96 lines
45 KiB
Text
96 lines
45 KiB
Text
<!DOCTYPE html>
|
|
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" class="no-js no-jr">
|
|
<head>
|
|
<!-- For pinger, set start time and add meta elements. -->
|
|
<script type="text/javascript">var ncbi_startTime = new Date();</script>
|
|
|
|
<!-- Logger begin -->
|
|
<meta name="ncbi_db" content="books">
|
|
<meta name="ncbi_pdid" content="book-part">
|
|
<meta name="ncbi_acc" content="NBK184580">
|
|
<meta name="ncbi_domain" content="handbook2e">
|
|
<meta name="ncbi_report" content="reader">
|
|
<meta name="ncbi_type" content="fulltext">
|
|
<meta name="ncbi_objectid" content="">
|
|
<meta name="ncbi_pcid" content="/NBK184580/?report=reader">
|
|
<meta name="ncbi_pagename" content="Small Molecules and Biological Activities - The NCBI Handbook - NCBI Bookshelf">
|
|
<meta name="ncbi_bookparttype" content="chapter">
|
|
<meta name="ncbi_app" content="bookshelf">
|
|
<!-- Logger end -->
|
|
|
|
<!--component id="Page" label="meta"/-->
|
|
<script type="text/javascript" src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.boots.min.js"> </script><title>Small Molecules and Biological Activities - The NCBI Handbook - NCBI Bookshelf</title>
|
|
<meta charset="utf-8">
|
|
<meta name="apple-mobile-web-app-capable" content="no">
|
|
<meta name="viewport" content="initial-scale=1,minimum-scale=1,maximum-scale=1,user-scalable=no">
|
|
<meta name="jr-col-layout" content="auto">
|
|
<meta name="jr-prev-unit" content="/books/n/handbook2e/Small.Molecules/?report=reader">
|
|
<meta name="jr-next-unit" content="/books/n/handbook2e/PubChemBioAssay/?report=reader">
|
|
<meta name="bk-toc-url" content="/books/n/handbook2e/?report=toc">
|
|
<meta name="robots" content="NOINDEX,NOFOLLOW,NOARCHIVE">
|
|
<meta name="citation_inbook_title" content="The NCBI Handbook [Internet]. 2nd edition">
|
|
<meta name="citation_title" content="Small Molecules and Biological Activities">
|
|
<meta name="citation_publisher" content="National Center for Biotechnology Information (US)">
|
|
<meta name="citation_date" content="2013/12/09">
|
|
<meta name="citation_author" content="Rana Morris">
|
|
<meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK184580/">
|
|
<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/">
|
|
<meta name="DC.Title" content="Small Molecules and Biological Activities">
|
|
<meta name="DC.Type" content="Text">
|
|
<meta name="DC.Publisher" content="National Center for Biotechnology Information (US)">
|
|
<meta name="DC.Contributor" content="Rana Morris">
|
|
<meta name="DC.Date" content="2013/12/09">
|
|
<meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK184580/">
|
|
<meta name="description" content="The chemical and bioactivity resources at the National Center for Biotechnology Information (NCBI) are coordinated as part of the PubChem Project with data accessible as part of the PubChem Compound and Substance databases and PubChem BioAssay database, respectively. Currently the PubChem set of resources provides access to information about over 36 million chemical compounds and experimental studies with results for over 700 thousand biological activity assays.">
|
|
<meta name="og:title" content="Small Molecules and Biological Activities">
|
|
<meta name="og:type" content="book">
|
|
<meta name="og:description" content="The chemical and bioactivity resources at the National Center for Biotechnology Information (NCBI) are coordinated as part of the PubChem Project with data accessible as part of the PubChem Compound and Substance databases and PubChem BioAssay database, respectively. Currently the PubChem set of resources provides access to information about over 36 million chemical compounds and experimental studies with results for over 700 thousand biological activity assays.">
|
|
<meta name="og:url" content="https://www.ncbi.nlm.nih.gov/books/NBK184580/">
|
|
<meta name="og:site_name" content="NCBI Bookshelf">
|
|
<meta name="og:image" content="https://www.ncbi.nlm.nih.gov/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-handbook2e-lrg.png">
|
|
<meta name="twitter:card" content="summary">
|
|
<meta name="twitter:site" content="@ncbibooks">
|
|
<meta name="warning" content="This publication is provided for historical reference only and the information may be out of date.">
|
|
<meta name="bk-non-canon-loc" content="/books/n/handbook2e/AboutSmallMolecules/?report=reader">
|
|
<link rel="canonical" href="https://www.ncbi.nlm.nih.gov/books/NBK184580/">
|
|
<link href="https://fonts.googleapis.com/css?family=Archivo+Narrow:400,700,400italic,700italic&subset=latin" rel="stylesheet" type="text/css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/jatsreader/ptpmc_3.22/css/libs.min.css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/jatsreader/ptpmc_3.22/css/jr.min.css">
|
|
<meta name="format-detection" content="telephone=no">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books.min.css" type="text/css">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css//books_print.min.css" type="text/css" media="print">
|
|
<link rel="stylesheet" href="/corehtml/pmc/css/bookshelf/2.26/css/books_reader.min.css" type="text/css">
|
|
<style type="text/css">.main-content {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/css/bookshelf/2.26/img/archive.png);background-size: auto, contain; padding:0 0 0 3em }</style>
|
|
<style type="text/css">p a.figpopup{display:inline !important} .bk_tt {font-family: monospace} .first-line-outdent .bk_ref {display: inline} .body-content h2, .body-content .h2 {border-bottom: 1px solid #97B0C8} .body-content h2.inline {border-bottom: none} a.page-toc-label , .jig-ncbismoothscroll a {text-decoration:none;border:0 !important} .temp-labeled-list .graphic {display:inline-block !important} .temp-labeled-list img{width:100%}</style>
|
|
|
|
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico">
|
|
<meta name="ncbi_phid" content="CE8CC6FA7C8BEAC1000000000071005E.m_5">
|
|
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/css/3852956/3849091.css"></head>
|
|
<body>
|
|
<!-- Book content! -->
|
|
|
|
|
|
<div id="jr" data-jr-path="/corehtml/pmc/jatsreader/ptpmc_3.22/"><div class="jr-unsupported"><table class="modal"><tr><td><span class="attn inline-block"></span><br />Your browser does not support the NLM PubReader view.<br />Go to <a href="/pmc/about/pr-browsers/">this page</a> to see a list of supported browsers<br />or return to the <br /><a href="/books/NBK184580/?report=classic">regular view</a>.</td></tr></table></div><div id="jr-ui" class="hidden"><nav id="jr-head"><div class="flexh tb"><div id="jr-tb1"><a id="jr-links-sw" class="hidden" title="Links"><svg xmlns="http://www.w3.org/2000/svg" version="1.1" x="0px" y="0px" viewBox="0 0 70.6 85.3" style="enable-background:new 0 0 70.6 85.3;vertical-align:middle" xml:space="preserve" width="24" height="24">
|
|
<style type="text/css">.st0{fill:#939598;}</style>
|
|
<g>
|
|
<path class="st0" d="M36,0C12.8,2.2-22.4,14.6,19.6,32.5C40.7,41.4-30.6,14,35.9,9.8"></path>
|
|
<path class="st0" d="M34.5,85.3c23.2-2.2,58.4-14.6,16.4-32.5c-21.1-8.9,50.2,18.5-16.3,22.7"></path>
|
|
<path class="st0" d="M34.7,37.1c66.5-4.2-4.8-31.6,16.3-22.7c42.1,17.9,6.9,30.3-16.4,32.5h1.7c-66.2,4.4,4.8,31.6-16.3,22.7 c-42.1-17.9-6.9-30.3,16.4-32.5"></path>
|
|
</g>
|
|
</svg> Books</a></div><div class="jr-rhead f1 flexh"><div class="head"><a href="/books/n/handbook2e/Small.Molecules/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="body"><div class="t">Small Molecules and Biological Activities</div><div class="j">The NCBI Handbook [Internet]. 2nd edition</div></div><div class="tail"><a href="/books/n/handbook2e/PubChemBioAssay/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></div><div id="jr-tb2"><a id="jr-bkhelp-sw" class="btn wsprkl hidden" title="Help with NLM PubReader">?</a><a id="jr-help-sw" class="btn wsprkl hidden" title="Settings and typography in NLM PubReader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" preserveAspectRatio="none"><path d="M462,283.742v-55.485l-29.981-10.662c-11.431-4.065-20.628-12.794-25.274-24.001 c-0.002-0.004-0.004-0.009-0.006-0.013c-4.659-11.235-4.333-23.918,0.889-34.903l13.653-28.724l-39.234-39.234l-28.72,13.652 c-10.979,5.219-23.68,5.546-34.908,0.889c-0.005-0.002-0.01-0.003-0.014-0.005c-11.215-4.65-19.933-13.834-24-25.273L283.741,50 h-55.484l-10.662,29.981c-4.065,11.431-12.794,20.627-24.001,25.274c-0.005,0.002-0.009,0.004-0.014,0.005 c-11.235,4.66-23.919,4.333-34.905-0.889l-28.723-13.653l-39.234,39.234l13.653,28.721c5.219,10.979,5.545,23.681,0.889,34.91 c-0.002,0.004-0.004,0.009-0.006,0.013c-4.649,11.214-13.834,19.931-25.271,23.998L50,228.257v55.485l29.98,10.661 c11.431,4.065,20.627,12.794,25.274,24c0.002,0.005,0.003,0.01,0.005,0.014c4.66,11.236,4.334,23.921-0.888,34.906l-13.654,28.723 l39.234,39.234l28.721-13.652c10.979-5.219,23.681-5.546,34.909-0.889c0.005,0.002,0.01,0.004,0.014,0.006 c11.214,4.649,19.93,13.833,23.998,25.271L228.257,462h55.484l10.595-29.79c4.103-11.538,12.908-20.824,24.216-25.525 c0.005-0.002,0.009-0.004,0.014-0.006c11.127-4.628,23.694-4.311,34.578,0.863l28.902,13.738l39.234-39.234l-13.66-28.737 c-5.214-10.969-5.539-23.659-0.886-34.877c0.002-0.005,0.004-0.009,0.006-0.014c4.654-11.225,13.848-19.949,25.297-24.021 L462,283.742z M256,331.546c-41.724,0-75.548-33.823-75.548-75.546s33.824-75.547,75.548-75.547 c41.723,0,75.546,33.824,75.546,75.547S297.723,331.546,256,331.546z"></path></svg></a><a id="jr-fip-sw" class="btn wsprkl hidden" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-rtoc-sw" class="btn wsprkl hidden" title="Table of Contents"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M20,20h10v8H20V20zM36,20h44v8H36V20zM20,37.33h10v8H20V37.33zM36,37.33h44v8H36V37.33zM20,54.66h10v8H20V54.66zM36,54.66h44v8H36V54.66zM20,72h10v8 H20V72zM36,72h44v8H36V72z"></path></svg></a></div></div></nav><nav id="jr-dash" class="noselect"><nav id="jr-dash" class="noselect"><div id="jr-pi" class="hidden"><a id="jr-pi-prev" class="hidden" title="Previous page"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a><div class="pginfo">Page <i class="jr-pg-pn">0</i> of <i class="jr-pg-lp">0</i></div><a id="jr-pi-next" class="hidden" title="Next page"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div><div id="jr-is-tb"><a id="jr-is-sw" class="btn wsprkl hidden" title="Switch between Figures/Tables strip and Progress bar"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><rect x="10" y="40" width="20" height="20"></rect><rect x="40" y="40" width="20" height="20"></rect><rect x="70" y="40" width="20" height="20"></rect></svg></a></div><nav id="jr-istrip" class="istrip hidden"><a id="jr-is-prev" href="#" class="hidden" title="Previous"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M80,40 60,65 80,90 70,90 50,65 70,40z M50,40 30,65 50,90 40,90 20,65 40,40z"></path><text x="35" y="25" textLength="60" style="font-size:25px">Prev</text></svg></a><a id="jr-is-next" href="#" class="hidden" title="Next"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M20,40 40,65 20,90 30,90 50,65 30,40z M50,40 70,65 50,90 60,90 80,65 60,40z"></path><text x="15" y="25" textLength="60" style="font-size:25px">Next</text></svg></a></nav><nav id="jr-progress"></nav></nav></nav><aside id="jr-links-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">NCBI Bookshelf</div></div><div class="cnt lol f1"><a href="/books/">Home</a><a href="/books/browse/">Browse All Titles</a><a class="btn share" target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/sharer/sharer.php?u=https://www.ncbi.nlm.nih.gov/books/NBK184580/"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 33" style="vertical-align:middle" width="24" height="24" preserveAspectRatio="none"><g><path d="M 17.996,32L 12,32 L 12,16 l-4,0 l0-5.514 l 4-0.002l-0.006-3.248C 11.993,2.737, 13.213,0, 18.512,0l 4.412,0 l0,5.515 l-2.757,0 c-2.063,0-2.163,0.77-2.163,2.209l-0.008,2.76l 4.959,0 l-0.585,5.514L 18,16L 17.996,32z"></path></g></svg> Share on Facebook</a><a class="btn share" target="_blank" rel="noopener noreferrer" href="https://twitter.com/intent/tweet?url=https://www.ncbi.nlm.nih.gov/books/NBK184580/&text=Small%20Molecules%20and%20Biological%20Activities"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 33" style="vertical-align:middle" width="24" height="24"><g><path d="M 32,6.076c-1.177,0.522-2.443,0.875-3.771,1.034c 1.355-0.813, 2.396-2.099, 2.887-3.632 c-1.269,0.752-2.674,1.299-4.169,1.593c-1.198-1.276-2.904-2.073-4.792-2.073c-3.626,0-6.565,2.939-6.565,6.565 c0,0.515, 0.058,1.016, 0.17,1.496c-5.456-0.274-10.294-2.888-13.532-6.86c-0.565,0.97-0.889,2.097-0.889,3.301 c0,2.278, 1.159,4.287, 2.921,5.465c-1.076-0.034-2.088-0.329-2.974-0.821c-0.001,0.027-0.001,0.055-0.001,0.083 c0,3.181, 2.263,5.834, 5.266,6.438c-0.551,0.15-1.131,0.23-1.73,0.23c-0.423,0-0.834-0.041-1.235-0.118 c 0.836,2.608, 3.26,4.506, 6.133,4.559c-2.247,1.761-5.078,2.81-8.154,2.81c-0.53,0-1.052-0.031-1.566-0.092 c 2.905,1.863, 6.356,2.95, 10.064,2.95c 12.076,0, 18.679-10.004, 18.679-18.68c0-0.285-0.006-0.568-0.019-0.849 C 30.007,8.548, 31.12,7.392, 32,6.076z"></path></g></svg> Share on Twitter</a></div></aside><aside id="jr-rtoc-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Table of Content</div></div><div class="cnt lol f1"><a href="/books/n/handbook2e/?report=reader">Title Information</a><a href="/books/n/handbook2e/toc/?report=reader">Table of Contents Page</a></div></aside><aside id="jr-help-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Settings</div></div><div class="cnt f1"><div id="jr-typo-p" class="typo"><div><a class="sf btn wsprkl">A-</a><a class="lf btn wsprkl">A+</a></div><div><a class="bcol-auto btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 200 100" preserveAspectRatio="none"><text x="10" y="70" style="font-size:60px;font-family: Trebuchet MS, ArialMT, Arial, sans-serif" textLength="180">AUTO</text></svg></a><a class="bcol-1 btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M15,25 85,25zM15,40 85,40zM15,55 85,55zM15,70 85,70z"></path></svg></a><a class="bcol-2 btn wsprkl"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M5,25 45,25z M55,25 95,25zM5,40 45,40z M55,40 95,40zM5,55 45,55z M55,55 95,55zM5,70 45,70z M55,70 95,70z"></path></svg></a></div></div><div class="lol"><a class="" href="/books/NBK184580/?report=classic">Switch to classic view</a><a href="/books/NBK184580/pdf/Bookshelf_NBK184580.pdf">PDF (647K)</a><a href="/books/n/handbook2e/pdf/">PDF (14M)</a><a href="/books/NBK184580/?report=printable">Print View</a></div></div></aside><aside id="jr-bkhelp-p" class="hidden flexv"><div class="tb sk-htbar flexh"><div><a class="jr-p-close btn wsprkl">Done</a></div><div class="title-text f1">Help</div></div><div class="cnt f1 lol"><a id="jr-helpobj-sw" data-path="/corehtml/pmc/jatsreader/ptpmc_3.22/" data-href="/corehtml/pmc/jatsreader/ptpmc_3.22/img/bookshelf/help.xml" href="">Help</a><a href="mailto:info@ncbi.nlm.nih.gov?subject=PubReader%20feedback%20%2F%20NBK184580%20%2F%20sid%3ACE8B5AF87C7FFCB1_0191SID%20%2F%20phid%3ACE8CC6FA7C8BEAC1000000000071005E.4">Send us feedback</a><a id="jr-about-sw" data-path="/corehtml/pmc/jatsreader/ptpmc_3.22/" data-href="/corehtml/pmc/jatsreader/ptpmc_3.22/img/bookshelf/about.xml" href="">About PubReader</a></div></aside><aside id="jr-objectbox" class="thidden hidden"><div class="jr-objectbox-close wsprkl">✘</div><div class="jr-objectbox-inner cnt"><div class="jr-objectbox-drawer"></div></div></aside><nav id="jr-pm-left" class="hidden"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 800" preserveAspectRatio="none"><text font-stretch="ultra-condensed" x="800" y="-15" text-anchor="end" transform="rotate(90)" font-size="18" letter-spacing=".1em">Previous Page</text></svg></nav><nav id="jr-pm-right" class="hidden"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 40 800" preserveAspectRatio="none"><text font-stretch="ultra-condensed" x="800" y="-15" text-anchor="end" transform="rotate(90)" font-size="18" letter-spacing=".1em">Next Page</text></svg></nav><nav id="jr-fip" class="hidden"><nav id="jr-fip-term-p"><input type="search" placeholder="search this page" id="jr-fip-term" autocorrect="off" autocomplete="off" /><a id="jr-fip-mg" class="wsprkl btn" title="Find"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 550 600" preserveAspectRatio="none"><path fill="none" stroke="#000" stroke-width="36" stroke-linecap="round" style="fill:#FFF" d="m320,350a153,153 0 1,0-2,2l170,170m-91-117 110,110-26,26-110-110"></path></svg></a><a id="jr-fip-done" class="wsprkl btn" title="Dismiss find">✘</a></nav><nav id="jr-fip-info-p"><a id="jr-fip-prev" class="wsprkl btn" title="Jump to previuos match">◀</a><button id="jr-fip-matches">no matches yet</button><a id="jr-fip-next" class="wsprkl btn" title="Jump to next match">▶</a></nav></nav></div><div id="jr-epub-interstitial" class="hidden"></div><div id="jr-content"><article data-type="main"><p class="vip-notice retraction"><strong>This publication is provided for historical reference only and the information may be out of date.</strong></p><div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><div class="fm-sec"><h1 id="_NBK184580_"><span class="title" itemprop="name">Small Molecules and Biological Activities</span></h1><p class="contribs">Morris R.</p><p class="fm-aai"><a href="#_NBK184580_pubdet_">Publication Details</a></p><p><em>Estimated reading time: 8 minutes</em></p></div></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="AboutSmallMolecules.Scope"><h2 id="_AboutSmallMolecules_Scope_">Scope</h2><p>The chemical and bioactivity resources at the National Center for Biotechnology Information (NCBI) are coordinated as part of the <a href="http://pubchem.ncbi.nlm.nih.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem Project</a> with data accessible as part of the PubChem Compound and Substance databases and PubChem BioAssay database, respectively. Currently the PubChem set of resources provides access to information about over <a href="http://ncbi.nlm.nih.gov/pccompound/?term=all%5Bfilter%5D" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">36 million chemical compound</a>s and experimental studies with results for over <a href="http://ncbi.nlm.nih.gov/pcassay/?term=all%5Bfilter%5D" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">700 thousand biological activity assays</a>.</p></div><div id="AboutSmallMolecules.History"><h2 id="_AboutSmallMolecules_History_">History</h2><p>The PubChem databases were originally developed to serve as a central data repository for the NIH-sponsored <a href="http://mli.nih.gov/mli" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Molecular Libraries Roadmap Project</a> (Pilot phase 2004–2008). The purpose of this project was to identify novel research reagents (protein function modulators and molecular probes) and discover candidate compounds for drug development. A large set of substances were tested for biological activity in high-throughput assays. The substances were cataloged in the PubChem Substance database and the description, supporting information, and results of the studies were stored in the PubChem BioAssay database. To increase the utility of these databases, a derivative database, PubChem Compound, was created by the PubChem group to consolidate and provide a cross-referencing platform for common chemical components of the substances.</p><p>Since its inception, the scope of these resources has been dramatically expanded for use by an expanding and diverse variety of researchers, from organic chemists to molecular biologists to drug design specialists. In addition to the data from the original NIH Molecular Libraries Initiative, substance information and biological activity assays are now submitted by various organizations:</p><ul><li class="half_rhythm"><div>NIH Molecular Libraries participants and other laboratories with Bioassay Screening Results</div></li><li class="half_rhythm"><div>The NIH Substance Repository</div></li><li class="half_rhythm"><div>Organizations specializing in these areas:</div><ul><li class="half_rhythm"><div>Biological Properties</div></li><li class="half_rhythm"><div>Chemical Reactions</div></li><li class="half_rhythm"><div>Database Vendors</div></li><li class="half_rhythm"><div>Imaging Agents</div></li><li class="half_rhythm"><div>Journal Publishers</div></li><li class="half_rhythm"><div>Metabolic Pathways</div></li><li class="half_rhythm"><div>Patents</div></li><li class="half_rhythm"><div>Physical Properties</div></li><li class="half_rhythm"><div>Protein 3D Structures</div></li><li class="half_rhythm"><div>siRNA Reagent Providers</div></li><li class="half_rhythm"><div>Substance Vendors</div></li><li class="half_rhythm"><div>Theoretical Properties</div></li><li class="half_rhythm"><div>Toxicology Properties</div></li></ul></li></ul></div><div id="AboutSmallMolecules.Dataflow"><h2 id="_AboutSmallMolecules_Dataflow_">Dataflow</h2><div id="AboutSmallMolecules.Data_Submissions_to"><h3>Data Submissions to PubChem</h3><p>The <a href="http://pubchem.ncbi.nlm.nih.gov/upload/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem Upload portal</a> enables researchers, laboratories, and organizations to submit small molecule and bioassay data to the PubChem Substance and PubChem BioAssay databases. Data can be submitted to the PubChem Substance or BioAssay databases in any of the following ways:</p><ul><li class="half_rhythm"><div>PubChem Submission Wizards—for small numbers of submissions, a series of guided forms assist novice submitters in entering substance and/or assay data without requiring knowledge of detailed data specifications. After data is typed or imported, the Upload system will prepare a properly formatted file that conforms to the data specifications.</div></li><li class="half_rhythm"><div>Pre-formatted File Uploads—for small or large numbers of records, Upload accepts pre-formatted files in several formats which may be GZIP-compressed. For PubChem Substances, formats include: SDF – Chemical Structure Data File, CSV – Comma-separated Variables, and for BioAssay formats include: ASN.1 – Abstract Syntax Notation 1, XML – Extensible Markup Language, CSV – Comma-separated Variables).</div></li><li class="half_rhythm"><div>FTP Depositions of Pre-formatted Files—for large and/or frequent data uploads, depositions of pre-formatted files by FTP are recommended. Once the data are in the FTP directory, submitters can review and edit them, and commit them to PubChem using the Upload system.</div></li></ul><p>While the PubChem group and the user community-at-large recommend that submitters supply as much information about their substances and bioactivity assays as possible (including such things as chemical structures of tested substances and related PubMed records), the following are the minimal data that must be submitted:</p><p>To PubChem Substance:</p><ul><li class="half_rhythm"><div>Submitter information</div><ul><li class="half_rhythm"><div>Name</div></li><li class="half_rhythm"><div>Organization</div></li><li class="half_rhythm"><div>Address</div></li><li class="half_rhythm"><div>Contact Information</div></li><li class="half_rhythm"><div>Source Classification</div></li><li class="half_rhythm"><div>Signed <a href="http://pubchem.ncbi.nlm.nih.gov/deposit/docs/PubChem_Data_Agreement.pdf" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Data Transfer Agreement</a></div></li></ul></li><li class="half_rhythm"><div>Substance “name”</div></li><li class="half_rhythm"><div>Source’s identifier</div></li></ul><p>To PubChem BioAssay:</p><ul><li class="half_rhythm"><div>Submitter information (same as PubChem Substance Submitter information)</div></li><li class="half_rhythm"><div>Assay Information</div><ul><li class="half_rhythm"><div>Descriptive Assay title</div></li><li class="half_rhythm"><div>Source’s identifier</div></li><li class="half_rhythm"><div>Assay Information</div></li><li class="half_rhythm"><div>Assay type</div></li><li class="half_rhythm"><div>List of Substances tested</div></li><li class="half_rhythm"><div>Description</div></li><li class="half_rhythm"><div>Protocol</div></li><li class="half_rhythm"><div>Data Table with Defined Outcomes</div></li><li class="half_rhythm"><div>Definitions</div></li></ul></li></ul><p>The PubChem Upload system can also be used for updating existing PubChem records. Existing PubChem Substance or BioAssay records can be retrieved and loaded into the Web interface for direct editing and review of the revised records. Once corrections have been made and verified, they will be committed and stored in the system.</p><p>The PubChem databases have a rolling update schedule. As new data is submitted to PubChem, it is processed for addition to both the relevant primary databases as well as to PubChem Compound (when applicable). Data is released to the website and updated on the FTP site as soon as it is ready, generally within 48 hours.</p></div><div id="AboutSmallMolecules.Primary_and_Derivati"><h3>Primary and Derivative Databases</h3><p>PubChem’s primary databases contain records of data as submitted to the PubChem group:</p><ul><li class="half_rhythm"><div><a href="http://ncbi.nlm.nih.gov/pcsubstance" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem Substance</a>: Information provided to PubChem by submitters. Substances may be of known or unknown chemical composition, and may contain a discrete compound or mixtures of compounds. Links and information in the record are provided and maintained by submitters. Please note that multiple records representing the same substances may be submitted by different laboratories or organizations.</div></li><li class="half_rhythm"><div><a href="http://ncbi.nlm.nih.gov/pcassay" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem BioAssay</a>: Information provided to PubChem by submitters including study background, protocol, and results for experimental bioactivity screens of chemical substances that have been submitted to PubChem Substance.</div></li></ul><p>The PubChem Compound database is a derivative database created by a consolidation of PubChem Substance Records with additional curated information created and maintained by the PubChem group.</p><ul><li class="half_rhythm"><div><a href="http://ncbi.nlm.nih.gov/pccompound" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem Compound</a>: Composed of discrete chemicals with known molecular structure. Summary reports are generated from the known chemical compounds described in PubChem Substance and are supplemented with additional information. Links back to related PubChem Substances, PubChem BioAssays, and other NCBI and external sites are provided by the PubChem group.</div></li></ul><p>
|
|
<span class="graphic"><img src="/books/NBK184580/bin/AboutSmallMolecules-Image001.jpg" alt="Image AboutSmallMolecules-Image001.jpg" /></span>
|
|
</p><p>For example, a Molecular Libraries Screening Center Laboratory at Emory University submitted an Estrogen Receptor-alpha coactivator high-throughput chemical binding screen. This was given the PubChem BioAssay Identifier <a href="http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=629" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">AID 629</a>. Around the same time, a collaborating group, the Molecular Libraries Screening Center’s Small Molecule Repository, submitted information about the substances in their system including 86,096 that were tested in this particular assay. One of those tested and found to be active in AID 629 was given the PubChem Substance Identifier <a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=855958" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">SID 855958</a>, which was one of the many linked to the PubChem BioAssay record.</p><p>In addition to AID 629, this same substance (SID 855958) was tested in over 2,900 assays by various groups. Further information about this chemical was uploaded to the PubChem group by several other organizations including biological property databases, journal publishers, and chemical vendors as submissions to create their own PubChem Substance records. As of December 1, 2013, 284 PubChem Substance records were submitted for this same chemical. The PubChem group then consolidated all information and submitted links for this chemical and included additional calculated chemical properties and information provided by several other key sources (NLM’s Medical Subject Headings, MeSH, DailyMed, and Hazardous Substances Data Bank [HSDB]) and created a reference record in the PubChem Compound database with a PubChem Compound identifier <a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4781" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">CID 4781</a>. This record contains links back to all corresponding PubChem Substance and BioAssay records.</p></div></div><div id="AboutSmallMolecules.Access"><h2 id="_AboutSmallMolecules_Access_">Access</h2><div id="AboutSmallMolecules.Searching_PubChem_Da"><h3>Searching PubChem Databases Using the Web Interface</h3><p>NCBI’s chemical and bioactivities data can be accessed through the NCBI website and the <a href="http://pubchem.ncbi.nlm.nih.gov" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem project homepage</a>. Searching for PubChem data can be performed through the common Web Search (Entrez) mechanism. For the <a href="http://ncbi.nlm.nih.gov/pccompound" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem Compound</a>, <a href="http://ncbi.nlm.nih.gov/pcsubstance" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem Substance</a> and <a href="http://ncbi.nlm.nih.gov/pcassay" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem BioAssay</a> databases, there are highly specialized and useful Limits pages to assist in specifying key types of data. These databases also maintain Entrez Advanced pages with Advanced Search Builders and Search History tables.</p><p>For users who would like to retrieve records from a list of PubChem-related record identifiers (PubChem Compound Identifiers – CIDs, PubChem Substance Identifiers – SIDs, and BioAssay Identifiers – AIDs), <a href="http://ncbi.nlm.nih.gov/sites/batchentrez" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCBI’s Batch Entrez</a> permits the upload of a text file with subsequent retrieval from the selected database.</p><p>In addition to text-based searches using the Web Search (Entrez) system, the PubChem group has created a <a href="http://pubchem.ncbi.nlm.nih.gov/search/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Chemical Structure Search</a> mechanism in which two dimensional drawings or textural representations of chemical structures (SMILES – Simplified molecular-input line-entry system, SMARTS – Smiles arbitrary target specification, InChIs – International Chemical Identifiers) can be used to query the PubChem Compound or Substance databases to find records for chemicals with matching or similar structures.</p></div><div id="AboutSmallMolecules.Downloading_PubChem"><h3>Downloading PubChem Data from the Web</h3><p>After performing a search, groups of retrieved records can be downloaded using the “Send to” function common to all Web Search (Entrez) displays. Individual PubChem records can be downloaded directly from the Web interface with links at the top-right-hand side of the screen. PubChem records display record download buttons for available file formats (SDF, CSV, ASN.1, XML).</p><p>The PubChem group has also created Download Facility tools which enable the quick upload of a list of PubChem record identifiers (CIDs, SIDs, or AIDs) and download of PubChem Compound or Substance information (<a href="http://pubchem.ncbi.nlm.nih.gov/pc_fetch/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem Structure Download Facility</a>) or PubChem BioAssay information (<a href="http://pubchem.ncbi.nlm.nih.gov/assay/assaydownload.cgi" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">BioAssay Download Facility</a>) in a number of file formats.</p><p>For users who would like to download the data in bulk, files are available on the <a href="ftp://ftp.ncbi.nlm.nih.gov/pubchem/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=ftp">PubChem FTP site</a>, which is mirrored on the <a href="http://ncbi.nlm.nih.gov/public" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Aspera-plugin version of the NCBI FTP site</a>.</p></div><div id="AboutSmallMolecules.Accessing_PubChem_Da"><h3>Accessing PubChem Data Using Programming Interfaces</h3><p>The PubChem group provides scripting access for users in a number of formats. As with other NCBI databases, the PubChem resources are accessible using the <a href="http://pubchem.ncbi.nlm.nih.gov/pug/pughelp.html#4" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">NCBI Entrez Utilities API Interface (EUtilities)</a>. In addition, the Group has developed a <a href="http://pubchem.ncbi.nlm.nih.gov/pug_rest/PUG_REST.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PubChem-specific RESTful API Interface (PUG-REST)</a> as well as an <a href="http://pubchem.ncbi.nlm.nih.gov/pug/pughelp.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">XML-intensive PubChem Power User Gateway (PUG)</a>.</p></div></div><div id="AboutSmallMolecules.Related_Tools"><h2 id="_AboutSmallMolecules_Related_Tools_">Related Tools</h2><p><a href="http://pubchem.ncbi.nlm.nih.gov/standardize/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Standardization Service</a> mimics the initial steps of PubChem’s data processing pipeline and, therefore, enables users to see how submitted structures would be handled. In addition, this service will enable the conversion of chemical structures in SMILES, InChI, or SDF formats to a different format. Standardization through this service is limited to a single structure at a time.</p><p><a href="http://pubchem.ncbi.nlm.nih.gov/idexchange/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Identifier Exchange Service</a> enables the upload and conversion of a list of identifiers (CIDs, SIDs, or Registry IDs), InChIs or synonyms with retrieval of identifiers for identical or similar PubChem Compound or Substance records. A file or correspondence table can be downloaded.</p><p><a href="http://dd.ncbi.nlm.nih.gov/datadicer/2/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Data Dicer</a> is an alternative to the Web Search (Entrez) Limits page, providing guided searches and tabular retrievals for information pertaining to bioactivity outcomes for gene/protein targets or screened small molecules in bioactivity assays listed in the PubChem BioAssay database.</p><p><a href="http://pubchem.ncbi.nlm.nih.gov/classification/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Classification Browser</a> searches PubChem records annotated with hierarchies/terms and displays the distribution of these in the context of the specific ontology. Please note that this only operates on the subset of PubChem records that have been annotated with terms from the available hierarchies.</p><p><a href="http://pubchem.ncbi.nlm.nih.gov/search/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Structure Search</a> searches for identical or similar chemical structure records using CID or SIDs, Names (SMILES, SMARTS, InChI, Synonyms, MeSH terms), Molecular Formulas, Molecular Weights, SDF file, or even hand-drawn structures. Similarity thresholds can be customized and record retrieval filters can be set using an interface similar to that of the PubChem Web Search (Entrez) Limits page or using search histories from PubChem Compound or Substance databases. The 2D structure searching strategy uses a modified-Tanimoto scoring system, while the 3D structure searching strategy is based on comparison of calculated shapes of 3D conformers with positions of the functional groups. Search results displayed sorted in decreasing order of the resulting calculated 2D- or 3D-similarity score are retrieved and displayed as a traditional PubChem Compound or Substance search results list.</p><p><a href="http://pubchem.ncbi.nlm.nih.gov/score_matrix/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Score Matrix Service</a> enables the downloading of 2D- or 3D-similarity scoring matrix values calculated by the PubChem Structure Search.</p><p><a href="http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?p=clustering" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Structure Clustering Tool</a> assists in exploration of chemical-structure space and displays chemical structural similarity and population diversity relationships in a tree format using the Single Linkage algorithm. Calculations are based on 2D-similarity scores (modified-Tanimoto scoring) or 3D-similarity scores (conformer, functional group scoring).</p><p><a href="https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?p=bioactivity" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">BioActivity Summary/DataTable</a> searches and retrieves biological screening results for individual or a set of chemical samples or displays the information content of PubChem BioAssay records. Tables are downloadable in a number of formats.</p><p><a href="http://pubchem.ncbi.nlm.nih.gov/assay/plot.cgi" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">BioActivity Plot Service</a> displays bioactivity assay data in customizable scatter plots or histograms.</p><p><a href="http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?p=heat" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Structure-Activity Relationship HeatMap</a> enables interactive visualization for exploring PubChem data, displaying a chemical structure tree on a Y-axis with the bioassays clustered by relatedness on the X-axis. Activity data values are shown as colored squares in the resulting grid. The display of the grid is customizable with respect to color and zoom level and can be downloaded.</p><p><a href="http://pubchem.ncbi.nlm.nih.gov/widget/docs/widget_help.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Webpage Widgets</a> provides code for configurable PubChem data displays including record summaries as well as tables for placement in Web pages.</p></div><div id="AboutSmallMolecules.References"><h2 id="_AboutSmallMolecules_References_">References</h2><div id="AboutSmallMolecules.The_PubChem_Project"><h3>The PubChem Project</h3><ol><li><div class="bk_ref" id="AboutSmallMolecules.REF.wang.2009">Wang Y, Xiao J, Suzek TO, Zhang J, Wang J, Bryant SH. PubChem: a public information system for analyzing bioactivities of small molecules. Nucleic Acids Res. 2009 Jul 1;37(Web Server issue):W623-33. Epub 2009 Jun 4. doi: 10.1093/nar/gkp456. [<a href="/pmc/articles/PMC2703903/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC2703903</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/19498078" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 19498078</span></a>] [<a href="http://dx.crossref.org/10.1093/nar/gkp456" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></li></ol></div><div id="AboutSmallMolecules.PubChem_Substance_an"><h3>PubChem Substance and PubChem Compound Databases</h3><ol><li><div class="bk_ref" id="AboutSmallMolecules.REF.bolton.2008">Bolton E, Wang Y, Thiessen PA, Bryant SH. PubChem: Integrated Platform of Small Molecules and Biological Activities. Chapter 12 IN Annual Reports in Computational Chemistry, Volume 4, American Chemical Society, Washington, DC, 2008 Apr.</div></li></ol></div><div id="AboutSmallMolecules.PubChem_BioAssay_Dat"><h3>PubChem BioAssay Database</h3><ol><li><div class="bk_ref" id="AboutSmallMolecules.REF.wang.2012">Wang Y, Xiao J, Suzek TO, Zhang J, Wang J, Zhou Z, Han L, Karapetyan K, Dracheva S, Shoemaker BA, Bolton E, Gindulyte A, Bryant SH. PubChem's BioAssay Database. Nucleic Acids Res. 2012 Jan;40(1):D400-12. (Epub 2011 Dec 2) doi: 10.1093/nar/gkr1132. [<a href="/pmc/articles/PMC3245056/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3245056</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22140110" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22140110</span></a>] [<a href="http://dx.crossref.org/10.1093/nar/gkr1132" ref="pagearea=cite-ref&targetsite=external&targetcat=link&targettype=uri">CrossRef</a>]</div></li></ol></div></div><div id="bk_toc_contnr"></div></div></div><div class="fm-sec"><h2 id="_NBK184580_pubdet_">Publication Details</h2><h3>Author Information and Affiliations</h3><p class="contrib-group"><h4>Authors</h4><span itemprop="author">Rana Morris</span><sup><img src="/corehtml/pmc/pmcgifs/corrauth.gif" alt="corresponding author" /></sup><sup>1</sup>.</p><h4>Affiliations</h4><div class="affiliation"><sup>1</sup> NCBI<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="vog.hin.mln.ibcn@crsirrom" class="oemail">vog.hin.mln.ibcn@crsirrom</a></div></div><div><sup><img src="/corehtml/pmc/pmcgifs/corrauth.gif" alt="corresponding author" /></sup>Corresponding author.</div><h3>Publication History</h3><p class="small">Created: <span itemprop="datePublished">December 9, 2013</span>.</p><h3>Copyright</h3><div><div class="half_rhythm"><a href="/books/about/copyright/">Copyright Notice</a></div></div><h3>Publisher</h3><p><a href="https://www.ncbi.nlm.nih.gov/" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">National Center for Biotechnology Information (US)</a>, Bethesda (MD)</p><h3>NLM Citation</h3><p>Morris R. Small Molecules and Biological Activities. 2013 Dec 9. In: The NCBI Handbook [Internet]. 2nd edition. Bethesda (MD): National Center for Biotechnology Information (US); 2013-. <span class="bk_cite_avail"></span></p></div><div class="small-screen-prev"><a href="/books/n/handbook2e/Small.Molecules/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M75,30 c-80,60 -80,0 0,60 c-30,-60 -30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Prev</text></svg></a></div><div class="small-screen-next"><a href="/books/n/handbook2e/PubChemBioAssay/?report=reader"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100" preserveAspectRatio="none"><path d="M25,30c80,60 80,0 0,60 c30,-60 30,0 0,-60"></path><text x="20" y="28" textLength="60" style="font-size:25px">Next</text></svg></a></div></article></div><div id="jr-scripts"><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/libs.min.js"> </script><script src="/corehtml/pmc/jatsreader/ptpmc_3.22/js/jr.min.js"> </script></div></div>
|
|
|
|
|
|
|
|
|
|
<!-- Book content -->
|
|
|
|
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"> </script>
|
|
|
|
|
|
<!-- CE8B5AF87C7FFCB1_0191SID /projects/books/PBooks@9.11 portal105 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
|
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
|
|
|
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4216699/js/3968615.js" snapshot="books"></script></body>
|
|
</html>
|