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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE,NOIMAGEINDEX" /><meta name="author" content="Forum on Microbial Health; Board on Global Health; Institute of Medicine" /><meta name="citation_title" content="Microbial Ecology in States of Health and Disease" /><meta name="citation_publisher" content="National Academies Press (US)" /><meta name="citation_date" content="2014/02/18" /><meta name="citation_author" content="Forum on Microbial Health" /><meta name="citation_author" content="Board on Global Health" /><meta name="citation_author" content="Institute of Medicine" /><meta name="citation_pmid" content="24555208" /><meta name="citation_doi" content="10.17226/18433" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK184832/" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Microbial Ecology in States of Health and Disease" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="National Academies Press (US)" /><meta name="DC.Contributor" content="Forum on Microbial Health" /><meta name="DC.Contributor" content="Board on Global Health" /><meta name="DC.Contributor" content="Institute of Medicine" /><meta name="DC.Date" content="2014/02/18" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK184832/" /><meta name="DC.Language" content="en" /><meta name="description" content="Individually and collectively, resident microbes play important roles in host health and survival. Shaping and shaped by their host environments, these microorganisms form intricate communities that are in a state of dynamic equilibrium. This ecologic and dynamic view of host-microbe interactions is rapidly redefining our view of health and disease. It is now accepted that the vast majority of microbes are, for the most part, not intrinsically harmful, but rather become established as persistent, co-adapted colonists in equilibrium with their environment, providing useful goods and services to their hosts while deriving benefits from these host associations. Disruption of such alliances may have consequences for host health, and investigations in a wide variety of organisms have begun to illuminate the complex and dynamic network of interaction - across the spectrum of hosts, microbes, and environmental niches - that influence the formation, function, and stability of host-associated microbial communities." /><meta name="og:title" content="Microbial Ecology in States of Health and Disease" /><meta name="og:type" content="book" /><meta name="og:description" content="Individually and collectively, resident microbes play important roles in host health and survival. Shaping and shaped by their host environments, these microorganisms form intricate communities that are in a state of dynamic equilibrium. This ecologic and dynamic view of host-microbe interactions is rapidly redefining our view of health and disease. It is now accepted that the vast majority of microbes are, for the most part, not intrinsically harmful, but rather become established as persistent, co-adapted colonists in equilibrium with their environment, providing useful goods and services to their hosts while deriving benefits from these host associations. Disruption of such alliances may have consequences for host health, and investigations in a wide variety of organisms have begun to illuminate the complex and dynamic network of interaction - across the spectrum of hosts, microbes, and environmental niches - that influence the formation, function, and stability of host-associated microbial communities." /><meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK184832/" /><meta name="og:site_name" content="NCBI Bookshelf" /><meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nap18433-lrg.png" /><meta name="twitter:card" content="summary" /><meta name="twitter:site" content="@ncbibooks" /><meta name="bk-non-canon-loc" content="/books/n/nap18433/toc/" /><link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK184832/" /><link rel="stylesheet" href="/corehtml/pmc/css/figpopup.css" type="text/css" media="screen" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css" /><link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_print.min.css" type="text/css" media="print" /><style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} </style><script type="text/javascript" src="/corehtml/pmc/js/jquery.hoverIntent.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18"> </script><script type="text/javascript" src="/corehtml/pmc/js/large-obj-scrollbars.min.js"> </script><script type="text/javascript">window.name="mainwindow";</script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/book-toc.min.js"> </script><script type="text/javascript" src="/corehtml/pmc/js/bookshelf/2.26/books.min.js"> </script><meta name="book-collection" content="napcollect" />
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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p></div><div class="pagination bk_noprnt"><span class="inactive page_link prev">< Prev</span><a class="active page_link next" href="/books/n/nap18433/sec_001/" title="Next page in this title">Next ></a></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/Book"><div class="meta-content fm-sec"><div class="iconblock whole_rhythm clearfix no_top_margin"><a href="http://www.nap.edu/catalog.php?record_id=18433" title="National Academies Press (US)" class="img_link icnblk_img" ref="pagearea=logo&targetsite=external&targetcat=link&targettype=publisher"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-nap18433-lrg.png" alt="Cover of Microbial Ecology in States of Health and Disease" /></a><div class="icnblk_cntnt"><h1 id="_NBK184832_"><span itemprop="name">Microbial Ecology in States of Health and Disease</span></h1><div class="subtitle">Workshop Summary</div><p class="contrib-group"><span itemprop="author">Forum on Microbial Health</span>; <span itemprop="author">Board on Global Health</span>; <span itemprop="author">Institute of Medicine</span>.</p><div class="half_rhythm">Washington (DC): <a href="http://www.nap.edu/" ref="pagearea=meta&targetsite=external&targetcat=link&targettype=publisher"><span itemprop="publisher">National Academies Press (US)</span></a>; <span itemprop="datePublished">2014 Feb 18</span>.<div class="small"><span class="label">ISBN-13: <span itemprop="isbn">978-0-309-29062-3</span></span>ISBN-10: <span itemprop="isbn">0-309-29062-7</span></div></div><div class="half_rhythm"><ul class="inline_list"><li><span class="label"><a data-jig="ncbidialog" href="#_ncbi_dlg_cpyrght_NBK184832" data-jigconfig="modal:true">Copyright and
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Permissions</a></span></li></ul></div><div id="_ncbi_dlg_cpyrght_NBK184832" style="display:none" title="Copyright and Permissions"><div><div>Copyright 2014 by the National Academy of Sciences. All rights reserved.</div><div>For more information, see the <a href="/books/about/copyright/">Bookshelf Copyright Notice</a>.</div></div></div><div class="small half_rhythm bk_noprnt"><a href="http://www.nap.edu/catalog.php?record_id=18433" ref="pagearea=body&targetsite=external&targetcat=link&targettype=publisher">Hardcopy Version at National Academies Press</a></div><div class="bk_noprnt"><form method="get" action="/books/n/nap18433/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search this book" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search this book" submit="false" style="padding: 0.1em 0.4em;" /></div></form></div></div></div></div><div class="body-content whole_rhythm" itemprop="text"><div itemprop="description"><p>Individually and collectively, resident microbes play important roles in host health
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and survival. Shaping and shaped by their host environments, these microorganisms
|
|
form intricate communities that are in a state of dynamic equilibrium. This ecologic
|
|
and dynamic view of host-microbe interactions is rapidly redefining our view of
|
|
health and disease. It is now accepted that the vast majority of microbes are, for
|
|
the most part, not intrinsically harmful, but rather become established as
|
|
persistent, co-adapted colonists in equilibrium with their environment, providing
|
|
useful goods and services to their hosts while deriving benefits from these host
|
|
associations. Disruption of such alliances may have consequences for host health,
|
|
and investigations in a wide variety of organisms have begun to illuminate the
|
|
complex and dynamic network of interaction - across the spectrum of hosts, microbes,
|
|
and environmental niches - that influence the formation, function, and stability of
|
|
host-associated microbial communities.</p><p>
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|
<i>Microbial Ecology in States of Health and Disease</i> is the summary of
|
|
a workshop convened by the Institute of Medicine's Forum on Microbial Threats in
|
|
March 2013 to explore the scientific and therapeutic implications of microbial
|
|
ecology in states of health and disease. Participants explored host-microbe
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interactions in humans, animals, and plants; emerging insights into how microbes may
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influence the development and maintenance of states of health and disease; the
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effects of environmental change(s) on the formation, function, and stability of
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microbial communities; and research challenges and opportunities for this emerging
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field of inquiry.</p></div><div><h2>Contents</h2><div class="bktoc_all_cntnr top align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div><ul id="toc_tllNBK184832_sec_001" class="simple-list toc toc-toggle"><li class="half_rhythm" id="toc_itm_NBK184832_sec_001"><a href="/books/n/nap18433/sec_001/" class="toc-item">THE NATIONAL ACADEMIES</a></li><li class="half_rhythm" id="toc_itm_NBK184832_sec_002"><a href="/books/n/nap18433/sec_002/" class="toc-item">PLANNING COMMITTEE FOR A WORKSHOP ON MICROBIAL ECOLOGY IN STATES OF HEALTH AND DISEASE</a></li><li class="half_rhythm" id="toc_itm_NBK184832_sec_003"><a href="/books/n/nap18433/sec_003/" class="toc-item">FORUM ON MICROBIAL THREATS</a></li><li class="half_rhythm" id="toc_itm_NBK184832_sec_005"><a href="/books/n/nap18433/sec_005/" class="toc-item">BOARD ON GLOBAL HEALTH</a></li><li class="half_rhythm" id="toc_itm_NBK184832_sec_007"><a href="/books/n/nap18433/sec_007/" class="toc-item">Reviewers</a></li><li class="half_rhythm" id="toc_itm_NBK184832_sec_008"><a href="/books/n/nap18433/sec_008/" class="toc-item">Acknowledgments</a></li><li class="half_rhythm" id="toc_itm_NBK184832_ov1"><a href="/books/n/nap18433/ov1/" class="toc-item">Workshop Overview</a><ul id="toc_lst_NBK184832_sec_014" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK184832_sec_014"><a href="/books/n/nap18433/ov1/#sec_014" class="toc-item">MICROBIAL ECOLOGY IN STATES OF HEALTH AND DISEASE</a></li><li class="half_rhythm" id="toc_itm_NBK184832_sec_018"><a href="/books/n/nap18433/ov1/#sec_018" class="toc-item">HUMANS, ANIMALS, AND PLANTS IN A MICROBIAL WORLD</a></li><li class="half_rhythm" id="toc_itm_NBK184832_sec_051"><a href="/books/n/nap18433/ov1/#sec_051" class="toc-item">CHALLENGES AND OPPORTUNITIES</a></li><li class="half_rhythm" id="toc_itm_NBK184832_reflist1"><a href="/books/n/nap18433/ov1/#reflist1" class="toc-item">References</a></li></ul></li><li class="half_rhythm" id="toc_itm_NBK184832_app-group_appA"><a href="/books/n/nap18433/app-group_appA/" class="toc-item">Appendixes</a><ul id="toc_lst_NBK184832_appA" class="simple-list toc bktoc_lst_exp"><li class="half_rhythm" id="toc_itm_NBK184832_appA"><a href="/books/n/nap18433/appA/" class="toc-item">Appendix A Contributed Manuscripts</a></li><li class="half_rhythm" id="toc_itm_NBK184832_appB"><a href="/books/n/nap18433/appB/" class="toc-item">Appendix B Agenda</a></li><li class="half_rhythm" id="toc_itm_NBK184832_appC"><a href="/books/n/nap18433/appC/" class="toc-item">Appendix C Acronyms</a></li><li class="half_rhythm" id="toc_itm_NBK184832_appD"><a href="/books/n/nap18433/appD/" class="toc-item">Appendix D Glossary</a></li><li class="half_rhythm" id="toc_itm_NBK184832_appE"><a href="/books/n/nap18433/appE/" class="toc-item">Appendix E Speaker Biographies</a></li></ul></li></ul><div class="bktoc_all_cntnr align_right" style="display:none"><ul class="inline_list_right"><li><a class="bktoc_all_exp" href="#">Expand All</a></li><li style="margin-left:.8em"><a class="bktoc_all_clps" href="#">Collapse All</a></li></ul></div></div><div><p>Rapporteurs: Eileen R. Choffnes, Leigh Anne Olsen, and Alison Mack.</p></div><div><p>Financial support for this activity was provided by
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the U.S. Department of Health and Human Services: National Institutes of Health,
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National Institute of Allergy and Infectious Diseases, Centers for Disease Control
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and Prevention, Food and Drug Administration, and the Fogarty International Center;
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U.S. Department of Defense: Armed Forces Health Surveillance Center, Defense Threat
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Reduction Agency, and Medical Research and Materiel Command; U.S. Department of
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Justice: Federal Bureau of Investigation; U.S. Department of Veterans Affairs; U.S.
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Department of Homeland Security; U.S. Agency for International Development;
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Uniformed Services University of the Health Sciences; Alfred P. Sloan Foundation;
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American Society for Microbiology; Burroughs Wellcome Fund; GlaxoSmithKline;
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Infectious Diseases Society of America; Johnson & Johnson; Merck Company
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Foundation; and sanofi pasteur. The views presented in this publication do not
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necessarily reflect the views of the organizations or agencies that provided support
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for this activity.</p></div><div><h4 class="inline">Suggested citation:</h4><p>IOM (Institute of Medicine). 2014. Microbial ecology
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in states of health and disease: Workshop summary. Washington, DC: The National
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Academies Press.</p></div><div><p>NOTICE: The workshop that is the subject of this workshop summary was approved by the
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Governing Board of the National Research Council, whose members are drawn from the
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councils of the National Academy of Sciences, the National Academy of Engineering,
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and the Institute of Medicine.</p></div></div></div>
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<div class="post-content"><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright</a> 2014 by the National Academy of Sciences. All rights
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