publicdata/nih-gov
2
0
Fork 0
Code Issues Pull requests Projects Releases Packages Wiki Activity Actions
nih-gov/www.ncbi.nlm.nih.gov/books/NBK190024/index.html?cmd=HTOff&
Scott Williams f361c7df98 Incremental update
2025-03-17 02:05:34 +00:00

487 lines
No EOL
88 KiB
XML
Raw Blame History

<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
<head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
<!-- AppResources meta begin -->
<meta name="paf-app-resources" content="" />
<script type="text/javascript">var ncbi_startTime = new Date();</script>
<!-- AppResources meta end -->
<!-- TemplateResources meta begin -->
<meta name="paf_template" content="" />
<!-- TemplateResources meta end -->
<!-- Logger begin -->
<meta name="ncbi_db" content="books" /><meta name="ncbi_pdid" content="book-toc" /><meta name="ncbi_acc" content="NBK190024" /><meta name="ncbi_domain" content="nap13164" /><meta name="ncbi_report" content="record" /><meta name="ncbi_type" content="fulltext" /><meta name="ncbi_objectid" content="" /><meta name="ncbi_pcid" content="/NBK190024/?cmd=HTOff&amp;" /><meta name="ncbi_pagename" content="Adverse Effects of Vaccines - NCBI Bookshelf" /><meta name="ncbi_bookparttype" content="toc" /><meta name="ncbi_app" content="bookshelf" />
<!-- Logger end -->
<title>Adverse Effects of Vaccines - NCBI Bookshelf</title>
<!-- AppResources external_resources begin -->
<link rel="stylesheet" href="/core/jig/1.15.2/css/jig.min.css" /><script type="text/javascript" src="/core/jig/1.15.2/js/jig.min.js"></script>
<!-- AppResources external_resources end -->
<!-- Page meta begin -->
<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE,NOIMAGEINDEX" /><meta name="author" content="Kathleen Stratton, Andrew Ford, Erin Rusch, Ellen Wright Clayton, Committee to Review Adverse Effects of Vaccines; Institute of Medicine" /><meta name="citation_title" content="Adverse Effects of Vaccines" /><meta name="citation_publisher" content="National Academies Press (US)" /><meta name="citation_date" content="2011/08/25" /><meta name="citation_author" content="Kathleen Stratton" /><meta name="citation_author" content="Andrew Ford" /><meta name="citation_author" content="Erin Rusch" /><meta name="citation_author" content="Ellen Wright Clayton" /><meta name="citation_author" content="Committee to Review Adverse Effects of Vaccines" /><meta name="citation_author" content="Institute of Medicine" /><meta name="citation_pmid" content="24624471" /><meta name="citation_doi" content="10.17226/13164" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK190024/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Adverse Effects of Vaccines" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Academies Press (US)" /><meta name="DC.Contributor" content="Kathleen Stratton" /><meta name="DC.Contributor" content="Andrew Ford" /><meta name="DC.Contributor" content="Erin Rusch" /><meta name="DC.Contributor" content="Ellen Wright Clayton" /><meta name="DC.Contributor" content="Committee to Review Adverse Effects of Vaccines" /><meta name="DC.Contributor" content="Institute of Medicine" /><meta name="DC.Date" content="2011/08/25" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK190024/" /><meta name="DC.Language" content="en" /><meta name="description" content="In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma." /><meta name="og:title" content="Adverse Effects of Vaccines" /><meta name="og:type" content="book" /><meta name="og:description" content="In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK190024/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nap13164-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/nap13164/toc/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK190024/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="NONE" />
<!-- Page meta end -->
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8E55757D69B5610000000000E200C0.m_13" />
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3985586/3808861/4121862/3974050/3917732/251717/4216701/14534/45193/4113719/3849091/3984811/3751656/4033350/3840896/3577051/3852958/4008682/4207974/4206132/4062871/12930/3964959/3854974/36029/4128070/9685/3549676/3609192/3609193/3609213/3395586.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3411343/3882866.css" media="print" /></head>
<body class="book-toc">
<div class="grid">
<div class="col twelve_col nomargin shadow">
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
<div class="sysmessages">
<noscript>
<p class="nojs">
<strong>Warning:</strong>
The NCBI web site requires JavaScript to function.
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
</p>
</noscript>
</div>
<!--/.sysmessage-->
<div class="wrap">
<div class="page">
<div class="top">
<div id="universal_header">
<section class="usa-banner">
<div class="usa-accordion">
<header class="usa-banner-header">
<div class="usa-grid usa-banner-inner">
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
<p>An official website of the United States government</p>
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
<span class="usa-banner-button-text">Here's how you know</span>
</button>
</div>
</header>
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
<div class="usa-banner-guidance-gov usa-width-one-half">
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
<div class="usa-media_block-body">
<p>
<strong>The .gov means it's official.</strong>
<br />
Federal government websites often end in .gov or .mil. Before
sharing sensitive information, make sure you're on a federal
government site.
</p>
</div>
</div>
<div class="usa-banner-guidance-ssl usa-width-one-half">
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
<div class="usa-media_block-body">
<p>
<strong>The site is secure.</strong>
<br />
The <strong>https://</strong> ensures that you are connecting to the
official website and that any information you provide is encrypted
and transmitted securely.
</p>
</div>
</div>
</div>
</div>
</section>
<div class="usa-overlay"></div>
<header class="ncbi-header" role="banner" data-section="Header">
<div class="usa-grid">
<div class="usa-width-one-whole">
<div class="ncbi-header__logo">
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
</a>
</div>
<div class="ncbi-header__account">
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
<span class="fa fa-user" aria-hidden="true">
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
<g style="fill: #fff">
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
</g>
</svg>
</span>
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
<span class="sr-only">Show account info</span>
</button>
</div>
<div class="ncbi-popup-anchor">
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
<div class="ncbi-popup-head">
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
<span class="fa fa-times">
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
</svg>
</span>
<span class="usa-sr-only">Close</span></button>
<h4>Account</h4>
</div>
<div class="account-user-info">
Logged in as:<br />
<b><span class="username" id="uname_long">username</span></b>
</div>
<div class="account-links">
<ul class="usa-unstyled-list">
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
</ul>
</div>
</div>
</div>
</div>
</div>
</header>
<div role="navigation" aria-label="access keys">
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
</div>
<section data-section="Alerts">
<div class="ncbi-alerts-placeholder"></div>
</section>
</div>
<div class="header">
<div class="res_logo"><h1 class="res_name"><a href="/books/" title="Bookshelf home">Bookshelf</a></h1><h2 class="res_tagline"></h2></div>
<div class="search"><form method="get" action="/books/"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="books" selected="selected" data-ac_dict="bookshelf-search">Books</option><option value="nuccore">Nucleotide</option><option value="taxonomy">Taxonomy</option><option value="omim" class="last">OMIM</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books" data-ac_dict="bookshelf-search">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search Books. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'bookshelf-search',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'no',afs:'no'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div></form><ul class="searchlinks inline_list"><li>
<a href="/books/browse/">Browse Titles</a>
</li><li>
<a href="/books/advanced/">Advanced</a>
</li><li class="help">
<a href="/books/NBK3833/">Help</a>
</li><li class="disclaimer">
<a target="_blank" data-ga-category="literature_resources" data-ga-action="link_click" data-ga-label="disclaimer_link" href="https://www.ncbi.nlm.nih.gov/books/about/disclaimer/">Disclaimer</a>
</li></ul></div>
</div>
<!--<component id="Page" label="headcontent"/>-->
</div>
<div class="content">
<!-- site messages -->
<!-- Custom content 1 -->
<div class="col1">
</div>
<div class="container">
<div id="maincontent" class="content eight_col col">
<!-- Custom content in the left column above book nav -->
<div class="col2">
</div>
<!-- Book content -->
<!-- Custom content between navigation and content -->
<div class="col3">
</div>
<div class="source">
<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">&lt; Prev</span><a class="active page_link next" href="/books/n/nap13164/sec_0001/" title="Next page in this title">Next &gt;</a></div></div></div>
<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="http://www.nap.edu/catalog.php?record_id=13164" title="National Academies Press (US)" class="img_link icnblk_img" ref="pagearea=logo&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nap13164-lrg.png" alt="Cover of Adverse Effects of Vaccines" /></a><div class="icnblk_cntnt"><h1 id="_NBK190024_"><span itemprop="name">Adverse Effects of Vaccines</span></h1><div class="subtitle">Evidence and Causality</div><p class="contrib-group">Editors: <span itemprop="editor">Kathleen Stratton</span>, <span itemprop="editor">Andrew Ford</span>, <span itemprop="editor">Erin Rusch</span>, and <span itemprop="editor">Ellen Wright Clayton</span>. Authors: <span itemprop="author">Committee to Review Adverse Effects of Vaccines</span>; <span itemprop="author">Institute of Medicine</span>.</p><div class="half_rhythm">Washington (DC): <a href="http://www.nap.edu/" ref="pagearea=meta&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher"><span itemprop="publisher">National Academies Press (US)</span></a>; <span itemprop="datePublished">2011 Aug 25</span>.<div class="small"><span class="label">ISBN-13: <span itemprop="isbn">978-0-309-21435-3</span></span>ISBN-10: <span itemprop="isbn">0-309-21435-1</span></div></div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK190024" data-jigconfig="modal:true">Copyright and
Permissions</a></span></li></ul></div><div id="_ncbi_dlg_cpyrght_NBK190024" style="display:none" title="Copyright and&#10; Permissions"><div><div>Copyright 2012 by the National Academy of Sciences. All rights reserved.</div><div>For more information, see the <a href="/books/about/copyright/">Bookshelf Copyright Notice</a>.</div></div></div><div class="small half_rhythm bk_noprnt"><a href="http://www.nap.edu/catalog.php?record_id=13164" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=publisher">Hardcopy Version at National Academies Press</a></div><div class="bk_noprnt"><form method="get" action="/books/n/nap13164/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div itemprop="description"><p>In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. <i>Adverse Effects of Vaccines</i> reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma.</p><p>
<i>Adverse Effects of Vaccines</i> will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.</p></div><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK190024_sec_0001" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0001"><a href="/books/n/nap13164/sec_0001/" class="toc-item">THE NATIONAL ACADEMIES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0002"><a href="/books/n/nap13164/sec_0002/" class="toc-item">COMMITTEE TO REVIEW ADVERSE EFFECTS OF VACCINES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0004"><a href="/books/n/nap13164/sec_0004/" class="toc-item">Reviewers</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0005"><a href="/books/n/nap13164/sec_0005/" class="toc-item">Preface</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0007"><a href="/books/n/nap13164/sec_0007/" class="toc-item">Acronyms</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sum1"><a href="/books/n/nap13164/sum1/" class="toc-item">Summary</a><ul id="toc_lst_NBK190024_sec_0008" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0008"><a href="/books/n/nap13164/sum1/#sec_0008" class="toc-item">CHARGE TO THE COMMITTEE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0009"><a href="/books/n/nap13164/sum1/#sec_0009" class="toc-item">ASSESSING THE WEIGHT OF EVIDENCE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0012"><a href="/books/n/nap13164/sum1/#sec_0012" class="toc-item">CAUSALITY ASSESSMENT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0013"><a href="/books/n/nap13164/sum1/#sec_0013" class="toc-item">CAUSALITY CONCLUSIONS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0018"><a href="/books/n/nap13164/sum1/#sec_0018" class="toc-item">SUSCEPTIBILITY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0019"><a href="/books/n/nap13164/sum1/#sec_0019" class="toc-item">CONCLUDING COMMENT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist1"><a href="/books/n/nap13164/sum1/#reflist1" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch1"><a href="/books/n/nap13164/ch1/" class="toc-item">1. Introduction</a><ul id="toc_lst_NBK190024_sec_0020" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0020"><a href="/books/n/nap13164/ch1/#sec_0020" class="toc-item">CHARGE TO THE COMMITTEE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0021"><a href="/books/n/nap13164/ch1/#sec_0021" class="toc-item">COMMITTEE PROCESS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0022"><a href="/books/n/nap13164/ch1/#sec_0022" class="toc-item">OUTLINE OF THE REPORT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist2"><a href="/books/n/nap13164/ch1/#reflist2" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch2"><a href="/books/n/nap13164/ch2/" class="toc-item">2. Approach</a><ul id="toc_lst_NBK190024_sec_0023" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0023"><a href="/books/n/nap13164/ch2/#sec_0023" class="toc-item">LITERATURE SEARCHING</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0024"><a href="/books/n/nap13164/ch2/#sec_0024" class="toc-item">WEIGHT OF EVIDENCE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0030"><a href="/books/n/nap13164/ch2/#sec_0030" class="toc-item">CAUSALITY ASSESSMENT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0035"><a href="/books/n/nap13164/ch2/#sec_0035" class="toc-item">SPECIAL CONSIDERATIONS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist3"><a href="/books/n/nap13164/ch2/#reflist3" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch3"><a href="/books/n/nap13164/ch3/" class="toc-item">3. Evaluating Biological Mechanisms of Adverse Events</a><ul id="toc_lst_NBK190024_sec_0036" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0036"><a href="/books/n/nap13164/ch3/#sec_0036" class="toc-item">LATENCY BETWEEN ANTIGEN EXPOSURE AND PEAK ADAPTIVE IMMUNE RESPONSE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0037"><a href="/books/n/nap13164/ch3/#sec_0037" class="toc-item">IMMUNE-MEDIATED MECHANISMS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0073"><a href="/books/n/nap13164/ch3/#sec_0073" class="toc-item">VIRAL ACTIVITY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0078"><a href="/books/n/nap13164/ch3/#sec_0078" class="toc-item">INJECTION-RELATED ADVERSE EVENTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0087"><a href="/books/n/nap13164/ch3/#sec_0087" class="toc-item">COAGULATION AND HYPERCOAGULABLE STATES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0088"><a href="/books/n/nap13164/ch3/#sec_0088" class="toc-item">INCREASED SUSCEPTIBILITY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0089"><a href="/books/n/nap13164/ch3/#sec_0089" class="toc-item">ALTERATIONS IN BRAIN DEVELOPMENT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0091"><a href="/books/n/nap13164/ch3/#sec_0091" class="toc-item">CONTRIBUTION OF ANIMAL MODELS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist4"><a href="/books/n/nap13164/ch3/#reflist4" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch4"><a href="/books/n/nap13164/ch4/" class="toc-item">4. Measles, Mumps, and Rubella Vaccine</a><ul id="toc_lst_NBK190024_sec_0095" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0095"><a href="/books/n/nap13164/ch4/#sec_0095" class="toc-item">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0100"><a href="/books/n/nap13164/ch4/#sec_0100" class="toc-item">MEASLES INCLUSION BODY ENCEPHALITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0106"><a href="/books/n/nap13164/ch4/#sec_0106" class="toc-item">ENCEPHALITIS AND ENCEPHALOPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0115"><a href="/books/n/nap13164/ch4/#sec_0115" class="toc-item">FEBRILE SEIZURES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0121"><a href="/books/n/nap13164/ch4/#sec_0121" class="toc-item">AFEBRILE SEIZURES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0127"><a href="/books/n/nap13164/ch4/#sec_0127" class="toc-item">MENINGITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0133"><a href="/books/n/nap13164/ch4/#sec_0133" class="toc-item">ATAXIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0139"><a href="/books/n/nap13164/ch4/#sec_0139" class="toc-item">AUTISM</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0145"><a href="/books/n/nap13164/ch4/#sec_0145" class="toc-item">ACUTE DISSEMINATED ENCEPHALOMYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0151"><a href="/books/n/nap13164/ch4/#sec_0151" class="toc-item">TRANSVERSE MYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0157"><a href="/books/n/nap13164/ch4/#sec_0157" class="toc-item">OPTIC NEURITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0163"><a href="/books/n/nap13164/ch4/#sec_0163" class="toc-item">NEUROMYELITIS OPTICA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0169"><a href="/books/n/nap13164/ch4/#sec_0169" class="toc-item">MULTIPLE SCLEROSIS ONSET IN ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0175"><a href="/books/n/nap13164/ch4/#sec_0175" class="toc-item">MULTIPLE SCLEROSIS ONSET IN CHILDREN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0181"><a href="/books/n/nap13164/ch4/#sec_0181" class="toc-item">GUILLAIN-BARR&#x000c9; SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0187"><a href="/books/n/nap13164/ch4/#sec_0187" class="toc-item">CHRONIC INFLAMMATORY DISSEMINATED POLYNEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0193"><a href="/books/n/nap13164/ch4/#sec_0193" class="toc-item">OPSOCLONUS MYOCLONUS SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0199"><a href="/books/n/nap13164/ch4/#sec_0199" class="toc-item">BRACHIAL NEURITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0205"><a href="/books/n/nap13164/ch4/#sec_0205" class="toc-item">ANAPHYLAXIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0211"><a href="/books/n/nap13164/ch4/#sec_0211" class="toc-item">TRANSIENT ARTHRALGIA IN WOMEN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0217"><a href="/books/n/nap13164/ch4/#sec_0217" class="toc-item">TRANSIENT ARTHRALGIA IN CHILDREN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0223"><a href="/books/n/nap13164/ch4/#sec_0223" class="toc-item">CHRONIC ARTHRALGIA IN WOMEN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0229"><a href="/books/n/nap13164/ch4/#sec_0229" class="toc-item">CHRONIC ARTHRITIS IN WOMEN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0235"><a href="/books/n/nap13164/ch4/#sec_0235" class="toc-item">CHRONIC ARTHROPATHY IN CHILDREN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0241"><a href="/books/n/nap13164/ch4/#sec_0241" class="toc-item">ARTHROPATHY IN MEN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0247"><a href="/books/n/nap13164/ch4/#sec_0247" class="toc-item">TYPE 1 DIABETES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0253"><a href="/books/n/nap13164/ch4/#sec_0253" class="toc-item">HEPATITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0259"><a href="/books/n/nap13164/ch4/#sec_0259" class="toc-item">CHRONIC FATIGUE SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0265"><a href="/books/n/nap13164/ch4/#sec_0265" class="toc-item">FIBROMYALGIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0271"><a href="/books/n/nap13164/ch4/#sec_0271" class="toc-item">HEARING LOSS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0277"><a href="/books/n/nap13164/ch4/#sec_0277" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist5"><a href="/books/n/nap13164/ch4/#reflist5" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch5"><a href="/books/n/nap13164/ch5/" class="toc-item">5. Varicella Virus Vaccine</a><ul id="toc_lst_NBK190024_sec_0278" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0278"><a href="/books/n/nap13164/ch5/#sec_0278" class="toc-item">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0279"><a href="/books/n/nap13164/ch5/#sec_0279" class="toc-item">DISSEMINATED OKA VZV WITHOUT OTHER ORGAN INVOLVEMENT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0287"><a href="/books/n/nap13164/ch5/#sec_0287" class="toc-item">DISSEMINATED OKA VZV WITH OTHER ORGAN INVOLVEMENT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0299"><a href="/books/n/nap13164/ch5/#sec_0299" class="toc-item">VACCINE-STRAIN VIRAL REACTIVATION WITHOUT OTHER ORGAN INVOLVEMENT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0306"><a href="/books/n/nap13164/ch5/#sec_0306" class="toc-item">VACCINE-STRAIN VIRAL REACTIVATION WITH OTHER ORGAN INVOLVEMENT</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0316"><a href="/books/n/nap13164/ch5/#sec_0316" class="toc-item">ENCEPHALOPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0322"><a href="/books/n/nap13164/ch5/#sec_0322" class="toc-item">SEIZURES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0328"><a href="/books/n/nap13164/ch5/#sec_0328" class="toc-item">CEREBELLAR ATAXIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0334"><a href="/books/n/nap13164/ch5/#sec_0334" class="toc-item">ACUTE DISSEMINATED ENCEPHALOMYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0340"><a href="/books/n/nap13164/ch5/#sec_0340" class="toc-item">TRANSVERSE MYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0346"><a href="/books/n/nap13164/ch5/#sec_0346" class="toc-item">GUILLAIN-BARR&#x000c9; SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0352"><a href="/books/n/nap13164/ch5/#sec_0352" class="toc-item">SMALL FIBER NEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0358"><a href="/books/n/nap13164/ch5/#sec_0358" class="toc-item">ANAPHYLAXIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0364"><a href="/books/n/nap13164/ch5/#sec_0364" class="toc-item">ONSET OR EXACERBATION OF ARTHROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0370"><a href="/books/n/nap13164/ch5/#sec_0370" class="toc-item">STROKE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0376"><a href="/books/n/nap13164/ch5/#sec_0376" class="toc-item">THROMBOCYTOPENIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0382"><a href="/books/n/nap13164/ch5/#sec_0382" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist6"><a href="/books/n/nap13164/ch5/#reflist6" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch6"><a href="/books/n/nap13164/ch6/" class="toc-item">6. Influenza Vaccine</a><ul id="toc_lst_NBK190024_sec_0383" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0383"><a href="/books/n/nap13164/ch6/#sec_0383" class="toc-item">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0384"><a href="/books/n/nap13164/ch6/#sec_0384" class="toc-item">ENCEPHALITIS AND ENCEPHALOPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0393"><a href="/books/n/nap13164/ch6/#sec_0393" class="toc-item">SEIZURES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0399"><a href="/books/n/nap13164/ch6/#sec_0399" class="toc-item">ACUTE DISSEMINATED ENCEPHALOMYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0405"><a href="/books/n/nap13164/ch6/#sec_0405" class="toc-item">TRANSVERSE MYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0411"><a href="/books/n/nap13164/ch6/#sec_0411" class="toc-item">OPTIC NEURITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0417"><a href="/books/n/nap13164/ch6/#sec_0417" class="toc-item">NEUROMYELITIS OPTICA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0423"><a href="/books/n/nap13164/ch6/#sec_0423" class="toc-item">MULTIPLE SCLEROSIS ONSET IN ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0429"><a href="/books/n/nap13164/ch6/#sec_0429" class="toc-item">MULTIPLE SCLEROSIS RELAPSE IN ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0435"><a href="/books/n/nap13164/ch6/#sec_0435" class="toc-item">GUILLAIN-BARR&#x000c9; SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0441"><a href="/books/n/nap13164/ch6/#sec_0441" class="toc-item">CHRONIC INFLAMMATORY DISSEMINATED POLYNEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0447"><a href="/books/n/nap13164/ch6/#sec_0447" class="toc-item">BELL'S PALSY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0453"><a href="/books/n/nap13164/ch6/#sec_0453" class="toc-item">BRACHIAL NEURITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0459"><a href="/books/n/nap13164/ch6/#sec_0459" class="toc-item">SMALL FIBER NEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0465"><a href="/books/n/nap13164/ch6/#sec_0465" class="toc-item">ANAPHYLAXIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0471"><a href="/books/n/nap13164/ch6/#sec_0471" class="toc-item">INACTIVATED INFLUENZA VACCINE AND ASTHMA EXACERBATION OR REACTIVE AIRWAY DISEASE EPISODES IN CHILDREN AND ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0477"><a href="/books/n/nap13164/ch6/#sec_0477" class="toc-item">LIVE ATTENUATED INFLUENZA VACCINE AND ASTHMA EXACERBATION OR REACTIVE AIRWAY DISEASE EPISODES IN CHILDREN YOUNGER THAN 5 YEARS OF AGE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0483"><a href="/books/n/nap13164/ch6/#sec_0483" class="toc-item">LIVE ATTENUATED INFLUENZA VACCINE AND ASTHMA EXACERBATION OR REACTIVE AIRWAY DISEASE EPISODES IN PERSONS 5 YEARS OF AGE OR OLDER</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0489"><a href="/books/n/nap13164/ch6/#sec_0489" class="toc-item">ONSET OR EXACERBATION OF SYSTEMIC LUPUS ERYTHEMATOSUS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0495"><a href="/books/n/nap13164/ch6/#sec_0495" class="toc-item">ONSET OR EXACERBATION OF VASCULITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0501"><a href="/books/n/nap13164/ch6/#sec_0501" class="toc-item">POLYARTERITIS NODOSA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0507"><a href="/books/n/nap13164/ch6/#sec_0507" class="toc-item">ONSET OR EXACERBATION OF ARTHROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0513"><a href="/books/n/nap13164/ch6/#sec_0513" class="toc-item">STROKE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0519"><a href="/books/n/nap13164/ch6/#sec_0519" class="toc-item">MYOCARDIAL INFARCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0525"><a href="/books/n/nap13164/ch6/#sec_0525" class="toc-item">FIBROMYALGIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0531"><a href="/books/n/nap13164/ch6/#sec_0531" class="toc-item">ALL-CAUSE MORTALITY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0537"><a href="/books/n/nap13164/ch6/#sec_0537" class="toc-item">OCULORESPIRATORY SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0543"><a href="/books/n/nap13164/ch6/#sec_0543" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist7"><a href="/books/n/nap13164/ch6/#reflist7" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch7"><a href="/books/n/nap13164/ch7/" class="toc-item">7. Hepatitis A Vaccine</a><ul id="toc_lst_NBK190024_sec_0544" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0544"><a href="/books/n/nap13164/ch7/#sec_0544" class="toc-item">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0545"><a href="/books/n/nap13164/ch7/#sec_0545" class="toc-item">ACUTE DISSEMINATED ENCEPHALOMYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0551"><a href="/books/n/nap13164/ch7/#sec_0551" class="toc-item">TRANSVERSE MYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0557"><a href="/books/n/nap13164/ch7/#sec_0557" class="toc-item">MULTIPLE SCLEROSIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0563"><a href="/books/n/nap13164/ch7/#sec_0563" class="toc-item">GUILLAIN-BARR&#x000c9; SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0569"><a href="/books/n/nap13164/ch7/#sec_0569" class="toc-item">CHRONIC INFLAMMATORY DISSEMINATED POLYNEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0575"><a href="/books/n/nap13164/ch7/#sec_0575" class="toc-item">BELL'S PALSY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0581"><a href="/books/n/nap13164/ch7/#sec_0581" class="toc-item">ANAPHYLAXIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0587"><a href="/books/n/nap13164/ch7/#sec_0587" class="toc-item">AUTOIMMUNE HEPATITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0593"><a href="/books/n/nap13164/ch7/#sec_0593" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist8"><a href="/books/n/nap13164/ch7/#reflist8" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch8"><a href="/books/n/nap13164/ch8/" class="toc-item">8. Hepatitis B Vaccine</a><ul id="toc_lst_NBK190024_sec_0594" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0594"><a href="/books/n/nap13164/ch8/#sec_0594" class="toc-item">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0595"><a href="/books/n/nap13164/ch8/#sec_0595" class="toc-item">ENCEPHALITIS AND ENCEPHALOPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0601"><a href="/books/n/nap13164/ch8/#sec_0601" class="toc-item">SEIZURES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0607"><a href="/books/n/nap13164/ch8/#sec_0607" class="toc-item">ACUTE DISSEMINATED ENCEPHALOMYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0613"><a href="/books/n/nap13164/ch8/#sec_0613" class="toc-item">TRANSVERSE MYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0619"><a href="/books/n/nap13164/ch8/#sec_0619" class="toc-item">OPTIC NEURITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0625"><a href="/books/n/nap13164/ch8/#sec_0625" class="toc-item">NEUROMYELITIS OPTICA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0631"><a href="/books/n/nap13164/ch8/#sec_0631" class="toc-item">MULTIPLE SCLEROSIS ONSET IN ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0637"><a href="/books/n/nap13164/ch8/#sec_0637" class="toc-item">MULTIPLE SCLEROSIS ONSET IN CHILDREN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0643"><a href="/books/n/nap13164/ch8/#sec_0643" class="toc-item">MULTIPLE SCLEROSIS RELAPSE IN ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0649"><a href="/books/n/nap13164/ch8/#sec_0649" class="toc-item">MULTIPLE SCLEROSIS RELAPSE IN CHILDREN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0655"><a href="/books/n/nap13164/ch8/#sec_0655" class="toc-item">FIRST DEMYELINATING EVENT IN ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0661"><a href="/books/n/nap13164/ch8/#sec_0661" class="toc-item">FIRST DEMYELINATING EVENT IN CHILDREN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0667"><a href="/books/n/nap13164/ch8/#sec_0667" class="toc-item">GUILLAIN-BARR&#x000c9; SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0673"><a href="/books/n/nap13164/ch8/#sec_0673" class="toc-item">CHRONIC INFLAMMATORY DISSEMINATED POLYNEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0679"><a href="/books/n/nap13164/ch8/#sec_0679" class="toc-item">BRACHIAL NEURITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0685"><a href="/books/n/nap13164/ch8/#sec_0685" class="toc-item">ANAPHYLAXIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0691"><a href="/books/n/nap13164/ch8/#sec_0691" class="toc-item">ERYTHEMA NODOSUM</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0697"><a href="/books/n/nap13164/ch8/#sec_0697" class="toc-item">ONSET OR EXACERBATION OF SYSTEMIC LUPUS ERYTHEMATOSUS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0703"><a href="/books/n/nap13164/ch8/#sec_0703" class="toc-item">ONSET OR EXACERBATION OF VASCULITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0709"><a href="/books/n/nap13164/ch8/#sec_0709" class="toc-item">ONSET OR EXACERBATION OF POLYARTERITIS NODOSA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0715"><a href="/books/n/nap13164/ch8/#sec_0715" class="toc-item">ONSET OR EXACERBATION OF PSORIATIC ARTHRITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0721"><a href="/books/n/nap13164/ch8/#sec_0721" class="toc-item">ONSET OR EXACERBATION OF REACTIVE ARTHRITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0727"><a href="/books/n/nap13164/ch8/#sec_0727" class="toc-item">ONSET OR EXACERBATION OF RHEUMATOID ARTHRITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0733"><a href="/books/n/nap13164/ch8/#sec_0733" class="toc-item">ONSET OR EXACERBATION OF JUVENILE IDIOPATHIC ARTHRITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0739"><a href="/books/n/nap13164/ch8/#sec_0739" class="toc-item">TYPE 1 DIABETES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0745"><a href="/books/n/nap13164/ch8/#sec_0745" class="toc-item">FIBROMYALGIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0751"><a href="/books/n/nap13164/ch8/#sec_0751" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist9"><a href="/books/n/nap13164/ch8/#reflist9" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch9"><a href="/books/n/nap13164/ch9/" class="toc-item">9. Human Papillomavirus Vaccine</a><ul id="toc_lst_NBK190024_sec_0752" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0752"><a href="/books/n/nap13164/ch9/#sec_0752" class="toc-item">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0753"><a href="/books/n/nap13164/ch9/#sec_0753" class="toc-item">ACUTE DISSEMINATED ENCEPHALOMYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0759"><a href="/books/n/nap13164/ch9/#sec_0759" class="toc-item">TRANSVERSE MYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0765"><a href="/books/n/nap13164/ch9/#sec_0765" class="toc-item">NEUROMYELITIS OPTICA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0771"><a href="/books/n/nap13164/ch9/#sec_0771" class="toc-item">MULTIPLE SCLEROSIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0777"><a href="/books/n/nap13164/ch9/#sec_0777" class="toc-item">GUILLAIN-BARR&#x000c9; SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0783"><a href="/books/n/nap13164/ch9/#sec_0783" class="toc-item">CHRONIC INFLAMMATORY DISSEMINATED POLYNEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0789"><a href="/books/n/nap13164/ch9/#sec_0789" class="toc-item">BRACHIAL NEURITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0795"><a href="/books/n/nap13164/ch9/#sec_0795" class="toc-item">AMYOTROPHIC LATERAL SCLEROSIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0801"><a href="/books/n/nap13164/ch9/#sec_0801" class="toc-item">ANAPHYLAXIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0807"><a href="/books/n/nap13164/ch9/#sec_0807" class="toc-item">TRANSIENT ARTHRALGIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0813"><a href="/books/n/nap13164/ch9/#sec_0813" class="toc-item">PANCREATITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0819"><a href="/books/n/nap13164/ch9/#sec_0819" class="toc-item">THROMBOEMBOLIC EVENTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0825"><a href="/books/n/nap13164/ch9/#sec_0825" class="toc-item">HYPERCOAGULABLE STATES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0831"><a href="/books/n/nap13164/ch9/#sec_0831" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist10"><a href="/books/n/nap13164/ch9/#reflist10" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch10"><a href="/books/n/nap13164/ch10/" class="toc-item">10. Diphtheria Toxoid&#x02013;, Tetanus Toxoid&#x02013;, and Acellular Pertussis&#x02013;Containing Vaccines</a><ul id="toc_lst_NBK190024_sec_0832" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0832"><a href="/books/n/nap13164/ch10/#sec_0832" class="toc-item">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0837"><a href="/books/n/nap13164/ch10/#sec_0837" class="toc-item">ENCEPHALITIS AND ENCEPHALOPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0843"><a href="/books/n/nap13164/ch10/#sec_0843" class="toc-item">INFANTILE SPASMS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0849"><a href="/books/n/nap13164/ch10/#sec_0849" class="toc-item">SEIZURES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0855"><a href="/books/n/nap13164/ch10/#sec_0855" class="toc-item">ATAXIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0861"><a href="/books/n/nap13164/ch10/#sec_0861" class="toc-item">AUTISM</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0867"><a href="/books/n/nap13164/ch10/#sec_0867" class="toc-item">ACUTE DISSEMINATED ENCEPHALOMYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0873"><a href="/books/n/nap13164/ch10/#sec_0873" class="toc-item">TRANSVERSE MYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0879"><a href="/books/n/nap13164/ch10/#sec_0879" class="toc-item">OPTIC NEURITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0885"><a href="/books/n/nap13164/ch10/#sec_0885" class="toc-item">MULTIPLE SCLEROSIS ONSET IN ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0891"><a href="/books/n/nap13164/ch10/#sec_0891" class="toc-item">MULTIPLE SCLEROSIS RELAPSE IN ADULTS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0897"><a href="/books/n/nap13164/ch10/#sec_0897" class="toc-item">MULTIPLE SCLEROSIS RELAPSE IN CHILDREN</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0903"><a href="/books/n/nap13164/ch10/#sec_0903" class="toc-item">GUILLAIN-BARR&#x000c9; SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0909"><a href="/books/n/nap13164/ch10/#sec_0909" class="toc-item">CHRONIC INFLAMMATORY DISSEMINATED POLYNEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0915"><a href="/books/n/nap13164/ch10/#sec_0915" class="toc-item">OPSOCLONUS MYOCLONUS SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0921"><a href="/books/n/nap13164/ch10/#sec_0921" class="toc-item">BELL'S PALSY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0927"><a href="/books/n/nap13164/ch10/#sec_0927" class="toc-item">ANAPHYLAXIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0933"><a href="/books/n/nap13164/ch10/#sec_0933" class="toc-item">CHRONIC URTICARIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0939"><a href="/books/n/nap13164/ch10/#sec_0939" class="toc-item">SERUM SICKNESS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0945"><a href="/books/n/nap13164/ch10/#sec_0945" class="toc-item">ARTHROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0951"><a href="/books/n/nap13164/ch10/#sec_0951" class="toc-item">TYPE 1 DIABETES</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0957"><a href="/books/n/nap13164/ch10/#sec_0957" class="toc-item">MYOCARDITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0963"><a href="/books/n/nap13164/ch10/#sec_0963" class="toc-item">FIBROMYALGIA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0969"><a href="/books/n/nap13164/ch10/#sec_0969" class="toc-item">SUDDEN INFANT DEATH SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0975"><a href="/books/n/nap13164/ch10/#sec_0975" class="toc-item">IMMUNE THROMBOCYTOPENIC PURPURA</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0981"><a href="/books/n/nap13164/ch10/#sec_0981" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist11"><a href="/books/n/nap13164/ch10/#reflist11" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch11"><a href="/books/n/nap13164/ch11/" class="toc-item">11. Meningococcal Vaccine</a><ul id="toc_lst_NBK190024_sec_0982" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_0982"><a href="/books/n/nap13164/ch11/#sec_0982" class="toc-item">INTRODUCTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0983"><a href="/books/n/nap13164/ch11/#sec_0983" class="toc-item">ENCEPHALITIS AND ENCEPHALOPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0989"><a href="/books/n/nap13164/ch11/#sec_0989" class="toc-item">ACUTE DISSEMINATED ENCEPHALOMYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_0995"><a href="/books/n/nap13164/ch11/#sec_0995" class="toc-item">TRANSVERSE MYELITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1001"><a href="/books/n/nap13164/ch11/#sec_1001" class="toc-item">MULTIPLE SCLEROSIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1007"><a href="/books/n/nap13164/ch11/#sec_1007" class="toc-item">GUILLAIN-BARR&#x000c9; SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1013"><a href="/books/n/nap13164/ch11/#sec_1013" class="toc-item">CHRONIC INFLAMMATORY DISSEMINATED POLYNEUROPATHY</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1019"><a href="/books/n/nap13164/ch11/#sec_1019" class="toc-item">ANAPHYLAXIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1025"><a href="/books/n/nap13164/ch11/#sec_1025" class="toc-item">CHRONIC HEADACHE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1031"><a href="/books/n/nap13164/ch11/#sec_1031" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist12"><a href="/books/n/nap13164/ch11/#reflist12" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch12"><a href="/books/n/nap13164/ch12/" class="toc-item">12. Injection-Related Adverse Events</a><ul id="toc_lst_NBK190024_sec_1032" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_1032"><a href="/books/n/nap13164/ch12/#sec_1032" class="toc-item">COMPLEX REGIONAL PAIN SYNDROME</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1038"><a href="/books/n/nap13164/ch12/#sec_1038" class="toc-item">DELTOID BURSITIS</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1044"><a href="/books/n/nap13164/ch12/#sec_1044" class="toc-item">SYNCOPE</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1050"><a href="/books/n/nap13164/ch12/#sec_1050" class="toc-item">CONCLUDING SECTION</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist13"><a href="/books/n/nap13164/ch12/#reflist13" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_ch13"><a href="/books/n/nap13164/ch13/" class="toc-item">13. Concluding Comments</a><ul id="toc_lst_NBK190024_sec_1051" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_sec_1051"><a href="/books/n/nap13164/ch13/#sec_1051" class="toc-item">MMR vaccine</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1052"><a href="/books/n/nap13164/ch13/#sec_1052" class="toc-item">Varicella vaccine</a></li><li class="half_rhythm" id="toc_itm_NBK190024_sec_1053"><a href="/books/n/nap13164/ch13/#sec_1053" class="toc-item">Anaphylaxis</a></li><li class="half_rhythm" id="toc_itm_NBK190024_reflist14"><a href="/books/n/nap13164/ch13/#reflist14" class="toc-item">REFERENCES</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK190024_app-group_app_A"><a href="/books/n/nap13164/app-group_app_A/" class="toc-item">APPENDIXES</a><ul id="toc_lst_NBK190024_app_A" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK190024_app_A"><a href="/books/n/nap13164/app_A/" class="toc-item">Appendix A Glossary</a></li><li class="half_rhythm" id="toc_itm_NBK190024_app_B"><a href="/books/n/nap13164/app_B/" class="toc-item">Appendix B List of Adverse Events</a></li><li class="half_rhythm" id="toc_itm_NBK190024_app_C"><a href="/books/n/nap13164/app_C/" class="toc-item">Appendix C Literature Search Strategy</a></li><li class="half_rhythm" id="toc_itm_NBK190024_app_D"><a href="/books/n/nap13164/app_D/" class="toc-item">Appendix D Causality Conclusion Tables</a></li><li class="half_rhythm" id="toc_itm_NBK190024_app_E"><a href="/books/n/nap13164/app_E/" class="toc-item">Appendix E References</a></li><li class="half_rhythm" id="toc_itm_NBK190024_app_F"><a href="/books/n/nap13164/app_F/" class="toc-item">Appendix F Committee Biosketches</a></li><li class="half_rhythm" id="toc_itm_NBK190024_app_G"><a href="/books/n/nap13164/app_G/" class="toc-item">Appendix G Meeting Agendas</a></li></ul></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div><p>This study was supported by Contract No. HHSH230200446009I, Task Order 13 between the National Academy of Sciences and the Health Resources and Services Administration of the U.S. Department of Health and Human Services. The Centers for Disease Control and Prevention and the National Vaccine Program Office also provided support through that contract. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.</p></div><div><h4 class="inline">Suggested citation:</h4><p>IOM (Institute of Medicine). 2012. Adverse effects of vaccines: Evidence and causality. Washington, DC: The National Academies Press.</p></div><div><p>NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.</p></div></div></div>
<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> 2012 by the National Academy of Sciences. All rights reserved.</div><div class="small"><span class="label">Bookshelf ID: NBK190024</span><span class="label">PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/24624471" title="PubMed record of this title" ref="pagearea=meta&amp;targetsite=entrez&amp;targetcat=link&amp;targettype=pubmed">24624471</a></span>DOI: <a href="http://dx.crossref.org/10.17226/13164" ref="pagearea=body&amp;targetsite=external&amp;targetcat=link&amp;targettype=uri">10.17226/13164</a></div><div style="margin-top:2em" class="bk_noprnt"><div class="pagination bk_noprnt"><span class="inactive page_link prev">&lt; Prev</span><a class="active page_link next" href="/books/n/nap13164/sec_0001/" title="Next page in this title">Next &gt;</a></div></div></div></div>
</div>
<!-- Custom content below content -->
<div class="col4">
</div>
<!-- Book content -->
<!-- Custom contetnt below bottom nav -->
<div class="col5">
</div>
</div>
<div id="rightcolumn" class="four_col col last">
<!-- Custom content above discovery portlets -->
<div class="col6">
<div id="ncbi_share_book"><a href="#" class="ncbi_share" data-ncbi_share_config="popup:false,shorten:true" ref="id=NBK190024&amp;db=books">Share</a></div>
</div>
<div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Views</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PDF_download" id="Shutter"></a></div><div class="portlet_content"><ul xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="simple-list"><li><a href="/books/NBK190024/?report=reader">PubReader</a></li><li><a href="/books/NBK190024/?report=printable">Print View</a></li><li><a data-jig="ncbidialog" href="#_ncbi_dlg_citbx_NBK190024" data-jigconfig="width:400,modal:true">Cite this Page</a><div id="_ncbi_dlg_citbx_NBK190024" style="display:none" title="Cite this Page"><div class="bk_tt">Committee to Review Adverse Effects of Vaccines; Institute of Medicine; Stratton K, Ford A, Rusch E, et al., editors. Adverse Effects of Vaccines: Evidence and Causality. Washington (DC): National Academies Press (US); 2011 Aug 25. <span class="bk_cite_avail"></span> doi: 10.17226/13164</div></div></li><li><a href="/books/n/nap13164/pdf/">PDF version of this title</a> (3.2M)</li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Related information</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper"><a class="brieflinkpopperctrl" href="/books/?Db=nlmcatalog&amp;DbFrom=books&amp;Cmd=Link&amp;LinkName=books_nlmcatalog&amp;IdsFromResult=3076020" ref="log$=recordlinks">NLM Catalog</a><div class="brieflinkpop offscreen_noflow">Related NLM Catalog Entries</div></li></ul></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Similar articles in PubMed</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="PBooksDiscovery_RA" id="Shutter"></a></div><div class="portlet_content"><ul><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/12825543" ref="ordinalpos=1&amp;linkpos=1&amp;log$=relatedarticles&amp;logdbfrom=pubmed">Surveillance for safety after immunization: Vaccine Adverse Event Reporting System (VAERS)--United States, 1991-2001.</a><span class="source">[MMWR Surveill Summ. 2003]</span><div class="brieflinkpop offscreen_noflow">Surveillance for safety after immunization: Vaccine Adverse Event Reporting System (VAERS)--United States, 1991-2001.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Zhou W, Pool V, Iskander JK, English-Bullard R, Ball R, Wise RP, Haber P, Pless RP, Mootrey G, Ellenberg SS, et al. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">MMWR Surveill Summ. 2003 Jan 24; 52(1):1-24. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/10557592" ref="ordinalpos=1&amp;linkpos=2&amp;log$=relatedarticles&amp;logdbfrom=pubmed">New vaccine information materials for hepatitis B, Haemophilus influenzae type b (Hib), and varicella (chickenpox) vaccines, and revised vaccine information materials for measles, mumps, rubella (MMR) vaccines. Centers for Disease Control and Prevention (CDC), Department of Health and Human Services. Notice.</a><span class="source">[Fed Regist. 1999]</span><div class="brieflinkpop offscreen_noflow">New vaccine information materials for hepatitis B, Haemophilus influenzae type b (Hib), and varicella (chickenpox) vaccines, and revised vaccine information materials for measles, mumps, rubella (MMR) vaccines. Centers for Disease Control and Prevention (CDC), Department of Health and Human Services. Notice.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Fed Regist. 1999 Feb 23; 64(35):9042-8. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/10558598" ref="ordinalpos=1&amp;linkpos=3&amp;log$=relatedarticles&amp;logdbfrom=pubmed">National Vaccine Injury Compensation Program: addition of vaccines against rotavirus to the program. Department of Health and Human Services (HHS), Public Health Service (PHS), Health Resources and Services Administration (HRSA). Final rule.</a><span class="source">[Fed Regist. 1999]</span><div class="brieflinkpop offscreen_noflow">National Vaccine Injury Compensation Program: addition of vaccines against rotavirus to the program. Department of Health and Human Services (HHS), Public Health Service (PHS), Health Resources and Services Administration (HRSA). Final rule.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Fed Regist. 1999 Jul 27; 64(143):40517-8. </em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/28876765" ref="ordinalpos=1&amp;linkpos=4&amp;log$=relatedreviews&amp;logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Vaccines to Children: Protective Effect and Adverse Events: A Systematic Review</a><span class="source">[ 2009]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Vaccines to Children: Protective Effect and Adverse Events: A Systematic Review<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Swedish Council on Health Technology Assessment. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">2009 Feb</em></div></div></li><li class="brieflinkpopper two_line"><a class="brieflinkpopperctrl" href="/pubmed/31982259" ref="ordinalpos=1&amp;linkpos=5&amp;log$=relatedreviews&amp;logdbfrom=pubmed"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Performance of the United States Vaccine Injury Compensation Program (VICP): 1988-2019.</a><span class="source">[Vaccine. 2020]</span><div class="brieflinkpop offscreen_noflow"><span xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="invert">Review</span> Performance of the United States Vaccine Injury Compensation Program (VICP): 1988-2019.<div class="brieflinkpopdesc"><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="author">Thompson KM, Orenstein WA, Hinman AR. </em><em xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="cit">Vaccine. 2020 Feb 24; 38(9):2136-2143. Epub 2020 Jan 22.</em></div></div></li></ul><a class="seemore" href="/sites/entrez?db=pubmed&amp;cmd=link&amp;linkname=pubmed_pubmed_reviews&amp;uid=24624471" ref="ordinalpos=1&amp;log$=relatedreviews_seeall&amp;logdbfrom=pubmed">See reviews...</a><a class="seemore" href="/sites/entrez?db=pubmed&amp;cmd=link&amp;linkname=pubmed_pubmed&amp;uid=24624471" ref="ordinalpos=1&amp;log$=relatedarticles_seeall&amp;logdbfrom=pubmed">See all...</a></div></div><div class="portlet"><div class="portlet_head"><div class="portlet_title"><h3><span>Recent Activity</span></h3></div><a name="Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="Shutter"></a></div><div class="portlet_content"><div xmlns:np="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" id="HTDisplay" class=""><div class="action"><a href="javascript:historyDisplayState('ClearHT')">Clear</a><a href="javascript:historyDisplayState('HTOff')" class="HTOn">Turn Off</a><a href="javascript:historyDisplayState('HTOn')" class="HTOff">Turn On</a></div><ul id="activity"><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d6a71167c23b31e0a2f6b8">Adverse Effects of Vaccines</a><div class="ralinkpop offscreen_noflow">Adverse Effects of Vaccines<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_qry two_line"><a class="htb" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d6a70a2f30673f7be84b7d">NLM Catalog Links for Books (Select 3076020) <span class="number">(1)</span></a><div class="tertiary">NLM Catalog</div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d6a7072f30673f7be83c49">Meeting Agendas - Adverse Effects of Vaccines</a><div class="ralinkpop offscreen_noflow">Meeting Agendas - Adverse Effects of Vaccines<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d6a7062f30673f7be83a08">Committee Biosketches - Adverse Effects of Vaccines</a><div class="ralinkpop offscreen_noflow">Committee Biosketches - Adverse Effects of Vaccines<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li><li class="ra_rcd ralinkpopper two_line"><a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d6a70567c23b31e0a2cd97">References - Adverse Effects of Vaccines</a><div class="ralinkpop offscreen_noflow">References - Adverse Effects of Vaccines<div class="brieflinkpopdesc"></div></div><div class="tertiary"></div></li></ul><p class="HTOn">Your browsing activity is empty.</p><p class="HTOff">Activity recording is turned off.</p><p id="turnOn" class="HTOff"><a href="javascript:historyDisplayState('HTOn')">Turn recording back on</a></p><a class="seemore" href="/sites/myncbi/recentactivity">See more...</a></div></div></div>
<!-- Custom content below discovery portlets -->
<div class="col7">
</div>
</div>
</div>
<!-- Custom content after all -->
<div class="col8">
</div>
<div class="col9">
</div>
<script type="text/javascript" src="/corehtml/pmc/js/jquery.scrollTo-1.4.2.js"></script>
<script type="text/javascript">
(function($){
$('.skiplink').each(function(i, item){
var href = $($(item).attr('href'));
href.attr('tabindex', '-1').addClass('skiptarget'); // ensure the target can receive focus
$(item).on('click', function(event){
event.preventDefault();
$.scrollTo(href, 0, {
onAfter: function(){
href.focus();
}
});
});
});
})(jQuery);
</script>
</div>
<div class="bottom">
<script type="text/javascript">
var PBooksSearchTermData = {
highlighter: "bold",
dateTime: "03/16/2025 05:16:39",
terms: [
'degeneration', 'disease', 'hepatolenticular', 'hepatolenticular degeneration', 'hepatolenticular degeneration', 'practice guideline', 'wilson', 'wilson disease'
]
};
</script>
<div id="NCBIFooter_dynamic">
<!--<component id="Breadcrumbs" label="breadcrumbs"/>
<component id="Breadcrumbs" label="helpdesk"/>-->
</div>
<div class="footer" id="footer">
<section class="icon-section">
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
<div class="grid-container container">
<div class="icon-section_container">
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<defs>
<style>
.cls-11 {
fill: #737373;
}
</style>
</defs>
<title>Twitter</title>
<path class="cls-11" d="M250.11,105.48c-7,3.14-13,3.25-19.27.14,8.12-4.86,8.49-8.27,11.43-17.46a78.8,78.8,0,0,1-25,9.55,39.35,39.35,0,0,0-67,35.85,111.6,111.6,0,0,1-81-41.08A39.37,39.37,0,0,0,81.47,145a39.08,39.08,0,0,1-17.8-4.92c0,.17,0,.33,0,.5a39.32,39.32,0,0,0,31.53,38.54,39.26,39.26,0,0,1-17.75.68,39.37,39.37,0,0,0,36.72,27.3A79.07,79.07,0,0,1,56,223.34,111.31,111.31,0,0,0,116.22,241c72.3,0,111.83-59.9,111.83-111.84,0-1.71,0-3.4-.1-5.09C235.62,118.54,244.84,113.37,250.11,105.48Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<title>Facebook</title>
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<title>LinkedIn</title>
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<defs>
<style>
.cls-11,
.cls-12 {
fill: #737373;
}
.cls-11 {
fill-rule: evenodd;
}
</style>
</defs>
<title>GitHub</title>
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
</path>
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
</path>
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
</path>
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
</path>
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
</path>
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
</path>
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
</svg></a>
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
<defs><style>.cls-1{fill:#737373;}</style></defs>
<title>NCBI Insights Blog</title>
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
</svg>
</a>
</div>
</div>
</section>
<section class="container-fluid bg-primary">
<div class="container pt-5">
<div class="row mt-3">
<div class="col-lg-3 col-12">
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
<ul class="list-inline social_media">
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" viewBox="0 0 249 249" style="enable-background:new 0 0 249 249;" xml:space="preserve">
<style type="text/css">
.st20 {
fill: #FFFFFF;
}
.st30 {
fill: none;
stroke: #FFFFFF;
stroke-width: 8;
stroke-miterlimit: 10;
}
</style>
<title>Twitter</title>
<g>
<g>
<g>
<path class="st20" d="M192.9,88.1c-5,2.2-9.2,2.3-13.6,0.1c5.7-3.4,6-5.8,8.1-12.3c-5.4,3.2-11.4,5.5-17.6,6.7 c-10.5-11.2-28.1-11.7-39.2-1.2c-7.2,6.8-10.2,16.9-8,26.5c-22.3-1.1-43.1-11.7-57.2-29C58,91.6,61.8,107.9,74,116 c-4.4-0.1-8.7-1.3-12.6-3.4c0,0.1,0,0.2,0,0.4c0,13.2,9.3,24.6,22.3,27.2c-4.1,1.1-8.4,1.3-12.5,0.5c3.6,11.3,14,19,25.9,19.3 c-11.6,9.1-26.4,13.2-41.1,11.5c12.7,8.1,27.4,12.5,42.5,12.5c51,0,78.9-42.2,78.9-78.9c0-1.2,0-2.4-0.1-3.6 C182.7,97.4,189.2,93.7,192.9,88.1z"></path>
</g>
</g>
<circle class="st30" cx="124.4" cy="128.8" r="108.2"></circle>
</g>
</svg></a></li>
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" viewBox="0 0 249 249" style="enable-background:new 0 0 249 249;" xml:space="preserve">
<style type="text/css">
.st10 {
fill: #FFFFFF;
}
.st110 {
fill: none;
stroke: #FFFFFF;
stroke-width: 8;
stroke-miterlimit: 10;
}
</style>
<title>Facebook</title>
<g>
<g>
<path class="st10" d="M159,99.1h-24V88.4c0-5,3.3-6.2,5.7-6.2h16.8V60l-24.4-0.1c-22.1,0-26.2,16.5-26.2,27.1v12.1H90v22.5h16.9 v67.5H135v-67.5h21.7L159,99.1z"></path>
</g>
</g>
<circle class="st110" cx="123.6" cy="123.2" r="108.2"></circle>
</svg>
</a></li>
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer"><svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" version="1.1" x="0px" y="0px" viewBox="0 0 249 249" style="enable-background:new 0 0 249 249;" xml:space="preserve">
<title>Youtube</title>
<style type="text/css">
.st4 {
fill: none;
stroke: #FFFFFF;
stroke-width: 8;
stroke-miterlimit: 10;
}
.st5 {
fill: #FFFFFF;
}
</style>
<circle class="st4" cx="124.2" cy="123.4" r="108.2"></circle>
<g transform="translate(0,-952.36218)">
<path class="st5" d="M88.4,1037.4c-10.4,0-18.7,8.3-18.7,18.7v40.1c0,10.4,8.3,18.7,18.7,18.7h72.1c10.4,0,18.7-8.3,18.7-18.7 v-40.1c0-10.4-8.3-18.7-18.7-18.7H88.4z M115.2,1058.8l29.4,17.4l-29.4,17.4V1058.8z"></path>
</g>
</svg></a></li>
</ul>
</div>
<div class="col-lg-3 col-12">
<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
</div>
</div>
<div class="row">
<div class="col-lg-12 centered-lg">
<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
</li>
<li>
<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
</li>
<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
</li>
</ul>
</nav>
</div>
</div>
</div>
</section>
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
</div>
</div>
</div>
<!--/.page-->
</div>
<!--/.wrap-->
</div><!-- /.twelve_col -->
</div>
<!-- /.grid -->
<span class="PAFAppResources"></span>
<!-- BESelector tab -->
<noscript><img alt="statistics" src="/stat?jsdisabled=true&amp;ncbi_db=books&amp;ncbi_pdid=book-toc&amp;ncbi_acc=NBK190024&amp;ncbi_domain=nap13164&amp;ncbi_report=record&amp;ncbi_type=fulltext&amp;ncbi_objectid=&amp;ncbi_pcid=/NBK190024/?cmd=HTOff&amp;&amp;ncbi_pagename=Adverse Effects of Vaccines - NCBI Bookshelf&amp;ncbi_bookparttype=toc&amp;ncbi_app=bookshelf" /></noscript>
<!-- usually for JS scripts at page bottom -->
<!--<component id="PageFixtures" label="styles"></component>-->
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal107 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3879255/4121861/3501987/4008961/3893018/3821238/4062932/4209313/4212053/4076480/3921943/3400083/3426610.js" snapshot="books"></script></body>
</html>
Reference in a new issue View git blame Copy permalink