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</div><div><span>Potter syndrome</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Potter syndrome</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Potter syndrome and Potter phenotype refers to a group of findings associated with a lack of <a test="test" href="./002220.htm">amniotic fluid</a> and <a test="test" href="./000501.htm">kidney failure</a> in an unborn infant. </p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>In Potter syndrome, the primary problem is kidney failure. The kidneys fail to develop properly as the baby is growing in the womb. The kidneys normally produce the amniotic fluid (as urine) that surrounds the unborn baby.</p><p>Potter phenotype refers to a typical facial appearance that occurs in a newborn when there is no amniotic fluid. The lack of amniotic fluid is called oligohydramnios. Without amniotic fluid, the infant is not cushioned from the walls of the uterus. The pressure of the uterine wall leads to an unusual facial appearance, including widely separated eyes.</p><p>Potter phenotype may also lead to abnormal limbs, or limbs that are held in abnormal positions or <a test="test" href="./003185.htm">contractures</a>.</p><p>Oligohydramnios also stops development of the lungs, so the lungs do not work properly at birth. </p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms include:</p><ul><li>Widely separated eyes with <a test="test" href="./003030.htm">epicanthal folds</a>, <a test="test" href="./003057.htm">broad nasal bridge</a>, <a test="test" href="./003303.htm">low set ears</a>, and <a test="test" href="./003306.htm">receding chin</a></li><li>Absence of urine output</li><li>Difficulty breathing</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>A pregnancy <a test="test" href="./003778.htm">ultrasound</a> may show lack of amniotic fluid, absence of fetal kidneys, or severely abnormal kidneys in the unborn baby.</p><p>The following tests may be used to help diagnose the condition in a newborn:</p><ul><li><a test="test" href="./003815.htm">X-ray of the abdomen</a></li><li><a test="test" href="./003804.htm">X-ray of the lungs</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Resuscitation at delivery may be attempted pending the diagnosis. Treatment will be provided for any urinary outlet obstruction.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>This is a very serious condition. Most of the time it is deadly. The short-term outcome depends on the severity of lung involvement. Long-term outcome depends on the severity of kidney involvement.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>There is no known prevention.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Potter phenotype; Potter's syndrome</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/17008t.jpg" alt="Amniotic fluid" title="Amniotic fluid" class="side-img"/><a href="../imagepages/17008.htm">Amniotic fluid</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/17097t.jpg" alt="Broad nasal bridge" title="Broad nasal bridge" class="side-img"/><a href="../imagepages/17097.htm">Broad nasal bridge</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Miyashita Y, Formeck C, Moritz M. Nephrology. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. <em>Zitelli and Davis' Atlas of Pediatric Physical Diagnosis</em>. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 14.</p><p>Marcdante KJ, Kliegman RM, Schuh AM. Congenital and developmental abnormalities of the urinary tract. In: Marcdante KJ, Kliegman RM, Schuh AM, eds. <em>Nelson Essentials of Pediatrics</em>. 9th ed. Philadelphia, PA: Elsevier; 2023:chap 168.</p><p>Mitchell AL. Congenital anomalies. In: Martin RJ, Fanaroff AA, Walsh MC, eds. <em>Fanaroff and Martin's Neonatal-Perinatal Medicine</em>. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 30.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 8/5/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Neil K. Kaneshiro, MD, MHA, Clinical Professor of Pediatrics, University of Washington School of Medicine, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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