85 lines
52 KiB
HTML
85 lines
52 KiB
HTML
<!DOCTYPE html>
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/*# sourceURL=/css/ampshared.css*/</style><meta property="og:locale" content="en_US"><meta property="og:type" content="article"><meta property="og:title" content="Now Available! Compare NCBI RefSeq and UniProt Datasets - NCBI Insights"><meta property="og:description" content="Do you need to compare and combine data based on NCBI RefSeq and UniProt datasets, and aren’t sure which proteins are comparable? For many years, NCBI Gene has provided information about the relationships between RefSeq and UniProt accessions courtesy of data imported from UniProt, but the tremendous growth of both datasets has led to large … Continue reading Now Available! Compare NCBI RefSeq and UniProt Datasets →"><meta property="og:url" content="https://ncbiinsights.ncbi.nlm.nih.gov/2023/11/08/compare-ncbi-refseq-and-uniprot-datasets/"><meta property="og:site_name" content="NCBI Insights"><meta property="article:publisher" content="https://www.facebook.com/ncbi.nlm"><meta property="article:published_time" content="2023-11-08T15:59:29+00:00"><meta property="og:image" content="https://ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2023/11/RefSeq_UniProt-1-e1699455671697.png"><meta property="og:image:width" content="1100"><meta property="og:image:height" content="575"><meta property="og:image:type" content="image/png"><meta name="author" content="NCBI Staff"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:creator" content="@NCBI"><meta name="twitter:site" content="@NCBI"><meta name="twitter:label1" content="Written by"><meta name="twitter:data1" content="NCBI Staff"><meta name="twitter:label2" content="Est. reading 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<h1 class="amp-wp-title">Now Available! Compare NCBI RefSeq and UniProt Datasets</h1>
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<amp-img width="1024" height="535" src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2023/11/RefSeq_UniProt-1-e1699455671697.png?fit=1024%2C535&ssl=1" class="attachment-large size-large wp-post-image amp-wp-enforced-sizes i-amphtml-layout-intrinsic i-amphtml-layout-size-defined" alt="Screenshot of NCBI webpage. Text says: Now available! Compare NCBI RefSeq and UniProt Datasets." data-hero-candidate="" layout="intrinsic" data-hero i-amphtml-ssr i-amphtml-layout="intrinsic"><i-amphtml-sizer slot="i-amphtml-svc" class="i-amphtml-sizer"><img alt="" aria-hidden="true" class="i-amphtml-intrinsic-sizer" role="presentation" src="data:image/svg+xml;base64,PHN2ZyBoZWlnaHQ9IjUzNSIgd2lkdGg9IjEwMjQiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyIgdmVyc2lvbj0iMS4xIi8+"></i-amphtml-sizer><img class="i-amphtml-fill-content i-amphtml-replaced-content" decoding="async" loading="lazy" alt="Screenshot of NCBI webpage. Text says: Now available! Compare NCBI RefSeq and UniProt Datasets." src="https://i0.wp.com/ncbiinsights.ncbi.nlm.nih.gov/wp-content/uploads/2023/11/RefSeq_UniProt-1-e1699455671697.png?fit=1024%2C535&ssl=1"></amp-img> </figure>
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<p><span data-contrast="auto">Do you need to compare and combine data based on </span><a href="https://www.ncbi.nlm.nih.gov/refseq/?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-uniprot-20231108"><span data-contrast="none">NCBI RefSeq</span></a><span data-contrast="auto"> and </span><a href="https://www.uniprot.org/"><span data-contrast="none">UniProt</span></a><span data-contrast="auto"> datasets, and aren’t sure which proteins are comparable? For many years, </span><a href="https://www.ncbi.nlm.nih.gov/gene?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-uniprot-20231108"><span data-contrast="none">NCBI Gene</span></a><span data-contrast="auto"> has provided information about the relationships between RefSeq and UniProt accessions courtesy of data imported from UniProt, but the tremendous growth of both datasets has led to large gaps in the data. We have developed a new process to compare the two datasets, first looking for 100% identical proteins and then checking the remaining sequences for similar matches in related taxa. The result is mapping information now covering over 170 million RefSeq proteins across the tree of life.</span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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<p><span data-contrast="auto">You can find links to related UniProt accessions on individual </span><a href="https://www.ncbi.nlm.nih.gov/gene/101688006?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-uniprot-20231108#reference-sequences"><span data-contrast="none">NCBI Gene records</span></a><span data-contrast="auto">. The entire dataset is available on our </span><a href="https://ftp.ncbi.nlm.nih.gov/gene/DATA/"><span data-contrast="none">FTP site</span></a><span data-contrast="auto">. </span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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<h5><b><span data-contrast="none">Stay up to date</span></b><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":240}'> </span></h5>
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<p><span data-contrast="none">This update was done as part of the </span><a href="https://www.ncbi.nlm.nih.gov/comparative-genomics-resource?utm_source=ncbi_insights&utm_medium=referral&utm_campaign=refseq-uniprot-20231108"><span data-contrast="none">NIH Comparative Genomics Resource (CGR)</span></a><span data-contrast="none">. CGR facilitates reliable comparative genomics analyses for all eukaryotic organisms through an NCBI Toolkit and community collaboration. </span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":240}'> </span></p>
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<p><span data-contrast="auto">This data was produced to maximize the reach of genomic data and enable better data exchange between community resources. We’ll be exploring ways to leverage these relationships as well similar mappings between NCBI RefSeq and </span><a href="https://ftp.ncbi.nlm.nih.gov/gene/DATA/gene2ensembl.gz"><span data-contrast="none">Ensembl</span></a><span data-contrast="auto">. These efforts will help interconnect data across the global research community.</span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559740":240}'> </span></p>
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<p><a href="https://public.govdelivery.com/accounts/USNLMOCPL/subscriber/new?topic_id=USNLMOCPL_50%22"><span data-contrast="none">Join our mailing list</span></a><span data-contrast="none"> to keep up to date with RefSeq and other CGR news.</span><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":240}'> </span></p>
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<h5><b><span data-contrast="none">Questions?</span></b><span data-ccp-props='{"134233117":true,"134233118":true,"201341983":0,"335559739":160,"335559740":240}'> </span></h5>
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