297 lines
No EOL
34 KiB
HTML
297 lines
No EOL
34 KiB
HTML
<!DOCTYPE html>
|
||
<html lang="en" id="article" class="nojs us" data-root="//medlineplus.gov" itemid="https://medlineplus.gov/ency/article/000787.htm" itemtype="http://schema.org/MedicalWebPage" itemscope="">
|
||
<head>
|
||
<meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1"/>
|
||
<meta http-equiv="window-target" content="_top"/>
|
||
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/>
|
||
<meta charset="utf-8"/>
|
||
<meta property="fb:app_id" content="1042245625821448"/>
|
||
<meta name="expires" content="Wed, 05 02 2025"/>
|
||
<meta name="ac-dictionary" content="medlineplus-ac-dictionary"/>
|
||
<link rel="shortcut icon" href="https://medlineplus.gov/images/favicon.ico" type="image/x-icon"/>
|
||
<link rel="apple-touch-icon" href="//medlineplus.gov/images/touch-icon.png"/>
|
||
<meta name="viewport" content="width=device-width, initial-scale=1"/>
|
||
<link rel="stylesheet" href="https://medlineplus.gov/css/common_new.css?04272023"/>
|
||
<!--[if IE 8]> <link rel="stylesheet" href="https://medlineplus.gov/css/ie8/common.css"><![endif]-->
|
||
<link rel="stylesheet" href="https://medlineplus.gov/uswds/css/uswds_styles.css"/>
|
||
<link rel="stylesheet" href="https://medlineplus.gov/css/ency/ency2.css?07162024"/>
|
||
<script type="text/javascript">document.querySelector("html").className = document.querySelector("html").className.replace(/nojs[\s]*/g, '');</script>
|
||
<script src="https://medlineplus.gov/uswds/js/uswds-init.min.js" type="text/javascript">
|
||
</script>
|
||
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-MMVM77');</script>
|
||
<link rel="canonical" href="https://medlineplus.gov/ency/article/000787.htm" itemprop="url"/>
|
||
<link rel="alternative" hreflang="es" href="https://medlineplus.gov/spanish/ency/article/000787.htm"/>
|
||
<link rel="alternative" hreflang="en" href="https://medlineplus.gov/ency/article/000787.htm"/><meta property="og:title" content="Tuberous sclerosis: MedlinePlus Medical Encyclopedia"/><meta property="og:url" content="https://medlineplus.gov/ency/article/000787.htm"/><meta property="twitter:title" content="Tuberous sclerosis: MedlinePlus Medical Encyclopedia"/><meta name="twitter:card" content="summary_large_image"/><meta name="description" content="Tuberous sclerosis is a genetic disorder that affects the skin, brain/nervous system, kidneys, heart, and lungs. The condition can also cause tumors to grow in the brain. These tumors have a tuber or root-shaped"/><meta itemprop="description" name="description" content="Tuberous sclerosis is a genetic disorder that affects the skin, brain/nervous system, kidneys, heart, and lungs. The condition can also cause tumors to grow in the brain. These tumors have a tuber or root-shaped"/><meta property="og:description" content="Tuberous sclerosis is a genetic disorder that affects the skin, brain/nervous system, kidneys, heart, and lungs. The condition can also cause tumors to grow in the brain. These tumors have a tuber or root-shaped"/><meta property="twitter:description" content="Tuberous sclerosis is a genetic disorder that affects the skin, brain/nervous system, kidneys, heart, and lungs. The condition can also cause tumors to grow in the brain. These tumors have a tuber or root-shaped"/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_1.jpg"/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_2.jpg"/><meta property="og:image" content="https://medlineplus.gov/images/share_ency_3.jpg"/><meta property="twitter:image" content="https://medlineplus.gov/images/share_ency_1.jpg"/>
|
||
<title>Tuberous sclerosis: MedlinePlus Medical Encyclopedia</title>
|
||
</head>
|
||
<body><link href="http://schema.org/Patient" itemprop="audience"/>
|
||
<!-- Google Tag Manager -->
|
||
<noscript><iframe title="googletagmanager" src="//www.googletagmanager.com/ns.html?id=GTM-MMVM77" height="0" width="0" style="display:none;visibility:hidden">
|
||
</iframe>
|
||
</noscript>
|
||
<!-- End Google Tag Manager -->
|
||
<a name="top" id="top">
|
||
</a>
|
||
<a class="hide-offscreen" href="#start">Skip navigation</a>
|
||
<section class="usa-banner" aria-label="Official website of the United States government">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner__header">
|
||
<div class="usa-banner__inner">
|
||
<div class="grid-col-auto">
|
||
<img aria-hidden="true" class="usa-banner__header-flag" src="https://medlineplus.gov/uswds/img/us_flag_small.png" alt=""/>
|
||
</div>
|
||
<div class="grid-col-fill tablet:grid-col-auto" aria-hidden="true">
|
||
<p class="usa-banner__header-text">
|
||
An official website of the United States government
|
||
</p>
|
||
<p class="usa-banner__header-action">Here’s how you know</p>
|
||
</div>
|
||
<button type="button" class="usa-accordion__button usa-banner__button" aria-expanded="false" aria-controls="gov-banner-default-default">
|
||
<span class="usa-banner__button-text">Here’s how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner__content usa-accordion__content" id="gov-banner-default-default">
|
||
<div class="grid-row grid-gap-lg">
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-dot-gov.svg" role="img" alt="" aria-hidden="true"/>
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Official websites use .gov</strong><br/>A
|
||
<strong>.gov</strong> website belongs to an official government
|
||
organization in the United States.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner__guidance tablet:grid-col-6">
|
||
<img class="usa-banner__icon usa-media-block__img" src="https://medlineplus.gov/uswds/img/icon-https.svg" role="img" alt="" aria-hidden="true"/>
|
||
<div class="usa-media-block__body">
|
||
<p>
|
||
<strong>Secure .gov websites use HTTPS</strong><br/>A
|
||
<strong>lock</strong> (
|
||
<span class="icon-lock"><svg xmlns="http://www.w3.org/2000/svg" width="52" height="64" viewBox="0 0 52 64" class="usa-banner__lock-image" role="img" aria-labelledby="banner-lock-description-default" focusable="false">
|
||
<title id="banner-lock-title-default">Lock</title>
|
||
<desc id="banner-lock-description-default">Locked padlock icon</desc>
|
||
<path fill="#000000" fill-rule="evenodd" d="M26 0c10.493 0 19 8.507 19 19v9h3a4 4 0 0 1 4 4v28a4 4 0 0 1-4 4H4a4 4 0 0 1-4-4V32a4 4 0 0 1 4-4h3v-9C7 8.507 15.507 0 26 0zm0 8c-5.979 0-10.843 4.77-10.996 10.712L15 19v9h22v-9c0-6.075-4.925-11-11-11z">
|
||
</path>
|
||
</svg> </span>) or <strong>https://</strong> means you’ve safely connected to
|
||
the .gov website. Share sensitive information only on official,
|
||
secure websites.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<div id="mplus-wrap">
|
||
<header>
|
||
<div id="mplus-header">
|
||
<!-- Orgs
|
||
================================================== -->
|
||
<div id="mplus-orgs">
|
||
<a title="National Institutes of Health" target="_blank" class="nih-org" href="//www.nih.gov/">
|
||
<img alt="National Institutes of Health" src="https://medlineplus.gov/images/nihlogo.png" class="nihlogo"/>
|
||
</a><a target="_blank" href="https://www.nlm.nih.gov/"> National Library of Medicine </a>
|
||
</div>
|
||
<!-- Logo
|
||
================================================== -->
|
||
<div id="mplus-logo" class="years-25">
|
||
<a href="https://medlineplus.gov">
|
||
<img src="https://medlineplus.gov/images/m_logo_25.png" title="MedlinePlus Trusted Health Information for You" alt="MedlinePlus Trusted Health Information for You"/>
|
||
</a>
|
||
</div>
|
||
<!-- Nav Menu
|
||
================================================== -->
|
||
<div id="mplus-nav">
|
||
<div class="sm-live-area hide-offscreen" aria-live="polite">The navigation menu has been collapsed.</div>
|
||
<!-- Menu Button-->
|
||
<button type="submit" aria-controls="mplus-menu-list" role="button" title="Menu" class="navmenu-btn" id="sm-menu-btn" aria-pressed="false" tabindex="0">Menu<span class="icon icon-nav-menu">
|
||
</span></button><ul class="nav-list" id="mplus-menu-list">
|
||
<li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li>
|
||
<li><a href="https://medlineplus.gov/druginformation.html">Drugs & Supplements</a></li>
|
||
<li><a href="https://medlineplus.gov/genetics/">Genetics</a></li>
|
||
<li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li>
|
||
<li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li>
|
||
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
|
||
</ul><button type="submit" aria-controls="mplus-search" role="button" title="Search" class="navmenu-btn" id="sm-search-btn" aria-pressed="false" tabindex="0"><span class="hide-offscreen">Show </span>Search<span class="icon icon-nav-search">
|
||
</span></button>
|
||
<div class="top-1">
|
||
<!-- Search
|
||
================================================== -->
|
||
<form target="_self" title="Search MedlinePlus" action="//vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta" method="get" id="mplus-search">
|
||
<input type="hidden" value="medlineplus" name="v:project"/>
|
||
<input type="hidden" value="medlineplus-bundle" name="v:sources"/>
|
||
<div class="form-box text-combo">
|
||
<div class="form-area"><label for="searchtext_primary" class="hide-offscreen">Search MedlinePlus</label>
|
||
<span role="status" aria-live="polite" class="ui-helper-hidden-accessible">
|
||
</span><input type="text" aria-haspopup="true" aria-autocomplete="list" role="textbox" autocomplete="off" name="query" size="40" maxlength="400" title="Site Search input" alt="Site Search input" placeholder="Search MedlinePlus" class="form-text ui-autocomplete-input" id="searchtext_primary"/>
|
||
</div>
|
||
<div class="button-area">
|
||
<button type="submit" alt="Search MedlinePlus" title="Search MedlinePlus" class="form-btn">GO</button>
|
||
</div>
|
||
</div>
|
||
</form>
|
||
<!-- Secondary Nav
|
||
================================================== -->
|
||
<div class="secondarynav">
|
||
<ul class="nav-list">
|
||
<li><a href="https://medlineplus.gov/about/"><span>About MedlinePlus</span></a></li>
|
||
<li><a href="https://medlineplus.gov/whatsnew/"><span>What's New</span></a></li>
|
||
<li><a href="https://medlineplus.gov/sitemap.html"><span>Site Map</span></a></li>
|
||
<li><a target="_blank" href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&category=medlineplus&from=//medlineplus.gov/ency/article/000787.htm"><span>Customer Support</span></a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
<!-- Nav Bar
|
||
================================================== -->
|
||
<div id="mplus-nav-bar">
|
||
<ul class="nav-list">
|
||
<li><a href="https://medlineplus.gov/healthtopics.html">Health Topics</a></li><li><a href="https://medlineplus.gov/druginformation.html">Drugs & Supplements</a></li><li><a href="https://medlineplus.gov/genetics/">Genetics</a></li><li><a href="https://medlineplus.gov/lab-tests/">Medical Tests</a></li><li><a href="https://medlineplus.gov/encyclopedia.html">Medical Encyclopedia</a></li>
|
||
</ul>
|
||
</div>
|
||
<a title="Español" id="mplus-lang-toggle" href="../../spanish/ency/article/000787.htm">Español</a>
|
||
</div>
|
||
</div>
|
||
</header>
|
||
<!-- Content
|
||
================================================== -->
|
||
<div id="mplus-content">
|
||
<!-- Breadrcumbs -->
|
||
<div id="breadcrumbs"><div itemtype="http://schema.org/BreadcrumbList" itemscope="" itemprop="breadcrumb"><span class="hide-offscreen">You Are Here:</span>
|
||
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
|
||
<a href="https://medlineplus.gov" itemprop="item"><span itemprop="name">Home</span></a>
|
||
→
|
||
<meta itemprop="position" content="1"/>
|
||
</div>
|
||
|
||
<div itemscope itemprop="itemListElement" itemtype="http://schema.org/ListItem">
|
||
<a href="https://medlineplus.gov/encyclopedia.html" itemprop="item"><span itemprop="name">Medical Encyclopedia</span></a>
|
||
→
|
||
<meta itemprop="position" content="2"/>
|
||
</div>
|
||
</div><div><span>Tuberous sclerosis</span></div></div>
|
||
<span class="page-url print-only">URL of this page: //medlineplus.gov/ency/article/000787.htm
|
||
</span>
|
||
<!-- Article -->
|
||
<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
|
||
</a><h1 class="with-also" itemprop="name">Tuberous sclerosis</h1>
|
||
</div><div class="page-actions">
|
||
</div>
|
||
<noscript>
|
||
<span class="js-disabled-message">To use the sharing features on this page, please enable JavaScript.</span>
|
||
</noscript></div><div class="main"><div id="ency_summary"><p>Tuberous sclerosis is a genetic disorder that affects the skin, brain/nervous system, kidneys, heart, and lungs. The condition can also cause tumors to grow in the brain. These tumors have a tuber or root-shaped appearance.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-1"><p>Tuberous sclerosis is a genetic condition. Changes (non-working gene variants or mutations) in one of two genes, <em>TSC1</em> and <em>TSC2</em>, are responsible for most cases.</p><p>Only one parent needs to pass on the non-working gene for the child to get the disease. However, two-thirds of cases are due to new gene changes. In most cases, there is no family history of tuberous sclerosis.</p><p>This condition is one of a group of diseases called neurocutaneous syndromes. Both the skin and <a test="test" href="./002311.htm">central nervous system</a> (brain and spinal cord) are involved.</p><p>There are no known risk factors, other than having a parent with tuberous sclerosis. In that case, each child has a 50% chance of inheriting the disease.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-2"><p>Skin symptoms include:</p><ul><li>Areas of the skin that are white (due to decreased pigment) and have either an ash leaf or confetti appearance</li><li>Red patches on the face containing many blood vessels (facial angiofibromas)</li><li>Raised patches of skin with an orange-peel texture (shagreen spots), often on the back</li></ul><p>Brain symptoms include:</p><ul><li><a test="test" href="./001526.htm">Autism</a> spectrum disorders</li><li>Developmental delays</li><li><a test="test" href="./001523.htm">Intellectual disability</a></li><li><a test="test" href="./003200.htm">Seizures</a></li></ul><p>Other symptoms include:</p><ul><li>Pitted tooth enamel.</li><li>Rough growths under or around the fingernails and toenails.</li><li>Rubbery noncancerous tumors on or around the tongue. </li><li>Lung disease known as LAM (lymphangioleiomyomatosis). This is more common in women. In many cases, there are no symptoms. In other people, this can lead to shortness of breath, coughing blood, and lung collapse.</li><li>A benign cardiac tumor known as a cardiac rhabdomyoma. This is common in children with tuberous sclerosis and can be seen on ultrasound before a baby is born.</li></ul><p>The symptoms vary from person to person. Some people have normal intelligence and no seizures. Others have intellectual disabilities or difficult-to-control seizures.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-3"><p>Signs may include:</p><ul><li>Abnormal heart rhythm (<a test="test" href="./001101.htm">arrhythmia</a>)</li><li>Calcium deposits in the brain</li><li>Noncancerous tumors in the brain</li><li>Rubbery growths on the tongue or gums</li><li>Tumor-like growth (hamartoma) on the retina, pale patches in the eye</li><li><a test="test" href="./001310.htm">Tumors</a> in the kidneys</li></ul><p>Tests may include:</p><ul><li><a test="test" href="./003786.htm">CT scan of the head</a></li><li><a test="test" href="./003788.htm">Chest CT</a></li><li><a test="test" href="./003869.htm">Echocardiogram</a> (ultrasound of the heart)</li><li><a test="test" href="./003791.htm">MRI of the head</a></li><li><a test="test" href="./003777.htm">Ultrasound of the kidney</a></li><li>Ultraviolet light examination of the skin</li></ul><p>DNA testing for the two genes that can cause this disease (<em>TSC1</em> or <em>TSC2</em>) is available.</p><p>Regular ultrasound checks of the kidneys are important to make sure there is no tumor growth.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-4"><p>There is no known cure for tuberous sclerosis. Because the disease can differ from person to person, treatment is based on the symptoms.</p><ul><li>Depending on the severity of the intellectual disability, the child may need special education.</li><li>Some seizures are controlled with medicine (vigabatrin is first line for infantile spasms). Other children may need surgery.</li><li>Small growths on the face (facial angiofibromas) may be removed by laser treatment. These growths tend to come back, and repeat treatments will be needed.</li><li>Cardiac rhabdomyomas commonly disappear after puberty. Surgery to remove them is usually not needed.</li><li>Brain tumors can be treated with medicines called mTOR inhibitors (sirolimus, everolimus).</li><li>Kidney tumors are treated with surgery, or by reducing the blood supply using special x-ray techniques. mTOR inhibitors are being studied as another treatment for kidney tumors.</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-5"><p>More information and support for people with tuberous sclerosis and their families can be found at: <a class="extln" target="_blank" href="https://www.tsalliance.org">www.tsalliance.org</a>.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-6"><p>Children with mild tuberous sclerosis most often do well. However, children with severe intellectual disability or uncontrollable seizures often need lifelong assistance.</p><p>Sometimes when a child is born with severe tuberous sclerosis, one of the parents is found to have had a mild case of tuberous sclerosis that was not diagnosed.</p><p>The tumors in this disease tend to be noncancerous (benign). However, some tumors (such as kidney or brain tumors) can become cancerous.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-7"><p>Complications may include:</p><ul><li>Brain tumors (<a test="test" href="./000768.htm">astrocytoma</a>)</li><li>Heart tumors (rhabdomyoma)</li><li>Severe intellectual disability</li><li>Uncontrollable seizures</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-8"><p>Contact your health care provider if:</p><ul><li><div>Either side of your family has a history of tuberous sclerosis</div></li><li><div>You notice symptoms of tuberous sclerosis in your child</div></li></ul><p>Contact a genetic specialist if your child is diagnosed with a cardiac rhabdomyoma. Tuberous sclerosis is the leading cause of this tumor.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-9"><p>Genetic counseling is recommended for couples who have a personal or family history of tuberous sclerosis and who want to have children. </p><p>Prenatal diagnosis is available for families with a known gene variant or history of this condition. However, tuberous sclerosis often appears as a new DNA mutation. These cases are not preventable.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-Alt"><p>Bourneville disease; Tuberous sclerosis complex (TSC)</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div name="Images" class="section-body" id="section-tnails"><ul class="img-grid group">
|
||
<li><img src="//medlineplus.gov/ency/images/ency/tnails/2367t.jpg" alt="Tuberous sclerosis, angiofibromas - face" title="Tuberous sclerosis, angiofibromas - face" class="side-img"/><a href="../imagepages/2367.htm">Tuberous sclerosis, angiofibromas - face</a></li>
|
||
<li><img src="//medlineplus.gov/ency/images/ency/tnails/2538t.jpg" alt="Tuberous sclerosis - hypopigmented macule" title="Tuberous sclerosis - hypopigmented macule" class="side-img"/><a href="../imagepages/2538.htm">Tuberous sclerosis - hypopigmented macule</a></li>
|
||
</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div class="section-body" id="section-Ref"><p>National Institute of Neurological Disorders and Stroke website. Tuberous sclerosis complex. <a href="https://www.ninds.nih.gov/health-information/disorders/tuberous-sclerosis-complex" target="_blank">www.ninds.nih.gov/health-information/disorders/tuberous-sclerosis-complex</a>. Updated July 19, 2024. Accessed September 13, 2024. </p><p>Safier RA, Cleves-Bavon C, Gaesser J. Neurology. In: Zitelli BJ, McIntire SC, Nowalk AJ, Garrison J, eds. <em>Zitelli and Davis' Atlas of Pediatric Physical Diagnosis</em>. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 16.</p><p>Sahin M, Ullrich N, Srivastava S, Pinto A. Neurocutaneous syndromes. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. <em>Nelson Textbook of Pediatrics</em>. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 636.</p><p>Tsao H, Luo S. Neurofibromatosis and tuberous sclerosis complex. In: Bolognia JL, Schaffer JV, Cerroni L, et al, eds. <em>Dermatology</em>. 5th ed. Philadelphia, PA: Elsevier; 2025:chap 61.</p></div></div></section>
|
||
<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 8/18/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div>
|
||
<div id="section-version" class="section-body"><p>Updated by: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
|
||
</div></div></section><section><div class="section ency-citation"><div class="section-header"><div class="section-title ency-citation"><div id="citation-how-to"><button><span>Learn how to cite this page</span></button></div></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Related MedlinePlus Health Topics</h2></div><div class="section-button"><button type="submit" aria-controls="section-mtp" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
|
||
</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
|
||
</div></div><div name="Related MedlinePlus Health Topics" class="section-body" id="section-mtp"><ul class="side-nav"><li><a href="https://medlineplus.gov/tuberoussclerosis.html">Tuberous Sclerosis</a></li>
|
||
|
||
|
||
</ul></div></div></section></div></div></article>
|
||
</div>
|
||
<footer>
|
||
|
||
<div class="provider-box group">
|
||
<div class="urac-logo">
|
||
<a href="https://accreditnet.urac.org/directory/#/certification/HCP-2/info"><img src="https://medlineplus.gov/images/CertifiedSeal.png"/></a>
|
||
<p class="urac-logo-info">Health Content Provider<br>06/01/2025</p>
|
||
</div>
|
||
<p class="adam-info">
|
||
<a href='javascript:urac_open();'>A.D.A.M., Inc. is accredited by URAC</a>, for Health Content Provider (www.urac.org). URAC's <a href='javascript:hwsopen();'>accreditation program</a> is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s <a href='javascript:edpolopen();'>editorial policy, editorial process</a>, and <a href='javascript:ppopen();'>privacy policy</a>. A.D.A.M. is also a founding member of Hi-Ethics. This site complies with the HONcode standard for trustworthy health information: <a href='javascript:honc_open();'>verify here</a>.
|
||
</p>
|
||
</div>
|
||
<p class="adam-info">
|
||
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only – they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997-2025 A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
|
||
</p>
|
||
<div class="adam-logo">
|
||
<a href="https://www.adam.com/about" target="_blank"><img width="49" height="10" alt="About A.D.A.M." src="https://medlineplus.gov/ency/images/ency/ftrAdamlogo.gif"/></a>
|
||
</div>
|
||
<div id="mplus-footer">
|
||
<div class="footer1">
|
||
<ul class="secondarynav">
|
||
<li><a href="https://medlineplus.gov/about/">About MedlinePlus</a></li>
|
||
<li><a href="https://medlineplus.gov/whatsnew/">What's New</a></li>
|
||
<li><a href="https://medlineplus.gov/sitemap.html">Site Map</a></li>
|
||
<li><a name="contact" target="_blank" href="https://support.nlm.nih.gov/knowledgebase/category/?id=CAT-01231&category=medlineplus&from="><span>Customer Support</span></a></li>
|
||
</ul>
|
||
<ul class="follow-footer">
|
||
<li><a href="https://medlineplus.gov/rss.html" class="follow-item">Subscribe to RSS<img src="https://medlineplus.gov/images/feed.png" class="social-media-toolkit-icon" alt="RSS" title="RSS"></a></li>
|
||
<li><span class="follow-label">Follow us</span>
|
||
<a href="https://twitter.com/medlineplus" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/i_share_twitter.png" class="follow-icon" alt="X" title="X"></a>
|
||
<a href="https://facebook.com/Mplus.gov/" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/i_share_fb.png" class="follow-icon" alt="Facebook" title="Facebook"></a>
|
||
<a href="https://www.instagram.com/mplusgov/" class="follow-item" target="_blank"><img src="https://medlineplus.gov/images/Instagram_Glyph_Gradient_RGB.png" class="follow-icon" alt="Instagram" title="Instagram"></a>
|
||
</li>
|
||
<li><a href="https://medlineplus.gov/social-media-toolkit/" class="social-media-toolkit-item">Social Media Toolkit<img src="https://medlineplus.gov/images/i_social_media_toolkit.png" class="social-media-toolkit-icon" alt="Social Media Toolkit" title="Social Media Toolkit"></a></li>
|
||
</ul>
|
||
</div>
|
||
<div class="footer2">
|
||
<ul>
|
||
<li><a href="https://www.nlm.nih.gov/web_policies.html" target="_blank">NLM Web Policies</a></li>
|
||
<li><a href="https://medlineplus.gov/about/using/usingcontent/" >Copyright</a></li>
|
||
<li><a href="//medlineplus.gov/accessibility.html">Accessibility</a></li>
|
||
<li><a href="https://medlineplus.gov/about/using/criteria/">Guidelines for Links</a></li>
|
||
<li><a href="//medlineplus.gov/plugins.html">Viewers & Players</a></li>
|
||
<li><a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" target="_blank">HHS Vulnerability Disclosure</a></li>
|
||
<li><a href="https://medlineplus.gov/medlineplus-connect/">MedlinePlus Connect for EHRs</a></li>
|
||
<li><a href="https://medlineplus.gov/about/developers/">For Developers</a></li>
|
||
</ul>
|
||
<div class="address">
|
||
<a href="//www.nlm.nih.gov" target="_blank">National Library of Medicine</a>
|
||
<span>8600 Rockville Pike, Bethesda, MD 20894</span>
|
||
<a href="//www.hhs.gov" target="_blank">U.S. Department of Health and Human Services</a>
|
||
<a href="//www.nih.gov" target="_blank">National Institutes of Health</a>
|
||
</div>
|
||
<div class="return-top"><a href="#top" title="Return to top"><img class="return-top-icon" alt="Return to top" src="https://medlineplus.gov/images/return-top.png"></a></div>
|
||
</div>
|
||
</div>
|
||
|
||
</footer>
|
||
</div><!-- End Wrap -->
|
||
<script src="https://medlineplus.gov/jslib/jquery-3.6.0.min.js" type="text/javascript">
|
||
</script>
|
||
<script src="https://medlineplus.gov/jslib/mplus-frontend-controls.js" type="text/javascript">
|
||
</script>
|
||
<!--[if lte IE 9]>
|
||
<script src="https://medlineplus.gov/jslib/jquery.placeholder.js" type="text/javascript"></script>
|
||
<![endif]-->
|
||
<script src="https://medlineplus.gov/jslib/mplus-share.js?id=1112022" type="text/javascript">
|
||
</script>
|
||
<script src="https://medlineplus.gov/jslib/control.js" type="text/javascript">
|
||
</script>
|
||
<script src="https://medlineplus.gov/uswds/js/uswds.min.js" type="text/javascript">
|
||
</script>
|
||
<script src="https://medlineplus.gov/jslib/ency/ency.js" type="text/javascript">
|
||
</script>
|
||
</body>
|
||
</html> |