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178 lines
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<title>4XR8: Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution</title>
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<section data-section="infor" id="structure-infor-section"><h1 class="structure-title" data-mmdbid="136141" data-pdbid="4XR8" id="structure-title"><a class="link title-pdbid" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=4XR8" style="font-weight:600;margin:0;">4XR8: </a><span>Crystal structure of the HPV16 E6/E6AP/p53 ternary complex at 2.25 A resolution</span></h1>
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<div class="floatClear" id="infor-detail"><div class="reference_section" data-pmids="26789255" id="reference-section"></div>
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<div class="property_section"><form action="/Structure/mmdb/mmdbsrv.cgi" method="post" id="reloadform" name="reloadform" style="margin:0;padding:0"><input type="hidden" name="uid" value="136141"/></form><table border="0" cellpadding="4" cellspacing="4"><tr><td class="H4 pdbid-download">PDB ID: </td>
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<td><a id="pdb_id_link" class="link" href="http://www.rcsb.org/pdb/explore/explore.do?structureId=4XR8" title="PDB ID">4XR8</a><a id="download-pdb-file" class="__button" tabindex="-1" href="https://files.rcsb.org/download/4XR8.pdb" title="Download PDB file" download="4XR8.pdb">Download</a><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvStructureViewDataSetPDBdataset" title="-click to see help"></a></td>
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<tr><td class="H4 property-name">MMDB ID: </td>
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<td style="font-weight:bold"><span class="info-item">136141</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvRecordIdentifiers" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">PDB Deposition Date: </td>
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<td><span id="depositionterm" style="padding-left: 0.2em;">2015/1/20<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDeposited" title="-click to see help"></a></span></td>
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</tr>
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<tr><td class="H4 property-name">Updated in MMDB: </td>
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<td class="text" nowrap><span id="mmdb_updated" style="padding-left:0.2em">2018/11</span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvUpdatedInMMDB" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">Experimental Method: </td>
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<td class="TEXT" nowrap><div id="expmethod"><span title="x-ray diffraction" class="info-item">x-ray diffraction</span> <a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvExperimentalMethod" title="-click to see help"></a></div></td>
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</tr>
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<tr><td class="H4 property-name">Resolution: </td>
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<td class="TEXT" id="resolution" nowrap>2.25 Å<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#SearchFieldResolution" title="-click to see help"></a></td>
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</tr>
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<tr><td class="H4 property-name">Source Organism: </td>
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<td class="text"><div id="taxonomy"><div id="taxonomyterm"><span id="multitaxon" style="display:inline-block"><span id="taxword" title="Human papillomavirus 16">Human papillomavirus 16</span><span arr="down" class="taxdrop_arrow">▼</span></span><a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvTaxonomy" title="-click to see help"></a></div>
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<div class="menupop" id="taxonomycontent"><table cellpadding="0" cellspacing="0" width="300"><tr><th width="50%">Taxonomy</th>
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<th width="50%">Molecule</th>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=333760" style="text-decoration:underline;">Human papillomavirus 16</a></td>
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<td>F, H</td>
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</tr>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=32630" style="text-decoration:underline;">synthetic construct</a></td>
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<td>A, B</td>
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</tr>
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<tr><td><a class="link taxcell" href="//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?lvl=0&id=9606" style="text-decoration:underline;">Homo sapiens</a></td>
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<td>C, D</td>
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</tr>
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</table></div>
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</div></td>
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<tr><td class="H4 property-name">Similar Structures: </td>
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<td><div id="vast-button-holder" style="width:100%;overflow:hidden;"><button class="__button" id="vast_button" type="submit">VAST+</button>
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<a class="help-img" href="/Structure/vastplus/docs/vastplus_help.html" title="-click to see help"></a></div></td>
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<tr><td colspan="2" style="text-align: center"><button class="__button" id="download_sequence" type="submit">Download sequence data</button>
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<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvDownaloadSequenceMMDB" title="-click to see help"></a></td></tr>
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</section>
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<!-- start annotations -->
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<div align="center" id="annotblock" style="margin-top:0.8em;"><div class="formbox" id="authormethod"><div id="bublock0"><div class="biotext" id="bublock0_unit_name">Biological Unit for 4XR8: trimeric; determined by author<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvBiologicalUnit" title="-click to see help"></a></div>
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<style>.unitschema-1{
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background-image:url("/Structure/mmdb/mmdbimage.fcgi?uid=136141&type=2&unm=1");
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}</style><section class="graph-section" data-section="graph" id="biounit-section-1"></section>
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<section class="content_block" data-section="table"><table border="1" class="bucontent"><caption class="butbl_caption">Molecular Components in 4XR8<a class="help-img" href="/Structure/MMDB/docs/mmdb_help.html#MmdbsrvMolecularComponents" title="-click to see help"></a></caption>
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<thead><tr><th>Label</th>
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<th>Count</th>
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<th>Molecule</th>
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</tr></thead>
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<tbody data-bun="1" data-type="protein" id="unit1_protein_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Proteins (3 molecules)</div></td></tr>
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<tr data-row="0"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-1" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/4XR8_A" id="mol-legend-1-1" class="protein-molecule-label-1" data-gi="985483762" data-molid="1" style="color:#FFFFFF;background-color:#FF00FF" title="-Select icon for molecule information"><div class="protein-table-chain-label">A</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Maltose-binding Periplasmic Protein, Ubiquitin Ligase E6ap">Maltose-binding Periplasmic Protein, Ubiquitin Ligase E6ap</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="1" data-molids="1" id="molgraph-p-1-1"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="1"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-2" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/4XR8_C" id="mol-legend-1-3" class="protein-molecule-label-1" data-gi="985483764" data-molid="3" style="color:#FFFFFF;background-color:#996633" title="-Select icon for molecule information"><div class="protein-table-chain-label">C</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Cellular Tumor Antigen P53">Cellular Tumor Antigen P53</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="3" data-molids="3" id="molgraph-p-1-3"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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<tr data-row="2"><td class="molecule-label-cell"><div class="identical-molecules floatClear" id="chain-list-1-3" style="text-align: center;"><a href="//www.ncbi.nlm.nih.gov/protein/4XR8_F" id="mol-legend-1-5" class="protein-molecule-label-1" data-gi="985483766" data-molid="5" style="color:#000000;background-color:#CCCCCC" title="-Select icon for molecule information"><div class="protein-table-chain-label">F</div></a></div></td>
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<td>1</td>
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<td class="annotation-cell"><div class="graph-annot"><div class="molecule-name" title="Protein E6">Protein E6</div>
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<div class="annot-img-block" data-bun="1" data-gmolid="5" data-molids="5" id="molgraph-p-1-5"><img alt="Molecule annotation" src="/Structure/mmdb/images/bigLoader.gif"></div>
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</div></td>
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</tr>
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</tbody>
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<tbody data-bun="1" data-type="chemical" id="unit1_chemical_annotation"><tr><td class="butbl_inner_tbl_tit" colspan="3"><div style="float:left">Chemicals and Non-standard biopolymers (10 molecules)</div></td></tr>
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<tr><td data-row="0"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-1" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="7,8" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264045">1</a></span></div></td>
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<td><div class="chem-label">2</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="310264045"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264045" title="alpha-D-glucopyranose">alpha-D-glucopyranose</a></span><span class="chem-image-holder" title="alpha-D-glucopyranose"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264045"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=310264045" alt="alpha-D-glucopyranose"></a></span></div></td>
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</tr>
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<tr><td data-row="1"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-2" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="11,15,19" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264047">2</a></span></div></td>
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<td><div class="chem-label">3</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="310264047"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264047" title="DI(HYDROXYETHYL)ETHER">DI(HYDROXYETHYL)ETHER</a></span><span class="chem-image-holder" title="DI(HYDROXYETHYL)ETHER"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264047"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=310264047" alt="DI(HYDROXYETHYL)ETHER"></a></span></div></td>
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</tr>
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<tr><td data-row="2"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-3" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="13,14,16,17" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=485962156">3</a></span></div></td>
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<td><div class="chem-label">4</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="485962156"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=485962156" title="ZINC ION">ZINC ION</a></span><span class="chem-image-holder" title="ZINC ION"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=485962156"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=485962156" alt="ZINC ION"></a></span></div></td>
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</tr>
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<tr><td data-row="3"><div class="chem-label-box"><span class="chemical-molecule-label" id="mol-chem-legend-1-4" title="-Select icon for PubChem compound information"><a class="link chem_label" data-molids="18" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=485962157">4</a></span></div></td>
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<td><div class="chem-label">1</div></td>
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<td><div class="chem-name-thumb floatClear"><span class="chem-name" data-sid="485962157"><a class="link mmdb-chem-name" href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=485962157" title="1,2-ETHANEDIOL">1,2-ETHANEDIOL</a></span><span class="chem-image-holder" title="1,2-ETHANEDIOL"><a href="//pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=485962157"><img type="thumb" class="chemthumb" align="absmiddle" src="//pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?sid=485962157" alt="1,2-ETHANEDIOL"></a></span></div></td>
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</tr>
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</tbody>
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</table>
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<div style="margin:0.5em 1em;text-align:left; font-size:85%;">* Click molecule labels to explore molecular sequence information.<br/></div>
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</section>
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</div></div></div>
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<!-- end annotations -->
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</td></tr>
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<div align="left" class="citing"><hr width="85%"/><div style="font-weight:bold">Citing MMDB</div><div class="citref" style="padding:0.2em;"><img style="border:0;text-align:left;height:15px;width:15px;margin-right:0.2em" src="//pubchem.ncbi.nlm.nih.gov/images/PubMed.gif"> <span style="color:#444"> Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. </span> <cite><a class="link" href="//www.ncbi.nlm.nih.gov/pubmed/24319143">"<span style="font-style:italic;"> MMDB and VAST+: tracking structural similarities between macromolecular complexes. <b style="font-size:90%">Nucleic Acids Res. 2014 Jan; 42(Database issue)</b>:D297-303</span></a></cite></div></div>
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