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|
||
<!-- Create alert and Create RSS are buttons that look like links -->
|
||
<!-- Better for them to look like buttons but no space -->
|
||
<div class="search-links-wrapper content-page-layout">
|
||
<div class="search-links">
|
||
<a href="/advanced/"
|
||
class="search-input-link adv-search-link"
|
||
data-ga-category="featured_link"
|
||
data-ga-action="adv_search">Advanced</a>
|
||
|
||
|
||
<a href="/clipboard/"
|
||
class="search-input-link clipboard-link hidden"
|
||
data-ga-category="featured_link"
|
||
data-ga-action="clipboard">
|
||
Clipboard <span class="amount-in-clipboard"></span>
|
||
</a>
|
||
</div>
|
||
|
||
<span class="search-input-link user-guide-link" role="navigation" aria-label="User guide">
|
||
<a href="/help/"
|
||
data-ga-category="featured_link"
|
||
data-ga-action="user_guide">
|
||
User Guide
|
||
</a>
|
||
</span>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</form>
|
||
|
||
|
||
<div id="article-page-header">
|
||
<div id="article-top-actions-bar" class="article-top-actions-bar">
|
||
<div class="inner-wrap">
|
||
<div class="actions-container">
|
||
<div class="return-to-search">
|
||
|
||
|
||
</div>
|
||
|
||
<div class="multiple-results-actions " role="region" aria-label="save, email, send to">
|
||
<button id="save-results-panel-trigger"
|
||
type="button"
|
||
class="save-results save-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="save-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="open">
|
||
Save
|
||
</button><button id="email-results-panel-trigger"
|
||
type="button"
|
||
class="email-results email-results-panel-trigger"
|
||
aria-expanded="false"
|
||
aria-controls="email-action-panel"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="open">
|
||
Email
|
||
</button><div class="more-actions dropdown-block"><button id="more-actions-trigger"
|
||
type="button"
|
||
class="trigger more-actions-trigger"
|
||
ref="linksrc=show_moreactions_btn"
|
||
aria-label="Send to"
|
||
aria-controls="more-actions-dropdown">Send to</button><div id="more-actions-dropdown" class="dropdown dropdown-container" hidden><div class="content"><ul class="more-actions-links"><li><a class="clipboard-panel-trigger dropdown-block-link "
|
||
href="#"
|
||
role="button"
|
||
data-ga-category="save_share"
|
||
data-ga-action="clipboard"
|
||
data-ga-label="send">
|
||
Clipboard
|
||
</a></li><li><a role="button" class="dropdown-block-link bibliography-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F27555459%2F%23open-bibliography-panel">My Bibliography</a></li><li><a role="button" class="dropdown-block-link collections-trigger-target" href="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F27555459%2F%23open-collections-panel">Collections</a></li><li><a role="button" class="citation-manager-panel-trigger dropdown-block-link citation-manager-trigger-target" href="#">Citation manager</a></li></ul></div></div></div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="display-options" data-format-key="format"
|
||
data-default-format-value="abstract"
|
||
data-current-format-value="abstract" role="region">
|
||
<button
|
||
class="trigger usa-button"
|
||
title="Change format"
|
||
data-ga-category="display_options"
|
||
data-ga-action="display_options_dialog">
|
||
<span class="button-label">Display options</span>
|
||
</button>
|
||
|
||
<div class="dropdown" hidden>
|
||
<div class="title">
|
||
Display options
|
||
</div>
|
||
|
||
<div class="content">
|
||
|
||
<div class="format-container">
|
||
<span class="option-label">
|
||
Format
|
||
</span>
|
||
<select name="format" data-initial-value="abstract" aria-label="Display format" id="article-display-format">
|
||
<option value="abstract">Abstract</option>
|
||
|
||
<option value="pubmed">PubMed</option>
|
||
|
||
<option value="pmid">PMID</option>
|
||
|
||
</select>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx">
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="article-panels-container" class="article-panels-container">
|
||
<div id="save-action-panel" class="save-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Save citation to file
|
||
</h2>
|
||
<form id="save-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="save-action-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="save-action-format" name="results-format" class="action-panel-selector">
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="pubmed-text">PubMed</option>
|
||
<option value="pmid">PMID</option>
|
||
<option value="abstract">Abstract (text)</option>
|
||
<option value="csv">CSV</option>
|
||
</select>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Save citations to file' panel"
|
||
ref="linksrc=close_save_panel"
|
||
aria-controls="save-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="save"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="email-action-panel"
|
||
class="email-action-panel action-panel"
|
||
aria-hidden="true"
|
||
data-recaptcha-script-url="https://www.recaptcha.net/recaptcha/enterprise.js?render=explicit&onload=onloadCaptchaCallback"
|
||
data-recaptcha-enabled="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Email citation
|
||
</h2>
|
||
<form id="email-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/send-email/"
|
||
data-by-search-action="/results-export-email-by-search-data/"
|
||
data-by-ids-action="/send-email/"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post"
|
||
method="post"
|
||
>
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<span class="action-panel-label">
|
||
Subject:
|
||
</span>
|
||
<span class="email-subject" id="email-subject" aria-label="Email subject">1 selected item: 27555459 - PubMed</span>
|
||
<input type="hidden" name="email-subject" value="1 selected item: 27555459"/>
|
||
<input type="hidden" name="email-subject-hash" value="55d6cef1040b185fa0c45a85e1f9901e9dc19096e580e9b456f02ad2f327efaa"/>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-to" class="action-panel-label required-field-asterisk">
|
||
To:
|
||
</label>
|
||
<input type="email" aria-label="Recipient Email Address" placeholder="email@example.com" id="email-to" class="email-to" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="100" required>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-from" class="action-panel-label">
|
||
From:
|
||
</label>
|
||
<input type="email" aria-label="Sender Email Address" placeholder="email@example.com" id="email-from" class="email-from" pattern="^[a-zA-Z0-9_.+-]+@[a-zA-Z0-9-]+\.[a-zA-Z0-9-.]+$" maxlength="256">
|
||
</div>
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="email-citation-format" class="action-panel-label">
|
||
Format:
|
||
</label>
|
||
<select id="email-citation-format" name="citation-format" class="action-panel-selector email-citation-format">
|
||
<option selected="selected" value="summary">Summary</option>
|
||
<option value="summary-text">Summary (text)</option>
|
||
<option value="abstract">Abstract</option>
|
||
<option value="abstract-text">Abstract (text)</option>
|
||
|
||
</select>
|
||
</div>
|
||
<div class="include-supplemental-container">
|
||
<input type="checkbox" aria-label="Include MeSH and other data" name="include-supplemental" id="email-include-supplemental" class="email-include-supplemental">
|
||
<label for="email-include-supplemental" class="email-include-supplemental-label">MeSH and other data</label>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="form-field recaptcha ">
|
||
|
||
|
||
|
||
<div class="g-recaptcha" id="id-recaptcha" data-sitekey="6LfsWHMdAAAAAClKbtOpjQ2pMjgsGxvv7NdZW9uI"></div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div id="captcha-error-message" class="usa-input-error-message captcha-validation-message" role="alert"></div>
|
||
|
||
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="send">
|
||
Send email
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Email citations' panel"
|
||
ref="linksrc=close_email_panel"
|
||
aria-controls="email-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="email"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
<input type="hidden" name="email-search-details" value="" />
|
||
<input type="hidden" name="email-search-details-hash" value="0e42663a6c3bd85498fcb88798998fed7bfdc45d457db35281e41afe13cc0524" />
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="collections-action-panel"
|
||
class="collections-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-collections-open-panel-enabled="false"
|
||
data-collections-open-panel-url-hash="#open-collections-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to Collections
|
||
</h3>
|
||
|
||
|
||
<form id="collections-action-panel-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-add-to-collection-max-amount="1000"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx">
|
||
|
||
|
||
|
||
<div class="choice-group" role="radiogroup">
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_new">
|
||
<label for="collections-action-panel-new">Create a new collection</label>
|
||
</li>
|
||
<li>
|
||
<input type="radio"
|
||
id="collections-action-panel-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="collections_radio_existing">
|
||
<label for="collections-action-panel-existing">Add to an existing collection</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="controls-wrapper">
|
||
<div class="action-panel-control-wrap new-collections-controls">
|
||
<label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label>
|
||
<input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-panel-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="save_share"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection">
|
||
<div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div>
|
||
</div>
|
||
<div class="action-panel-control-wrap existing-collections-controls">
|
||
<label for="collections-action-panel-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label>
|
||
<select id="collections-action-panel-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="save_share"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'">
|
||
</select>
|
||
<div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="add">
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="collections"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="bibliography-action-panel"
|
||
class="bibliography-action-panel action-panel in-progress-dots-panel"
|
||
aria-hidden="true"
|
||
data-bibliography-open-panel-enabled="false"
|
||
data-bibliography-open-panel-url-hash="#open-bibliography-panel">
|
||
<div class="inner-wrap">
|
||
<h3 class="action-panel-heading">
|
||
Add to My Bibliography
|
||
</h3>
|
||
<form id="bibliography-action-panel-form"
|
||
class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-add-to-bibliography-max-amount="100"
|
||
data-add-to-bibliography-batch-size="10"
|
||
data-bibliography-delegates-url="/list-bibliography-delegates/"
|
||
data-add-to-bibliography-url="/add-to-bibliography/"
|
||
data-get-article-ids-by-search-url="/get-article-ids-by-search/"
|
||
data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx">
|
||
|
||
|
||
|
||
<div class="action-panel-control-wrap bibliographies-controls">
|
||
<div class="choice-group">
|
||
<ul class="bibliographies-action-add radio-group-items">
|
||
<li>
|
||
<input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/>
|
||
<label for="my-bibliography">My Bibliography</label>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your delegates due to an error<br>
|
||
<a href="#">Please try again</a>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore>
|
||
Add
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Add to bibliography' panel"
|
||
ref="linksrc=close_bibliography_panel"
|
||
aria-controls="bibliography-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="mybib"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true"
|
||
data-saved-search-open-panel-enabled="false"
|
||
data-saved-search-open-panel-url-hash="#open-saved-search-panel">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your saved search
|
||
</h2>
|
||
|
||
<form id="saved-search-action-panel-form"
|
||
class="saved-search-action-panel-form action-panel-content action-form"
|
||
data-create-saved-search-url="/create-saved-search/"
|
||
data-try-search-terms-url="/try-search-term/"
|
||
data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk">
|
||
Name of saved search:
|
||
</label>
|
||
<input maxlength="200"
|
||
type="text"
|
||
name="saved-search-name"
|
||
id="saved-search-name"
|
||
class="saved-search-name"
|
||
value=""
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-term" class="action-panel-label required-field-asterisk">
|
||
Search terms:
|
||
</label>
|
||
<textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea>
|
||
</div>
|
||
<div class="test-search-term-wrap">
|
||
<a href="#" class="try-search-term">Test search terms</a>
|
||
</div>
|
||
<div class="choice-group action-panel-extra-margin-top">
|
||
<span class="action-panel-label" id="fieldset-label">
|
||
Would you like email updates of new search results?
|
||
</span>
|
||
<fieldset id="saved-search-alert" aria-describedby="fieldset-label">
|
||
<legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend>
|
||
<ul class="radio-group-items">
|
||
<li>
|
||
<input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked>
|
||
<label for="saved-search-alert-yes" class="action-panel-label">Yes</label>
|
||
</li>
|
||
<li>
|
||
<input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no">
|
||
<label for="saved-search-alert-no" class="action-panel-label">No</label>
|
||
</li>
|
||
</ul>
|
||
</fieldset>
|
||
</div>
|
||
|
||
<div class="alert-schedule-wrap">
|
||
<div class="action-panel-control-wrap">
|
||
<label class="action-panel-label">
|
||
Email:
|
||
</label>
|
||
<span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span>
|
||
</div>
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="saved-search-frequency" class="action-panel-label">
|
||
Frequency:
|
||
</label>
|
||
<select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency">
|
||
<option value="monthly">Monthly</option>
|
||
<option value="weekly">Weekly</option>
|
||
<option value="daily">Daily</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-monthly-additional">
|
||
<label for="saved-search-monthly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-monthly-on-day" class="no-border-panel-selector">
|
||
<option value="Sunday">The first Sunday</option>
|
||
<option value="Monday">The first Monday</option>
|
||
<option value="Tuesday">The first Tuesday</option>
|
||
<option value="Wednesday">The first Wednesday</option>
|
||
<option value="Thursday">The first Thursday</option>
|
||
<option value="Friday">The first Friday</option>
|
||
<option value="Saturday">The first Saturday</option>
|
||
<option value="day">The first day</option>
|
||
<option value="weekday">The first weekday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap saved-search-weekly-additional">
|
||
<label for="saved-search-weekly-on-day" class="action-panel-label">
|
||
Which day?
|
||
</label>
|
||
<select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day">
|
||
<option value="Sunday">Sunday</option>
|
||
<option value="Monday">Monday</option>
|
||
<option value="Tuesday">Tuesday</option>
|
||
<option value="Wednesday">Wednesday</option>
|
||
<option value="Thursday">Thursday</option>
|
||
<option value="Friday">Friday</option>
|
||
<option value="Saturday">Saturday</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-report" class="action-panel-label">
|
||
Report format:
|
||
</label>
|
||
<select id="saved-search-report" class="no-border-panel-selector saved-search-report">
|
||
<option value="DocSum">Summary</option>
|
||
<option value="DocSumText">Summary (text)</option>
|
||
<option value="Abstract">Abstract</option>
|
||
<option value="AbstractText">Abstract (text)</option>
|
||
<option value="MEDLINE">PubMed</option>
|
||
</select>
|
||
</div>
|
||
<div class="action-panel-control-wrap">
|
||
<label for="saved-search-amount" class="action-panel-label">
|
||
Send at most:
|
||
</label>
|
||
<select id="saved-search-amount" class="no-border-panel-selector saved-search-amount">
|
||
<option value="1">1 item</option>
|
||
<option value="5" selected>5 items</option>
|
||
<option value="10">10 items</option>
|
||
<option value="20">20 items</option>
|
||
<option value="50">50 items</option>
|
||
<option value="100">100 items</option>
|
||
<option value="200">200 items</option>
|
||
</select>
|
||
</div>
|
||
<div>
|
||
<input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result">
|
||
<label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox">
|
||
Send even when there aren't any new results
|
||
</label>
|
||
</div>
|
||
<div class="action-panel-control-wrap option-text-in-email-wrap">
|
||
<label for="saved-search-email-text" class="action-panel-label">
|
||
Optional text in email:
|
||
</label>
|
||
<textarea name="saved-search-email-text"
|
||
id="saved-search-email-text"
|
||
class="saved-search-email-text"></textarea>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Saving..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Save
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your saved search' panel"
|
||
ref="linksrc=close_saved_search_panel"
|
||
aria-controls="saved-search-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
<div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Create a file for external citation management software
|
||
</h2>
|
||
<form id="citation-manager-action-panel-form"
|
||
class="action-panel-content action-form"
|
||
action="/results-export-ids/"
|
||
data-by-search-action="/results-export-search-data/"
|
||
data-by-ids-action="/results-export-ids/"
|
||
method="post"
|
||
data-by-search-method="post"
|
||
data-by-ids-method="post">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx">
|
||
|
||
|
||
|
||
<input name="results-format" type="hidden" value="pubmed"/>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Sending..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="save">
|
||
Create file
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Send citations to citation manager' panel"
|
||
ref="linksrc=close_citation_manager_panel"
|
||
aria-controls="citation-manager-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="citation_manager"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true">
|
||
<div class="inner-wrap">
|
||
<h2 class="action-panel-heading">
|
||
Your RSS Feed
|
||
</h2>
|
||
|
||
<form id="rss-action-panel-form"
|
||
class="rss-action-panel-form action-panel-content action-form"
|
||
data-create-rss-feed-url="/create-rss-feed-url/"
|
||
data-search-form-term-value="">
|
||
|
||
<input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx">
|
||
|
||
<div class="action-panel-control-wrap">
|
||
<label for="rss-name" class="action-panel-label required-field-asterisk">
|
||
Name of RSS Feed:
|
||
</label>
|
||
<input maxlength="200"
|
||
placeholder="Name"
|
||
type="text"
|
||
name="rss-name"
|
||
id="rss-name"
|
||
class="rss-name"
|
||
value=''
|
||
required
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/">
|
||
</div>
|
||
|
||
<div class="rss-limit-wrap">
|
||
<div class="action-panel-control-wrap action-panel-extra-margin-top">
|
||
<label for="rss-limit" class="action-panel-label">
|
||
Number of items displayed:
|
||
</label>
|
||
<select id="rss-limit" class="no-border-panel-selector rss-limit">
|
||
<option value="5">5</option>
|
||
<option value="10">10</option>
|
||
<option value="15" selected="selected">15</option>
|
||
<option value="20">20</option>
|
||
<option value="50">50</option>
|
||
<option value="100">100</option>
|
||
</select>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="action-panel-actions">
|
||
<button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Creating..."
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="save">
|
||
Create RSS
|
||
</button>
|
||
<button class="action-panel-cancel"
|
||
aria-label="Close 'Your RSS' panel"
|
||
ref="linksrc=close_rss_panel"
|
||
aria-controls="rss-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="save_share"
|
||
data-ga-action="alert"
|
||
data-ga-label="cancel">
|
||
Cancel
|
||
</button>
|
||
</div>
|
||
|
||
<div class="action-panel-control-wrap rss-link-copy-wrap">
|
||
<label for="rss-link" class="usa-sr-only">RSS Link</label>
|
||
<input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link">
|
||
<button
|
||
type="button"
|
||
disabled
|
||
class="rss-link-copy-button disabled"
|
||
data-ga-category="save_share"
|
||
data-ga-action="rss"
|
||
data-ga-label="copy">
|
||
Copy
|
||
</button>
|
||
</div>
|
||
</form>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="article-page" id="article-page" data-article-pmid="27555459">
|
||
<aside class="page-sidebar">
|
||
<div class="inner-wrap">
|
||
|
||
<div class="full-text-links">
|
||
<div class="full-view">
|
||
<h3 class="title">
|
||
Full text links
|
||
</h3>
|
||
<div class="full-text-links-list">
|
||
<a class="link-item
|
||
|
||
dialog-focus"
|
||
href="https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(16)30623-6"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3048&itool=Abstract-def&log$=linkouticon&uid=27555459&db=pubmed&nlmid=1275002"
|
||
title="See full text options at Elsevier Science"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="Elsevier Science"
|
||
data-ga-label="27555459"
|
||
><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--linkinghub.elsevier.com-ihub-images-elsevieroa.png" alt="Elsevier Science full text link"><span class="text">
|
||
|
||
Elsevier Science
|
||
|
||
</span></a><a class="link-item
|
||
pmc
|
||
"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/27555459/"
|
||
target="_blank"
|
||
rel="noopener"
|
||
|
||
ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=27555459&db=pubmed&nlmid=1275002"
|
||
title="Free full text at PubMed Central"
|
||
|
||
data-ga-category="full_text"
|
||
data-ga-action="PMC"
|
||
data-ga-label="27555459"
|
||
><span class="text">
|
||
|
||
Free PMC article
|
||
|
||
</span></a>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="short-view">
|
||
<a href="#" class="full-text-links-button full-text-links-dialog-trigger">
|
||
Full text links
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="actions-buttons sidebar"><h3 class="title">Actions</h3><div class="inner-wrap"><button class="citation-button citation-dialog-trigger"
|
||
aria-label="Open dialog with citation text in different styles"
|
||
data-ga-category="save_share"
|
||
data-ga-action="cite"
|
||
data-ga-label="open"
|
||
data-all-citations-url="/27555459/citations/"
|
||
data-citation-style="nlm"
|
||
data-pubmed-format-link="/27555459/export/"><span class="button-label">Cite</span></button><link type="text/css" href="ncbi-overlay-block/src/overlay-block.css"><div class="collections-button-container" data-article-id="27555459" data-article-db="pubmed"><button class="collections-button collections-dialog-trigger"
|
||
aria-label="Save article in MyNCBI collections."
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_button"
|
||
data-collections-open-dialog-enabled="false"
|
||
data-collections-open-dialog-url="https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F27555459%2F%23open-collections-dialog"
|
||
data-in-collections="false"><span class="button-label">Collections</span></button><div class="overlay" role="dialog"><div id="collections-action-dialog"
|
||
class="dialog collections-dialog"
|
||
aria-hidden="true"><div class="title">Add to Collections</div><div class="collections-action-panel action-panel"><form id="collections-action-dialog-form"
|
||
class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors"
|
||
data-existing-collections-url="/list-existing-collections/"
|
||
data-add-to-existing-collection-url="/add-to-existing-collection/"
|
||
data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/"
|
||
data-myncbi-max-collection-name-length="100"
|
||
data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="h2mUOFCHwyB2g0dzWfryqcOPk9D1W92dyP6Zrv5369owarjpzy4AUkktSdldPKAx"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio"
|
||
id="collections-action-dialog-new"
|
||
class="collections-new"
|
||
name="collections"
|
||
value="new"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio"
|
||
id="collections-action-dialog-existing"
|
||
class="collections-existing"
|
||
name="collections"
|
||
value="existing"
|
||
checked="true"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk">
|
||
Name your collection:
|
||
</label><input
|
||
type="text"
|
||
name="add-to-new-collection"
|
||
id="collections-action-dialog-add-to-new"
|
||
class="collections-action-add-to-new"
|
||
pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"
|
||
maxlength="100"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="create_collection"
|
||
data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message">
|
||
Name must be less than 100 characters
|
||
</div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label">
|
||
Choose a collection:
|
||
</label><select id="collections-action-dialog-add-to-existing"
|
||
class="action-panel-selector collections-action-add-to-existing"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="select_collection"
|
||
data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message">
|
||
Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit"
|
||
type="submit"
|
||
data-loading-label="Adding..."
|
||
data-pinger-ignore
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="add">
|
||
Add
|
||
</button><button class="action-panel-cancel"
|
||
aria-label="Close 'Add to Collections' panel"
|
||
ref="linksrc=close_collections_panel"
|
||
aria-controls="collections-action-panel"
|
||
aria-expanded="false"
|
||
data-ga-category="collections_button"
|
||
data-ga-action="click"
|
||
data-ga-label="cancel">
|
||
Cancel
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Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study
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data-ga-label="Timothy Ronan Leahy">Timothy Ronan Leahy</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital Crumlin, Dublin, Ireland." href="#full-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Doffinger+R&cauthor_id=27555459"
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data-ga-label="Rainer Doffinger">Rainer Doffinger</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom; National Institute for Health Research, Cambridge Biomedical Research Centre, Cambridge, United Kingdom." href="#full-view-affiliation-11" ref="linksrc=author_aff">
|
||
11
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Baxendale+H&cauthor_id=27555459"
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data-ga-label="Helen Baxendale">Helen Baxendale</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Papworth Hospital NHS trust, Papworth Everard, Cambridge, United Kingdom." href="#full-view-affiliation-12" ref="linksrc=author_aff">
|
||
12
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Bernatoniene+J&cauthor_id=27555459"
|
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ref="linksrc=author_name_link"
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data-ga-label="Jolanta Bernatoniene">Jolanta Bernatoniene</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Infectious Disease and Immunology, University Hospitals Bristol NHS Foundation Trust, Bristol Royal Hospital for Children, Bristol, United Kingdom." href="#full-view-affiliation-13" ref="linksrc=author_aff">
|
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13
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Edgar+JD&cauthor_id=27555459"
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data-ga-label="J David M Edgar">J David M Edgar</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Regional Immunology Service, The Royal Hospitals, Belfast, United Kingdom." href="#full-view-affiliation-9" ref="linksrc=author_aff">
|
||
9
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Longhurst+HJ&cauthor_id=27555459"
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data-ga-label="Hilary J Longhurst">Hilary J Longhurst</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Barts Health NHS Trust, London, United Kingdom." href="#full-view-affiliation-14" ref="linksrc=author_aff">
|
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14
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Ehl+S&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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||
data-ga-label="Stephan Ehl">Stephan Ehl</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany." href="#full-view-affiliation-15" ref="linksrc=author_aff">
|
||
15
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Speckmann+C&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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data-ga-label="Carsten Speckmann">Carsten Speckmann</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany; Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany." href="#full-view-affiliation-16" ref="linksrc=author_aff">
|
||
16
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Grimbacher+B&cauthor_id=27555459"
|
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ref="linksrc=author_name_link"
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||
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||
data-ga-label="Bodo Grimbacher">Bodo Grimbacher</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany." href="#full-view-affiliation-15" ref="linksrc=author_aff">
|
||
15
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Sediva+A&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Anna Sediva">Anna Sediva</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunology, University Hospital Motol, Prague, Czech Republic." href="#full-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Milota+T&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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|
||
data-ga-label="Tomas Milota">Tomas Milota</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunology, University Hospital Motol, Prague, Czech Republic." href="#full-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Faust+SN&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Saul N Faust">Saul N Faust</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, United Kingdom; NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom." href="#full-view-affiliation-18" ref="linksrc=author_aff">
|
||
18
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Williams+AP&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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data-ga-label="Anthony P Williams">Anthony P Williams</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, United Kingdom." href="#full-view-affiliation-19" ref="linksrc=author_aff">
|
||
19
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Hayman+G&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
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||
data-ga-label="Grant Hayman">Grant Hayman</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, Epsom & St Helier University Hospitals NHS Trust, Surrey, United Kingdom." href="#full-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Kucuk+ZY&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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data-ga-label="Zeynep Yesim Kucuk">Zeynep Yesim Kucuk</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio." href="#full-view-affiliation-21" ref="linksrc=author_aff">
|
||
21
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Hague+R&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Rosie Hague">Rosie Hague</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Royal Hospital for Children, Glasgow, United Kingdom." href="#full-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=French+P&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
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data-ga-action="author_link"
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||
data-ga-label="Paul French">Paul French</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pathology, Queen Elizabeth University Hospital, Glasgow, United Kingdom." href="#full-view-affiliation-23" ref="linksrc=author_aff">
|
||
23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Brooker+R&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
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||
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||
data-ga-label="Richard Brooker">Richard Brooker</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Royal Aberdeen Childrens' Hospital, Aberdeen, United Kingdom." href="#full-view-affiliation-24" ref="linksrc=author_aff">
|
||
24
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Forsyth+P&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Peter Forsyth">Peter Forsyth</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Raigmore Hospital, Inverness, United Kingdom." href="#full-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Herriot+R&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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||
data-ga-label="Richard Herriot">Richard Herriot</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Royal Aberdeen Childrens' Hospital, Aberdeen, United Kingdom." href="#full-view-affiliation-24" ref="linksrc=author_aff">
|
||
24
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Cancrini+C&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
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|
||
data-ga-label="Caterina Cancrini">Caterina Cancrini</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata", Rome, Italy." href="#full-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Palma+P&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
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||
data-ga-label="Paolo Palma">Paolo Palma</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata", Rome, Italy." href="#full-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Ariganello+P&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
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|
||
data-ga-label="Paola Ariganello">Paola Ariganello</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata", Rome, Italy." href="#full-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Conlon+N&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Niall Conlon">Niall Conlon</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, School of Medicine, Trinity College, Dublin, and St James's Hospital, Dublin, Ireland." href="#full-view-affiliation-26" ref="linksrc=author_aff">
|
||
26
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Feighery+C&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Conleth Feighery">Conleth Feighery</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, School of Medicine, Trinity College, Dublin, and St James's Hospital, Dublin, Ireland." href="#full-view-affiliation-26" ref="linksrc=author_aff">
|
||
26
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Gavin+PJ&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Patrick J Gavin">Patrick J Gavin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital Crumlin, Dublin, Ireland." href="#full-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Jones+A&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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|
||
data-ga-label="Alison Jones">Alison Jones</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom." href="#full-view-affiliation-27" ref="linksrc=author_aff">
|
||
27
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Imai+K&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
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|
||
data-ga-label="Kohsuke Imai">Kohsuke Imai</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Community Pediatrics, Perinatal and Maternal Medicine Tokyo Medical and Dental University (TMDU), Tokyo, Japan." href="#full-view-affiliation-28" ref="linksrc=author_aff">
|
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28
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Ibrahim+MA&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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data-ga-label="Mohammad A A Ibrahim">Mohammad A A Ibrahim</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="King's College London, King's Health Partners, King's College Hospital NHS Foundation Trust, School of Medicine, Division of Asthma, Allergy & Lung Biology, Department of Immunological Medicine, London, United Kingdom." href="#full-view-affiliation-29" ref="linksrc=author_aff">
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29
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||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Markelj+G&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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data-ga-category="search"
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||
data-ga-label="Gašper Markelj">Gašper Markelj</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Ljubljana, Slovenia." href="#full-view-affiliation-30" ref="linksrc=author_aff">
|
||
30
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Abinun+M&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Mario Abinun">Mario Abinun</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom." href="#full-view-affiliation-31" ref="linksrc=author_aff">
|
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31
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||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Rieux-Laucat+F&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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||
data-ga-label="Frédéric Rieux-Laucat">Frédéric Rieux-Laucat</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#full-view-affiliation-32" ref="linksrc=author_aff">
|
||
32
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||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Latour+S&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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||
data-ga-label="Sylvain Latour">Sylvain Latour</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#full-view-affiliation-32" ref="linksrc=author_aff">
|
||
32
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||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Pellier+I&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-label="Isabelle Pellier">Isabelle Pellier</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Unité d'Onco-hémato-immunologie Pédiatrique, CHU Angers, Angers, France; Centre de Référence Déficits Immunitaires Héréditaires, AP-HP, Paris, France; Inserm UMR 892, Angers, France; CNRS UMR 6299, Angers, France." href="#full-view-affiliation-33" ref="linksrc=author_aff">
|
||
33
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||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Fischer+A&cauthor_id=27555459"
|
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ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Alain Fischer">Alain Fischer</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Collège de France, Paris, France." href="#full-view-affiliation-34" ref="linksrc=author_aff">
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34
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Fabien Touzot">Fabien Touzot</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Départment de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#full-view-affiliation-35" ref="linksrc=author_aff">
|
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35
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Jean-Laurent Casanova">Jean-Laurent Casanova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Necker Children's Hospital, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY; Howard Hughes Medical Institute, Chevy Chase, Md." href="#full-view-affiliation-36" ref="linksrc=author_aff">
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36
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Anne Durandy">Anne Durandy</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#full-view-affiliation-32" ref="linksrc=author_aff">
|
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32
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Siobhan O Burns">Siobhan O Burns</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University College London Institute of Immunity and Transplantation, London, United Kingdom." href="#full-view-affiliation-37" ref="linksrc=author_aff">
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37
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Sinisa Savic">Sinisa Savic</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom." href="#full-view-affiliation-38" ref="linksrc=author_aff">
|
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38
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="D S Kumararatne">D S Kumararatne</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom." href="#full-view-affiliation-39" ref="linksrc=author_aff">
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39
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Despina Moshous">Despina Moshous</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France." href="#full-view-affiliation-40" ref="linksrc=author_aff">
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40
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Sven Kracker">Sven Kracker</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#full-view-affiliation-32" ref="linksrc=author_aff">
|
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32
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Bart Vanhaesebroeck">Bart Vanhaesebroeck</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="UCL Cancer Institute, University College London, London, United Kingdom." href="#full-view-affiliation-41" ref="linksrc=author_aff">
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41
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Klaus Okkenhaug">Klaus Okkenhaug</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Lymphocyte Signalling & Development, Babraham Institute, Cambridge, United Kingdom." href="#full-view-affiliation-42" ref="linksrc=author_aff">
|
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42
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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data-ga-label="Capucine Picard">Capucine Picard</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Centre de Référence Déficits Immunitaires Héréditaires, AP-HP, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Necker Children's Hospital, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY." href="#full-view-affiliation-43" ref="linksrc=author_aff">
|
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43
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Nejentsev+S&cauthor_id=27555459"
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data-ga-label="Sergey Nejentsev">Sergey Nejentsev</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of Cambridge, Cambridge, United Kingdom." href="#full-view-affiliation-5" ref="linksrc=author_aff">
|
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5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Condliffe+AM&cauthor_id=27555459"
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data-ga-label="Alison M Condliffe">Alison M Condliffe</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom. Electronic address: a.m.condliffe@sheffield.ac.uk." href="#full-view-affiliation-44" ref="linksrc=author_aff">
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44
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
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href="/?term=Cant+AJ&cauthor_id=27555459"
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data-ga-label="Andrew James Cant">Andrew James Cant</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom." href="#full-view-affiliation-31" ref="linksrc=author_aff">
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31
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</a></sup></span>
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<div class="short-article-details">
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Affiliations
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<div class="affiliations">
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<h3 class="title">
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Affiliations
|
||
</h3>
|
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<ul class="item-list">
|
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<li data-affiliation-id="full-view-affiliation-1"
|
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id="full-view-affiliation-1"
|
||
><sup class="key">1</sup> Department of Immunology, School of Medicine, Trinity College, Dublin, and St James's Hospital, Dublin, Ireland; Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-2"
|
||
id="full-view-affiliation-2"
|
||
><sup class="key">2</sup> Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom; Lymphocyte Signalling & Development, Babraham Institute, Cambridge, United Kingdom; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-3"
|
||
id="full-view-affiliation-3"
|
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><sup class="key">3</sup> Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom; Northern England Haemato-Oncology Diagnostic Service, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-4"
|
||
id="full-view-affiliation-4"
|
||
><sup class="key">4</sup> Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-5"
|
||
id="full-view-affiliation-5"
|
||
><sup class="key">5</sup> Department of Medicine, University of Cambridge, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-6"
|
||
id="full-view-affiliation-6"
|
||
><sup class="key">6</sup> Department of Radiology, Papworth Hospital NHS Foundation Trust, Papworth Everard Hospital, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-7"
|
||
id="full-view-affiliation-7"
|
||
><sup class="key">7</sup> Department of Pathology, Western General Hospital, Edinburgh, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-8"
|
||
id="full-view-affiliation-8"
|
||
><sup class="key">8</sup> Raigmore Hospital, Inverness, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-9"
|
||
id="full-view-affiliation-9"
|
||
><sup class="key">9</sup> Regional Immunology Service, The Royal Hospitals, Belfast, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-10"
|
||
id="full-view-affiliation-10"
|
||
><sup class="key">10</sup> Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-11"
|
||
id="full-view-affiliation-11"
|
||
><sup class="key">11</sup> Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom; National Institute for Health Research, Cambridge Biomedical Research Centre, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-12"
|
||
id="full-view-affiliation-12"
|
||
><sup class="key">12</sup> Papworth Hospital NHS trust, Papworth Everard, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-13"
|
||
id="full-view-affiliation-13"
|
||
><sup class="key">13</sup> Department of Infectious Disease and Immunology, University Hospitals Bristol NHS Foundation Trust, Bristol Royal Hospital for Children, Bristol, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-14"
|
||
id="full-view-affiliation-14"
|
||
><sup class="key">14</sup> Barts Health NHS Trust, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-15"
|
||
id="full-view-affiliation-15"
|
||
><sup class="key">15</sup> Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-16"
|
||
id="full-view-affiliation-16"
|
||
><sup class="key">16</sup> Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany; Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-17"
|
||
id="full-view-affiliation-17"
|
||
><sup class="key">17</sup> Institute of Immunology, University Hospital Motol, Prague, Czech Republic.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-18"
|
||
id="full-view-affiliation-18"
|
||
><sup class="key">18</sup> Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, United Kingdom; NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-19"
|
||
id="full-view-affiliation-19"
|
||
><sup class="key">19</sup> Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-20"
|
||
id="full-view-affiliation-20"
|
||
><sup class="key">20</sup> Department of Immunology, Epsom & St Helier University Hospitals NHS Trust, Surrey, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-21"
|
||
id="full-view-affiliation-21"
|
||
><sup class="key">21</sup> Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-22"
|
||
id="full-view-affiliation-22"
|
||
><sup class="key">22</sup> Department of Royal Hospital for Children, Glasgow, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-23"
|
||
id="full-view-affiliation-23"
|
||
><sup class="key">23</sup> Department of Pathology, Queen Elizabeth University Hospital, Glasgow, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-24"
|
||
id="full-view-affiliation-24"
|
||
><sup class="key">24</sup> Royal Aberdeen Childrens' Hospital, Aberdeen, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-25"
|
||
id="full-view-affiliation-25"
|
||
><sup class="key">25</sup> Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata", Rome, Italy.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-26"
|
||
id="full-view-affiliation-26"
|
||
><sup class="key">26</sup> Department of Immunology, School of Medicine, Trinity College, Dublin, and St James's Hospital, Dublin, Ireland.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-27"
|
||
id="full-view-affiliation-27"
|
||
><sup class="key">27</sup> Department of Immunology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-28"
|
||
id="full-view-affiliation-28"
|
||
><sup class="key">28</sup> Department of Community Pediatrics, Perinatal and Maternal Medicine Tokyo Medical and Dental University (TMDU), Tokyo, Japan.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-29"
|
||
id="full-view-affiliation-29"
|
||
><sup class="key">29</sup> King's College London, King's Health Partners, King's College Hospital NHS Foundation Trust, School of Medicine, Division of Asthma, Allergy & Lung Biology, Department of Immunological Medicine, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-30"
|
||
id="full-view-affiliation-30"
|
||
><sup class="key">30</sup> Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Ljubljana, Slovenia.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-31"
|
||
id="full-view-affiliation-31"
|
||
><sup class="key">31</sup> Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-32"
|
||
id="full-view-affiliation-32"
|
||
><sup class="key">32</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-33"
|
||
id="full-view-affiliation-33"
|
||
><sup class="key">33</sup> Unité d'Onco-hémato-immunologie Pédiatrique, CHU Angers, Angers, France; Centre de Référence Déficits Immunitaires Héréditaires, AP-HP, Paris, France; Inserm UMR 892, Angers, France; CNRS UMR 6299, Angers, France.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-34"
|
||
id="full-view-affiliation-34"
|
||
><sup class="key">34</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Collège de France, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-35"
|
||
id="full-view-affiliation-35"
|
||
><sup class="key">35</sup> Départment de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="full-view-affiliation-36"
|
||
id="full-view-affiliation-36"
|
||
><sup class="key">36</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Necker Children's Hospital, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY; Howard Hughes Medical Institute, Chevy Chase, Md.</li>
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<li data-affiliation-id="full-view-affiliation-37"
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<li data-affiliation-id="full-view-affiliation-38"
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|
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|
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<li data-affiliation-id="full-view-affiliation-40"
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><sup class="key">40</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France.</li>
|
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><sup class="key">43</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Centre de Référence Déficits Immunitaires Héréditaires, AP-HP, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Necker Children's Hospital, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY.</li>
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Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study
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href="/?term=Ehl+S&cauthor_id=27555459"
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data-ga-label="Stephan Ehl">Stephan Ehl</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany." href="#short-view-affiliation-15" ref="linksrc=author_aff">
|
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15
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Speckmann+C&cauthor_id=27555459"
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data-ga-label="Carsten Speckmann">Carsten Speckmann</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany; Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany." href="#short-view-affiliation-16" ref="linksrc=author_aff">
|
||
16
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Grimbacher+B&cauthor_id=27555459"
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data-ga-label="Bodo Grimbacher">Bodo Grimbacher</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany." href="#short-view-affiliation-15" ref="linksrc=author_aff">
|
||
15
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Sediva+A&cauthor_id=27555459"
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data-ga-label="Anna Sediva">Anna Sediva</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunology, University Hospital Motol, Prague, Czech Republic." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Milota+T&cauthor_id=27555459"
|
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data-ga-label="Tomas Milota">Tomas Milota</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Institute of Immunology, University Hospital Motol, Prague, Czech Republic." href="#short-view-affiliation-17" ref="linksrc=author_aff">
|
||
17
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Faust+SN&cauthor_id=27555459"
|
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data-ga-label="Saul N Faust">Saul N Faust</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, United Kingdom; NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom." href="#short-view-affiliation-18" ref="linksrc=author_aff">
|
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18
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Williams+AP&cauthor_id=27555459"
|
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ref="linksrc=author_name_link"
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data-ga-label="Anthony P Williams">Anthony P Williams</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, United Kingdom." href="#short-view-affiliation-19" ref="linksrc=author_aff">
|
||
19
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Hayman+G&cauthor_id=27555459"
|
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ref="linksrc=author_name_link"
|
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data-ga-label="Grant Hayman">Grant Hayman</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, Epsom & St Helier University Hospitals NHS Trust, Surrey, United Kingdom." href="#short-view-affiliation-20" ref="linksrc=author_aff">
|
||
20
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Kucuk+ZY&cauthor_id=27555459"
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data-ga-label="Zeynep Yesim Kucuk">Zeynep Yesim Kucuk</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio." href="#short-view-affiliation-21" ref="linksrc=author_aff">
|
||
21
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Hague+R&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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data-ga-label="Rosie Hague">Rosie Hague</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Royal Hospital for Children, Glasgow, United Kingdom." href="#short-view-affiliation-22" ref="linksrc=author_aff">
|
||
22
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=French+P&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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data-ga-label="Paul French">Paul French</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pathology, Queen Elizabeth University Hospital, Glasgow, United Kingdom." href="#short-view-affiliation-23" ref="linksrc=author_aff">
|
||
23
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Brooker+R&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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data-ga-label="Richard Brooker">Richard Brooker</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Royal Aberdeen Childrens' Hospital, Aberdeen, United Kingdom." href="#short-view-affiliation-24" ref="linksrc=author_aff">
|
||
24
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Forsyth+P&cauthor_id=27555459"
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data-ga-label="Peter Forsyth">Peter Forsyth</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Raigmore Hospital, Inverness, United Kingdom." href="#short-view-affiliation-8" ref="linksrc=author_aff">
|
||
8
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Herriot+R&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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data-ga-label="Richard Herriot">Richard Herriot</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Royal Aberdeen Childrens' Hospital, Aberdeen, United Kingdom." href="#short-view-affiliation-24" ref="linksrc=author_aff">
|
||
24
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Cancrini+C&cauthor_id=27555459"
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ref="linksrc=author_name_link"
|
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data-ga-label="Caterina Cancrini">Caterina Cancrini</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata", Rome, Italy." href="#short-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Palma+P&cauthor_id=27555459"
|
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ref="linksrc=author_name_link"
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data-ga-category="search"
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data-ga-label="Paolo Palma">Paolo Palma</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata", Rome, Italy." href="#short-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Ariganello+P&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-label="Paola Ariganello">Paola Ariganello</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata", Rome, Italy." href="#short-view-affiliation-25" ref="linksrc=author_aff">
|
||
25
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Conlon+N&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Niall Conlon">Niall Conlon</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, School of Medicine, Trinity College, Dublin, and St James's Hospital, Dublin, Ireland." href="#short-view-affiliation-26" ref="linksrc=author_aff">
|
||
26
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Feighery+C&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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data-ga-label="Conleth Feighery">Conleth Feighery</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, School of Medicine, Trinity College, Dublin, and St James's Hospital, Dublin, Ireland." href="#short-view-affiliation-26" ref="linksrc=author_aff">
|
||
26
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Gavin+PJ&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
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data-ga-label="Patrick J Gavin">Patrick J Gavin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital Crumlin, Dublin, Ireland." href="#short-view-affiliation-10" ref="linksrc=author_aff">
|
||
10
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Jones+A&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
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||
data-ga-label="Alison Jones">Alison Jones</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Immunology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom." href="#short-view-affiliation-27" ref="linksrc=author_aff">
|
||
27
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Imai+K&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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||
data-ga-label="Kohsuke Imai">Kohsuke Imai</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Community Pediatrics, Perinatal and Maternal Medicine Tokyo Medical and Dental University (TMDU), Tokyo, Japan." href="#short-view-affiliation-28" ref="linksrc=author_aff">
|
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28
|
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Ibrahim+MA&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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data-ga-label="Mohammad A A Ibrahim">Mohammad A A Ibrahim</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="King's College London, King's Health Partners, King's College Hospital NHS Foundation Trust, School of Medicine, Division of Asthma, Allergy & Lung Biology, Department of Immunological Medicine, London, United Kingdom." href="#short-view-affiliation-29" ref="linksrc=author_aff">
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29
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Markelj+G&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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data-ga-label="Gašper Markelj">Gašper Markelj</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Ljubljana, Slovenia." href="#short-view-affiliation-30" ref="linksrc=author_aff">
|
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30
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Abinun+M&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
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||
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data-ga-label="Mario Abinun">Mario Abinun</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom." href="#short-view-affiliation-31" ref="linksrc=author_aff">
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31
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Rieux-Laucat+F&cauthor_id=27555459"
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||
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||
data-ga-label="Frédéric Rieux-Laucat">Frédéric Rieux-Laucat</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#short-view-affiliation-32" ref="linksrc=author_aff">
|
||
32
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Latour+S&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Sylvain Latour">Sylvain Latour</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#short-view-affiliation-32" ref="linksrc=author_aff">
|
||
32
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Pellier+I&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Isabelle Pellier">Isabelle Pellier</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Unité d'Onco-hémato-immunologie Pédiatrique, CHU Angers, Angers, France; Centre de Référence Déficits Immunitaires Héréditaires, AP-HP, Paris, France; Inserm UMR 892, Angers, France; CNRS UMR 6299, Angers, France." href="#short-view-affiliation-33" ref="linksrc=author_aff">
|
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33
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Fischer+A&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Alain Fischer">Alain Fischer</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Collège de France, Paris, France." href="#short-view-affiliation-34" ref="linksrc=author_aff">
|
||
34
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
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href="/?term=Touzot+F&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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||
data-ga-category="search"
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||
data-ga-label="Fabien Touzot">Fabien Touzot</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Départment de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#short-view-affiliation-35" ref="linksrc=author_aff">
|
||
35
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Casanova+JL&cauthor_id=27555459"
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ref="linksrc=author_name_link"
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data-ga-category="search"
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data-ga-label="Jean-Laurent Casanova">Jean-Laurent Casanova</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Necker Children's Hospital, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY; Howard Hughes Medical Institute, Chevy Chase, Md." href="#short-view-affiliation-36" ref="linksrc=author_aff">
|
||
36
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Durandy+A&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-action="author_link"
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||
data-ga-label="Anne Durandy">Anne Durandy</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#short-view-affiliation-32" ref="linksrc=author_aff">
|
||
32
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Burns+SO&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-action="author_link"
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data-ga-label="Siobhan O Burns">Siobhan O Burns</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="University College London Institute of Immunity and Transplantation, London, United Kingdom." href="#short-view-affiliation-37" ref="linksrc=author_aff">
|
||
37
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</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Savic+S&cauthor_id=27555459"
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||
ref="linksrc=author_name_link"
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||
data-ga-category="search"
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data-ga-action="author_link"
|
||
data-ga-label="Sinisa Savic">Sinisa Savic</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom." href="#short-view-affiliation-38" ref="linksrc=author_aff">
|
||
38
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Kumararatne+DS&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="D S Kumararatne">D S Kumararatne</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom." href="#short-view-affiliation-39" ref="linksrc=author_aff">
|
||
39
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Moshous+D&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Despina Moshous">Despina Moshous</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France." href="#short-view-affiliation-40" ref="linksrc=author_aff">
|
||
40
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Kracker+S&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Sven Kracker">Sven Kracker</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France." href="#short-view-affiliation-32" ref="linksrc=author_aff">
|
||
32
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Vanhaesebroeck+B&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Bart Vanhaesebroeck">Bart Vanhaesebroeck</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="UCL Cancer Institute, University College London, London, United Kingdom." href="#short-view-affiliation-41" ref="linksrc=author_aff">
|
||
41
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Okkenhaug+K&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Klaus Okkenhaug">Klaus Okkenhaug</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Lymphocyte Signalling & Development, Babraham Institute, Cambridge, United Kingdom." href="#short-view-affiliation-42" ref="linksrc=author_aff">
|
||
42
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Picard+C&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Capucine Picard">Capucine Picard</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Centre de Référence Déficits Immunitaires Héréditaires, AP-HP, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Necker Children's Hospital, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY." href="#short-view-affiliation-43" ref="linksrc=author_aff">
|
||
43
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Nejentsev+S&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Sergey Nejentsev">Sergey Nejentsev</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of Cambridge, Cambridge, United Kingdom." href="#short-view-affiliation-5" ref="linksrc=author_aff">
|
||
5
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Condliffe+AM&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Alison M Condliffe">Alison M Condliffe</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom. Electronic address: a.m.condliffe@sheffield.ac.uk." href="#short-view-affiliation-44" ref="linksrc=author_aff">
|
||
44
|
||
</a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name"
|
||
href="/?term=Cant+AJ&cauthor_id=27555459"
|
||
ref="linksrc=author_name_link"
|
||
data-ga-category="search"
|
||
data-ga-action="author_link"
|
||
data-ga-label="Andrew James Cant">Andrew James Cant</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom." href="#short-view-affiliation-31" ref="linksrc=author_aff">
|
||
31
|
||
</a></sup></span>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="affiliations">
|
||
<h3 class="title">
|
||
Affiliations
|
||
</h3>
|
||
<ul class="item-list">
|
||
|
||
<li data-affiliation-id="short-view-affiliation-1"
|
||
id="short-view-affiliation-1"
|
||
><sup class="key">1</sup> Department of Immunology, School of Medicine, Trinity College, Dublin, and St James's Hospital, Dublin, Ireland; Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-2"
|
||
id="short-view-affiliation-2"
|
||
><sup class="key">2</sup> Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom; Lymphocyte Signalling & Development, Babraham Institute, Cambridge, United Kingdom; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-3"
|
||
id="short-view-affiliation-3"
|
||
><sup class="key">3</sup> Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom; Northern England Haemato-Oncology Diagnostic Service, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-4"
|
||
id="short-view-affiliation-4"
|
||
><sup class="key">4</sup> Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-5"
|
||
id="short-view-affiliation-5"
|
||
><sup class="key">5</sup> Department of Medicine, University of Cambridge, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-6"
|
||
id="short-view-affiliation-6"
|
||
><sup class="key">6</sup> Department of Radiology, Papworth Hospital NHS Foundation Trust, Papworth Everard Hospital, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-7"
|
||
id="short-view-affiliation-7"
|
||
><sup class="key">7</sup> Department of Pathology, Western General Hospital, Edinburgh, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-8"
|
||
id="short-view-affiliation-8"
|
||
><sup class="key">8</sup> Raigmore Hospital, Inverness, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-9"
|
||
id="short-view-affiliation-9"
|
||
><sup class="key">9</sup> Regional Immunology Service, The Royal Hospitals, Belfast, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-10"
|
||
id="short-view-affiliation-10"
|
||
><sup class="key">10</sup> Department of Paediatric Immunology and Infectious Diseases, Our Lady's Children's Hospital Crumlin, Dublin, Ireland.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-11"
|
||
id="short-view-affiliation-11"
|
||
><sup class="key">11</sup> Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom; National Institute for Health Research, Cambridge Biomedical Research Centre, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-12"
|
||
id="short-view-affiliation-12"
|
||
><sup class="key">12</sup> Papworth Hospital NHS trust, Papworth Everard, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-13"
|
||
id="short-view-affiliation-13"
|
||
><sup class="key">13</sup> Department of Infectious Disease and Immunology, University Hospitals Bristol NHS Foundation Trust, Bristol Royal Hospital for Children, Bristol, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-14"
|
||
id="short-view-affiliation-14"
|
||
><sup class="key">14</sup> Barts Health NHS Trust, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-15"
|
||
id="short-view-affiliation-15"
|
||
><sup class="key">15</sup> Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-16"
|
||
id="short-view-affiliation-16"
|
||
><sup class="key">16</sup> Center for Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany; Department of Pediatrics and Adolescent Medicine, University Medical Center, Freiburg, Germany.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-17"
|
||
id="short-view-affiliation-17"
|
||
><sup class="key">17</sup> Institute of Immunology, University Hospital Motol, Prague, Czech Republic.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-18"
|
||
id="short-view-affiliation-18"
|
||
><sup class="key">18</sup> Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, United Kingdom; NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-19"
|
||
id="short-view-affiliation-19"
|
||
><sup class="key">19</sup> Faculty of Medicine and Institute of Life Sciences, University of Southampton, Southampton, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-20"
|
||
id="short-view-affiliation-20"
|
||
><sup class="key">20</sup> Department of Immunology, Epsom & St Helier University Hospitals NHS Trust, Surrey, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-21"
|
||
id="short-view-affiliation-21"
|
||
><sup class="key">21</sup> Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-22"
|
||
id="short-view-affiliation-22"
|
||
><sup class="key">22</sup> Department of Royal Hospital for Children, Glasgow, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-23"
|
||
id="short-view-affiliation-23"
|
||
><sup class="key">23</sup> Department of Pathology, Queen Elizabeth University Hospital, Glasgow, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-24"
|
||
id="short-view-affiliation-24"
|
||
><sup class="key">24</sup> Royal Aberdeen Childrens' Hospital, Aberdeen, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-25"
|
||
id="short-view-affiliation-25"
|
||
><sup class="key">25</sup> Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata", Rome, Italy.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-26"
|
||
id="short-view-affiliation-26"
|
||
><sup class="key">26</sup> Department of Immunology, School of Medicine, Trinity College, Dublin, and St James's Hospital, Dublin, Ireland.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-27"
|
||
id="short-view-affiliation-27"
|
||
><sup class="key">27</sup> Department of Immunology, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-28"
|
||
id="short-view-affiliation-28"
|
||
><sup class="key">28</sup> Department of Community Pediatrics, Perinatal and Maternal Medicine Tokyo Medical and Dental University (TMDU), Tokyo, Japan.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-29"
|
||
id="short-view-affiliation-29"
|
||
><sup class="key">29</sup> King's College London, King's Health Partners, King's College Hospital NHS Foundation Trust, School of Medicine, Division of Asthma, Allergy & Lung Biology, Department of Immunological Medicine, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-30"
|
||
id="short-view-affiliation-30"
|
||
><sup class="key">30</sup> Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Center, Ljubljana, Slovenia.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-31"
|
||
id="short-view-affiliation-31"
|
||
><sup class="key">31</sup> Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-32"
|
||
id="short-view-affiliation-32"
|
||
><sup class="key">32</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-33"
|
||
id="short-view-affiliation-33"
|
||
><sup class="key">33</sup> Unité d'Onco-hémato-immunologie Pédiatrique, CHU Angers, Angers, France; Centre de Référence Déficits Immunitaires Héréditaires, AP-HP, Paris, France; Inserm UMR 892, Angers, France; CNRS UMR 6299, Angers, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-34"
|
||
id="short-view-affiliation-34"
|
||
><sup class="key">34</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Collège de France, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-35"
|
||
id="short-view-affiliation-35"
|
||
><sup class="key">35</sup> Départment de Biothérapie, Centre d'Investigation Clinique intégré en Biothérapies, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-36"
|
||
id="short-view-affiliation-36"
|
||
><sup class="key">36</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Necker Children's Hospital, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY; Howard Hughes Medical Institute, Chevy Chase, Md.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-37"
|
||
id="short-view-affiliation-37"
|
||
><sup class="key">37</sup> University College London Institute of Immunity and Transplantation, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-38"
|
||
id="short-view-affiliation-38"
|
||
><sup class="key">38</sup> Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-39"
|
||
id="short-view-affiliation-39"
|
||
><sup class="key">39</sup> Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-40"
|
||
id="short-view-affiliation-40"
|
||
><sup class="key">40</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-41"
|
||
id="short-view-affiliation-41"
|
||
><sup class="key">41</sup> UCL Cancer Institute, University College London, London, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-42"
|
||
id="short-view-affiliation-42"
|
||
><sup class="key">42</sup> Lymphocyte Signalling & Development, Babraham Institute, Cambridge, United Kingdom.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-43"
|
||
id="short-view-affiliation-43"
|
||
><sup class="key">43</sup> Université Paris Descartes-Sorbonne Paris Cité, Institut Imagine, Paris, France; INSERM UMR1163, Paris, France; Department of Pediatric Immunology, Hematology and Rheumatology, AP-HP, Necker Children's Hospital, Paris, France; Centre de Référence Déficits Immunitaires Héréditaires, AP-HP, Paris, France; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR1163, Imagine Institute, Necker Children's Hospital, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY.</li>
|
||
|
||
<li data-affiliation-id="short-view-affiliation-44"
|
||
id="short-view-affiliation-44"
|
||
><sup class="key">44</sup> Department of Medicine, University of Cambridge, Cambridge, United Kingdom; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom. Electronic address: a.m.condliffe@sheffield.ac.uk.</li>
|
||
|
||
</ul>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<ul class="identifiers" id="short-view-identifiers">
|
||
|
||
<li>
|
||
<span class="identifier pubmed">
|
||
<span class="id-label">
|
||
|
||
PMID:
|
||
|
||
</span>
|
||
|
||
|
||
<strong class="current-id" title="PubMed ID">27555459</strong>
|
||
|
||
|
||
|
||
</span>
|
||
|
||
</li>
|
||
|
||
<li>
|
||
<span class="identifier pmc">
|
||
<span class="id-label">
|
||
|
||
PMCID:
|
||
|
||
</span>
|
||
|
||
|
||
<a class="id-link"
|
||
target="_blank"
|
||
rel="noopener"
|
||
ref="linksrc=article_id_link&article_id=PMC5292996&id_type=PMC"
|
||
href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5292996/"
|
||
data-ga-category="full_text"
|
||
data-ga-action="PMCID"
|
||
>
|
||
PMC5292996
|
||
</a>
|
||
|
||
|
||
|
||
</span>
|
||
|
||
</li>
|
||
|
||
<li>
|
||
<span class="identifier doi">
|
||
<span class="id-label">
|
||
|
||
DOI:
|
||
|
||
</span>
|
||
|
||
|
||
<a class="id-link"
|
||
target="_blank"
|
||
rel="noopener"
|
||
ref="linksrc=article_id_link&article_id=10.1016/j.jaci.2016.06.021&id_type=DOI"
|
||
href="https://doi.org/10.1016/j.jaci.2016.06.021"
|
||
data-ga-category="full_text"
|
||
data-ga-action="DOI"
|
||
>
|
||
10.1016/j.jaci.2016.06.021
|
||
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<strong class="sub-title">
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Background:
|
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Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in PIK3CD, the gene encoding the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ).
|
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Objective:
|
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</strong>
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We sought to review the clinical, immunologic, histopathologic, and radiologic features of APDS in a large genetically defined international cohort.
|
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<strong class="sub-title">
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Methods:
|
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</strong>
|
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||
We applied a clinical questionnaire and performed review of medical notes, radiology, histopathology, and laboratory investigations of 53 patients with APDS.
|
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</p>
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Results:
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Recurrent sinopulmonary infections (98%) and nonneoplastic lymphoproliferation (75%) were common, often from childhood. Other significant complications included herpesvirus infections (49%), autoinflammatory disease (34%), and lymphoma (13%). Unexpectedly, neurodevelopmental delay occurred in 19% of the cohort, suggesting a role for PI3Kδ in the central nervous system; consistent with this, PI3Kδ is broadly expressed in the developing murine central nervous system. Thoracic imaging revealed high rates of mosaic attenuation (90%) and bronchiectasis (60%). Increased IgM levels (78%), IgG deficiency (43%), and CD4 lymphopenia (84%) were significant immunologic features. No immunologic marker reliably predicted clinical severity, which ranged from asymptomatic to death in early childhood. The majority of patients received immunoglobulin replacement and antibiotic prophylaxis, and 5 patients underwent hematopoietic stem cell transplantation. Five patients died from complications of APDS.
|
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<p>
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<strong class="sub-title">
|
||
Conclusion:
|
||
</strong>
|
||
|
||
APDS is a combined immunodeficiency with multiple clinical manifestations, many with incomplete penetrance and others with variable expressivity. The severity of complications in some patients supports consideration of hematopoietic stem cell transplantation for severe childhood disease. Clinical trials of selective PI3Kδ inhibitors offer new prospects for APDS treatment.
|
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</p>
|
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<p>
|
||
|
||
<strong class="sub-title">
|
||
Keywords:
|
||
</strong>
|
||
|
||
Activated phosphoinositide 3-kinase δ syndrome; PIK3CD gene; bronchiectasis; hematopoietic stem cell transplantation; immunodeficiency; p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency; phosphoinositide 3-kinase inhibitor; phosphoinositide 3-kinase δ.
|
||
</p>
|
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|
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|
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|
||
|
||
</div>
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||
<p class="copyright" id="copyright">
|
||
Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
|
||
</p>
|
||
|
||
|
||
<p class="disclaimer" id="disclaimer">
|
||
<a href="/disclaimer/" target="_blank" data-ga-category="literature_resources"
|
||
data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a>
|
||
</p>
|
||
|
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|
||
|
||
|
||
|
||
|
||
<div class="figures" id="figures">
|
||
<h2 class="title">
|
||
Figures
|
||
</h2>
|
||
|
||
<div class="figures-list" id="slides-container"
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|
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data-figure-id="figE1">
|
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<img class="figure-thumb" itemprop="thumbnail"
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id="article-image-0"
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/a55d6936cf26/fx1.gif"
|
||
alt="Fig E1" />
|
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<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Fig E1 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> EBV-positive diffuse large B-cell lymphoma… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
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|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Fig E1 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> EBV-positive diffuse large B-cell lymphoma in patients with APDS. <i> 1 </i> , A diffuse… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Fig E1
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">EBV-positive diffuse large B-cell lymphoma in patients with APDS. <i>1</i>, A diffuse infiltrate of large atypical lymphoid cells and some atypical plasmacytoid cells was present in the cerebellum. <i>2</i>, Immunohistochemical staining showed large B cells expressing CD20, CD79a, Pax5, and interferon regulatory factor 4 but not Bcl6 or CD10. <i>3</i>, Most neoplastic cells showed positive <i>in situ</i> hybridization for EBV EBER. <i>4</i>, Plasmacytoid cells expressed CD138 and showed λ restricted immunoglobulin light chain <i>in situ</i> hybridization. <i>H&E</i>, Hematoxylin and eosin.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="1"
|
||
data-label-slug="fig-e2">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/5860965c741a/fx2.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-1"
|
||
role="button"
|
||
data-image-width="697"
|
||
data-image-height="611"
|
||
data-image-alt="Fig E2"
|
||
data-pmc-id="PMC5292996"
|
||
data-figure-id="figE2">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-1"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/20f18f641518/fx2.gif"
|
||
alt="Fig E2" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="697">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="611">
|
||
|
||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Fig E2 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Primary cutaneous anaplastic large cell… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Fig E2 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Primary cutaneous anaplastic large cell lymphoma in patients with APDS. <i> 1 </i> and <i> 2… </i> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Fig E2
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Primary cutaneous anaplastic large cell lymphoma in patients with APDS. <i>1</i> and <i>2</i>, A multinodular cutaneous tumor on the chest of an 11-year-old boy (Fig E2, <i>1</i>), which regressed to a flat plaque (Fig E2, <i>2</i>) on 6 weeks of treatment with rapamycin. <i>3</i> and <i>4</i>, The dermis and subcutis contained a diffuse infiltrate of large atypical lymphoid cells. <i>5</i> and <i>6</i>, Immunohistochemical staining showed large T cells expressing CD3 (Fig E2, <i>5</i>), CD30 (Fig E2, <i>6</i>), CD2, interferon regulatory factor 4, T-cell receptor β, and perforin but not CD4, CD8, or ALK. <i>H&E</i>, Hematoxylin and eosin.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
|
||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
|
||
itemprop="associatedMedia"
|
||
data-slide-index="2"
|
||
data-label-slug="fig-1">
|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/5745375fa631/gr1.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-2"
|
||
role="button"
|
||
data-image-width="664"
|
||
data-image-height="495"
|
||
data-image-alt="Fig 1"
|
||
data-pmc-id="PMC5292996"
|
||
data-figure-id="fig1">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-2"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/38b9230c000c/gr1.gif"
|
||
alt="Fig 1" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="664">
|
||
<meta itemprop="height" itemtype="http://schema.org/ImageObject" content="495">
|
||
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||
|
||
<div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true">
|
||
|
||
<div class="caption-wrap">
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Fig 1 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> BCG-induced granulomatous inflammation in patients… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Fig 1 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> BCG-induced granulomatous inflammation in patients with APDS. <i> 1 </i> , Granulomatous skin lesion in… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
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||
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||
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|
||
Fig 1
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">BCG-induced granulomatous inflammation in patients with APDS. <i>1</i>, Granulomatous skin lesion in a 4-year-old at the site of BCG vaccination administered at 4 months of age. <i>2</i>, Skin biopsy specimen showing granulomatous inflammation.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
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||
<figure class="figure-item "
|
||
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|
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|
||
<a class="figure-link"
|
||
href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/cce6dd7df3d3/gr2.jpg"
|
||
itemprop="contentUrl"
|
||
aria-describedby="figure-caption-3"
|
||
role="button"
|
||
data-image-width="797"
|
||
data-image-height="803"
|
||
data-image-alt="Fig 2"
|
||
data-pmc-id="PMC5292996"
|
||
data-figure-id="fig2">
|
||
<img class="figure-thumb" itemprop="thumbnail"
|
||
id="article-image-3"
|
||
src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/aa8766b10823/gr2.gif"
|
||
alt="Fig 2" />
|
||
</a>
|
||
|
||
<meta itemprop="width" itemtype="http://schema.org/ImageObject" content="797">
|
||
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|
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|
||
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||
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||
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||
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|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Fig 2 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Lymphoid hyperplasia. <i> 1 </i> and <i> 2… </i> </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="figure-caption-medium figure-caption-text" aria-hidden="true">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
<p> Fig 2 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Lymphoid hyperplasia. <i> 1 </i> and <i> 2 </i> , Lymph node showing atypical follicular hyperplasia with… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<strong class="figure-label">
|
||
Fig 2
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Lymphoid hyperplasia. <i>1</i> and <i>2</i>, Lymph node showing atypical follicular hyperplasia with disrupted follicles <i>(arrows)</i> and monocytoid B cells <i>(arrowheads)</i>. <i>3-5</i>, Disrupted germinal centers were highlighted by staining for CD20 (Fig 2, <i>3</i> and <i>4</i>) and Bcl6 (Fig 2, <i>5</i>). <i>6</i> and <i>7</i>, Follicles were infiltrated by T cells (Fig 2, <i>6</i>), many of which expressed PD1, CD57, or both (Fig 2, <i>7</i>). <i>8</i>, IgM-positive plasma cells were present, but IgG-positive plasma cells were reduced or absent. <i>9</i>, Several lymph nodes contained CMV or EBV (EBER). <i>10</i>, Tracheal endoscopy showing mucosal nodules. <i>11</i> and <i>12</i>, Lung showing peribronchiolar lymphoid hyperplasia (Fig 2, <i>11</i>) with disrupted follicles (Fig 2, <i>12</i>). <i>H&E</i>, Hematoxylin and eosin.</div>
|
||
|
||
|
||
|
||
|
||
</figcaption>
|
||
|
||
|
||
</figure>
|
||
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||
<figure class="figure-item "
|
||
itemscope itemtype="http://schema.org/ImageObject"
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||
itemprop="associatedMedia"
|
||
data-slide-index="4"
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||
data-label-slug="fig-3">
|
||
<a class="figure-link"
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/a8e2a1b2dc67/gr3.gif"
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<p> Fig 3 </p>
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<div class="figure-caption-contents"><p> p110δ expression in the mouse… </p></div>
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<p> Fig 3 </p>
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</strong>
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<div class="figure-caption-contents"><p> p110δ expression in the mouse brain. Brain sections of adult wild-type (−lacZ cassette)… </p></div>
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Fig 3
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</strong>
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<div class="figure-caption-contents">p110δ expression in the mouse brain. Brain sections of adult wild-type (−lacZ cassette) mice <i>(1)</i> and p110 d kinase dead (+lacZ cassette) β-gal reporter mice16 <i>(2)</i> stained with the neuronal stain cresyl violet <i>(purple)</i> and X-gal <i>(blue)</i> representing p110δ expression. Strong expression of p110δ was observed in areas of the hippocampus, cerebral cortex, and thalamus.</div>
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src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/139d/5292996/850f35c61f53/gr4.gif"
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<strong class="figure-label">
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<p> Fig 4 </p>
|
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<div class="figure-caption-contents"><p> Radiology of patients with APDS.… </p></div>
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<strong class="figure-label">
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<p> Fig 4 </p>
|
||
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<div class="figure-caption-contents"><p> Radiology of patients with APDS. <i> 1 </i> , CT scan of the chest (2-year-old… </p></div>
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Fig 4
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Radiology of patients with APDS. <i>1</i>, CT scan of the chest (2-year-old boy), demonstrating right paratracheal lymphadenopathy <i>(A)</i>, right upper lobe consolidation, and centrilobular nodules <i>(B)</i>, progressing 2 years later to severe right upper lobe bronchiectasis <i>(C)</i>. <i>2</i>, CT scan of the chest <i>(A-C)</i> in a 7-year-old boy reveals widespread mosaic attenuation (indicative of small airways disease), mild right upper lobe bronchiectasis <i>(A)</i> and atelectasis (<i>B</i>, <i>black arrows</i>). <i>3</i>, CT scan of the chest <i>(A)</i>, abdomen <i>(B)</i>, and pelvis <i>(C)</i> of an 8-year-old boy showing axillary, paratracheal, para-aortic <i>(black arrow)</i>, mesenteric and inguinal lymphadenopathy <i>(white arrows)</i>, and splenomegaly.</div>
|
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data-image-width="650"
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data-image-height="372"
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data-image-alt="Fig 5"
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<p> Fig 5 </p>
|
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<div class="figure-caption-contents"><p> Age-related changes in B-cell counts… </p></div>
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<p> Fig 5 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Age-related changes in B-cell counts in patients with APDS. Age-related median B-cell count… </p></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
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|
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<figcaption id="figure-caption-6" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
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<strong class="figure-label">
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Fig 5
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Age-related changes in B-cell counts in patients with APDS. Age-related median B-cell count <i>(white dots)</i>, B-cell count 5th to 95th percentile normal range <i>(checked area)</i>, and less than 5th percentile normal B-cell count <i>(spotted area)</i> were plotted.</div>
|
||
|
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data-image-width="790"
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data-image-height="194"
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data-image-alt="Fig 6"
|
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|
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data-figure-id="fig6">
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|
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<strong class="figure-label">
|
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<p> Fig 6 </p>
|
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|
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|
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|
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|
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<div class="figure-caption-contents"><p> Variation in clinical phenotypes of… </p></div>
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|
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<strong class="figure-label">
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<p> Fig 6 </p>
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents"><p> Variation in clinical phenotypes of APDS. Each <i> column </i> represents a patient with APDS.… </p></div>
|
||
|
||
|
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<figcaption id="figure-caption-7" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description">
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<strong class="figure-label">
|
||
Fig 6
|
||
</strong>
|
||
|
||
|
||
|
||
<div class="figure-caption-contents">Variation in clinical phenotypes of APDS. Each <i>column</i> represents a patient with APDS. Each <i>row</i> represents a frequent or serious complication of APDS. <i>White boxes</i> and <i>gray boxes</i> depict the absence or presence of a complication, respectively.</div>
|
||
|
||
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||
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||
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</figcaption>
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Chantry D., Vojtek A., Kashishian A., Holtzman D.A., Wood C., Gray P.W. p110δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem. 1997;272:19236–19241.
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Kok K., Geering B., Vanhaesebroeck B. Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem Sci. 2009;34:115–127.
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Cohort Studies
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Herpesviridae Infections / therapy
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
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Immunologic Deficiency Syndromes / genetics*
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Immunologic Deficiency Syndromes / mortality
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Immunologic Deficiency Syndromes / therapy
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aria-label="Dropdown menu for keyword Immunologic Deficiency Syndromes / therapy"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Immunologic+Deficiency+Syndromes%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Immunologic+Deficiency+Syndromes%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-search-term=""Immunologic Deficiency Syndromes/therapy"[MeSH]"
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data-ga-label=""Immunologic Deficiency Syndromes/therapy"[MeSH]"
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Infant"
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aria-expanded="false"
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|
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Infant
|
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</button><div id="keyword-actions-mesh-terms-20"
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class="keyword-actions-dropdown dropdown dropdown-container"
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|
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aria-label="Dropdown menu for keyword Infant"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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data-href="/?term=%22Infant%22%5BMeSH%5D&sort=date&sort_order=desc"
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International Cooperation
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aria-label="Dropdown menu for keyword International Cooperation"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22International+Cooperation%22%5BMeSH%5D&sort=date&sort_order=desc"
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
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aria-label="Toggle dropdown menu for keyword Lymphoproliferative Disorders / genetics*"
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Lymphoproliferative Disorders / genetics*
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aria-label="Dropdown menu for keyword Lymphoproliferative Disorders / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Lymphoproliferative+Disorders%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Lymphoproliferative+Disorders%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc"
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Lymphoproliferative Disorders / mortality
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hidden
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aria-label="Dropdown menu for keyword Lymphoproliferative Disorders / mortality"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Lymphoproliferative+Disorders%2Fmortality%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Lymphoproliferative+Disorders%2Fmortality%22%5BMeSH%5D&sort=date&sort_order=desc"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Lymphoproliferative Disorders/mortality"[MeSH]"
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data-ga-category="search"
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data-ga-action="add_to_search"
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data-ga-label=""Lymphoproliferative Disorders/mortality"[MeSH]"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Lymphoproliferative Disorders / therapy"
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aria-expanded="false"
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data-pinger-ignore>
|
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Lymphoproliferative Disorders / therapy
|
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword Lymphoproliferative Disorders / therapy"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Lymphoproliferative+Disorders%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Lymphoproliferative+Disorders%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc"
|
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Lymphoproliferative Disorders/therapy"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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Search in MeSH
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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role="button"
|
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data-search-term=""Lymphoproliferative Disorders/therapy"[MeSH]"
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data-ga-category="search"
|
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data-ga-action="add_to_search"
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data-ga-label=""Lymphoproliferative Disorders/therapy"[MeSH]"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Male"
|
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tabindex="0"
|
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|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Male
|
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</button><div id="keyword-actions-mesh-terms-25"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Male"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Male"[MeSH]"
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Search in PubMed
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Search in MeSH
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data-search-term=""Male"[MeSH]"
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data-ga-category="search"
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|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
|
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aria-label="Toggle dropdown menu for keyword Mice"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-26"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Mice
|
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</button><div id="keyword-actions-mesh-terms-26"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Mice"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Mice%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mice"[MeSH]"
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data-search-term=""Mice"[MeSH]"
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data-ga-category="search"
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|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Middle Aged"
|
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tabindex="0"
|
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aria-expanded="false"
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data-pinger-ignore>
|
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Middle Aged
|
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</button><div id="keyword-actions-mesh-terms-27"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Middle Aged"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Middle Aged"[MeSH]"
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Search in PubMed
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</a></li><li><a class="search-in-mesh-link dropdown-block-link"
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|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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data-search-term=""Middle Aged"[MeSH]"
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data-ga-category="search"
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href="#">
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
|
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aria-label="Toggle dropdown menu for keyword Mutation / genetics*"
|
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tabindex="0"
|
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aria-controls="keyword-actions-mesh-terms-major-28"
|
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aria-expanded="false"
|
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data-pinger-ignore>
|
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Mutation / genetics*
|
||
</button><div id="keyword-actions-mesh-terms-major-28"
|
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class="keyword-actions-dropdown dropdown dropdown-container"
|
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hidden
|
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aria-label="Dropdown menu for keyword Mutation / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Mutation%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc"
|
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data-href="/?term=%22Mutation%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Mutation/genetics"[MAJR]"
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Search in MeSH
|
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</a></li><li><a class="add-to-search-link dropdown-block-link"
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Recurrence"
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aria-expanded="false"
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Recurrence
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</button><div id="keyword-actions-mesh-terms-29"
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class="keyword-actions-dropdown dropdown dropdown-container"
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aria-label="Dropdown menu for keyword Recurrence"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Recurrence%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Recurrence%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Recurrence"[MeSH]"
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major"
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Respiratory Tract Infections / genetics*
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</button><div id="keyword-actions-mesh-terms-major-30"
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aria-label="Dropdown menu for keyword Respiratory Tract Infections / genetics*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Respiratory+Tract+Infections%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Respiratory+Tract+Infections%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc"
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Respiratory Tract Infections / mortality
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Respiratory Tract Infections / therapy
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hidden
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aria-label="Dropdown menu for keyword Respiratory Tract Infections / therapy"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
|
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href="/?term=%22Respiratory+Tract+Infections%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Respiratory+Tract+Infections%2Ftherapy%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Respiratory Tract Infections/therapy"[MeSH]"
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Search in PubMed
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Surveys and Questionnaires"
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aria-expanded="false"
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data-pinger-ignore>
|
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Surveys and Questionnaires
|
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</button><div id="keyword-actions-mesh-terms-33"
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hidden
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aria-label="Dropdown menu for keyword Surveys and Questionnaires"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Surveys+and+Questionnaires%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Surveys+and+Questionnaires%22%5BMeSH%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&mesh="Surveys and Questionnaires"[MeSH]"
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Search in PubMed
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Add to Search
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Survival Analysis"
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aria-expanded="false"
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|
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Survival Analysis
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</button><div id="keyword-actions-mesh-terms-34"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
|
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aria-label="Dropdown menu for keyword Survival Analysis"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Survival+Analysis%22%5BMeSH%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Survival+Analysis%22%5BMeSH%5D&sort=date&sort_order=desc"
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Add to Search
|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Young Adult"
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Young Adult
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</button><div id="keyword-actions-mesh-terms-35"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword Young Adult"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Young+Adult%22%5BMeSH%5D&sort=date&sort_order=desc"
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</a></li></ul></div></div></div></li></ul>
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</div>
|
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|
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|
||
|
||
|
||
|
||
<div id="substances" class="substances keywords-section">
|
||
<h2 class="title">
|
||
Substances
|
||
</h2>
|
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|
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<ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-label="Toggle dropdown menu for keyword Enzyme Inhibitors"
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tabindex="0"
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Enzyme Inhibitors
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</button><div id="keyword-actions-substances-0"
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class="keyword-actions-dropdown dropdown dropdown-container"
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hidden
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aria-label="Dropdown menu for keyword Enzyme Inhibitors"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link"
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href="/?term=%22Enzyme+Inhibitors%22%5Bnm%5D&sort=date&sort_order=desc"
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data-href="/?term=%22Enzyme+Inhibitors%22%5Bnm%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Enzyme Inhibitors"[nm]"
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Search in PubMed
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|
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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aria-expanded="false"
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data-pinger-ignore>
|
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Immunoglobulins, Intravenous
|
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hidden
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data-href="/?term=%22Immunoglobulins%2C+Intravenous%22%5Bnm%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Immunoglobulins, Intravenous"[nm]"
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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link"
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Class I Phosphatidylinositol 3-Kinases
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data-href="/?term=%22Class+I+Phosphatidylinositol+3-Kinases%22%5Bnm%5D&sort=date&sort_order=desc"
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ref="linksrc=search_in_pubmed_keyword_link&keyword="Class I Phosphatidylinositol 3-Kinases"[nm]"
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