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<h1>Tissue Chip for Drug Screening</h1>
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The Tissue Chip for Drug Screening program aims to develop bioengineered devices to improve the process of predicting whether drugs will be safe or toxic in humans.
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<a href="/research/research-activities/tissue-chip/faq" class="first" data-drupal-link-system-path="node/27778">Frequently Asked Questions</a>
|
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</li>
|
||
<li>
|
||
<a href="/research/research-activities/tissue-chip/meet-chip" data-drupal-link-system-path="node/27769">Meet Chip</a>
|
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</li>
|
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<li>
|
||
<a href="/research/research-activities/tissue-chip/collaborations" data-drupal-link-system-path="node/27812">Program Collaborations and Partnerships</a>
|
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</li>
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<li>
|
||
<a href="/research/research-activities/tissue-chip/projects" data-drupal-link-system-path="node/27737">Projects & Initiatives</a>
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</li>
|
||
<li class="last">
|
||
<a href="/research/research-activities/tissue-chip/templates" class="last" data-drupal-link-system-path="node/27766">Tissue Chip Template Agreements</a>
|
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</li>
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</div>
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<div class="container news-content Advancing">
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<h2 class="section-heading">Tissue Chip Overview</h2>
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</style><div class="contact-and-image-box"><div class="contact-box"><h4>Contact</h4><p><a href="mailto:Danilo.Tagle@nih.gov"><u>Danilo Tagle, Ph.D.</u></a></p><hr><p><a href="/sites/default/files/2024-02/NCATS-2023-3D-Tissue-Models-Fact-Sheet-508.pdf">View the 3-D Tissue Models fact sheet</a> (PDF - 222KB)</p></div><div class="image-box"><p><img class="img-responsive" src="/sites/default/files/inline-images/Chip1.jpg" data-entity-uuid="5bbf60c7-007f-4431-820e-199632388414" data-entity-type="file" width="205" height="137"></p></div></div><p>Many promising medications have failed to be safe and effective in human clinical trials despite promising preclinical studies. We are addressing this problem through the Tissue Chip for Drug Screening program. We coordinate with other <a href="https://www.nih.gov/institutes-nih">NIH institutes and centers</a> and the <a href="http://www.fda.gov/">U.S. Food and Drug Administration (FDA)</a>.</p><p>Tissue chips are built from human cells. Also called organs-on-chips, they mimic the structure and function of our heart, kidneys, lungs and other organ systems. Scientists are developing and using tissue chips to test the potential effects of drugs on those tissues in a faster and more effective way than current methods. <a href="/research/research-activities/tissue-chip/projects">Learn more about these projects</a>.</p><p>With flexible funding from the <a href="/about/advisory-committees/can">Cures Acceleration Network</a>, we focus on developing high-need cures and reducing major barriers between research discovery and clinical trials. Our Tissue Chip for Drug Screening program aims to speed the translation of basic discoveries into the clinic. By creating an <a href="/research/research-activities/tissue-chip/meet-chip">integrated human body-on-a-chip</a>, researchers will be able to test the possible effects of a drug or other substance across the entire body before testing in people.</p><p>Because they use human cells, tissue chips are also useful research tools to study human diseases and conditions when animal models do not mirror the pathology or are unavailable. They support <a href="https://grants.nih.gov/grants/policy/air/alternatives">NIH’s position</a> that non-animal model approaches can reduce the need for animals in research but will require further improvement to completely replace them.</p>
|
||
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||
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||
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<hr class="section-divider">
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</div>
|
||
</section>
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
<h2 class="section-heading"> Tissue Chip News</h2>
|
||
|
||
|
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<div class="paragraph paragraph--type--view paragraph--view-mode--default">
|
||
|
||
|
||
<div class="views-element-container"><div class="row col js-view-dom-id-618dffd0c0d1ffa21fab2a4ef66eb0481970e71c8e8bd936252d72691d65dbb8">
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<div class="views-element-container"><div class="row col js-view-dom-id-4a1f89dd76d1d81eea1dd24c8309173e0be97ba5f6e0430edffb70be41940910">
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<div class="row">
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<div class="col-md-4 col-lg-2">
|
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||
|
||
<img loading="lazy" src="/sites/default/files/styles/media_library/public/image_1.png?itok=ZCyal1a4" width="220" height="113" alt="A normal liver (left) and a diseased liver (right) " />
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="col-md-8 col-lg-10">
|
||
<h3 class="title">NIH-Funded Centers Look to Make Tissue Chips FDA-Ready Tools</h3>
|
||
<p class="m-0"><i>July 25, 2024 - NCATS News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Tissue Chip for Drug Screening</i></li>
|
||
</ul>
|
||
|
||
|
||
<p><span class="ui-provider a b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">New centers are strengthening the use of tissue chip technology to develop drugs and potentially reduce the need for animals in rese</span></p>
|
||
|
||
<a href="https://ncats.nih.gov/news-events/news/nih-funded-centers-look-to-make-tissue-chips-fda-ready">Read Article</a>
|
||
</div>
|
||
</div>
|
||
</div></div>
|
||
|
||
|
||
|
||
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||
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||
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||
</div>
|
||
</div>
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||
|
||
<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
|
||
<div class="usa-card__body">
|
||
<h3 class="title">Warp Drive: Conducting Experiments in Space Allows Speedy Results</h3>
|
||
<p class="m-0"><i>October 3, 2024 - Media Coverage</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Tissue Chip for Drug Screening</i></li>
|
||
</ul>
|
||
|
||
</div>
|
||
<div class="usa-card__footer">
|
||
<a href="https://pharmaceutical-journal.com/article/feature/warp-drive-conducting-experiments-in-space-allows-speedy-results">Read Article</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
|
||
<div class="usa-card__body">
|
||
<h3 class="title">EU Roadmap : Key Recommendations, First Roadmap on OoC Devices, Awards to Non-Animal Methods, Artificial Organs Closer to Reality and More</h3>
|
||
<p class="m-0"><i>September 4, 2024 - Grantee/Partner News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Tissue Chip for Drug Screening</i></li>
|
||
</ul>
|
||
|
||
</div>
|
||
<div class="usa-card__footer">
|
||
<a href="https://www.proanima.fr/en/blog/eu-roadmap-key-recommendations/">Read Article</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
|
||
<div class="usa-card__body">
|
||
<h3 class="title">The Beauty of Accelerated Aging: Using Tissue Chips to Explore Age-Related Muscle Loss in Microgravity</h3>
|
||
<p class="m-0"><i>August 29, 2024 - Grantee/Partner News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Tissue Chip for Drug Screening</i></li>
|
||
</ul>
|
||
|
||
</div>
|
||
<div class="usa-card__footer">
|
||
<a href="https://www.issnationallab.org/upward72-uf-malany-sarcopenia/">Read Article</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<div class="text-center button-wrap">
|
||
<button class="buttons btn-1 mt-4"><a href="/news-events/news?program%5B0%5D=Tissue%20Chip%20for%20Drug%20Screening">See More Tissue Chip News</a></button>
|
||
</div>
|
||
|
||
|
||
<hr class="section-divider">
|
||
</div>
|
||
</section>
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
|
||
|
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<div class="row vertical-line two-col">
|
||
<div class="col-xl-6 col-wrap">
|
||
<div class="pe-lg-4 p-0 col">
|
||
|
||
|
||
<div class="paragraph paragraph--type--body-content paragraph--view-mode--default">
|
||
|
||
|
||
<h2>Why Tissue Chips Matter</h2><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed/zVlEr8c-OJk?si=UdpCcRFH1v6WZ-Rm?ecver=1&rel=0"></iframe></div><p>Watch the <a href="https://youtu.be/zVlEr8c-OJk">Tissue Chip for Drug Screening video</a> (video length: 3:49) to learn more about the program. </p>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="col-xl-6 col-wrap">
|
||
<div class="ps-lg-4 p-0 col">
|
||
|
||
|
||
<h2>Tissue Chip Funding </h2>
|
||
<img src="/sites/default/files/2023-09/Forms%20and%20Model%20Agreements_746x370.png" class="w-100 mt-2">
|
||
<div class="description pt-4">
|
||
|
||
<p>Find <a href="/funding/funding-opportunities?keyword=tissue+chip">funding opportunities</a> for the Tissue Chip for Drug Screening program. </p>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
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||
<hr class="section-divider">
|
||
</div>
|
||
</section>
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
<h2 class="section-heading">Related Research</h2>
|
||
|
||
|
||
<div class="row mb-4 three-pic-cards">
|
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<div class="col-xl-4 ps-xl-3 mb-4">
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<div class="card border-0 p-0 radius-10 h-100">
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<div class="row p-20 g-4 align-items-stretch">
|
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<div class="col-xl-12 col-lg-6">
|
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<img src="/sites/default/files/2023-09/SCTL%20Related%20Research%20card_746x370.png" class="img-fluid">
|
||
</div>
|
||
<div class="col-xl-12 col-lg-6">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">Stem Cell Translation Laboratory</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>Our experts develop methods and standards to use stem cell technology (using cells derived from skin<br>or blood) to advance treatment approaches.</p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
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<a href="/research/research-activities/SCTL">Learn More</a>
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</div>
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</div>
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<div class="col-xl-4 ps-xl-3 mb-4">
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<div class="card border-0 p-0 radius-10 h-100">
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<div class="row p-20 g-4 align-items-stretch">
|
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<div class="col-xl-12 col-lg-6">
|
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<img src="/sites/default/files/2023-09/3D%20Bioprinting%20Card%20Related%20Research_746x370.png" class="img-fluid">
|
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</div>
|
||
<div class="col-xl-12 col-lg-6">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">3-D Tissue Bioprinting</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>Our scientists are creating and using 3-D printing techniques to make tissue models that closely resemble the complex structure and organization of our cells.</p>
|
||
|
||
</p>
|
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|
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<div class="card-footer bg-white border-0 p-0">
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<a href="/research/research-activities/bioprinting">Learn More</a>
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<div class="card border-0 p-0 radius-10 h-100">
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<div class="row p-20 g-4 align-items-stretch">
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<div class="col-xl-12 col-lg-6">
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<img src="/sites/default/files/2023-09/Matrix_746x370.png" class="img-fluid">
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</div>
|
||
<div class="col-xl-12 col-lg-6">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">Matrix Combination Screening</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>Our experts use matrix combination screening technology to quickly identify promising drug combinations with the most potential to help patients.</p>
|
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|
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</p>
|
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<a href="/research/research-activities/matrix">Learn More</a>
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