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</div><div><span>C1 esterase inhibitor</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">C1 esterase inhibitor</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>C1 esterase inhibitor (C1-INH) is a protein found in the fluid part of your blood. It controls a protein called C1, which is part of the complement system.</p><p>The complement system is a group of nearly 60 proteins in blood plasma or on the surface of some cells. The complement proteins work with your immune system to protect the body from infections. They also help remove dead cells and foreign material. There are nine major complement proteins. They are labeled C1 through C9. Rarely, people may inherit deficiency of some complement proteins. These people are prone to certain infections or autoimmune disorders.</p><p>This article discusses the test that is done to measure the amount of C1-INH in your blood.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>A blood sample is needed. This is most often taken through a vein. The procedure is called a <a test="test" href="./003423.htm">venipuncture</a>.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How to Prepare for the Test</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>No special preparation is needed.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>How the Test will Feel</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>When the needle is inserted to draw blood, some people feel moderate pain. Others may feel only a prick or stinging sensation. Afterward, there may be some throbbing.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Why the Test is Performed</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>You may need this test if you have signs of hereditary or acquired angioedema, which is a type of tissue swelling. Both forms of angioedema are caused by low levels of C1-INH.</p><p>Complement factors may also be important in testing for autoimmune diseases, such as systemic lupus erythematosus.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Normal Results</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Normal value ranges may vary slightly among different laboratories. Your health care provider will also measure the functional activity level of your C1 esterase inhibitor. Talk to your provider about the meaning of your specific test results.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What Abnormal Results Mean</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Low levels of C1-INH may cause certain types of angioedema. Angioedema results in sudden swelling of the tissues of the face, upper throat and tongue. It may also cause difficulty breathing. Swelling in the intestine and abdominal pain may also occur. There are two types of angioedema that result from decreased levels of C1-INH. Hereditary angioedema affects children and young adults under age 20. Acquired angioedema is seen in adults older than age 40. Adults with acquired angioedema are much more likely to also have other conditions, such as cancer or autoimmune disease.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Risks</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Risks associated with having blood drawn are slight, but may include:</p><ul><li>Excessive bleeding</li><li>Fainting or feeling lightheaded</li><li>Hematoma (blood accumulating under the skin)</li><li>Infection (a slight risk any time the skin is broken)</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>C1 inhibiting factor; C1-INH</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/10026t.jpg" alt="Blood test" title="Blood test" class="side-img"/><a href="../imagepages/10026.htm">Blood test</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Atkinson JP, Liszewski MK, Java A, Kulkarni HS. Complement and complement disorders. In: Rich RR, Fleisher TA, Schroeder HW, Weyand CM, Corry DB, Puck JM, eds. <em>Clinical Immunology: Principles and Practice</em>. 6th ed. Philadelphia, PA: Elsevier; 2023:chap 40.</p><p>Cicardi M, Aberer W, Banerji A, et al. Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group. <em>Allergy</em>. 2014;69(5):602-616. PMID: 24673465 <a href="https://pubmed.ncbi.nlm.nih.gov/24673465/" target="_blank">pubmed.ncbi.nlm.nih.gov/24673465/</a>.</p><p>Leslie TA. Hereditary angioedema. In: Lebwohl MG, Heymann WR, Coulson IH, Murrell DF, eds. <em>Treatment of Skin Disease: Comprehensive Therapeutic Strategies</em>. 6th ed. Philadelphia, PA: Elsevier; 2022:chap 101.</p><p>Zanichelli A, Azin GM, Wu MA, et al. Diagnosis, course, and management of angioedema in patients with acquired C1-inhibitor deficiency. <em>J Allergy Clin Immunol Pract</em>. 2017;5(5):1307-1313. PMID: 28284781 <a href="https://pubmed.ncbi.nlm.nih.gov/28284781/" target="_blank">pubmed.ncbi.nlm.nih.gov/28284781/</a>.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 1/25/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Neil J. Gonter, MD, Assistant Professor of Medicine, Columbia University, NY and private practice specializing in Rheumatology at Rheumatology Associates of North Jersey, Teaneck, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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