192 lines
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192 lines
23 KiB
Text
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<title>7MXE: Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab</title>
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<meta name="keywords" content="8ANC195 G52K5 Fab heavy chain, 8ANC195 G52K5 Fab light chain, Ab1245 Fab heavy chain, Ab1245 Fab light chain, Envelope glycoprotein BG505 SOSIP.664 gp120, HIV-1 Envelope Glycoprotein BG505 SOSIP.664 gp41, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, beta-D-mannopyranose, MMDB, Protein structure, protein interaction">
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<!-- StructureInfo start -->
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<section data-section="infor" id="structure-infor-section"><h1 class="structure-title" data-mmdbid="208161" data-pdbid="7MXE" id="structure-title"><a class="link title-pdbid" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=7MXE" style="font-weight:600;margin:0;">7MXE: </a><span>Ab1245 Fab in complex with BG505 SOSIP.664 and 8ANC195 Fab</span></h1>
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<div class="floatClear" id="infor-detail"><div class="reference_section" data-pmids="34697307" id="reference-section"></div>
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<div class="property_section"><form action="/Structure/mmdb/mmdbsrv.cgi" method="post" id="reloadform" name="reloadform" style="margin:0;padding:0"><input type="hidden" name="uid" value="208161"/></form><table border="0" cellpadding="4" cellspacing="4"><tr><td class="H4 pdbid-download">PDB ID: </td>
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<td><a id="pdb_id_link" class="link" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=7MXE" title="PDB ID">7MXE</a><a id="download-pdb-file" class="__button" tabindex="-1" href="https://files.rcsb.org/download/7MXE.pdb" title="Download PDB file" download="7MXE.pdb">Download</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvStructureViewDataSetPDBdataset" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">MMDB ID: </td>
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<td style="font-weight:bold"><span class="info-item">208161</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvRecordIdentifiers" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">PDB Deposition Date: </td>
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<td><span id="depositionterm" style="padding-left: 0.2em;">2021/5/19<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDeposited" title="-click to see help"></a></span></td>
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</tr>
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<tr><td class="H4 property-name">Updated in MMDB: </td>
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<td class="text" nowrap><span id="mmdb_updated" style="padding-left:0.2em">2021/11</span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvUpdatedInMMDB" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">Experimental Method: </td>
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<td class="TEXT" nowrap><div id="expmethod"><span title="electron microscopy" class="info-item">electron microscopy</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvExperimentalMethod" title="-click to see help"></a></div></td>
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</tr>
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<tr><td class="H4 property-name">Resolution: </td>
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<td class="TEXT" id="resolution" nowrap>3.7 Å<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#SearchFieldResolution" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">Source Organism: </td>
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<td class="text"><div id="taxonomy"><div id="taxonomyterm"><span id="multitaxon" style="display:inline-block"><span id="taxword" title="Human immunodeficiency virus 1">Human immunodeficiency virus 1</span><span arr="down" class="taxdrop_arrow">▼</span></span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvTaxonomy" title="-click to see help"></a></div>
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<div class="menupop" id="taxonomycontent"><table cellpadding="0" cellspacing="0" width="300"><tr><th width="50%">Taxonomy</th>
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<th width="50%">Molecule</th>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=11676" style="text-decoration:underline;">Human immunodeficiency virus 1</a></td>
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<td>C, D, F, G, J, P</td>
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</tr>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=9606" style="text-decoration:underline;">Homo sapiens</a></td>
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<td>A, B, H, L, M, O</td>
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</tr>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=9544" style="text-decoration:underline;">Macaca mulatta</a></td>
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<td>R, W</td>
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</tr>
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</table></div>
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</div></td>
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</tr>
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<tr><td class="H4 property-name">Similar Structures: </td>
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<td><div id="vast-button-holder" style="width:100%;overflow:hidden;"><button class="__button" id="vast_button" type="submit">VAST+</button>
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<a class="help-img" href="/Structure/vastplus/docs/vastplus_help.html" title="-click to see help"></a></div></td>
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<tr><td colspan="2" style="text-align: center"><button class="__button" id="download_sequence" type="submit">Download sequence data</button>
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<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDownaloadSequenceMMDB" title="-click to see help"></a></td></tr>
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</table>
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</div>
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</section>
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<!-- start annotations -->
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<div align="center" id="annotblock" style="margin-top:0.8em;"><div class="formbox" id="authormethod"><div id="bublock0"><div class="biotext" id="bublock0_unit_name">Biological Unit for 7MXE: 14-meric; determined by author<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvBiologicalUnit" title="-click to see help"></a></div>
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<style>.unitschema-1{
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background-image:url("/Structure/mmdb/mmdbimage.fcgi?uid=208161&type=2&unm=1");
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}</style><section class="graph-section" data-section="graph" id="biounit-section-1"></section>
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<section class="content_block" data-section="table"><table border="1" class="bucontent"><caption class="butbl_caption">Molecular Components in 7MXE<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents" title="-click to see help"></a></caption>
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<thead><tr><th>Label</th>
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<th>Count</th>
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<th>Molecule</th>
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</tr></thead>
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<tbody data-bun="1" data-type="protein" id="unit1_protein_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Proteins (14 molecules)</div></td></tr>
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<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-1"><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_A" id="mol-legend-1-1" class="protein-molecule-label-1" data-gi="2125200696" data-molid="1" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">A</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_H" id="mol-legend-1-7" class="protein-molecule-label-1" data-gi="2125200702" data-molid="7" style="color:#000000;background-color:#FF6666" title="-Select icon for molecule information"><div class="protein-table-chain-label">H</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_M" id="mol-legend-1-10" class="protein-molecule-label-1" data-gi="2125200705" data-molid="10" style="color:#000000;background-color:#FFFF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">M</div></a></div></td>
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<td>3</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="8anc195 G52k5 FAB Heavy Chain">8anc195 G52k5 FAB Heavy Chain</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="1" data-molids="1,7,10" id="molgraph-p-1-1"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-2"><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_B" id="mol-legend-1-2" class="protein-molecule-label-1" data-gi="2125200697" data-molid="2" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">B</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_L" id="mol-legend-1-9" class="protein-molecule-label-1" data-gi="2125200704" data-molid="9" style="color:#000000;background-color:#00FFFF" title="-Select icon for molecule information"><div class="protein-table-chain-label">L</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_O" id="mol-legend-1-11" class="protein-molecule-label-1" data-gi="2125200706" data-molid="11" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">O</div></a></div></td>
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<td>3</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="8anc195 G52k5 FAB Light Chain">8anc195 G52k5 FAB Light Chain</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="2" data-molids="2,9,11" id="molgraph-p-1-2"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="2"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-3"><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_C" id="mol-legend-1-3" class="protein-molecule-label-1" data-gi="2125200698" data-molid="3" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">C</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_D" id="mol-legend-1-4" class="protein-molecule-label-1" data-gi="2125200699" data-molid="4" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">D</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_F" id="mol-legend-1-5" class="protein-molecule-label-1" data-gi="2125200700" data-molid="5" style="color:#000000;background-color:#CCCCCC" title="-Select icon for molecule information"><div class="protein-table-chain-label">F</div></a></div></td>
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<td>3</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Hiv-1 Envelope Glycoprotein Bg505 Sosip.664 Gp41">Hiv-1 Envelope Glycoprotein Bg505 Sosip.664 Gp41</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="3" data-molids="3,4,5" id="molgraph-p-1-3"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="3"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-4"><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_G" id="mol-legend-1-6" class="protein-molecule-label-1" data-gi="2125200701" data-molid="6" style="color:#000000;background-color:#FF9900" title="-Select icon for molecule information"><div class="protein-table-chain-label">G</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_J" id="mol-legend-1-8" class="protein-molecule-label-1" data-gi="2125200703" data-molid="8" style="color:#000000;background-color:#00FF00" title="-Select icon for molecule information"><div class="protein-table-chain-label">J</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_P" id="mol-legend-1-12" class="protein-molecule-label-1" data-gi="2125200707" data-molid="12" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">P</div></a></div></td>
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<td>3</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Envelope Glycoprotein Bg505 Sosip.664 Gp120">Envelope Glycoprotein Bg505 Sosip.664 Gp120</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="6" data-molids="6,8,12" id="molgraph-p-1-6"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="4"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-5" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_R" id="mol-legend-1-13" class="protein-molecule-label-1" data-gi="2125200708" data-molid="13" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">R</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Ab1245 FAB Heavy Chain">Ab1245 FAB Heavy Chain</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="13" data-molids="13" id="molgraph-p-1-13"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="5"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-6" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7MXE_W" id="mol-legend-1-14" class="protein-molecule-label-1" data-gi="2125200709" data-molid="14" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">W</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Ab1245 FAB Light Chain">Ab1245 FAB Light Chain</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="14" data-molids="14" id="molgraph-p-1-14"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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</tbody>
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<tbody data-bun="1" data-type="chemical" id="unit1_chemical_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Chemicals and Non-standard biopolymers (128 molecules)</div></td></tr>
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<tr><td data-row="0"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-1" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,35,36,41,42,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,73,74,83,84,86,87,89,90,91,92,93,94,95,96,97,98,100,101,103,104,113,114,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597702">1</a></span></div></td>
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<td><div class="chem-label">87</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="445597702"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597702" title="2-acetamido-2-deoxy-beta-D-glucopyranose">2-acetamido-2-deoxy-beta-D-glucopyranose</a></span><span class="chem-image-holder" title="2-acetamido-2-deoxy-beta-D-glucopyranose"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597702"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=445597702" alt="2-acetamido-2-deoxy-beta-D-glucopyranose"></a></span></div></td>
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</tr>
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<tr><td data-row="1"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-2" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="33,37,43,70,75,85,88,99,102,105,115" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597704">2</a></span></div></td>
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<td><div class="chem-label">11</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="445597704"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597704" title="beta-D-mannopyranose">beta-D-mannopyranose</a></span><span class="chem-image-holder" title="beta-D-mannopyranose"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597704"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=445597704" alt="beta-D-mannopyranose"></a></span></div></td>
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</tr>
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<tr><td data-row="2"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-3" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="34,38,39,40,44,45,46,47,48,49,50,51,71,72,76,77,78,79,80,81,82,106,107,108,109,110,111,112,116,117" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597705">3</a></span></div></td>
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<td><div class="chem-label">30</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="445597705"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597705" title="alpha-D-mannopyranose">alpha-D-mannopyranose</a></span><span class="chem-image-holder" title="alpha-D-mannopyranose"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=445597705"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=445597705" alt="alpha-D-mannopyranose"></a></span></div></td>
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<div style="margin:0.5em 1em;text-align:left; font-size:85%;">* Click molecule labels to explore molecular sequence information.<br/></div>
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<div align="left" class="citing"><hr width="85%"/><div style="font-weight:bold">Citing MMDB</div><div class="citref" style="padding:0.2em;"><img style="border:0;text-align:left;height:15px;width:15px;margin-right:0.2em" src="//pubchem.ncbi.nlm.nih.gov/images/PubMed.gif"> <span style="color:#444"> Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. </span> <cite><a class="link" href="//www.ncbi.nlm.nih.gov/pubmed/24319143">"<span style="font-style:italic;"> MMDB and VAST+: tracking structural similarities between macromolecular complexes. <b style="font-size:90%">Nucleic Acids Res. 2014 Jan; 42(Database issue)</b>:D297-303</span></a></cite></div></div>
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