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</div><div><span>Culture - colonic tissue </span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Culture - colonic tissue </h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>A colonic tissue culture is a lab test to check for the cause of disease. The sample of tissue for the test is taken from the large intestine during a sigmoidoscopy or colonoscopy.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>The health care provider removes a piece of tissue from your large intestine. This is done during a sigmoidoscopy or <a test="test" href="./003886.htm">colonoscopy</a>.</p><ul><li>The sample is sent to a lab.</li><li>It is placed in a special dish that contains a gel. Bacteria and other organisms can grow in this gel. The dish is then stored at a certain temperature.</li><li>The lab team checks the sample daily. They check to see if bacteria, viruses, or fungi have grown.</li></ul><p>If certain germs grow, more tests will be done to identify them. This helps decide the best treatment.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>There is no specific preparation needed for a culture itself. However, you will have to prepare for the sigmoidoscopy or colonoscopy if that is how your provider is getting the tissue sample. Speak with your provider about how to prepare.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Once the sample is taken, the culture does not involve you. Therefore, there is no pain.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Your provider may order this test if you have signs or symptoms of a large intestine infection. Colonic tissue culture is only done occasionally. More often, tests are done on stool to identify a large intestine infection. A colonic tissue culture is most often done only when other tests, such as a <a test="test" href="./003758.htm">stool culture</a>, could not identify the cause of infection.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>A normal result means that no disease-causing organisms have grown in the lab dish.</p><p>Some "healthy" bacteria, called bowel flora, are normally found in the gut. The growth of such bacteria during this test does not mean there is an infection.</p><p>Normal value ranges may vary slightly among different laboratories. Talk to your provider about your test results.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>An abnormal result means that disease-causing organisms have grown in the lab dish. These organisms may include:</p><ul><li><em>Clostridioides difficile</em> bacteria</li><li>Cytomegalovirus </li><li><em>Mycobacterium tuberculosis</em> bacteria</li><li><a test="test" href="./000294.htm">Salmonella bacteria</a></li><li>Shigella bacteria </li></ul><p>These organisms may lead to colon infections or <a test="test" href="./003126.htm">diarrhea</a>.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>There is very minimal risk associated with the procedure. In rare cases, excessive bleeding could occur when a tissue sample is taken. <br/></p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Colonic tissue culture</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/8751t.jpg" alt="Colonoscopy" title="Colonoscopy" class="side-img"/><a href="../imagepages/8751.htm">Colonoscopy</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/9246t.jpg" alt="Colon culture" title="Colon culture" class="side-img"/><a href="../imagepages/9246.htm">Colon culture</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Fleckenstein JM. Approach to the patient with suspected enteric infection. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 262.</p><p>Melia JMP, Sears CL. Infectious enteritis and proctocolitis. In: Feldman M, Friedman LS, Brandt LJ, eds. <em>Sleisenger and Fordtran's Gastrointestinal and Liver Disease</em>. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 110.</p><p>Siddiqi HA, Rabinowitz S, Axiotis CA. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. <em>Henry's Clinical Diagnosis and Management by Laboratory Methods</em>. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 23.</p><p>Wojewoda CM, Stempak LM. Medical bacteriology. In: McPherson RA, Pincus MR, eds. <em>Henry's Clinical Diagnosis and Management by Laboratory Methods</em>. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 57.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 6/11/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Jenifer K. Lehrer, MD, Department of Gastroenterology, Aria - Jefferson Health Torresdale, Jefferson Digestive Diseases Network, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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