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<meta name="robots" content="INDEX,FOLLOW,NOARCHIVE" /><meta name="citation_inbook_title" content="GeneReviews® [Internet]" /><meta name="citation_title" content="Lymphedema-Distichiasis Syndrome" /><meta name="citation_publisher" content="University of Washington, Seattle" /><meta name="citation_date" content="2019/04/04" /><meta name="citation_author" content="Sahar Mansour" /><meta name="citation_author" content="Glen W Brice" /><meta name="citation_author" content="Steve Jeffery" /><meta name="citation_author" content="Peter Mortimer" /><meta name="citation_pmid" content="20301630" /><meta name="citation_fulltext_html_url" content="https://www.ncbi.nlm.nih.gov/books/NBK1457/" /><meta name="citation_keywords" content="Forkhead box protein C2" /><meta name="citation_keywords" content="FOXC2" /><meta name="citation_keywords" content="Lymphedema-Distichiasis Syndrome" /><link rel="schema.DC" href="http://purl.org/DC/elements/1.0/" /><meta name="DC.Title" content="Lymphedema-Distichiasis Syndrome" /><meta name="DC.Type" content="Text" /><meta name="DC.Publisher" content="University of Washington, Seattle" /><meta name="DC.Contributor" content="Sahar Mansour" /><meta name="DC.Contributor" content="Glen W Brice" /><meta name="DC.Contributor" content="Steve Jeffery" /><meta name="DC.Contributor" content="Peter Mortimer" /><meta name="DC.Date" content="2019/04/04" /><meta name="DC.Identifier" content="https://www.ncbi.nlm.nih.gov/books/NBK1457/" /><meta name="description" content="Lymphedema-distichiasis syndrome (referred to as LDS in this GeneReview) is characterized by lower-limb lymphedema, and distichiasis (aberrant eyelashes ranging from a full set of extra eyelashes to a single hair). Lymphedema typically appears in late childhood or puberty, is confined to the lower limbs with or without involvement of the external genitalia, and is often asymmetric; severity varies within families. Males develop edema at an earlier age and have more problems with cellulitis than females. Distichiasis, which may be present at birth, is observed in 94% of affected individuals. About 75% of affected individuals have ocular findings including corneal irritation, recurrent conjunctivitis, and photophobia; other common findings include varicose veins and ptosis." /><meta name="og:title" content="Lymphedema-Distichiasis Syndrome" /><meta name="og:type" content="book" /><meta name="og:description" content="Lymphedema-distichiasis syndrome (referred to as LDS in this GeneReview) is characterized by lower-limb lymphedema, and distichiasis (aberrant eyelashes ranging from a full set of extra eyelashes to a single hair). Lymphedema typically appears in late childhood or puberty, is confined to the lower limbs with or without involvement of the external genitalia, and is often asymmetric; severity varies within families. Males develop edema at an earlier age and have more problems with cellulitis than females. Distichiasis, which may be present at birth, is observed in 94% of affected individuals. 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<div class="pre-content"><div><div class="bk_prnt"><p class="small">NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.</p><p>Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2025. </p></div><div class="iconblock clearfix whole_rhythm no_top_margin bk_noprnt"><a class="img_link icnblk_img" title="All GeneReviews" href="/books/n/gene/"><img class="source-thumb" src="/corehtml/pmc/pmcgifs/bookshelf/thumbs/th-gene-lrg.png" alt="Cover of GeneReviews®" height="100px" width="80px" /></a><div class="icnblk_cntnt eight_col"><h2>GeneReviews<sup>®</sup> [Internet].</h2><a data-jig="ncbitoggler" href="#__NBK1457_dtls__">Show details</a><div style="display:none" class="ui-widget" id="__NBK1457_dtls__"><div>Adam MP, Feldman J, Mirzaa GM, et al., editors.</div><div>Seattle (WA): <a href="http://www.washington.edu" ref="pagearea=page-banner&targetsite=external&targetcat=link&targettype=publisher">University of Washington, Seattle</a>; 1993-2025.</div></div><div class="half_rhythm"><ul class="inline_list"><li style="margin-right:1em"><a class="bk_cntns" href="/books/n/gene/">GeneReviews by Title</a></li></ul></div><div class="bk_noprnt"><form method="get" action="/books/n/gene/" id="bk_srch"><div class="bk_search"><label for="bk_term" class="offscreen_noflow">Search term</label><input type="text" title="Search GeneReviews" id="bk_term" name="term" value="" data-jig="ncbiclearbutton" /> <input type="submit" class="jig-ncbibutton" value="Search GeneReviews" submit="false" style="padding: 0.1em 0.4em;" /></div></form><div><ul class="inline_list"><li><a href="/books/n/gene/advanced/">GeneReviews Advanced Search</a></li><li style="margin-left:.5em"><a href="/books/n/gene/helpadvsearch/">Help</a></li></ul></div></div></div><div class="icnblk_cntnt two_col"><div class="pagination bk_noprnt"><a class="active page_link prev" href="/books/n/gene/lowe/" title="Previous page in this title">< Prev</a><a class="active page_link next" href="/books/n/gene/hnpcc/" title="Next page in this title">Next ></a></div></div></div></div></div>
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<div class="main-content lit-style" itemscope="itemscope" itemtype="http://schema.org/CreativeWork"><div class="meta-content fm-sec"><h1 id="_NBK1457_"><span class="title" itemprop="name">Lymphedema-Distichiasis Syndrome</span></h1><p class="contrib-group"><span itemprop="author">Sahar Mansour</span>, FRCP, <span itemprop="author">Glen W Brice</span>, RGN, BSc (Hons), <span itemprop="author">Steve Jeffery</span>, PhD, and <span itemprop="author">Peter Mortimer</span>, MD, FRCP.</p><a data-jig="ncbitoggler" href="#__NBK1457_ai__" style="border:0;text-decoration:none">Author Information and Affiliations</a><div style="display:none" class="ui-widget" id="__NBK1457_ai__"><div class="contrib half_rhythm"><span itemprop="author">Sahar Mansour</span>, FRCP<div class="affiliation small">Consultant Geneticist, SW Thames Regional Genetics Department<br />St George's, University of London<br />London, United Kingdom<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ku.ca.lugs@ruosnams" class="oemail">ku.ca.lugs@ruosnams</a></div></div></div><div class="contrib half_rhythm"><span itemprop="author">Glen W Brice</span>, RGN, BSc (Hons)<div class="affiliation small">SW Thames Regional Genetics Department<br />St George's, University of London<br />London, United Kingdom<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ku.ca.lugs@ecirbg" class="oemail">ku.ca.lugs@ecirbg</a></div></div></div><div class="contrib half_rhythm"><span itemprop="author">Steve Jeffery</span>, PhD<div class="affiliation small">Division of Medical Genetics<br />St George's, University of London<br />London, United Kingdom<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ku.ca.lugs@001tggs" class="oemail">ku.ca.lugs@001tggs</a></div></div></div><div class="contrib half_rhythm"><span itemprop="author">Peter Mortimer</span>, MD, FRCP<div class="affiliation small">Department of Cardiac and Vascular Sciences (Dermatology)<br />St George's, University of London<br />London, United Kingdom<div><span class="email-label">Email: </span><a href="mailto:dev@null" data-email="ku.ca.lugs@remitrom" class="oemail">ku.ca.lugs@remitrom</a></div></div></div></div><p class="small">Initial Posting: <span itemprop="datePublished">March 29, 2005</span>; Last Update: <span itemprop="dateModified">April 4, 2019</span>.</p><p><em>Estimated reading time: 18 minutes</em></p></div><div class="jig-ncbiinpagenav body-content whole_rhythm" data-jigconfig="allHeadingLevels: ['h2'],smoothScroll: false" itemprop="text"><div id="lds.Summary" itemprop="description"><h2 id="_lds_Summary_">Summary</h2><div><h4 class="inline">Clinical characteristics.</h4><p>Lymphedema-distichiasis syndrome (referred to as LDS in this <i>GeneReview</i>) is characterized by lower-limb lymphedema, and distichiasis (aberrant eyelashes ranging from a full set of extra eyelashes to a single hair). Lymphedema typically appears in late childhood or puberty, is confined to the lower limbs with or without involvement of the external genitalia, and is often asymmetric; severity varies within families. Males develop edema at an earlier age and have more problems with cellulitis than females. Distichiasis, which may be present at birth, is observed in 94% of affected individuals. About 75% of affected individuals have ocular findings including corneal irritation, recurrent conjunctivitis, and photophobia; other common findings include varicose veins and ptosis.</p></div><div><h4 class="inline">Diagnosis/testing.</h4><p>The clinical diagnosis of LDS is established in a <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> with either lymphedema and distichiasis, distichiasis and a family history of lower-limb lymphedema, or lower-limb lymphedema and a family history of distichiasis. If clinical findings are not diagnostic, the identification of a <a class="def" href="/books/n/gene/glossary/def-item/heterozygous/">heterozygous</a> <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> by <a class="def" href="/books/n/gene/glossary/def-item/molecular-genetic-testing/">molecular genetic testing</a> confirms the diagnosis.</p></div><div><h4 class="inline">Management.</h4><p><i>Treatment of manifestations:</i> Lubrication, plucking, cryotherapy, electrolysis, or lid splitting for treatment of distichiasis; fitted compression garments and bandaging to improve swelling and discomfort associated with edema. To prevent secondary cellulitis, good skin care and prompt treatment of infected skin lesions; prompt treatment of cellulitis with antibiotics. The implementation of hosiery prior to the development of lymphedema may help reduce the extent of edema. Diuretics are not effective in the treatment of lymphedema.</p></div><div><h4 class="inline">Genetic counseling.</h4><p>LDS is inherited in an <a class="def" href="/books/n/gene/glossary/def-item/autosomal-dominant/">autosomal dominant</a> manner. Approximately 75% of affected individuals have an affected parent; about 25% have a <a class="def" href="/books/n/gene/glossary/def-item/de-novo/"><i>de novo</i></a> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a>. Each child of an individual with LDS has a 50% chance of inheriting the pathogenic variant. Disease severity cannot be predicted and is variable even within the same family. If the <i>FOXC2</i> pathogenic variant has been identified in an affected family member, <a class="def" href="/books/n/gene/glossary/def-item/prenatal-testing/">prenatal testing</a> for a pregnancy at increased risk and <a class="def" href="/books/n/gene/glossary/def-item/preimplantation-genetic-testing/">preimplantation genetic testing</a> are possible. Fetal echocardiography is recommended because of the increased risk for <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a> heart disease, renal abnormalities, cleft palate, and hydrothoraces or hydrops fetalis.</p></div></div><div id="lds.Diagnosis"><h2 id="_lds_Diagnosis_">Diagnosis</h2><div id="lds.Suggestive_Findings"><h3>Suggestive Findings</h3><p>Lymphedema-distichiasis syndrome (LDS) <b>should be suspected</b> in individuals with the following clinical findings:</p><ul><li class="half_rhythm"><div><b>Primary lymphedema</b> (chronic swelling of the extremities caused by an intrinsic dysfunction of the lymphatic vessels) typically affecting the lower limbs ± genitalia with onset in late childhood or puberty</div></li><li class="half_rhythm"><div><b>Distichiasis</b> (aberrant, extra eyelashes arising from the meibomian glands on the inner aspects of the inferior and/or superior eyelids, ranging from a full set of extra eyelashes to a single hair</div></li><li class="half_rhythm"><div><b>Varicose veins</b> in the lower limbs presenting at puberty or early adulthood</div></li><li class="half_rhythm"><div><b>Ptosis</b> (drooping upper eyelid) of one or both eyes</div></li><li class="half_rhythm"><div>Other less frequent findings:</div><ul><li class="half_rhythm"><div>Congenital heart disease including bicuspid aortic valves</div></li><li class="half_rhythm"><div>Cleft palate ± Pierre Robin sequence</div></li><li class="half_rhythm"><div>Renal anomalies</div></li><li class="half_rhythm"><div>Spinal extradural arachnoid cysts</div></li><li class="half_rhythm"><div>Nonimmune hydrops fetalis</div></li><li class="half_rhythm"><div>Antenatal hydrothoraces</div></li><li class="half_rhythm"><div>Neck webbing</div></li></ul></li></ul></div><div id="lds.Establishing_the_Diagnosis"><h3>Establishing the Diagnosis</h3><p>The clinical diagnosis of LDS <b>is established</b> in a <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> with <b>one</b> of the following:</p><ul><li class="half_rhythm"><div>Distichiasis and lymphedema (although a young child may have no evidence of lymphedema)</div></li><li class="half_rhythm"><div>Distichiasis and a family history of lower-limb lymphedema</div></li><li class="half_rhythm"><div>Lower-limb lymphedema and a family history of distichiasis</div></li></ul><p>If clinical findings are not diagnostic, the identification of a <a class="def" href="/books/n/gene/glossary/def-item/heterozygous/">heterozygous</a> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> in <i>FOXC2</i> by <a class="def" href="/books/n/gene/glossary/def-item/molecular-genetic-testing/">molecular genetic testing</a> can confirm the diagnosis (see <a href="/books/NBK1457/table/lds.T.molecular_genetic_testing_used_in/?report=objectonly" target="object" rid-ob="figobldsTmoleculargenetictestingusedin">Table 1</a>).</p><p>Molecular genetic testing approaches can include a combination of <b><a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a>-targeted testing</b> (single-gene testing, <a class="def" href="/books/n/gene/glossary/def-item/multigene-panel/">multigene panel</a>) and <b>comprehensive</b>
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<b><a class="def" href="/books/n/gene/glossary/def-item/genomic/">genomic</a> testing</b> (<a class="def" href="/books/n/gene/glossary/def-item/exome-sequencing/">exome sequencing</a>, <a class="def" href="/books/n/gene/glossary/def-item/exome-array/">exome array</a>, <a class="def" href="/books/n/gene/glossary/def-item/genome-sequencing/">genome sequencing</a>) depending on the <a class="def" href="/books/n/gene/glossary/def-item/phenotype/">phenotype</a>.</p><p>Gene-targeted testing requires that the clinician determine which <a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a>(s) are likely involved, whereas <a class="def" href="/books/n/gene/glossary/def-item/genomic/">genomic</a> testing does not. Because the <a class="def" href="/books/n/gene/glossary/def-item/phenotype/">phenotype</a> of LDS can be specific to this condition, individuals with the distinctive findings described in <a href="#lds.Suggestive_Findings">Suggestive Findings</a> are likely to be diagnosed using gene-targeted testing (see <a href="#lds.Option_1">Option 1</a>), whereas those in whom the diagnosis of LDS has not been considered are more likely to be diagnosed using genomic testing (see <a href="#lds.Option_2">Option 2</a>).</p><div id="lds.Option_1"><h4>Option 1</h4><p>When the phenotypic findings suggest the diagnosis of LDS, <a class="def" href="/books/n/gene/glossary/def-item/molecular-genetic-testing/">molecular genetic testing</a> approaches can include <b>single-<a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a> testing</b> or use of a <b><a class="def" href="/books/n/gene/glossary/def-item/multigene-panel/">multigene panel</a></b>:</p><ul><li class="half_rhythm"><div class="half_rhythm"><b>Single-<a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a> testing.</b> Sequence analysis of <i>FOXC2</i> detects small intragenic deletions/insertions and <a class="def" href="/books/n/gene/glossary/def-item/missense/">missense</a>, <a class="def" href="/books/n/gene/glossary/def-item/nonsense-variant/">nonsense</a>, and <a class="def" href="/books/n/gene/glossary/def-item/splice-site/">splice site</a> variants; typically, <a class="def" href="/books/n/gene/glossary/def-item/exon/">exon</a> or whole-gene deletions/duplications are not detected. Perform <a class="def" href="/books/n/gene/glossary/def-item/sequence-analysis/">sequence analysis</a> first. If no <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> is found, perform gene-targeted <a class="def" href="/books/n/gene/glossary/def-item/deletion-duplication-analysis/">deletion/duplication analysis</a> to detect intragenic deletions or duplications.</div></li><li class="half_rhythm"><div class="half_rhythm"><b>A primary lymphedema</b>
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<b><a class="def" href="/books/n/gene/glossary/def-item/multigene-panel/">multigene panel</a></b> that includes <i>FOXC2</i> and other genes of interest (see <a href="#lds.Differential_Diagnosis">Differential Diagnosis</a>) is most likely to identify the genetic cause of the condition at the most reasonable cost while limiting identification of variants of <a class="def" href="/books/n/gene/glossary/def-item/uncertain-significance/">uncertain significance</a> and pathogenic variants in genes that do not explain the underlying <a class="def" href="/books/n/gene/glossary/def-item/phenotype/">phenotype</a>. Note: (1) The genes included in the panel and the diagnostic <a class="def" href="/books/n/gene/glossary/def-item/sensitivity/">sensitivity</a> of the testing used for each <a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a> vary by laboratory and are likely to change over time. (2) Some multigene panels may include genes not associated with the condition discussed in this <i>GeneReview</i>. (3) In some laboratories, panel options may include a custom laboratory-designed panel and/or custom phenotype-focused <a class="def" href="/books/n/gene/glossary/def-item/exome/">exome</a> analysis that includes genes specified by the clinician. (4) Methods used in a panel may include <a class="def" href="/books/n/gene/glossary/def-item/sequence-analysis/">sequence analysis</a>, <a class="def" href="/books/n/gene/glossary/def-item/deletion-duplication-analysis/">deletion/duplication analysis</a>, and/or other non-sequencing-based tests.</div><div class="half_rhythm">For an introduction to multigene panels click <a href="/books/n/gene/app5/#app5.Multigene_Panels">here</a>. More detailed information for clinicians ordering genetic tests can be found <a href="/books/n/gene/app5/#app5.Multigene_Panels_FAQs">here</a>.</div></li></ul></div><div id="lds.Option_2"><h4>Option 2</h4><p>When the diagnosis of LDS is not considered because an individual has atypical phenotypic features, <b>comprehensive <a class="def" href="/books/n/gene/glossary/def-item/genomic/">genomic</a> testing</b> (which does not require the clinician to determine which <a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a>[s] are likely involved) is the best option. <b>Exome sequencing</b> is the most commonly used genomic testing method; <b><a class="def" href="/books/n/gene/glossary/def-item/genome-sequencing/">genome sequencing</a></b> is also possible.</p><p>If <a class="def" href="/books/n/gene/glossary/def-item/exome-sequencing/">exome sequencing</a> is not diagnostic, <b><a class="def" href="/books/n/gene/glossary/def-item/exome-array/">exome array</a></b> (when clinically available) may be considered to detect (multi)<a class="def" href="/books/n/gene/glossary/def-item/exon/">exon</a> deletions or duplications that cannot be detected by <a class="def" href="/books/n/gene/glossary/def-item/sequence-analysis/">sequence analysis</a>.</p><p>For an introduction to comprehensive <a class="def" href="/books/n/gene/glossary/def-item/genomic/">genomic</a> testing click <a href="/books/n/gene/app5/#app5.Comprehensive_Genomic_Testing">here</a>. More detailed information for clinicians ordering genomic testing can be found <a href="/books/n/gene/app5/#app5.Comprehensive_Genomic_Testing_1">here</a>.</p><div id="lds.T.molecular_genetic_testing_used_in" class="table"><h3><span class="label">Table 1. </span></h3><div class="caption"><p>Molecular Genetic Testing Used in Lymphedema-Distichiasis Syndrome</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK1457/table/lds.T.molecular_genetic_testing_used_in/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__lds.T.molecular_genetic_testing_used_in_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_lds.T.molecular_genetic_testing_used_in_1_1_1_1" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Gene <sup>1</sup></th><th id="hd_h_lds.T.molecular_genetic_testing_used_in_1_1_1_2" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Method</th><th id="hd_h_lds.T.molecular_genetic_testing_used_in_1_1_1_3" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Proportion of Probands with a Pathogenic Variant <sup>2</sup> Detectable by Method</th></tr></thead><tbody><tr><td headers="hd_h_lds.T.molecular_genetic_testing_used_in_1_1_1_1" rowspan="2" scope="row" colspan="1" style="text-align:left;vertical-align:middle;">
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<i>FOXC2</i>
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</td><td headers="hd_h_lds.T.molecular_genetic_testing_used_in_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Sequence analysis <sup>3</sup></td><td headers="hd_h_lds.T.molecular_genetic_testing_used_in_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">~95%</td></tr><tr><td headers="hd_h_lds.T.molecular_genetic_testing_used_in_1_1_1_2" colspan="1" scope="row" rowspan="1" style="text-align:left;vertical-align:middle;">Gene-targeted <a class="def" href="/books/n/gene/glossary/def-item/deletion-duplication-analysis/">deletion/duplication analysis</a> <sup>4</sup></td><td headers="hd_h_lds.T.molecular_genetic_testing_used_in_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Unknown; none reported <sup>5</sup></td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1. </dt><dd><div id="lds.TF.1.1"><p class="no_margin">See <a href="/books/NBK1457/#lds.molgen.TA">Table A. Genes and Databases</a> for <a class="def" href="/books/n/gene/glossary/def-item/chromosome/">chromosome</a> <a class="def" href="/books/n/gene/glossary/def-item/locus/">locus</a> and protein.</p></div></dd><dt>2. </dt><dd><div id="lds.TF.1.2"><p class="no_margin">See <a href="#lds.Molecular_Genetics">Molecular Genetics</a> for information on allelic variants detected in this <a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a>.</p></div></dd><dt>3. </dt><dd><div id="lds.TF.1.3"><p class="no_margin">Sequence analysis detects variants that are benign, <a class="def" href="/books/n/gene/glossary/def-item/likely-benign/">likely benign</a>, of <a class="def" href="/books/n/gene/glossary/def-item/uncertain-significance/">uncertain significance</a>, <a class="def" href="/books/n/gene/glossary/def-item/likely-pathogenic/">likely pathogenic</a>, or pathogenic. Pathogenic variants may include small intragenic deletions/insertions and <a class="def" href="/books/n/gene/glossary/def-item/missense/">missense</a>, <a class="def" href="/books/n/gene/glossary/def-item/nonsense-variant/">nonsense</a>, and <a class="def" href="/books/n/gene/glossary/def-item/splice-site/">splice site</a> variants; typically, <a class="def" href="/books/n/gene/glossary/def-item/exon/">exon</a> or whole-<a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a> deletions/duplications are not detected. For issues to consider in interpretation of <a class="def" href="/books/n/gene/glossary/def-item/sequence-analysis/">sequence analysis</a> results, click <a href="/books/n/gene/app2/">here</a>.</p></div></dd><dt>4. </dt><dd><div id="lds.TF.1.4"><p class="no_margin">Gene-targeted <a class="def" href="/books/n/gene/glossary/def-item/deletion-duplication-analysis/">deletion/duplication analysis</a> detects intragenic deletions or duplications. Methods used may include <a class="def" href="/books/n/gene/glossary/def-item/quantitative-pcr/">quantitative PCR</a>, long-range PCR, multiplex ligation-dependent probe amplification (MLPA), and a <a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a>-targeted microarray designed to detect single-<a class="def" href="/books/n/gene/glossary/def-item/exon/">exon</a> deletions or duplications.</p></div></dd><dt>5. </dt><dd><div id="lds.TF.1.5"><p class="no_margin">No data on detection rate of <a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a>-targeted <a class="def" href="/books/n/gene/glossary/def-item/deletion-duplication-analysis/">deletion/duplication analysis</a> are available.</p></div></dd></dl></div></div></div></div></div></div><div id="lds.Clinical_Characteristics"><h2 id="_lds_Clinical_Characteristics_">Clinical Characteristics</h2><div id="lds.Clinical_Description"><h3>Clinical Description</h3><p>Lymphedema-distichiasis syndrome (LDS) is characterized by lymphedema with onset in late childhood or puberty and is confined to the lower limbs and/or genitalia. Varicose veins are a frequent association and may develop before the onset of the lymphedema. Distichiasis, which may be present at birth, can be associated with ocular problems such as corneal irritation, recurrent conjunctivitis, and photophobia. Congenital ptosis involving one or both eyes may be present. Other less common findings include <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a> heart disease, cleft palate, webbed neck, and renal anomalies. Severity varies within and between families, with some affected neonates presenting with hydrops fetalis.</p><p><b>Lymphedema</b> is present in most individuals with LDS. While it typically appears in late childhood or puberty (age range: 7-40 years) [<a class="bk_pop" href="#lds.REF.erickson.2001.761">Erickson et al 2001</a>, <a class="bk_pop" href="#lds.REF.brice.2002.478">Brice et al 2002</a>], <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a> onset has been reported [<a class="bk_pop" href="#lds.REF.finegold.2001.1185">Finegold et al 2001</a>]. In females, pregnancy or use of oral contraceptives may precipitate the onset of swelling.</p><p>Lymphedema is confined to the lower limbs, is often asymmetric, and can be unilateral. The severity of the lymphedema varies within families. Males develop edema at a significantly earlier age and have more problems with cellulitis than females. Sixty-five percent of males in one series complained of recurrent cellulitis in the edematous leg, compared to 25% of females [<a class="bk_pop" href="#lds.REF.brice.2002.478">Brice et al 2002</a>].</p><p>Whereas primary lymphedema is usually associated with hypoplasia or aplasia of the lymphatic vessels, LDS is associated with an increased number of lymphatic vessels and inguinal lymph nodes [<a class="bk_pop" href="#lds.REF.dale.1987.170">Dale 1987</a>, <a class="bk_pop" href="#lds.REF.brice.2003.89">Brice 2003</a>]. The valves in the lymphatic vessels and veins are small and dysplastic, resulting in reflux and edema [<a class="bk_pop" href="#lds.REF.petrova.2004.974">Petrova et al 2004</a>].</p><p>Isotope lymphoscintigraphy can be used to demonstrate that the swelling is caused by lymphedema. Radioactive colloid is injected into the toe web spaces and uptake in the ilioinguinal nodes is measured at intervals. Low uptake can be demonstrated in most affected individuals in association with dermal backflow, indicating lymph reflux into the lower limbs. This technique replaces lymphangiography (x-ray after injection of dye into the lymphatic vessels in the foot).</p><p><b>Distichiasis</b> describes the presence of aberrant eyelashes arising from the meibomian glands on the inner aspects of the inferior and superior eyelids. These range from a full set of extra eyelashes to a single hair. Distichiasis is observed in 94% of individuals with LDS [<a class="bk_pop" href="#lds.REF.brice.2002.478">Brice et al 2002</a>]. Although distichiasis may be present at birth, it may not be recognized until early childhood.</p><p>About 75% of affected individuals have ocular problems related to distichiasis, including corneal irritation, recurrent conjunctivitis, and photophobia. About 25% of individuals have no symptoms from distichiasis and are thus not aware of it. Therefore, any individual with primary lymphedema of the lower limbs should be examined carefully for the presence of distichiasis.</p><p><a class="bk_pop" href="#lds.REF.finegold.2001.1185">Finegold et al [2001]</a> described one family with a <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> with lymphedema only; however, only three individuals were affected and it is not known whether they were examined by slit lamp for evidence of distichiasis, which can sometimes be very subtle. In a study of 23 probands reported to have Meige disease (see <a href="#lds.Differential_Diagnosis">Differential Diagnosis</a>) only one had a pathogenic variant in <i>FOXC2</i>. More extensive examination of the individuals in this family revealed that although the <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> did not have distichiasis, four affected relatives had evidence of distichiasis on slit lamp examination [<a class="bk_pop" href="#lds.REF.rezaie.2008.300">Rezaie et al 2008</a>].</p><p>In one family, distichiasis was associated with a <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> in <i>FOXC2</i> but none of the affected individuals had evidence of lymphedema. The two affected individuals in the family were the 13-year-old <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> (in whom lymphedema could still develop) and her father [<a class="bk_pop" href="#lds.REF.brooks.2003.354">Brooks et al 2003</a>].</p><p><b>Varicose veins.</b> The incidence of varicose veins is much higher (and onset earlier) in individuals with LDS than in the general population. About 50% of individuals with LDS have clinically evident varicose veins [<a class="bk_pop" href="#lds.REF.brice.2002.478">Brice et al 2002</a>]. In one family, light-reflective rheography and Doppler studies showed bilateral incompetence at the sapheno-femoral junction and long saphenous vein, which were presumed to be <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a> abnormalities affecting both deep and superficial veins [<a class="bk_pop" href="#lds.REF.rosbotham.2000.148">Rosbotham et al 2000</a>]. Ongoing studies of venous abnormalities suggest that they are present in all individuals with <i>FOXC2</i> pathogenic variants [<a class="bk_pop" href="#lds.REF.mellor.2007.1912">Mellor et al 2007</a>]<i>. FOXC2</i> is essential for lymphatic and venous valve formation in the embryo [<a class="bk_pop" href="#lds.REF.lyons.2017.2437">Lyons et al 2017</a>].</p><p><b>Ptosis.</b> Approximately 30% of individuals with LDS have unilateral or bilateral <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a> ptosis of variable severity.</p><p><b>Congenital heart disease</b> occurs in 7%-10% of individuals with LDS. Structural abnormalities include ventricular septal defect, atrial septal defect, patent ductus arteriosis, bicuspid aortic valve, and tetralogy of Fallot. Cardiac arrhythmia, most commonly sinus bradycardia, may also occur.</p><p><b>Cleft palate.</b> About 4% of individuals have cleft palate with or without Pierre Robin sequence [<a class="bk_pop" href="#lds.REF.papoff.2016.384">Papoff et al 2016</a>].</p><p>
|
||
<b>Other findings</b>
|
||
</p><ul><li class="half_rhythm"><div>Nonimmune hydrops fetalis or antenatal hydrothoraces have been reported as a rare complication of LDS. Hydrops fetalis can be caused by lymphatic abnormalities [<a class="bk_pop" href="#lds.REF.bellini.2015.1082">Bellini et al 2015</a>]. If the fetus or neonate survives, the hydrops may resolve completely. It has been suggested that the hydrops and respiratory failure may be due to severe pulmonary lymphangiectasia [<a class="bk_pop" href="#lds.REF.de_bruyn.2012.447">de Bruyn et al 2012</a>, <a class="bk_pop" href="#lds.REF.sargent.2014.2802">Sargent et al 2014</a>].</div></li><li class="half_rhythm"><div>Spinal extradural arachnoid cyst (SEDAC) is a cyst in the spinal canal that protrudes into the epidural space from a defect in the dura mater. Thus, SEDAC caused by a <a class="def" href="/books/n/gene/glossary/def-item/heterozygous/">heterozygous</a> <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/loss-of-function/">loss-of-function</a> variant should be considered a feature of LDS. It may manifest as the sole finding, but more frequently the family history is positive for SEDAC, distichiasis, and/or lymphedema [<a class="bk_pop" href="#lds.REF.kanaan.2006.162">Kanaan et al 2006</a>, <a class="bk_pop" href="#lds.REF.ogura.2013.e80548">Ogura et al 2013</a>].</div></li><li class="half_rhythm"><div>Renal anomalies include hydronephrosis, ectopic kidney, and renal agenesis, which may be detected by antenatal ultrasound examination [<a class="bk_pop" href="#lds.REF.jones.2017.2251">Jones et al 2017</a>].</div></li></ul><p>Other abnormalities include scoliosis, neck webbing, uterine anomalies, strabismus, and synophrys. Neonatal chylothorax has been reported in one case in association with <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a> heart disease [<a class="bk_pop" href="#lds.REF.chen.1996.273">Chen et al 1996</a>]. One paper suggested an association with yellow nails, but discolored nails are a common feature of chronic lymphedema regardless of cause.</p></div><div id="lds.GenotypePhenotype_Correlations"><h3>Genotype-Phenotype Correlations</h3><p>No <a class="def" href="/books/n/gene/glossary/def-item/genotype-phenotype-correlations/">genotype-phenotype correlations</a> for the major clinical signs have been reported.</p></div><div id="lds.Penetrance"><h3>Penetrance</h3><p>Approximately 80% of individuals with lymphedema-distichiasis syndrome have lymphedema by early adulthood (age 30 years), although a few individuals may develop lymphedema later.</p><p>Approximately 94% of affected individuals have distichiasis. In all families with <i>FOXC</i> pathogenic variants reported, at least one individual has had distichiasis.</p></div><div id="lds.Nomenclature"><h3>Nomenclature</h3><p>Lymphedema and ptosis, once described as a separate entity, is thought to be the same as lymphedema-distichiasis syndrome [<a class="bk_pop" href="#lds.REF.finegold.2001.1185">Finegold et al 2001</a>].</p></div><div id="lds.Prevalence"><h3>Prevalence</h3><p>The prevalence of lymphedema-distichiasis syndrome is not known; it is a well-recognized and relatively frequent cause of <a class="def" href="/books/n/gene/glossary/def-item/autosomal-dominant/">autosomal dominant</a> primary lymphedema.</p></div></div><div id="lds.Genetically_Related_Allelic_Disorder"><h2 id="_lds_Genetically_Related_Allelic_Disorder_">Genetically Related (Allelic) Disorders</h2><p>No other phenotypes are known to be associated with <i>FOXC2</i> pathogenic variants. However, a twin study suggested a link between <i>FOXC2</i> and early onset of varicose veins [<a class="bk_pop" href="#lds.REF.ng.2005.235">Ng et al 2005</a>].</p></div><div id="lds.Differential_Diagnosis"><h2 id="_lds_Differential_Diagnosis_">Differential Diagnosis</h2><div id="lds.T.disorders_to_consider_in_the_diffe" class="table"><h3><span class="label">Table 2. </span></h3><div class="caption"><p>Disorders to Consider in the Differential Diagnosis of Lymphedema-Distichiasis Syndrome (LDS)</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK1457/table/lds.T.disorders_to_consider_in_the_diffe/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__lds.T.disorders_to_consider_in_the_diffe_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" rowspan="2" scope="col" colspan="1" headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" style="text-align:left;vertical-align:middle;">DiffDx Disorder</th><th id="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" rowspan="2" scope="col" colspan="1" headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" style="text-align:left;vertical-align:middle;">Gene(s)</th><th id="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" rowspan="2" scope="col" colspan="1" headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" style="text-align:left;vertical-align:middle;">MOI</th><th id="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4" colspan="2" scope="colgroup" rowspan="1" style="text-align:center;vertical-align:middle;">Clinical Features of DiffDx Disorder</th></tr><tr><th headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4" id="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_1" colspan="1" scope="colgroup" rowspan="1" style="text-align:left;vertical-align:middle;">Overlapping w/LDS</th><th headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4" id="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_2" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Distinguishing from LDS</th></tr></thead><tbody><tr><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
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<a href="/books/n/gene/milroy/">Milroy disease</a>
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||
</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<i>FLT4</i>
|
||
</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">AD</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_1" rowspan="7" colspan="1" style="text-align:left;vertical-align:middle;">Lymphedema <sup>1</sup></td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Typically <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a>-onset lymphedema (very rarely presents later)</div></li><li class="half_rhythm"><div>Absence of distichiasis</div></li></ul>
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||
</td></tr><tr><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Meige disease<br />(OMIM <a href="https://omim.org/entry/153200" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">153200</a>)</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Unknown</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">AD</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_2" colspan="1" rowspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Absence of distichiasis</div></li></ul>
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||
</td></tr><tr><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Hypotrichosis-lymphedema-telangiectasia syndrome<br />(OMIM <a href="https://omim.org/entry/607823" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">607823</a>)</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<i>SOX18</i>
|
||
</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">AR</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_2" rowspan="2" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Loss of hair</div></li><li class="half_rhythm"><div>Telangiectasia, particularly in the palms</div></li><li class="half_rhythm"><div>Absence of distichiasis</div></li></ul>
|
||
</td></tr><tr><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome<br />(OMIM <a href="https://omim.org/entry/137940" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">137940</a>)</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" colspan="1" rowspan="1" style="text-align:left;vertical-align:middle;">AD</td></tr><tr><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Lymphedema microcephaly<br />(OMIM <a href="https://omim.org/entry/152950" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">152950</a>)</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<i>KIF11</i>
|
||
</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">AD</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_2" colspan="1" rowspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Small head circumference</div></li><li class="half_rhythm"><div>May be associated w/chorioretinopathy &/or ID</div></li><li class="half_rhythm"><div>Absence of distichiasis</div></li></ul>
|
||
</td></tr><tr><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Yellow nail syndrome<br />(OMIM <a href="https://omim.org/entry/153300" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">153300</a>)</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Unknown</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">AD <sup>2</sup></td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_2" colspan="1" rowspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Very slow-growing nails w/transverse overcurvature & hardening of the nail plate <sup>3</sup></div></li><li class="half_rhythm"><div>Absence of distichiasis</div></li></ul>
|
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</td></tr><tr><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Emberger syndrome<br />(OMIM <a href="https://omim.org/entry/614038" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">614038</a>)</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
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||
<i>GATA2</i>
|
||
</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">AD</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_2" colspan="1" rowspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Myelodysplasia</div></li><li class="half_rhythm"><div>Immunodeficiency</div></li><li class="half_rhythm"><div>Absence of distichiasis</div></li></ul>
|
||
</td></tr><tr><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Blepharocheilodontic syndrome<br />(OMIM <a href="https://omim.org/phenotypicSeries/PS119580" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">PS119580</a>)</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<i>CDH1</i>
|
||
<br />
|
||
<i>CTNND1</i>
|
||
</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">AD</td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_1" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Distichiasis <sup>4</sup></td><td headers="hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_1_4 hd_h_lds.T.disorders_to_consider_in_the_diffe_1_1_2_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Lagophthalmos (inability to fully close eyes)</div></li><li class="half_rhythm"><div>Cleft lip & palate</div></li><li class="half_rhythm"><div>Atrial septal defect</div></li><li class="half_rhythm"><div>Oligodontia</div></li><li class="half_rhythm"><div>Absence of lymphedema</div></li></ul>
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</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div><p class="no_margin">AD = <a class="def" href="/books/n/gene/glossary/def-item/autosomal-dominant/">autosomal dominant</a>; AR = <a class="def" href="/books/n/gene/glossary/def-item/autosomal-recessive/">autosomal recessive</a>; DiffDx = differential diagnosis; ID = intellectual disability; MOI = <a class="def" href="/books/n/gene/glossary/def-item/mode-of-inheritance/">mode of inheritance</a>; XL = <a class="def" href="/books/n/gene/glossary/def-item/x-linked/">X-linked</a></p></div></dd><dt>1. </dt><dd><div id="lds.TF.2.1"><p class="no_margin">The presence of lymphatic vessels on lymphoscintigraphy in LDS contrasts with other causes of primary lymphedema, including Milroy disease and Meige disease, which show aplasia or hypoplasia of the lymphatic vessels.</p></div></dd><dt>2. </dt><dd><div id="lds.TF.2.2"><p class="no_margin">Inheritance is said to be <a class="def" href="/books/n/gene/glossary/def-item/autosomal-dominant/">autosomal dominant</a>; most affected individuals represent <a class="def" href="/books/n/gene/glossary/def-item/simplex/">simplex</a> cases (i.e., a single occurrence in a family) [<a class="bk_pop" href="#lds.REF.hoque.2007.1230">Hoque et al 2007</a>].</p></div></dd><dt>3. </dt><dd><div id="lds.TF.2.3"><p class="no_margin">Nail changes are different from the typically discolored nails often associated with chronic lymphedema.</p></div></dd><dt>4. </dt><dd><div id="lds.TF.2.4"><p class="no_margin">Distichiasis should also be clinically distinguished from trichiasis, a more common condition in which lashes arise normally from the anterior lamella of the eyelids but are misdirected. The misdirected lashes can cause symptoms similar to distichiasis (e.g., corneal irritation and photophobia).</p></div></dd></dl></div></div></div></div><div id="lds.Management"><h2 id="_lds_Management_">Management</h2><div id="lds.Evaluations_Following_Initial_Diagno"><h3>Evaluations Following Initial Diagnosis</h3><p>To establish the extent of disease and needs of in an individual diagnosed with lymphedema-distichiasis syndrome (LDS), the evaluations summarized in <a href="/books/NBK1457/table/lds.T.recommended_evaluations_following/?report=objectonly" target="object" rid-ob="figobldsTrecommendedevaluationsfollowing">Table 3</a> (if not performed as part of the evaluation that led to the diagnosis) are recommended.</p><div id="lds.T.recommended_evaluations_following" class="table"><h3><span class="label">Table 3. </span></h3><div class="caption"><p>Recommended Evaluations Following Initial Diagnosis in Individuals with Lymphedema-Distichiasis Syndrome</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK1457/table/lds.T.recommended_evaluations_following/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__lds.T.recommended_evaluations_following_lrgtbl__"><table><thead><tr><th id="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">System/<br />Concern</th><th id="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Evaluation</th><th id="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Comment</th></tr></thead><tbody><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
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<b>Eyes</b>
|
||
</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Ophthalmologic eval</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Slit lamp eval for distichiasis & related problems of corneal irritation, recurrent conjunctivitis, & photophobia</div></li><li class="half_rhythm"><div>Assess for ptosis.</div></li><li class="half_rhythm"><div>Assess for strabismus.</div></li></ul>
|
||
</td></tr><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Lymphedema</b>
|
||
</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Physical exam of lower legs to document presence of lymphedema & any evidence of cellulitis</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Isotope lymphoscintigraphy to detect lymphatic weakness before onset of swelling</td></tr><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Vascular</b>
|
||
</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Physical exam of varicose veins w/young onset (adolescence / early adulthood)</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Venous duplex scans</td></tr><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Cleft palate</b>
|
||
</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Assess for cleft palate or Pierre Robin sequence.</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Cardiovascular</b>
|
||
</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Assess for <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a> heart defects.</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Echocardiogram</div></li><li class="half_rhythm"><div>Further eval if clinical evidence suggests arrhythmias</div></li></ul>
|
||
</td></tr><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" rowspan="2" scope="row" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Spine</b>
|
||
</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Assess for spinal extradural arachnoid cyst.</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"><ul><li class="half_rhythm"><div>Cysts can result in fluctuating symptoms (e.g., when enlarged, they may compress the root or cord & result in pain or weakness).</div></li><li class="half_rhythm"><div>Spinal MRI if symptomatic</div></li></ul>
|
||
</td></tr><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" colspan="1" scope="col" rowspan="1" style="text-align:left;vertical-align:middle;">Assess for scoliosis.</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Renal</b>
|
||
</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Renal ultrasound eval</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Assess for renal anomalies.</td></tr><tr><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Miscellaneous/</b>
|
||
<br />
|
||
<b>Other</b>
|
||
</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Consultation w/clinical geneticist &/or genetic counselor</td><td headers="hd_h_lds.T.recommended_evaluations_following_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr></tbody></table></div></div></div><div id="lds.Treatment_of_Manifestations"><h3>Treatment of Manifestations</h3><p>
|
||
<b>Eyes</b>
|
||
</p><ul><li class="half_rhythm"><div>Conservative management of symptomatic distichiasis with lubrication or epilation (plucking), or more definitive management with cryotherapy, electrolysis, or lid splitting [<a class="bk_pop" href="#lds.REF.odonnell.1993.289">O'Donnell & Collin 1993</a>]. Recurrence is possible even with more definitive treatment.</div></li><li class="half_rhythm"><div>Surgery for ptosis if clinically indicated (e.g., obscured vision, cosmetic appearance)</div></li></ul><p><b>Lymphedema.</b> Refer to a lymphedema therapist for management of edema (fitting hosiery, massage). Although the edema cannot be cured, some improvement may be possible with the use of carefully fitted hosiery and/or bandaging, which may reduce the size of the swelling as well as the associated discomfort. The implementation of hosiery prior to the development of lymphedema may be beneficial in reducing the extent of edema [P Mortimer, personal communication].</p><p>The following are appropriate:</p><ul><li class="half_rhythm"><div>Prevention of secondary cellulitis in areas with lymphedema, particularly as cellulitis may aggravate the degree of edema. Prophylactic antibiotics (e.g., penicillin V 500 mg/day) are recommended for recurrent cellulitis.</div></li><li class="half_rhythm"><div>Prompt treatment of early cellulitis with appropriate antibiotics. It may be necessary to give the first few doses intravenously if there is severe systemic upset.</div></li><li class="half_rhythm"><div>Prevention of foot infections (particularly athlete's foot / infected eczema) by treatment with appropriate creams/ointments</div></li></ul><p>Note: (1) Diuretics are not effective in the treatment of lymphedema. (2) Cosmetic surgery is often associated with disappointing results.</p><p>See <a href="https://vascern.eu/wp-content/uploads/2018/12/Fiches_Pediatric_and_Primary_Lymphedema_FINAL-web.pdf" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">fact sheet</a> for more information.</p><p><b>Varicose veins.</b> Manage varicose veins conservatively with compression garments if possible, as surgery could aggravate the edema and increase the risk of infection or cellulitis.</p><p><b>Cardiac anomalies/arrhythmia.</b> Manage as per standard practice.</p><p>
|
||
<b>Spine</b>
|
||
</p><ul><li class="half_rhythm"><div><b>Spinal extradural arachnoid cyst.</b> Refer individuals with symptomatic spinal cysts (i.e., any neurologic signs or symptoms, especially in the lower limbs) to a neurosurgeon.</div></li><li class="half_rhythm"><div><b>Scoliosis.</b> Standard treatment</div></li></ul><p><b>Renal malformations.</b> Standard treatment</p></div><div id="lds.Surveillance"><h3>Surveillance</h3><div id="lds.T.recommended_surveillance_for_indiv" class="table"><h3><span class="label">Table 4. </span></h3><div class="caption"><p>Recommended Surveillance for Individuals with Lymphedema-Distichiasis Syndrome</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK1457/table/lds.T.recommended_surveillance_for_indiv/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__lds.T.recommended_surveillance_for_indiv_lrgtbl__"><table class="no_bottom_margin"><thead><tr><th id="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_1" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">System/Concern</th><th id="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_2" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Evaluation</th><th id="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_3" scope="col" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Frequency</th></tr></thead><tbody><tr><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Eyes</b>
|
||
</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Slit lamp exam of the eyes</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">As required for control of symptoms from distichiasis</td></tr><tr><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Lymphedema</b>
|
||
</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Lymphoscintigraphy at diagnosis, then clinical assessment</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1-2x/yr, but regular lymphedema therapy (every 6 mos) <sup>1</sup></td></tr><tr><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Varicose veins</b>
|
||
</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Clinical assessment</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">1-2x/yr</td></tr><tr><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Cleft palate</b>
|
||
</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Per craniofacial team</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Cardiovascular</b>
|
||
</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Per cardiologist</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Spine</b>
|
||
</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Investigate w/spine MRI; only if symptomatic.</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr><tr><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_1" scope="row" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">
|
||
<b>Renal</b>
|
||
</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_2" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;">Per treating nephrologist/urologist</td><td headers="hd_h_lds.T.recommended_surveillance_for_indiv_1_1_1_3" rowspan="1" colspan="1" style="text-align:left;vertical-align:middle;"></td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt>1. </dt><dd><div id="lds.TF.4.1"><p class="no_margin">See <a href="https://vascern.eu/wp-content/uploads/2018/12/Fiches_Pediatric_and_Primary_Lymphedema_FINAL-web.pdf" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">fact sheet</a> for more information.</p></div></dd></dl></div></div></div></div><div id="lds.Evaluation_of_Relatives_at_Risk"><h3>Evaluation of Relatives at Risk</h3><p>See <a href="#lds.Related_Genetic_Counseling_Issues">Genetic Counseling</a> for issues related to testing of at-risk relatives for <a class="def" href="/books/n/gene/glossary/def-item/genetic-counseling/">genetic counseling</a> purposes.</p></div><div id="lds.Pregnancy_Management"><h3>Pregnancy Management</h3><p>Edema may be exacerbated during pregnancy, but often improves after delivery. The patient should continue compression and bandage treatment as long as possible but this should be adapted to the patient's needs (e.g., thigh-length compression garments instead of tights). See <a href="https://vascern.eu/wp-content/uploads/2018/12/Fiches_Pediatric_and_Primary_Lymphedema_FINAL-web.pdf" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">fact sheet</a> for more information.</p></div><div id="lds.Therapies_Under_Investigation"><h3>Therapies Under Investigation</h3><p>Search <a href="http://clinicaltrials.gov/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">ClinicalTrials.gov</a> in the US and <a href="http://www.clinicaltrialsregister.eu/ctr-search/search" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">EU Clinical Trials Register</a> in Europe for information on clinical studies for a wide range of diseases and conditions. Note: There may not be clinical trials for this disorder.</p></div></div><div id="lds.Genetic_Counseling"><h2 id="_lds_Genetic_Counseling_">Genetic Counseling</h2><p>
|
||
<i>Genetic counseling is the process of providing individuals and families with
|
||
information on the nature, mode(s) of inheritance, and implications of genetic disorders to help them
|
||
make informed medical and personal decisions. The following section deals with genetic
|
||
risk assessment and the use of family history and genetic testing to clarify genetic
|
||
status for family members; it is not meant to address all personal, cultural, or
|
||
ethical issues that may arise or to substitute for consultation with a genetics
|
||
professional</i>. —ED.</p><div id="lds.Mode_of_Inheritance"><h3>Mode of Inheritance</h3><p>Lymphedema-distichiasis syndrome (LDS) is inherited in an <a class="def" href="/books/n/gene/glossary/def-item/autosomal-dominant/">autosomal dominant</a> manner.</p></div><div id="lds.Risk_to_Family_Members"><h3>Risk to Family Members</h3><p>
|
||
<b>Parents of a <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a></b>
|
||
</p><ul><li class="half_rhythm"><div>Most individuals diagnosed with LDS have an affected parent.</div></li><li class="half_rhythm"><div>A <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> with LDS may have the disorder as the result of a <a class="def" href="/books/n/gene/glossary/def-item/de-novo/"><i>de novo</i></a>
|
||
<i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a>. The proportion of cases caused by a <i>de novo</i> pathogenic variant is about 25% [<a class="bk_pop" href="#lds.REF.brice.2002.478">Brice et al 2002</a>].</div></li><li class="half_rhythm"><div>If the <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> found in the <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> cannot be detected in the leukocyte DNA of either parent, possible explanations include a <a class="def" href="/books/n/gene/glossary/def-item/de-novo/"><i>de novo</i></a> pathogenic variant in the proband or <a class="def" href="/books/n/gene/glossary/def-item/germline-mosaicism/">germline mosaicism</a> in a parent. Though theoretically possible, no instances of germline mosaicism have been reported.</div></li><li class="half_rhythm"><div>The family history of some individuals diagnosed with LDS may appear to be negative because of failure to recognize the disorder in family members as a result of <a class="def" href="/books/n/gene/glossary/def-item/variable-expressivity/">variable expressivity</a>. Therefore, an apparently negative family history cannot be confirmed unless appropriate clinical evaluation and/or <a class="def" href="/books/n/gene/glossary/def-item/molecular-genetic-testing/">molecular genetic testing</a> has been performed on the parents of the <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a>.</div></li></ul><p><b>Sibs of a <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a>.</b> The risk to the sibs of the proband depends on the clinical/genetic status of the proband's parents:</p><ul><li class="half_rhythm"><div>If a parent of the <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> is affected and/or is known to have the <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> identified in the proband, the risk to the sibs is 50%. Manifestations of the disorder in sibs who inherit a <i>FOXC2</i> pathogenic variant cannot be accurately predicted and may be variable within the same family.</div></li><li class="half_rhythm"><div>If the parents are clinically unaffected and/or the <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> has a known <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> that cannot be detected in the leukocyte DNA of either parent, the <a class="def" href="/books/n/gene/glossary/def-item/recurrence-risk/">recurrence risk</a> to sibs is estimated to be 1% because of the theoretic possibility of parental <a class="def" href="/books/n/gene/glossary/def-item/germline-mosaicism/">germline mosaicism</a> [<a class="bk_pop" href="#lds.REF.rahbari.2016.126">Rahbari et al 2016</a>].</div></li></ul><p><b>Offspring of a <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a>.</b> Each child of an individual with LDS has a 50% chance of inheriting the <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a>. Manifestations of the disorder in offspring who inherit a <i>FOXC2</i> pathogenic variant cannot be accurately predicted and may be variable within the same family.</p><p><b>Other family members.</b> The risk to other family members depends on the genetic status of the <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a>'s parents: if a parent has the <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a>, his or her family members may be at risk.</p></div><div id="lds.Related_Genetic_Counseling_Issues"><h3>Related Genetic Counseling Issues</h3><p><b>Considerations in families with an apparent <a class="def" href="/books/n/gene/glossary/def-item/de-novo/"><i>de novo</i></a> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a>.</b> When neither parent of a <a class="def" href="/books/n/gene/glossary/def-item/proband/">proband</a> with an <a class="def" href="/books/n/gene/glossary/def-item/autosomal-dominant/">autosomal dominant</a> condition has the pathogenic variant identified in the proband or clinical evidence of the disorder, the pathogenic variant is likely <i>de novo</i>. However, non-medical explanations including <a class="def" href="/books/n/gene/glossary/def-item/alternate-paternity/">alternate paternity</a> or maternity (e.g., with assisted reproduction) and undisclosed adoption could also be explored.</p><p>
|
||
<b>Family planning</b>
|
||
</p><ul><li class="half_rhythm"><div>The optimal time for determination of genetic risk and discussion of the availability of prenatal/<a class="def" href="/books/n/gene/glossary/def-item/preimplantation-genetic-testing/">preimplantation genetic testing</a> is before pregnancy.</div></li><li class="half_rhythm"><div>It is appropriate to offer <a class="def" href="/books/n/gene/glossary/def-item/genetic-counseling/">genetic counseling</a> (including discussion of potential risks to offspring and reproductive options) to young adults who are affected or at risk.</div></li></ul><p><b>DNA banking</b> is the storage of DNA (typically extracted from white blood cells) for possible future use. Because it is likely that testing methodology and our understanding of genes, allelic variants, and diseases will improve in the future, consideration should be given to banking DNA of affected individuals.</p></div><div id="lds.Prenatal_Testing_and_Preimplantation"><h3>Prenatal Testing and Preimplantation Genetic Testing</h3><p><b>Molecular genetic testing.</b> Once the <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/pathogenic-variant/">pathogenic variant</a> has been detected in an affected family member, <a class="def" href="/books/n/gene/glossary/def-item/prenatal-diagnosis/">prenatal diagnosis</a> for a pregnancy at increased risk and <a class="def" href="/books/n/gene/glossary/def-item/preimplantation-genetic-testing/">preimplantation genetic testing</a> for LDS are possible.</p><p>
|
||
<b>Ultrasonography</b>
|
||
</p><ul><li class="half_rhythm"><div>Fetal echocardiography at 16 to 20 weeks' gestation is recommended because of the increased risk for <a class="def" href="/books/n/gene/glossary/def-item/congenital/">congenital</a> heart disease.</div></li><li class="half_rhythm"><div>Additional fetal scans may be warranted because of the increased risk for cleft palate.</div></li><li class="half_rhythm"><div>An additional scan in the third trimester is recommended because of the increased risk of hydrothoraces or hydrops fetalis.</div></li></ul></div></div><div id="lds.Resources"><h2 id="_lds_Resources_">Resources</h2><p>
|
||
<i>GeneReviews staff has selected the following disease-specific and/or umbrella
|
||
support organizations and/or registries for the benefit of individuals with this disorder
|
||
and their families. GeneReviews is not responsible for the information provided by other
|
||
organizations. For information on selection criteria, click <a href="/books/n/gene/app4/">here</a>.</i></p>
|
||
<ul><li class="half_rhythm"><div>
|
||
<b>LE&RN</b>
|
||
</div><div>Lymphatic Education and Research Network</div><div>261 Madison Avenue</div><div>9th Floor</div><div>New York NY 10016</div><div><b>Phone:</b> 516-625-9675</div><div><b>Fax:</b> 516-625-9410</div><div><b>Email:</b> lern@lymphaticnetwork.org</div><div>
|
||
<a href="https://lymphaticnetwork.org/living-with-lymphedema" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Living with lymphedema and lymphatic disease</a>
|
||
</div></li><li class="half_rhythm"><div>
|
||
<b>Lymphoedema Support Network (LSN)</b>
|
||
</div><div>St. Luke's Crypt</div><div>Sydney Street</div><div>London SW3 6NH</div><div>United Kingdom</div><div><b>Phone:</b> 020 7351 4480 (Information and Support); 020 7351 0990 (Administration)</div><div><b>Fax:</b> 020 7349 9809</div><div><b>Email:</b> adminlsn@lymphoedema.freeserve.co.uk</div><div>
|
||
<a href="https://www.lymphoedema.org" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">www.lymphoedema.org</a>
|
||
</div></li><li class="half_rhythm"><div>
|
||
<b>National Lymphedema Network (NLN)</b>
|
||
</div><div>116 New Montgomery Street</div><div>Suite 235</div><div>San Francisco CA 94105</div><div><b>Phone:</b> 800-541-3259 (toll-free); 415-908-3681</div><div><b>Fax:</b> 415-908-3813</div><div><b>Email:</b> nln@lymphnet.org</div><div>
|
||
<a href="http://www.lymphnet.org" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">www.lymphnet.org</a>
|
||
</div></li><li class="half_rhythm"><div>
|
||
<b>Medline Plus</b>
|
||
</div><div>
|
||
<a href="http://www.nlm.nih.gov/medlineplus/lymphaticdiseases.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Lymphatic diseases</a>
|
||
</div></li><li class="half_rhythm"><div>
|
||
<b>The International Lymphatic Disease and Lymphedema Patient Registry & Biorepository</b>
|
||
</div><div>
|
||
<a href="https://lernregistry.stanford.edu/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">www.lernregistry.stanford.edu</a>
|
||
</div></li></ul>
|
||
</div><div id="lds.Molecular_Genetics"><h2 id="_lds_Molecular_Genetics_">Molecular Genetics</h2><p><i>Information in the Molecular Genetics and OMIM tables may differ from that elsewhere in the GeneReview: tables may contain more recent information. —</i>ED.</p><div id="lds.molgen.TA" class="table"><h3><span class="label">Table A.</span></h3><div class="caption"><p>Lymphedema-Distichiasis Syndrome: Genes and Databases</p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK1457/table/lds.molgen.TA/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__lds.molgen.TA_lrgtbl__"><table class="no_bottom_margin"><tbody><tr><th id="hd_b_lds.molgen.TA_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">Gene</th><th id="hd_b_lds.molgen.TA_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">Chromosome Locus</th><th id="hd_b_lds.molgen.TA_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">Protein</th><th id="hd_b_lds.molgen.TA_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">Locus-Specific Databases</th><th id="hd_b_lds.molgen.TA_1_1_1_5" rowspan="1" colspan="1" style="vertical-align:top;">HGMD</th><th id="hd_b_lds.molgen.TA_1_1_1_6" rowspan="1" colspan="1" style="vertical-align:top;">ClinVar</th></tr><tr><td headers="hd_b_lds.molgen.TA_1_1_1_1" rowspan="1" colspan="1" style="vertical-align:top;">
|
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<a href="/gene/2303" ref="pagearea=body&targetsite=entrez&targetcat=link&targettype=gene">
|
||
<i>FOXC2</i>
|
||
</a>
|
||
</td><td headers="hd_b_lds.molgen.TA_1_1_1_2" rowspan="1" colspan="1" style="vertical-align:top;">
|
||
<a href="https://www.ncbi.nlm.nih.gov/genome/gdv/?context=gene&acc=2303" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">16q24<wbr style="display:inline-block"></wbr>.1</a>
|
||
</td><td headers="hd_b_lds.molgen.TA_1_1_1_3" rowspan="1" colspan="1" style="vertical-align:top;">
|
||
<a href="http://www.uniprot.org/uniprot/Q99958" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">Forkhead box protein C2</a>
|
||
</td><td headers="hd_b_lds.molgen.TA_1_1_1_4" rowspan="1" colspan="1" style="vertical-align:top;">
|
||
<a href="http://databases.lovd.nl/shared/genes/FOXC2" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">FOXC2 database</a>
|
||
</td><td headers="hd_b_lds.molgen.TA_1_1_1_5" rowspan="1" colspan="1" style="vertical-align:top;">
|
||
<a href="http://www.hgmd.cf.ac.uk/ac/gene.php?gene=FOXC2" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">FOXC2</a>
|
||
</td><td headers="hd_b_lds.molgen.TA_1_1_1_6" rowspan="1" colspan="1" style="vertical-align:top;">
|
||
<a href="https://www.ncbi.nlm.nih.gov/clinvar/?term=FOXC2[gene]" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">FOXC2</a>
|
||
</td></tr></tbody></table></div><div><div><dl class="temp-labeled-list small"><dt></dt><dd><div id="lds.TFA.1"><p class="no_margin">Data are compiled from the following standard references: <a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a> from
|
||
<a href="http://www.genenames.org/index.html" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">HGNC</a>;
|
||
<a class="def" href="/books/n/gene/glossary/def-item/chromosome/">chromosome</a> <a class="def" href="/books/n/gene/glossary/def-item/locus/">locus</a> from
|
||
<a href="http://www.omim.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">OMIM</a>;
|
||
protein from <a href="http://www.uniprot.org/" ref="pagearea=body&targetsite=external&targetcat=link&targettype=uri">UniProt</a>.
|
||
For a description of databases (Locus Specific, HGMD, ClinVar) to which links are provided, click
|
||
<a href="/books/n/gene/app1/">here</a>.</p></div></dd></dl></div></div></div><div id="lds.molgen.TB" class="table"><h3><span class="label">Table B.</span></h3><div class="caption"><p>OMIM Entries for Lymphedema-Distichiasis Syndrome (<a href="/omim/153400,602402" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=omim">View All in OMIM</a>) </p></div><p class="large-table-link" style="display:none"><span class="right"><a href="/books/NBK1457/table/lds.molgen.TB/?report=objectonly" target="object">View in own window</a></span></p><div class="large_tbl" id="__lds.molgen.TB_lrgtbl__"><table><tbody><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<a href="/omim/153400" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=omim">153400</a></td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">LYMPHEDEMA-DISTICHIASIS SYNDROME; LPHDST</td></tr><tr><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">
|
||
<a href="/omim/602402" ref="pagearea=body&targetsite=entrez&targetcat=term&targettype=omim">602402</a></td><td rowspan="1" colspan="1" style="text-align:left;vertical-align:top;">FORKHEAD BOX C2; FOXC2</td></tr></tbody></table></div></div><div id="lds.Molecular_Pathogenesis"><h3>Molecular Pathogenesis</h3><p><i>FOXC2</i> has a major role in the formation of the lymphatic and venous valves [<a class="bk_pop" href="#lds.REF.petrova.2004.974">Petrova et al 2004</a>] and in cardiac neural crest cell migration [<a class="bk_pop" href="#lds.REF.inman.2018.1286">Inman et al 2018</a>].</p><p><b>Mechanism of disease causation.</b>
|
||
<i>FOXC2</i> variants causing lymphedema-distichiasis syndrome are thought to be <a class="def" href="/books/n/gene/glossary/def-item/loss-of-function/">loss-of-function</a> variants. Evidence in support of a loss-of-function mechanism would be a large partial- or whole-<a class="def" href="/books/n/gene/glossary/def-item/gene/">gene</a> <i>FOXC2</i> <a class="def" href="/books/n/gene/glossary/def-item/deletion/">deletion</a>; no such variants have been described. However, a 256-kb <a class="def" href="/books/n/gene/glossary/def-item/contiguous-gene-deletion/">contiguous gene deletion</a>, involving <i>FOXC2</i> and multiple adjacent genes, was reported; a number of clinical features of this individual were likely caused by the deletion of <i>FOXC2</i> [<a class="bk_pop" href="#lds.REF.butler.2012.839">Butler et al 2012</a>].</p></div></div><div id="lds.References"><h2 id="_lds_References_">References</h2><div id="lds.Literature_Cited"><h3>Literature Cited</h3><ul class="simple-list"><li class="half_rhythm"><div class="bk_ref" id="lds.REF.bellini.2015.1082">Bellini C, Donarini G, Paladini D, Calevo MG, Bellini T, Ramenghi LA, Hennekam RC. Etiology of non-immune hydrops fetalis: an update. <span><span class="ref-journal">Am J Med Genet A. </span>2015;<span class="ref-vol">167A</span>:1082–8.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/25712632" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25712632</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.brice.2003.89">Brice G. Diagnostic difficulties in lympedema distichiasis. <span><span class="ref-journal">Pediatr Dermatol. </span>2003;<span class="ref-vol">20</span>:89.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/12558856" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12558856</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.brice.2002.478">Brice G, Mansour S, Bell R, Collin JR, Child AH, Brady AF, Sarfarazi M, Burnand KG, Jeffery S, Mortimer P, Murday VA. Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24. <span><span class="ref-journal">J Med Genet. </span>2002;<span class="ref-vol">39</span>:478–83.</span> [<a href="/pmc/articles/PMC1735188/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1735188</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/12114478" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 12114478</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.brooks.2003.354">Brooks BP, Dagenais SL, Nelson CC, Glynn MW, Caulder MS, Downs CA, Glover TW. Mutation of the FOXC2 gene in familial distichiasis. <span><span class="ref-journal">J AAPOS. </span>2003;<span class="ref-vol">7</span>:354–7.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/14566319" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 14566319</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.butler.2012.839">Butler MG, Dagenais SL, Garcia-Perez JL, Brouillard P, Vikkula M, Strouse P, Innis JW, Glover TW. Microcephaly, intellectual impairment, bilateral vesicoureteral reflux, distichiasis, and glomuvenous malformations associated with a 16q24.3 contiguous gene deletion and a Glomulin mutation. <span><span class="ref-journal">Am J Med Genet A. </span>2012;<span class="ref-vol">158A</span>:839–49.</span> [<a href="/pmc/articles/PMC3314153/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3314153</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/22407726" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 22407726</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.chen.1996.273">Chen E, Larabell SK, Daniels JM, Goldstein S. Distichiasis-lymphedema syndrome: tetralogy of Fallot, chylothorax, and neonatal death. <span><span class="ref-journal">Am J Med Genet. </span>1996;<span class="ref-vol">66</span>:273–5.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/8985486" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8985486</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.dale.1987.170">Dale RF. Primary lymphoedema when found with distichiasis is of the type defined as bilateral hyperplasia by lymphography. <span><span class="ref-journal">J Med Genet. </span>1987;<span class="ref-vol">24</span>:170–1.</span> [<a href="/pmc/articles/PMC1049951/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1049951</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/3573000" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 3573000</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.de_bruyn.2012.447">de Bruyn G, Casaer A, Devolder K, Van Acker G, Logghe H, Devriendt K, Cornette L. Hydrops fetalis and pulmonary lymphangiectasia due to FOXC2 mutation: an autosomal dominant hereditary lymphedema syndrome with variable expression. <span><span class="ref-journal">Eur J Pediatr. </span>2012;<span class="ref-vol">171</span>:447–50.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/21918810" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 21918810</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.erickson.2001.761">Erickson RP, Dagenais SL, Caulder MS, Downs CA, Herman G, Jones MC, Kerstjens-Frederikse WS, Lidral AC, McDonald M, Nelson CC, Witte M, Glover TW. Clinical heterogeneity in lymphoedema-distichiasis with FOXC2 truncating mutations. <span><span class="ref-journal">J Med Genet. </span>2001;<span class="ref-vol">38</span>:761–6.</span> [<a href="/pmc/articles/PMC1734771/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1734771</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/11694548" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11694548</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.finegold.2001.1185">Finegold DN, Kimak MA, Lawrence EC, Levinson KL, Cherniske EM, Pober BR, Dunlap JW, Ferrell RE. Truncating mutations in FOXC2 cause multiple lymphedema syndromes. <span><span class="ref-journal">Hum Mol Genet. </span>2001;<span class="ref-vol">10</span>:1185–9.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/11371511" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 11371511</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.hoque.2007.1230">Hoque SR, Mansour S, Mortimer PS. Yellow nail syndrome: not a genetic disorder? Eleven new cases and a review of the literature. <span><span class="ref-journal">Br J Dermatol. </span>2007;<span class="ref-vol">156</span>:1230–4.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17459037" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17459037</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.inman.2018.1286">Inman KE, Caiaffa CD, Melton KR, Sandell LL, Achilleos A, Kume T, Trainor PA. Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion. <span><span class="ref-journal">Dev Dyn. </span>2018;<span class="ref-vol">247</span>:1286–96.</span> [<a href="/pmc/articles/PMC6275097/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC6275097</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/30376688" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 30376688</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.jones.2017.2251">Jones GE, Richmond AK, Navti O, Mousa HA, Abbs S, Thompson E, Mansour S, Vasudevan PC. Renal anomalies and lymphedema distichiasis syndrome. A rare association? <span><span class="ref-journal">Am J Med Genet A. </span>2017;<span class="ref-vol">173</span>:2251–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/28544699" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28544699</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.kanaan.2006.162">Kanaan IN, Sakati N, Otaibi F. Type I congenital multiple intraspinal extradural cysts associated with distichiasis and lymphedema syndrome. <span><span class="ref-journal">Surg Neurol. </span>2006;<span class="ref-vol">65</span>:162–6.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/16427414" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 16427414</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.lyons.2017.2437">Lyons O, Saha P, Seet C, Kuchta A, Arnold A, Grover S, Rashbrook V, Sabine A, Vizcay-Barrena G, Patel A, Ludwinski F, Padayachee S, Kume T, Kwak BR, Brice G, Mansour S, Ostergaard P, Mortimer P, Jeffery S, Brown N, Makinen T, Petrova TV, Modarai B, Smith A. Human venous valve disease caused by mutations in FOXC2 and GJC2. <span><span class="ref-journal">J Exp Med. </span>2017;<span class="ref-vol">214</span>:2437–52.</span> [<a href="/pmc/articles/PMC5551565/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5551565</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/28724617" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 28724617</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.mellor.2007.1912">Mellor RH, Brice G, Stanton AW, French J, Smith A, Jeffery S, Levick JR, Burnand KG, Mortimer PS. Mutations in FOXC2 are strongly associated with primary valve failure in veins of the lower limb. <span><span class="ref-journal">Circulation. </span>2007;<span class="ref-vol">115</span>:1912–20.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/17372167" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 17372167</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.ng.2005.235">Ng MY, Andrew T, Spector TD, Jeffery S. Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs. <span><span class="ref-journal">J Med Genet. </span>2005;<span class="ref-vol">42</span>:235–9.</span> [<a href="/pmc/articles/PMC1736007/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC1736007</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/15744037" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15744037</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.odonnell.1993.289">O'Donnell BA, Collin JR. Distichiasis: management with cryotherapy to the posterior lamella. <span><span class="ref-journal">Br J Ophthalmol. </span>1993;<span class="ref-vol">77</span>:289–92.</span> [<a href="/pmc/articles/PMC504507/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC504507</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/8318465" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 8318465</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.ogura.2013.e80548">Ogura Y, Yabuki S, Iida A, Kou I, Nakajima M, Kano H, Shiina M, Kikuchi S, Toyama Y, Ogata K, Nakamura M, Matsumoto M, Ikegawa S. FOXC2 mutations in familial and sporadic spinal extradural arachnoid cyst. <span><span class="ref-journal">PLoS One. </span>2013;<span class="ref-vol">8</span>:e80548. </span> [<a href="/pmc/articles/PMC3838418/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC3838418</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/24278289" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 24278289</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.papoff.2016.384">Papoff P, Castori M, Manganaro L, Midulla F, Moretti C, Cascone P. Early mandibular distraction to relieve Robin severe airway obstruction in two siblings with lymphedema-distichiasis syndrome. <span><span class="ref-journal">J Maxillofac Oral Surg. </span>2016;<span class="ref-vol">15</span>:384–9.</span> [<a href="/pmc/articles/PMC5048309/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC5048309</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/27752211" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 27752211</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.petrova.2004.974">Petrova TV, Karpanen T, Norrmen C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Yla-Herttuala S, Miura N, Alitalo K. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. <span><span class="ref-journal">Nat Med. </span>2004;<span class="ref-vol">10</span>:974–81.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/15322537" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 15322537</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.rahbari.2016.126">Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Turki SA, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR, Hurles ME, et al. Timing, rates and spectra of human germline mutation. <span><span class="ref-journal">Nat Genet. </span>2016;<span class="ref-vol">48</span>:126–33.</span> [<a href="/pmc/articles/PMC4731925/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4731925</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/26656846" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 26656846</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.rezaie.2008.300">Rezaie T, Ghoroghchian R, Bell R, Brice G, Hasan A, Burnand K, Vernon S, Mansour S, Mortimer P, Jeffery S, Child A, Sarfarazi M. Primary non-syndromic lymphoedema (Meige disease) is not caused by mutations in FOXC2. <span><span class="ref-journal">Eur J Hum Genet. </span>2008;<span class="ref-vol">16</span>:300–4.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/18197197" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 18197197</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.rosbotham.2000.148">Rosbotham JL, Brice GW, Child AH, Nunan TO, Mortimer PS, Burnand KG. Distichiasis-lymphoedema: clinical features, venous function and lymphoscintigraphy. <span><span class="ref-journal">Br J Dermatol. </span>2000;<span class="ref-vol">142</span>:148–52.</span> [<a href="https://pubmed.ncbi.nlm.nih.gov/10651712" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 10651712</span></a>]</div></li><li class="half_rhythm"><div class="bk_ref" id="lds.REF.sargent.2014.2802">Sargent C, Bauer J, Khalil M, Filmore P, Bernas M, Witte M, Pearson MP, Erickson RP. A five generation family with a novel mutation in FOXC2 and lymphedema worsening to hydrops in the youngest generation. <span><span class="ref-journal">Am J Med Genet A. </span>2014;<span class="ref-vol">164A</span>:2802–7.</span> [<a href="/pmc/articles/PMC4205179/" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pmc">PMC free article<span class="bk_prnt">: PMC4205179</span></a>] [<a href="https://pubmed.ncbi.nlm.nih.gov/25252123" ref="pagearea=cite-ref&targetsite=entrez&targetcat=link&targettype=pubmed">PubMed<span class="bk_prnt">: 25252123</span></a>]</div></li></ul></div></div><div id="lds.Chapter_Notes"><h2 id="_lds_Chapter_Notes_">Chapter Notes</h2><div id="lds.Revision_History"><h3>Revision History</h3><ul><li class="half_rhythm"><div>4 April 2019 (bp) Comprehensive update posted live</div></li><li class="half_rhythm"><div>24 May 2012 (me) Comprehensive update posted live</div></li><li class="half_rhythm"><div>2 August 2007 (me) Comprehensive update posted live</div></li><li class="half_rhythm"><div>4 January 2007 (sm) Revision: <i>FOXC2</i> mutations and Meige disease</div></li><li class="half_rhythm"><div>16 June 2006 (cd) Revision: <a class="def" href="/books/n/gene/glossary/def-item/prenatal-testing/">prenatal testing</a> clinically available</div></li><li class="half_rhythm"><div>6 March 2006 (cd) Revision: FOXC2 testing clinically available</div></li><li class="half_rhythm"><div>29 March 2005 (me) Review posted live</div></li><li class="half_rhythm"><div>13 September 2004 (sm) Original submission</div></li></ul></div></div><div id="bk_toc_contnr"></div></div></div>
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