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<title>7KZR: Structure of the human Fanconi Anaemia Core-UBE2T-ID complex</title>
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<table cellspacing="0" id="mmdb_logo_links" cellpadding="0" width="100%"><tr><td><a class="ncbi_home_logo" href="/" alt="NBI HOME Logo">NCBI</a><div class="NLMLogo">National Center for<br/>Biotechnology Information</div></td><td class="titletext" align="left"><!--a href="/Structure/MMDB/mmdb.shtml"--><img border=0 src="/Structure/MMDB/strbanner.jpg" alt="7KZR - NCBI MMDB Logo"><!--/a--></td><td style="padding-bottom:1em;vertical-align:bottom"><form id="mmdbsearch" method="get" name="mmdbsearch" action="/Structure/pdb/" style="margin:0;padding:0;vertical-align: bottom;"><div class="mmdb-search-holder" style="height:100%;line-height:100%"><input accesskey="S" id="mmdb-search-box" type="search" name="uid" placeholder="Enter PDB ID or MMDB ID" value = "" aria-describedby="mmdb-search-uid" title="Enter PDB ID or MMDB ID"><button id="mmdb-search-button" class="__button mmdb-search-button" style="height:100%;line-height:100%;margin-right:-3px;" type="submit">Search</button></div></form></td></tr></table>
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<!-- StructureInfo start -->
<section data-section="infor" id="structure-infor-section"><h1 class="structure-title" data-mmdbid="199699" data-pdbid="7KZR" id="structure-title"><a class="link title-pdbid" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=7KZR" style="font-weight:600;margin:0;">7KZR: </a><span>Structure of the human Fanconi Anaemia Core-UBE2T-ID complex</span></h1>
<div class="floatClear" id="infor-detail"><div class="reference_section" data-pmids="33686268" id="reference-section"></div>
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<td><a id="pdb_id_link" class="link" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=7KZR" title="PDB ID">7KZR</a><a id="download-pdb-file" class="__button" tabindex="-1" href="https://files.rcsb.org/download/7KZR.pdb" title="Download PDB file" download="7KZR.pdb">Download</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvStructureViewDataSetPDBdataset" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">MMDB ID: </td>
<td style="font-weight:bold"><span class="info-item">199699</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvRecordIdentifiers" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">PDB Deposition Date: </td>
<td><span id="depositionterm" style="padding-left: 0.2em;">2020/12/10<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDeposited" title="-click to see help"></a></span></td>
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<tr><td class="H4 property-name">Updated in MMDB: </td>
<td class="text" nowrap><span id="mmdb_updated" style="padding-left:0.2em">2024/03</span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvUpdatedInMMDB" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">Experimental Method: </td>
<td class="TEXT" nowrap><div id="expmethod"><span title="electron microscopy" class="info-item">electron microscopy</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvExperimentalMethod" title="-click to see help"></a></div></td>
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<tr><td class="H4 property-name">Resolution: </td>
<td class="TEXT" id="resolution" nowrap>4.4&nbsp; &#197;<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#SearchFieldResolution" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">Source Organism: </td>
<td class="text"><div id="taxonomy"><a id="taxword" class="link" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=9606" title="Homo sapiens">Homo sapiens</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvTaxonomy" title="-click to see help"></a></div></td>
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<tr><td class="H4 property-name">Similar Structures: </td>
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<div align="center" id="annotblock" style="margin-top:0.8em;"><div class="formbox" id="authormethod"><div id="bublock0"><div class="biotext" id="bublock0_unit_name">Biological Unit for 7KZR: heptadecameric; determined by author<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvBiologicalUnit" title="-click to see help"></a></div>
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<section class="content_block" data-section="table"><table border="1" class="bucontent"><caption class="butbl_caption">Molecular Components in 7KZR<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents" title="-click to see help"></a></caption>
<thead><tr><th>Label</th>
<th>Count</th>
<th>Molecule</th>
</tr></thead>
<tbody data-bun="1" data-type="protein" id="unit1_protein_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Proteins (17 molecules)</div></td></tr>
<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-1" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_A" id="mol-legend-1-1" class="protein-molecule-label-1" data-gi="2003953566" data-molid="1" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">A</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_S" id="mol-legend-1-13" class="protein-molecule-label-1" data-gi="2003953578" data-molid="13" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">S</div></a></div></td>
<td>2</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group a Protein">Fanconi Anemia Group a Protein</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2175" alt="FA complementation group A">FANCA</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="1" data-molids="1,13" id="molgraph-p-1-1"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-2" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_B" id="mol-legend-1-2" class="protein-molecule-label-1" data-gi="2003953567" data-molid="2" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">B</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_O" id="mol-legend-1-10" class="protein-molecule-label-1" data-gi="2003953575" data-molid="10" style="color:#000000;background-color:#FFFF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">O</div></a></div></td>
<td>2</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group B Protein">Fanconi Anemia Group B Protein</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2187" alt="FA complementation group B">FANCB</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="2" data-molids="2,10" id="molgraph-p-1-2"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="2"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-3" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_C" id="mol-legend-1-3" class="protein-molecule-label-1" data-gi="2003953568" data-molid="3" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">C</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group C Protein">Fanconi Anemia Group C Protein</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2176" alt="FA complementation group C">FANCC</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="3" data-molids="3" id="molgraph-p-1-3"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="3"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-4" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_E" id="mol-legend-1-4" class="protein-molecule-label-1" data-gi="2003953569" data-molid="4" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">E</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group E Protein">Fanconi Anemia Group E Protein</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2178" alt="FA complementation group E">FANCE</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="4" data-molids="4" id="molgraph-p-1-4"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="4"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-5" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_F" id="mol-legend-1-5" class="protein-molecule-label-1" data-gi="2003953570" data-molid="5" style="color:#000000;background-color:#CCCCCC" title="-Select icon for molecule information"><div class="protein-table-chain-label">F</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group F Protein">Fanconi Anemia Group F Protein</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2188" alt="FA complementation group F">FANCF</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="5" data-molids="5" id="molgraph-p-1-5"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="5"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-6" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_G" id="mol-legend-1-6" class="protein-molecule-label-1" data-gi="2003953571" data-molid="6" style="color:#000000;background-color:#FF9900" title="-Select icon for molecule information"><div class="protein-table-chain-label">G</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_H" id="mol-legend-1-7" class="protein-molecule-label-1" data-gi="2003953572" data-molid="7" style="color:#000000;background-color:#FF6666" title="-Select icon for molecule information"><div class="protein-table-chain-label">H</div></a></div></td>
<td>2</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group G Protein">Fanconi Anemia Group G Protein</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2189" alt="FA complementation group G">FANCG</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="6" data-molids="6,7" id="molgraph-p-1-6"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="6"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-7" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_L" id="mol-legend-1-8" class="protein-molecule-label-1" data-gi="2003953573" data-molid="8" style="color:#000000;background-color:#00FF00" title="-Select icon for molecule information"><div class="protein-table-chain-label">L</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_M" id="mol-legend-1-9" class="protein-molecule-label-1" data-gi="2003953574" data-molid="9" style="color:#000000;background-color:#00FFFF" title="-Select icon for molecule information"><div class="protein-table-chain-label">M</div></a></div></td>
<td>2</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="E3 Ubiquitin-protein Ligase Fancl">E3 Ubiquitin-protein Ligase Fancl</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/55120" alt="FA complementation group L">FANCL</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="8" data-molids="8,9" id="molgraph-p-1-8"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="7"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-8" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_P" id="mol-legend-1-11" class="protein-molecule-label-1" data-gi="2003953576" data-molid="11" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">P</div></a><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_Q" id="mol-legend-1-12" class="protein-molecule-label-1" data-gi="2003953577" data-molid="12" style="color:#FFFFFF;background-color:#0000FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">Q</div></a></div></td>
<td>2</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Core Complex-associated Protein 100">Fanconi Anemia Core Complex-associated Protein 100</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/80233" alt="FA core complex associated protein 100">FAAP100</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="11" data-molids="11,12" id="molgraph-p-1-11"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="8"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-9" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_W" id="mol-legend-1-14" class="protein-molecule-label-1" data-gi="2003953579" data-molid="14" style="color:#000000;background-color:#00FF99" title="-Select icon for molecule information"><div class="protein-table-chain-label">W</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Core Complex-associated Protein 20">Fanconi Anemia Core Complex-associated Protein 20</div>
<div class="annot-img-block" data-bun="1" data-gmolid="14" data-molids="14" id="molgraph-p-1-14"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="9"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-10" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_U" id="mol-legend-1-15" class="protein-molecule-label-1" data-gi="2003953580" data-molid="15" style="color:#000000;background-color:#CCCCCC" title="-Select icon for molecule information"><div class="protein-table-chain-label">U</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia, Complementation Group I">Fanconi Anemia, Complementation Group I</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/55215" alt="FA complementation group I">FANCI</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="15" data-molids="15" id="molgraph-p-1-15"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="10"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-11" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_V" id="mol-legend-1-16" class="protein-molecule-label-1" data-gi="2003953581" data-molid="16" style="color:#000000;background-color:#FF9900" title="-Select icon for molecule information"><div class="protein-table-chain-label">V</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Fanconi Anemia Group D2 Protein">Fanconi Anemia Group D2 Protein</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/2177" alt="FA complementation group D2">FANCD2</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="16" data-molids="16" id="molgraph-p-1-16"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
<tr data-row="11"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-12" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/7KZR_X" id="mol-legend-1-17" class="protein-molecule-label-1" data-gi="2003953582" data-molid="17" style="color:#000000;background-color:#FF6666" title="-Select icon for molecule information"><div class="protein-table-chain-label">X</div></a></div></td>
<td>1</td>
<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Ubiquitin-conjugating Enzyme E2 T">Ubiquitin-conjugating Enzyme E2 T</div>
<div class="gene-symbol">(Gene symbol: <a href="//www.ncbi.nlm.nih.gov/gene/29089" alt="ubiquitin conjugating enzyme E2 T">UBE2T</a>)</div><div class="annot-img-block" data-bun="1" data-gmolid="17" data-molids="17" id="molgraph-p-1-17"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
</div></td>
</tr>
</tbody>
<tbody data-bun="1" data-type="chemical" id="unit1_chemical_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Chemicals and Non-standard biopolymers (5 molecules)</div></td></tr>
<tr><td data-row="0"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-1" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="18,19,20,21,22" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=440790101">1</a></span></div></td>
<td><div class="chem-label">5</div></td>
<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="440790101"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=440790101" title="ZINC ION">ZINC ION</a></span><span class="chem-image-holder" title="ZINC ION"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=440790101"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=440790101" alt="ZINC ION"></a></span></div></td>
</tr>
</tbody>
</table>
<div style="margin:0.5em 1em;text-align:left; font-size:85%;">&#42; Click molecule labels to explore molecular sequence information.<br/></div>
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<div align="left" class="citing"><hr width="85%"/><div style="font-weight:bold">Citing MMDB</div><div class="citref" style="padding:0.2em;"><img style="border:0;text-align:left;height:15px;width:15px;margin-right:0.2em" src="//pubchem.ncbi.nlm.nih.gov/images/PubMed.gif"> <span style="color:#444"> Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. </span> <cite><a class="link" href="//www.ncbi.nlm.nih.gov/pubmed/24319143">"<span style="font-style:italic;"> MMDB and VAST+: tracking structural similarities between macromolecular complexes. <b style="font-size:90%">Nucleic Acids Res. 2014 Jan; 42(Database issue)</b>:D297-303</span></a></cite></div></div>
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