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<h1>Rare Diseases Clinical Research Network (RDCRN)</h1>
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The Rare Diseases Clinical Research Network (RDCRN) program is designed to advance medical research on rare diseases by providing support for clinical studies and facilitating collaboration, study enrollment and data sharing.
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<a href="/research/research-activities/rdcrn/applicant-information" class="first" data-drupal-link-system-path="node/43021">RDCRN Applicant Information</a>
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</li>
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<li class="last">
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<a href="/research/research-activities/rdcrn/consortia" class="last" data-drupal-link-system-path="node/29840">Current RDCRN Consortia</a>
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<div class="container news-content Advancing">
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<h2 class="section-heading">About the RDCRN</h2>
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</style><div class="contact-and-image-box"><div class="contact-box"><h4>Contact</h4><p><a href="mailto:tiina.urv@nih.gov">Tiina Urv, Ph.D.</a></p><hr><p><a href="/sites/default/files/2023-10/RDCRN-factsheet-october-2019.pdf">Download the RDCRN fact sheet</a> (PDF - 490KB)</p></div><div class="image-box"><img src="/sites/default/files/inline-images/Picture6.jpg" data-entity-uuid="218acc87-1dca-44f6-a12f-3f930215722c" data-entity-type="file" alt="Cells under a microscope." width="154" height="68"><div class="caption-text"><p>Human eosinophils, a type of white blood cell, are shown isolated from blood. In patients with eosinophilic esophagitis, these cells store and release packages of inflammatory proteins (red) that can damage the throat and esophagus. (Cincinnati Children’s Hospital Medical Center Photo/Julie Caldwell)</p></div></div></div><p>The Rare Diseases Clinical Research Network (RDCRN) program advances medical research on rare diseases by providing support for clinical studies and facilitating collaboration, study enrollment and data sharing. Through a network of consortia, scientists from multiple disciplines at hundreds of clinical sites around the world work in partnership with patients and patient advocacy groups to study more than 280 rare diseases. The program is federally mandated by Congress: The Rare Diseases Act of 2002 directed the Division of Rare Diseases Research Innovation to support regional "RDCRCs of Excellence" for clinical research, career enhancement, and demonstration of diagnostic, prevention, control and treatment methods for rare diseases.</p><p>The RDCRN is designed to promote highly collaborative, multi-site, patient-centric, translational and clinical research. The Rare Diseases Clinical Research Consortia (RDCRCs) focus on unmet clinical trial readiness needs that will move the field of research forward from its current state to one closer to successfully developing treatments for patients.</p><p>The RDCRN facilitates clinical research in rare diseases through support for consortia via:</p><ul><li>Collaborative activities, including multisite longitudinal studies of individuals with rare diseases and/or clinical trials</li><li>Career enhancement — encouraging the next generation of rare disease researchers</li><li>Pilot and feasibility projects</li></ul><p>The consortia within the RDCRN are supported by a Data Management and Coordinating Center that provides:</p><ul><li>Data management to facilitate high quality data standards, collection, storage and sharing</li><li>Clinical research support</li><li>Access to information about rare diseases for basic and clinical researchers, academic and practicing physicians, patients and the public</li></ul><h3>RDCRN Clinical Research</h3><p>RDCRN consortia support a broad range of clinical research, including clinical trial readiness, natural history studies, identification of biomarkers and outcome measures, and early phase clinical trials.</p><h3>A Collaborative Environment</h3><p>Funding and scientific oversight for the RDCRN are provided by NCATS and nine other NIH entities: the <em>Eunice Kennedy Shriver </em>National Institute of Child Health and Human Development; the National Heart, Lung and Blood Institute; the National Institute of Allergy and Infectious Diseases; the National Institute of Arthritis and Musculoskeletal and Skin Diseases; the National Institute of Dental and Craniofacial Research; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Institute of Mental Health; the National Institute of Neurological Disorders and Stroke; and the Office of Dietary Supplements. In addition, patient advocacy organizations may contribute funding.</p><p>Data sharing is a key aspect of the RDCRN framework and a priority for many stakeholders involved with the network and the RDCRN Data Management and Coordinating Center provides non-binding guidance to consortia on general principles for data sharing and key factors to consider when developing data sharing policies. For more information, review the <a href="https://ncats.nih.gov/sites/default/files/2024-07/RDCRN-data-sharing-policies-guidance-508.pdf">RDCRN Data Sharing Guidance</a>.</p>
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<h2 class="section-heading">RDCRN News</h2>
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<img loading="lazy" src="/sites/default/files/styles/media_library/public/shutterstock_1959330751_900w.png?itok=GDRKKwcC" width="220" height="124" alt="3D illustration of a human brain and a DNA strand." />
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|
||
</div>
|
||
<div class="col-md-8 col-lg-10">
|
||
<h3 class="title">A Combination of Tests Shows Learning Capabilities of Nonverbal Children with Rare Brain Disorder</h3>
|
||
<p class="m-0"><i>February 25, 2025 - NCATS News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Our Impact on Rare Diseases</i></li>
|
||
<li><i>Rare Diseases Clinical Research Network (RDCRN)</i></li>
|
||
</ul>
|
||
|
||
|
||
<p>NCATS-funded scientists found that a pair of tests can measure nonverbal learning skills and show the cognitive abilities of children with Aicardi-Goutières syndrome. The tests could improve the support and therapy doctors provide.</p>
|
||
|
||
<a href="https://ncats.nih.gov/news-events/news/a-combination-of-tests-shows-learning-capabilities-of-nonverbal-children-with-rare-brain-disorder">Read Article</a>
|
||
</div>
|
||
</div>
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||
</div></div>
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</div>
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||
<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
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||
<div class="usa-card__body">
|
||
<h3 class="title">Study Finds Genetic Variant Among People Who Experience a Rare Recovery From ALS</h3>
|
||
<p class="m-0"><i>July 30, 2024 - Grantee/Partner News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Rare Diseases Clinical Research Network (RDCRN)</i></li>
|
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</ul>
|
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<div class="usa-card__footer">
|
||
<a href="https://corporate.dukehealth.org/news/study-finds-genetic-variant-among-people-who-experience-rare-recovery-als">Read Article</a>
|
||
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<div class="col-sm-4 mb-4 views-row"><div class="usa-card__container">
|
||
<div class="usa-card__body">
|
||
<h3 class="title">Bridging the Gap: Why Translational Research Is Key to Unlocking Cell & Gene Therapy Innovation</h3>
|
||
<p class="m-0"><i>July 22, 2024 - Grantee/Partner News</i>
|
||
</p>
|
||
<ul class="list-pipe">
|
||
<li><i>Rare Diseases Clinical Research Network (RDCRN)</i></li>
|
||
</ul>
|
||
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||
</div>
|
||
<div class="usa-card__footer">
|
||
<a href="https://www.asgct.org/publications/news/july-2024/translational-research-key-to-unlocking-cell-gene">Read Article</a>
|
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<div class="usa-card__body">
|
||
<h3 class="title">New Research Shows Female OTC Carriers (Heterozygous Females) Face More Symptoms, Risks Than Expected</h3>
|
||
<p class="m-0"><i>June 28, 2024 - Grantee/Partner News</i>
|
||
</p>
|
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<ul class="list-pipe">
|
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<li><i>Rare Diseases Clinical Research Network (RDCRN)</i></li>
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<div class="usa-card__footer">
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<a href="https://nucdf.org/news.html/article/2024/06/28/new-research-shows-female-otc-carriers-heterozygous-females-face-more-symptoms-risks-than-expected">Read Article</a>
|
||
</div>
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||
</div>
|
||
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|
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<button class="buttons btn-1 mt-4"><a href="/news-events/news?program%5B0%5D=RDCRN">See More RDCRN News</a></button>
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<div class="paragraph paragraph--type--body-content paragraph--view-mode--default">
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||
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||
<h2>I Am Translational Science Video</h2><div style="height:0;overflow:hidden;padding-bottom:56.25%;padding-top:0;position:relative;"><iframe style="height:100%;left:0;position:absolute;top:0;width:100%;" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen frameborder="0" title="YouTube video player" src="https://www.youtube.com/embed/lpftKfmBY0Y?si=2aoOxG3nsonU3SRk?ecver=1&rel=0"></iframe></div><p>Child neurologist Mustafa Sahin, M.D., Ph.D., shares how advances in translation helped his team provide new treatments to young patients with rare neurodevelopmental disorders.</p>
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<div class="text-center button-wrap">
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<button class="buttons btn-1 mt-4"><a href="https://youtu.be/lpftKfmBY0Y?si=AOwJ-Q4W3vzjfRcT">View Video</a></button>
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<h2>RDCRN Open Funding Opportunities</h2>
|
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<p>Find open funding opportunities for RDCRN. </p>
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<button class="buttons btn-1 mt-4"><a href="/funding/funding-opportunities?keyword=%22rare%20diseases%20clinical%20research%20network%22">See RDCRN Open Funding Opportunities</a></button>
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<div class="container news-content Advancing">
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<h2 class="section-heading">Related Research</h2>
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<div class="card-body px-0 pt-0">
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<h3 class="">Rare Diseases Registry Program (RaDaR)</h3>
|
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<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>We provide easily accessible guidance to the rare diseases community on how to set up and maintain high-quality registries.</p>
|
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</div>
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<div class="col-xl-12 col-lg-6">
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<div class="card-body px-0 pt-0">
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<h3 class="">Bespoke Gene Therapy Consortium (BGTC)</h3>
|
||
<p class="py-xl-0 py-lg-4 py-md-4 py-sm-4 py-2">
|
||
|
||
<p>The Bespoke Gene Therapy Consortium focuses on developing platforms and standards to speed the development and delivery of gene therapies for rare diseases.</p>
|
||
|
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|
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|
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<p>Our Toolkit for Patient-Focused Therapy Development is a collection of online resources to assist patient groups in the research and development of new treatments.</p>
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