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<meta name="description" content="Understanding the human immune system is key to diagnosing and managing a number of physiological conditions — from wound healing and natural responses to such pathogens as flu viruses to cancer and autoimmune diseases. Furthermore, the immune system’s wound healing and repair processes can be impaired by such diseases as diabetes, which affects more than 30 million people in the United States. Gaining a better understanding of the immune system and its interactions with other physiological systems is a critical research need." />
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<a href="/research/research-activities/tissue-chip/projects/immune" class="active active-trail active-trail is-active" data-drupal-link-system-path="node/27862">Tissue Chips for Modeling the Immune System</a>
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<a href="/research/research-activities/tissue-chip/projects/covid-19" data-drupal-link-system-path="node/27810">Tissue Chips for Studying COVID-19</a>
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<h2 class="section-heading">Tissue Chips for Modeling the Immune System</h2>
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<div class="sidebar-right"><div class="contact-box"><h4>Contact</h4><p><a href="mailto:Danilo.Tagle@nih.gov?subject=Tissue%20Chip%20program%20inquiry" target="_blank" title="Email Danilo Tagle">Danilo Tagle, Ph.D.</a></p></div><div class="image-box"><img src="/sites/default/files/inline-images/image_2.png" data-entity-uuid="78dc65da-4d1d-4376-9f44-209bc7eaac23" data-entity-type="file" alt="Astronaut holding a Tissue Chip"></div></div><p>Understanding the human immune system is key to diagnosing and managing a number of physiological conditions — from wound healing and natural responses to such pathogens as flu viruses to cancer and autoimmune diseases. Furthermore, the immune system’s wound healing and repair processes can be impaired by such diseases as diabetes, which affects more than 30 million people in the United States. Gaining a better understanding of the immune system and its interactions with other physiological systems is a critical research need.</p><p>To help address this need, in 2019, the <a href="https://www.nibib.nih.gov/">National Institute of Biomedical Imaging and Bioengineering</a> and NCATS funded four research projects focused on developing tissue chips that model components of the human immune system.</p><p>The awards are part of the broader Tissue Chip program and were made in response to <a href="https://grants.nih.gov/grants/guide/pa-files/par-19-138.html">PAR-19-138</a>. </p><h3>Montana State University </h3><h5><a href="https://reporter.nih.gov/project-details/9893635">Integration of Mononuclear Phagocytes Into the Human Gastrointestinal GOFlowChip for Investigation of Luminal Antigen Sampling</a></h5><p><strong>Principal Investigators: </strong>Seth T. Walk, Ph.D., Diane Bimczok, D.V.M., Ph.D., and James Nolen Wilking, Ph.D. <br><strong>Grant Number: </strong>1-U01-EB-029242-01</p><h3>University of Colorado Denver </h3><h5><a href="https://reporter.nih.gov/project-details/9882046">A Microphysiological Mimicry of Human Lung–Bone Marrow Organ-Organ Cross-Talk On-a-Chip</a></h5><p><strong>Principal Investigator:</strong> Kambez Hajipouran Benam, D.Phil. <br><strong>Grant Number: </strong>1-U01-EB-029085-01</p><h3>Massachusetts Institute of Technology </h3><h5><a href="https://reporter.nih.gov/project-details/9882620">Microvascular Permeability, Inflammation and Lesion Physiology in Endometriosis: A Microphysiological Systems Approach</a></h5><p><strong>Principal Investigator:</strong> Linda G. Griffith, Ph.D. <br><strong>Grant Number: </strong>1-U01-EB-029132-01</p><h3>University of Virginia </h3><h5><a href="https://reporter.nih.gov/project-details/9882717">A Spatially Organized Microphysiological Model of a Human Lymph Node</a> </h5><p><strong>Principal Investigator:</strong> Rebecca R. Pompano, Ph.D. <br><strong>Grant Number:</strong> 1-U01-EB-029127-01 </p>
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