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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Urine protein electrophoresis test</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>The urine protein electrophoresis (UPEP) test is used to measure how much of certain proteins are in the urine.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>A <a test="test" href="./007487.htm">clean-catch urine sample</a> is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, your health care provider may give you a special clean-catch kit that contains a cleansing solution and sterile wipes. Follow the instructions exactly.</p><p>After you provide a urine sample, it is sent to the lab. There, a lab specialist will place the urine sample on special paper and apply an electric current. The proteins move and form visible bands. These reveal the general amounts of each protein.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Your provider may tell you to stop taking certain medicines that could interfere with the test. Medicines that can affect test results include:</p><ul><li>Chlorpromazine</li><li>Corticosteroids</li><li>Isoniazid</li><li>Neomycin</li><li>Phenacemide</li><li>Salicylates</li><li>Sulfonamides</li><li>Tolbutamide </li></ul><p>Do not stop taking any medicine without first talking to your provider.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>This test involves only normal urination. There is no discomfort.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Normally there is no protein, or only a small amount of protein in the urine. An abnormally high amount of protein in the urine can be a sign of many different disorders.</p><p>UPEP may be recommended to help determine the cause of protein in the urine. Or it may be done as a screening test to measure the various amounts of different types of proteins in urine. UPEP detects 2 types of protein: albumin and globulins.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>No significant amount of globulins are found in the urine. Urine albumin is less than 5 mg/dL.</p><p>Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different specimens. Talk to your provider about the meaning of your specific test results.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>If the urine sample has a significant amount of globulins or higher than normal level of albumin, it may mean any of the following:</p><ul><li><a test="test" href="./002215.htm">Acute</a> inflammation</li><li>Abnormal protein buildup in tissues and organs (<a test="test" href="./000533.htm">amyloidosis</a>)</li><li>Decreased kidney function</li><li>
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Kidney disease due to diabetes (<a test="test" href="./000494.htm">diabetic nephropathy</a>)</li><li><a test="test" href="./000501.htm">Kidney failure</a></li><li>
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A type of blood cancer called <a test="test" href="./000583.htm">multiple myeloma</a></li><li>
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Group of symptoms that include protein in the urine, low protein level in the blood, swelling (<a test="test" href="./000490.htm">nephrotic syndrome</a>)</li><li>Acute <a test="test" href="./000521.htm">urinary tract infection</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>There are no risks with this test.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Urine protein electrophoresis; UPEP; Multiple myeloma - UPEP; Waldenström macroglobulinemia - UPEP; Amyloidosis - UPEP
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</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/10022t.jpg" alt="Male urinary system" title="Male urinary system" class="side-img"/><a href="../imagepages/10022.htm">Male urinary system</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Gertz MA, Dispenzieri A. Amyloidosis. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 174.</p><p>McPherson RA. Specific proteins. In: McPherson RA, Pincus MR, eds. <em>Henry's Clinical Diagnosis and Management by Laboratory Methods</em>. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 20.</p><p>Rajkumar SV, Dispenzieri A. Multiple myeloma and related disorders. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. <em>Abeloff's Clinical Oncology</em>. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 101.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 6/17/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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