://www.nap.edu/catalog.php?record_id=13164" title="National Academies Press (US)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nap13164-lrg.png" alt="Cover of Adverse Effects of Vaccines" /></a></div><div class="bkr_bib"><h1 id="_NBK190024_"><span itemprop="name">Adverse Effects of Vaccines</span></h1><div class="subtitle">Evidence and Causality</div><p class="contrib-group"><h4>Contributors</h4>Editors: <span itemprop="editor">Kathleen Stratton</span>, <span itemprop="editor">Andrew Ford</span>, <span itemprop="editor">Erin Rusch</span>, and <span itemprop="editor">Ellen Wright Clayton</span>. Authors: <span itemprop="author">Committee to Review Adverse Effects of Vaccines</span>; <span itemprop="author">Institute of Medicine</span>.</p><div class="half_rhythm">Washington (DC): <a href="http://www.nap.edu/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Academies Press (US)</span></a>; <span itemprop="datePublished">2011 Aug 25</span>.<div class="small"><span class="label">ISBN-13: <span itemprop="isbn">978-0-309-21435-3</span></span>ISBN-10: <span itemprop="isbn">0-309-21435-1</span></div></div><div><a href="/books/about/copyright/">Copyright</a> 2012 by the National Academy of Sciences. All rights reserved.</div><div class="small half_rhythm bk_noprnt"><a href="http://www.nap.edu/catalog.php?record_id=13164" ref="pagearea=body&targetsite=external&targetcat=link&targettype=publisher">Hardcopy Version at National Academies Press</a></div><a class="btn wsprkl bkr_rd" href="/books/n/nap13164/sec_0001/?report=reader">Read</a></div><div class="bkr_clear"></div></div><div class="bkr_bottom_sep bkr_bottom_margin body-content whole_rhythm"><div itemprop="description"><p>In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. <i>Adverse Effects of Vaccines</i> reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma.</p><p>
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<i>Adverse Effects of Vaccines</i> will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.</p></div></div></div><div class="fm-sec"><div><p>This study was supported by Contract No. HHSH230200446009I, Task Order 13 between the National Academy of Sciences and the Health Resources and Services Administration of the U.S. Department of Health and Human Services. The Centers for Disease Control and Prevention and the National Vaccine Program Office also provided support through that contract. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.</p></div><div><h4 class="inline">Suggested citation:</h4><p>IOM (Institute of Medicine). 2012. Adverse effects of vaccines: Evidence and causality. Washington, DC: The National Academies Press.</p></div><div><p>NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.</p></div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> 2012 by the National Academy of Sciences. All rights reserved.</div><div class="small"><span class="label">Bookshelf ID: NBK190024</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/24624471" title="PubMed record of this title" ref="pagearea=meta&targetsite=entrez&targetcat=link&targettype=pubmed">24624471</a></span>DOI: <a href="http://dx.crossref.org/10.17226/13164" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">10.17226/13164</a></div></div><div class="small-screen-prev"></div><div class="small-screen-next"></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
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