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<li class="first">
|
||
<a href="/research/research-activities/Tox21/assays" class="first" data-drupal-link-system-path="node/27654">Tox21 Assays</a>
|
||
</li>
|
||
<li>
|
||
<a href="/research/research-activities/Tox21/operational-model" data-drupal-link-system-path="node/27643">Tox21 Operational Model</a>
|
||
</li>
|
||
<li>
|
||
<a href="/research/research-activities/Tox21/program-goals" data-drupal-link-system-path="node/27647">Tox21 Program Goals</a>
|
||
</li>
|
||
<li>
|
||
<a href="/research/research-activities/Tox21/projects" data-drupal-link-system-path="node/27625">Tox21 Projects</a>
|
||
</li>
|
||
<li>
|
||
<a href="/research/research-activities/Tox21/scientific-capabilities" data-drupal-link-system-path="node/27626">Tox21 Scientific Capabilities</a>
|
||
</li>
|
||
<li class="last">
|
||
<a href="/research/research-activities/Tox21/work" class="last" data-drupal-link-system-path="node/27627">Work with Tox21</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
</nav>
|
||
|
||
|
||
</div>
|
||
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
<h2 class="section-heading">Tox21 Overview</h2>
|
||
|
||
|
||
<div class="paragraph paragraph--type--body-content paragraph--view-mode--default">
|
||
|
||
|
||
<style>
|
||
.contact-box {
|
||
color: var(--black, #000);
|
||
float: right;
|
||
font-family: Arial;
|
||
font-size: 16px;
|
||
font-style: normal;
|
||
font-weight: 400;
|
||
line-height: 24px; /* 150% */
|
||
background-color: white;
|
||
padding: 30px;
|
||
margin-left: 1em;
|
||
width: 400px;
|
||
height: auto;
|
||
}
|
||
.contact-and-image-box {
|
||
float: right;
|
||
width: 400px;
|
||
height: auto;
|
||
margin-left: 1em;
|
||
margin-bottom: 1em;
|
||
}
|
||
.image-box {
|
||
width: 400px;
|
||
height: auto;
|
||
margin-top: 1em;
|
||
}
|
||
.image-box img {
|
||
width:100%;
|
||
}
|
||
</style><div class="contact-and-image-box"><div class="contact-box"><h4>Contact</h4><p><a href="mailto:anna.rossoshek@nih.gov">Anna Rossoshek</a></p></div><div class="image-box"><p><img src="/sites/default/files/inline-images/Tox21.png" data-entity-uuid="58694326-5406-45d2-a9c2-2b5436340434" data-entity-type="file" width="267" height="140" alt="Four boxes of magnified cells."></p></div></div><p>The Toxicology in the 21st Century (Tox21) program is a federal collaboration among NCATS, the National Toxicology Program at the National Institute of Environmental Health Sciences; the U.S. Environmental Protection Agency; and the U.S. Food and Drug Administration. Tox21 researchers aim to develop better toxicity assessment methods to quickly and efficiently test whether certain chemical compounds have the potential to disrupt processes in the human body that may lead to negative health effects. <a href="/research/research-activities/Tox21/program-goals"><u>Learn more about the goals of the Tox21 program</u></a>.</p><p>Using the center’s high-throughput robotic screening system, NCATS scientists are testing a collection of 10,000 environmental chemicals and approved drugs (called the Tox21 10K library) for their potential to disrupt biological pathways that may result in toxicity. The team prioritizes promising compounds identified from primary screening for further in-depth investigation. <a href="/research/research-activities/Tox21/operational-model"><u>Learn more about how the Tox21 program works</u></a>.</p><h3>Tox21 History</h3><p>Since Tox21 began in 2008, the collaborative research team has developed and validated <em>in vitro</em> cell-based assays (tests) using quantitative high-throughput screening. The researchers have identified, developed, optimized and screened more than 100 assays.</p><p>Tox21 program includes three research phases, structured with guidance from two reports — <a href="https://pubmed.ncbi.nlm.nih.gov/20574894/">Toxicology in the 21st Century: The Role of the National Toxicology Program and Toxicity Testing in the 21st Century: A Vision and a Strategy</a> and <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664816/">The U.S. Federal Tox21 Program: A Strategic and Operational Plan for Continued Leadership</a>.</p>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<hr class="section-divider">
|
||
</div>
|
||
</section>
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
<h2 class="section-heading">Our Team</h2>
|
||
<div class="description">
|
||
|
||
<p>Meet our team.</p>
|
||
</div>
|
||
|
||
|
||
<div class="paragraph paragraph--type--view paragraph--view-mode--default">
|
||
|
||
|
||
<div class="views-element-container"><div class="row staff views-row js-view-dom-id-c03daf17888c5a433eab88b5b72433421948fe3193c5f111ddf41ebf8de1e000">
|
||
|
||
|
||
|
||
|
||
<header>
|
||
|
||
</header>
|
||
|
||
|
||
|
||
|
||
<div class="col-sm-4 mb-4 views-row">
|
||
|
||
|
||
<div class="card staff-card-container">
|
||
<div class="row">
|
||
<div class="col-sm-4 staff-img">
|
||
<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/David-Gerhold_900x1000px.jpg?itok=RhspFuFw" alt="Portrait of David L. Gerhold, Ph.D." />
|
||
|
||
|
||
</div>
|
||
<div class="col-sm-8 staff-text">
|
||
<h6 class="title"><a href="/about/our-staff/gerholddl">David L. Gerhold, Ph.D.</a></h6>
|
||
<p class="position">Leader</p>
|
||
<p class="branch">
|
||
|
||
|
||
</p>
|
||
<p class="mb-1">Division of Preclinical Innovation </p>
|
||
<!--<p class="division"></p>-->
|
||
<p class="email"><a href="mailto:david.gerhold@nih.gov">
|
||
|
||
david.gerhold@nih.gov
|
||
</a></p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-sm-4 mb-4 views-row">
|
||
|
||
|
||
<div class="card staff-card-container">
|
||
<div class="row">
|
||
<div class="col-sm-4 staff-img">
|
||
<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/Ruili-Huang_900x1000px.jpg?itok=iHvuf-i-" alt="Ruili Huang" />
|
||
|
||
|
||
</div>
|
||
<div class="col-sm-8 staff-text">
|
||
<h6 class="title"><a href="/about/our-staff/huangru">Ruili Huang, Ph.D.</a></h6>
|
||
<p class="position">Senior Scientist, Leader (Informatics)</p>
|
||
<p class="branch">
|
||
|
||
|
||
</p>
|
||
<p class="mb-1">Division of Preclinical Innovation </p>
|
||
<!--<p class="division"></p>-->
|
||
<p class="email"><a href="mailto:huangru@mail.nih.gov">
|
||
|
||
huangru@mail.nih.gov
|
||
</a></p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-sm-4 mb-4 views-row">
|
||
|
||
|
||
<div class="card staff-card-container">
|
||
<div class="row">
|
||
<div class="col-sm-4 staff-img">
|
||
<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/rossoshek_900x1000px.jpg?itok=rndnyuLl" alt="Portrait of Anna J. Rossoshek" />
|
||
|
||
|
||
</div>
|
||
<div class="col-sm-8 staff-text">
|
||
<h6 class="title"><a href="/about/our-staff/rossosheka">Anna J. Rossoshek, M.S., M.B.A.</a></h6>
|
||
<p class="position">Head of Quality and Reporting</p>
|
||
<p class="branch">
|
||
|
||
|
||
</p>
|
||
<p class="mb-1">Division of Preclinical Innovation </p>
|
||
<!--<p class="division"></p>-->
|
||
<p class="email"><a href="mailto:rossosheka@mail.nih.gov">
|
||
|
||
rossosheka@mail.nih.gov
|
||
</a></p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-sm-4 mb-4 views-row">
|
||
|
||
|
||
<div class="card staff-card-container">
|
||
<div class="row">
|
||
<div class="col-sm-4 staff-img">
|
||
<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/Tammi-van-Neel_900x1000px.jpg?itok=XK2ryzG1" alt="Portrait of Tammi L. van Neel" />
|
||
|
||
|
||
</div>
|
||
<div class="col-sm-8 staff-text">
|
||
<h6 class="title"><a href="/about/our-staff/vanneeltl">Tammi L. van Neel, Ph.D.</a></h6>
|
||
<p class="position">Intramural Research Training Award Postdoctoral Fellow</p>
|
||
<p class="branch">
|
||
Chemical Genomics Branch
|
||
|
||
</p>
|
||
<p class="mb-1">Division of Preclinical Innovation </p>
|
||
<!--<p class="division"></p>-->
|
||
<p class="email"><a href="mailto:tammi.vanneel@nih.gov">
|
||
|
||
tammi.vanneel@nih.gov
|
||
</a></p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-sm-4 mb-4 views-row">
|
||
|
||
|
||
<div class="card staff-card-container">
|
||
<div class="row">
|
||
<div class="col-sm-4 staff-img">
|
||
<img class="staff-image" src="/sites/default/files/styles/staff/public/staff/Menghang-Xia_900x1000px.jpg?itok=dlRg83tp" alt="Portrait of Menghang Xia" />
|
||
|
||
|
||
</div>
|
||
<div class="col-sm-8 staff-text">
|
||
<h6 class="title"><a href="/about/our-staff/mxia">Menghang Xia, Ph.D.</a></h6>
|
||
<p class="position">Leader (Systems Toxicology)</p>
|
||
<p class="branch">
|
||
Chemical Genomics Branch
|
||
|
||
</p>
|
||
<p class="mb-1">Division of Preclinical Innovation </p>
|
||
<!--<p class="division"></p>-->
|
||
<p class="email"><a href="mailto:mxia@mail.nih.gov">
|
||
|
||
mxia@mail.nih.gov
|
||
</a></p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<hr class="section-divider">
|
||
</div>
|
||
</section>
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
<h2 class="section-heading">Tox21 News</h2>
|
||
|
||
|
||
<div class="paragraph paragraph--type--view paragraph--view-mode--default">
|
||
|
||
|
||
<div class="views-element-container"><div class="row col js-view-dom-id-e6d5c596d843219c6bf56f1547c7e4ad74137cef3f2765390f16689e95f93a64">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="views-element-container"><div class="row col js-view-dom-id-71075909e4f23bd0ad1bbd3deb0d371593f62b0a9e9b844793b5575757363f57">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="mb-4 featured views-row"><div class="featured usa-card__container mb-4 p-4">
|
||
<div class="row">
|
||
<div class="col-md-4 col-lg-2">
|
||
|
||
|
||
<img loading="lazy" src="/sites/default/files/styles/media_library/public/Tox21_Library_900x600.png?itok=77qsxkgf" width="220" height="147" alt="Chemical dispensing unit above test tubes." />
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="col-md-8 col-lg-10">
|
||
<h3 class="title">Comprehensive Testing Confirms Quality of Tox21 Library’s Chemical Compounds</h3>
|
||
<p class="m-0"><i>January 14, 2025 - NCATS News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Assay Development and Screening Technology (ADST)</i></li>
|
||
<li><i>Our Impact on Tools and Technologies</i></li>
|
||
<li><i>Toxicology in the 21st Century (Tox21)</i></li>
|
||
</ul>
|
||
|
||
|
||
<p>NCATS researchers assessed how well the Tox21 library’s chemicals hold up in real-world research conditions to ensure scientifically valid outcomes.</p>
|
||
|
||
<a href="https://ncats.nih.gov/news-events/news/comprehensive-testing-confirms-quality-tox21-librarys-chemical-compounds">Read Article</a>
|
||
</div>
|
||
</div>
|
||
</div></div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
|
||
<div class="usa-card__body">
|
||
<h3 class="title">Tox21 Team Finds Environmental Chemicals That Could Trigger Early Puberty in Girls</h3>
|
||
<p class="m-0"><i>December 9, 2024 - NCATS News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Toxicology in the 21st Century (Tox21)</i></li>
|
||
</ul>
|
||
|
||
|
||
<p>A chemical commonly used in fragranced hygiene products may trigger the onset of premature puberty in girls.</p>
|
||
|
||
</div>
|
||
<div class="usa-card__footer">
|
||
<a href="https://ncats.nih.gov/news-events/news/tox21-team-finds-environmental-chemicals-that-could-trigger-early-puberty-in-girls">Read Article</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
|
||
<div class="usa-card__body">
|
||
<h3 class="title">Early Puberty may be Linked to a Common Chemical Used in Personal Care Products</h3>
|
||
<p class="m-0"><i>September 10, 2024 - NCATS News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Toxicology in the 21st Century (Tox21)</i></li>
|
||
</ul>
|
||
|
||
|
||
<p>The age when girls hit puberty has been falling at an alarming rate for decades, and scientists have struggled to explain why.</p>
|
||
|
||
</div>
|
||
<div class="usa-card__footer">
|
||
<a href="https://www.nbcnews.com/health/womens-health/early-puberty-may-linked-common-chemical-used-personal-care-products-rcna169967">Read Article</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
|
||
<div class="usa-card__body">
|
||
<h3 class="title">Unexpectedly Following a Translational Science Path</h3>
|
||
<p class="m-0"><i>February 22, 2022 - Media Coverage</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Toxicology in the 21st Century (Tox21)</i></li>
|
||
</ul>
|
||
|
||
|
||
<p>NCATS supports several training and career development programs that not only inspire students to become scientists but also help grow the translational science workforce.</p>
|
||
|
||
</div>
|
||
<div class="usa-card__footer">
|
||
<a href="/news-events/news/postbac-program">Read Article</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<div class="text-center button-wrap">
|
||
<button class="buttons btn-1 mt-4"><a href="/news-events/news?program%5B0%5D=Tox21">See More Tox21 News</a></button>
|
||
</div>
|
||
|
||
|
||
<hr class="section-divider">
|
||
</div>
|
||
</section>
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
|
||
|
||
<div class="row vertical-line two-col">
|
||
<div class="col-xl-6 col-wrap">
|
||
<div class="pe-lg-4 p-0 col">
|
||
|
||
|
||
<h2>Tox21 ASR Video 2021 Lab Tour</h2>
|
||
<div class="description pt-4">
|
||
|
||
<div style="height:0;margin-top:-15px;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed/23gTe3-cXWg?si=dfjqSI50Wc0iUy4L?ecver=1&rel=0"></iframe></div><p style="padding-top:1.5rem;">This video briefly describes the instruments and analytical methods used in the Tox21 Program at NCATS to further toxicological testing.</p>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="col-xl-6 col-wrap">
|
||
<div class="ps-lg-4 p-0 col">
|
||
|
||
|
||
<h2>Work With Us</h2>
|
||
<img src="/sites/default/files/2024-11/Tox21_work-with-us_612x344.jpg" class="w-100 mt-2">
|
||
<div class="description pt-4">
|
||
|
||
<p>Tox21 currently is accepting assay proposals from investigators in all areas, both within and outside NIH and the federal government. <a href="/research/research-activities/Tox21/work-with-tox21">Follow the instructions provided to nominate an assay</a>.</p>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<hr class="section-divider">
|
||
</div>
|
||
</section>
|
||
<section>
|
||
<div class="container news-content Advancing">
|
||
<h2 class="section-heading">More About the Program</h2>
|
||
|
||
|
||
<div class="row mb-4 three-pic-cards">
|
||
|
||
|
||
<div class="col-xl-4 ps-xl-3 mb-4">
|
||
<div class="card border-0 p-0 radius-10 h-100">
|
||
<div class="row p-20 g-4 align-items-stretch">
|
||
<div class="col-xl-12 col-lg-6">
|
||
<img src="/sites/default/files/2023-09/Tox21-4.jpg" class="img-fluid">
|
||
</div>
|
||
<div class="col-xl-12 col-lg-6">
|
||
<div class="card-body px-0 pt-0">
|
||
<h3 class="">Scientific Capabilities</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>Tox21 experts carry out automated quantitative high-throughput screening using a library of approximately 10,000 compounds (Tox21 10K).</p>
|
||
|
||
</p>
|
||
</div>
|
||
<div class="card-footer bg-white border-0 p-0">
|
||
<a href="/research/research-activities/Tox21/scientific-capabilities">Learn More</a>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="col-xl-4 ps-xl-3 mb-4">
|
||
<div class="card border-0 p-0 radius-10 h-100">
|
||
<div class="row p-20 g-4 align-items-stretch">
|
||
<div class="col-xl-12 col-lg-6">
|
||
<img src="/sites/default/files/2023-09/Research%20Activities%20Card_746x370.png" class="img-fluid">
|
||
</div>
|
||
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