189 lines
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189 lines
21 KiB
Text
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<title>9ETH: Complex structure of IL-36R D1-D2 domain with 36R-P192 and BI655130 Fab</title>
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<section data-section="infor" id="structure-infor-section"><h1 class="structure-title" data-mmdbid="260026" data-pdbid="9ETH" id="structure-title"><a class="link title-pdbid" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=9ETH" style="font-weight:600;margin:0;">9ETH: </a><span>Complex structure of IL-36R D1-D2 domain with 36R-P192 and BI655130 Fab</span></h1>
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<div class="floatClear" id="infor-detail"><div class="reference_section" data-pmids="39955284" id="reference-section"></div>
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<div class="property_section"><form action="/Structure/mmdb/mmdbsrv.cgi" method="post" id="reloadform" name="reloadform" style="margin:0;padding:0"><input type="hidden" name="uid" value="260026"/></form><table border="0" cellpadding="4" cellspacing="4"><tr><td class="H4 pdbid-download">PDB ID: </td>
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<td><a id="pdb_id_link" class="link" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=9ETH" title="PDB ID">9ETH</a><a id="download-pdb-file" class="__button" tabindex="-1" href="https://files.rcsb.org/download/9ETH.pdb" title="Download PDB file" download="9ETH.pdb">Download</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvStructureViewDataSetPDBdataset" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">MMDB ID: </td>
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<td style="font-weight:bold"><span class="info-item">260026</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvRecordIdentifiers" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">PDB Deposition Date: </td>
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<td><span id="depositionterm" style="padding-left: 0.2em;">2024/3/26<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDeposited" title="-click to see help"></a></span></td>
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<tr><td class="H4 property-name">Updated in MMDB: </td>
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<td class="text" nowrap><span id="mmdb_updated" style="padding-left:0.2em">2025/03</span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvUpdatedInMMDB" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">Experimental Method: </td>
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<td class="TEXT" nowrap><div id="expmethod"><span title="x-ray diffraction" class="info-item">x-ray diffraction</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvExperimentalMethod" title="-click to see help"></a></div></td>
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</tr>
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<tr><td class="H4 property-name">Resolution: </td>
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<td class="TEXT" id="resolution" nowrap>2.3 Å<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#SearchFieldResolution" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">Source Organism: </td>
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<td class="text"><div id="taxonomy"><div id="taxonomyterm"><span id="multitaxon" style="display:inline-block"><span id="taxword" title="synthetic construct">synthetic construct</span><span arr="down" class="taxdrop_arrow">▼</span></span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvTaxonomy" title="-click to see help"></a></div>
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<div class="menupop" id="taxonomycontent"><table cellpadding="0" cellspacing="0" width="300"><tr><th width="50%">Taxonomy</th>
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<th width="50%">Molecule</th>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=32630" style="text-decoration:underline;">synthetic construct</a></td>
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<td>P</td>
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</tr>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=9606" style="text-decoration:underline;">Homo sapiens</a></td>
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<td>H, L, R</td>
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</tr>
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</table></div>
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</div></td>
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<tr><td class="H4 property-name">Similar Structures: </td>
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<td><div id="vast-button-holder" style="width:100%;overflow:hidden;"><button class="__button" id="vast_button" type="submit">VAST+</button>
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<a class="help-img" href="/Structure/vastplus/docs/vastplus_help.html" title="-click to see help"></a></div></td>
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<tr><td colspan="2" style="text-align: center"><button class="__button" id="download_sequence" type="submit">Download sequence data</button>
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<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDownaloadSequenceMMDB" title="-click to see help"></a></td></tr>
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</table>
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</section>
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<!-- start annotations -->
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<div align="center" id="annotblock" style="margin-top:0.8em;"><div class="formbox" id="authormethod"><div id="bublock0"><div class="biotext" id="bublock0_unit_name">Biological Unit for 9ETH: tetrameric; determined by author<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvBiologicalUnit" title="-click to see help"></a></div>
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<style>.unitschema-1{
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background-image:url("/Structure/mmdb/mmdbimage.fcgi?uid=260026&type=2&unm=1");
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}</style><section class="graph-section" data-section="graph" id="biounit-section-1"></section>
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<section class="content_block" data-section="table"><table border="1" class="bucontent"><caption class="butbl_caption">Molecular Components in 9ETH<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents" title="-click to see help"></a></caption>
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<thead><tr><th>Label</th>
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<th>Count</th>
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<th>Molecule</th>
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</tr></thead>
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<tbody data-bun="1" data-type="protein" id="unit1_protein_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Proteins (4 molecules)</div></td></tr>
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<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-1" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/9ETH_H" id="mol-legend-1-1" class="protein-molecule-label-1" data-gi="2917411080" data-molid="1" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">H</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Bi00655130 FAB Heavy Chain">Bi00655130 FAB Heavy Chain</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="1" data-molids="1" id="molgraph-p-1-1"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-2" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/9ETH_L" id="mol-legend-1-2" class="protein-molecule-label-1" data-gi="2917411081" data-molid="2" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">L</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Bi00655130 FAB Light Chain">Bi00655130 FAB Light Chain</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="2" data-molids="2" id="molgraph-p-1-2"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="2"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-3" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/9ETH_P" id="mol-legend-1-3" class="protein-molecule-label-1" data-gi="2917411082" data-molid="3" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">P</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Ace-phe-val-glu-5cw-3pn-trp-asp-tyr-val-chg-6g5-ser-glu-cys-nh2">Ace-phe-val-glu-5cw-3pn-trp-asp-tyr-val-chg-6g5-ser-glu-cys-nh2</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="3" data-molids="3" id="molgraph-p-1-3"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="3"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-4" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/9ETH_R" id="mol-legend-1-4" class="protein-molecule-label-1" data-gi="2917411083" data-molid="4" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">R</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Interleukin-1 Receptor-like 2">Interleukin-1 Receptor-like 2</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="4" data-molids="4" id="molgraph-p-1-4"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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</tbody>
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<tbody data-bun="1" data-type="chemical" id="unit1_chemical_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Chemicals and Non-standard biopolymers (19 molecules)</div></td></tr>
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<tr><td data-row="0"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-1" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="5,6,7,8,11,21" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945635">1</a></span></div></td>
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<td><div class="chem-label">6</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505945635"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945635" title="2-acetamido-2-deoxy-beta-D-glucopyranose">2-acetamido-2-deoxy-beta-D-glucopyranose</a></span><span class="chem-image-holder" title="2-acetamido-2-deoxy-beta-D-glucopyranose"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945635"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505945635" alt="2-acetamido-2-deoxy-beta-D-glucopyranose"></a></span></div></td>
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</tr>
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<tr><td data-row="1"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-2" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="9" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945637">2</a></span></div></td>
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<td><div class="chem-label">1</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505945637"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945637" title="beta-D-mannopyranose">beta-D-mannopyranose</a></span><span class="chem-image-holder" title="beta-D-mannopyranose"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945637"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505945637" alt="beta-D-mannopyranose"></a></span></div></td>
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</tr>
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<tr><td data-row="2"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-3" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="10,12" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945638">3</a></span></div></td>
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<td><div class="chem-label">2</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505945638"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945638" title="alpha-D-mannopyranose">alpha-D-mannopyranose</a></span><span class="chem-image-holder" title="alpha-D-mannopyranose"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945638"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505945638" alt="alpha-D-mannopyranose"></a></span></div></td>
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</tr>
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<tr><td data-row="3"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-4" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="13,14,15,17,18,19,20,22" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945639">4</a></span></div></td>
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<td><div class="chem-label">8</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505945639"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945639" title="SULFATE ION">SULFATE ION</a></span><span class="chem-image-holder" title="SULFATE ION"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945639"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505945639" alt="SULFATE ION"></a></span></div></td>
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</tr>
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<tr><td data-row="4"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-5" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="16" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945640">5</a></span></div></td>
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<td><div class="chem-label">1</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505945640"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945640" title="SODIUM ION">SODIUM ION</a></span><span class="chem-image-holder" title="SODIUM ION"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945640"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505945640" alt="SODIUM ION"></a></span></div></td>
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</tr>
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<tr><td data-row="5"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-6" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="23" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945641">6</a></span></div></td>
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<td><div class="chem-label">1</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="505945641"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945641" title="GLYCEROL">GLYCEROL</a></span><span class="chem-image-holder" title="GLYCEROL"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=505945641"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=505945641" alt="GLYCEROL"></a></span></div></td>
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</tr>
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</tbody>
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</table>
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<div style="margin:0.5em 1em;text-align:left; font-size:85%;">* Click molecule labels to explore molecular sequence information.<br/></div>
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</section>
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</div></div></div>
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<!-- end annotations -->
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</td></tr>
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</table>
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<div align="left" class="citing"><hr width="85%"/><div style="font-weight:bold">Citing MMDB</div><div class="citref" style="padding:0.2em;"><img style="border:0;text-align:left;height:15px;width:15px;margin-right:0.2em" src="//pubchem.ncbi.nlm.nih.gov/images/PubMed.gif"> <span style="color:#444"> Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. </span> <cite><a class="link" href="//www.ncbi.nlm.nih.gov/pubmed/24319143">"<span style="font-style:italic;"> MMDB and VAST+: tracking structural similarities between macromolecular complexes. <b style="font-size:90%">Nucleic Acids Res. 2014 Jan; 42(Database issue)</b>:D297-303</span></a></cite></div></div>
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