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</div><div><span>Amyotrophic lateral sclerosis (ALS)</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Amyotrophic lateral sclerosis (ALS)</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Amyotrophic lateral sclerosis, or ALS, is a disease of the nerve cells in the brain, brain stem and spinal cord that control voluntary muscle movement.</p><p>ALS is also known as Lou Gehrig disease.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>One in 10 cases of ALS is due to a genetic variant. The cause is unknown in most other cases.</p><p>In ALS, motor nerve cells (neurons) waste away or die, and can no longer send messages to muscles. This eventually leads to muscle weakening, twitching, and an inability to move the arms, legs, and body. The condition continues to get worse. When the muscles in the chest area stop working, it becomes hard or impossible to breathe.</p><p>ALS affects approximately 7 out of every 100,000 people worldwide.</p><p>Having a family member who has a hereditary form of the disease is a risk factor for ALS. Other risks include military service. The reasons for this are unclear, but it may have to do with environmental exposure to toxins.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms usually do not develop until after age 50, but they can start in younger people. People with ALS have a loss of muscle strength and coordination that eventually gets worse and makes it impossible for them to do routine tasks such as going up steps, getting out of a chair, or swallowing.</p><p>Weakness can first affect the arms or legs, or the ability to breathe or swallow. As the disease gets worse, more muscle groups develop problems.</p><p>ALS does not affect the senses (sight, smell, taste, hearing, touch). Most people are able to think normally, although a small number develop dementia, causing problems with memory.</p><p>Muscle weakness starts in one body part, such as the arm or hand, and slowly gets worse until it leads to the following:</p><ul><li>Difficulty lifting, climbing stairs, and walking</li><li>Difficulty breathing</li><li>Difficulty swallowing -- choking easily, drooling, or gagging</li><li>Head drop due to weakness of the neck muscles</li><li>Speech problems, such as a slow or abnormal speech pattern (slurring of words)</li><li>Voice changes, hoarseness</li></ul><p>Other findings include:</p><ul><li><a test="test" href="./003213.htm">Depression</a></li><li>Changing expressions of emotions (emotional lability)</li><li><a test="test" href="./003193.htm">Muscle cramps</a></li><li>Muscle stiffness, called spasticity</li><li><a test="test" href="./003193.htm">Muscle contractions</a>, called fasciculations</li><li>Weight loss</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Your health care provider will examine you and ask about your medical history and symptoms.</p><p>The physical exam may show:</p><ul><li>Weakness, often beginning in one area of the body</li><li>Muscle tremors, spasms, twitching, or loss of muscle tissue</li><li>Twitching of the tongue (common)</li><li>Abnormal reflexes</li><li>Stiff or clumsy walk</li><li>Decreased or increased reflexes at the joints</li><li>Difficulty controlling crying or laughing (sometimes called emotional incontinence)</li><li>Loss of gag reflex </li></ul><p>Tests that may be done include:</p><ul><li>
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Blood tests to check for other conditions
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</li><li>
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Breathing test to see if lung muscles are affected
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</li><li><a test="test" href="./007351.htm">Cervical spine CT</a> or <a test="test" href="./007354.htm">MRI</a> to be sure there is no disease or injury to the neck, which can mimic ALS
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</li><li><a test="test" href="./003929.htm">Electromyography</a> (EMG) to see which nerves or muscles do not work properly
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</li><li>
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Genetic testing, especially if there is a family history of ALS
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</li><li><a test="test" href="./003786.htm">Head CT</a> or <a test="test" href="./003791.htm">MRI</a> to rule out other conditions
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</li><li>
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Swallowing studies
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</li><li>
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Spinal tap (lumbar puncture)
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</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>There is no known cure for ALS. Two medicines are available that help slow the progression of symptoms and may help people live slightly longer:</p><ul><li>Riluzole (Rilutek)</li><li>Edaravone (Radicava)</li></ul><p>Treatments to control other symptoms include:</p><ul><li>
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Baclofen or diazepam for <a test="test" href="./003297.htm">spasticity</a> that interferes with daily activities
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</li><li>
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Trihexyphenidyl or amitriptyline for people with problems swallowing their own saliva
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</li></ul><p>Trials of gene therapy are now underway for some specific hereditary causes.</p><p>Physical therapy, rehabilitation, use of braces or a wheelchair, or other measures may be needed to help with muscle function and general health. Ongoing oversight by a physical medicine provider is helpful, given continuously changing symptoms.</p><p>People with ALS tend to lose weight. The illness itself increases the need for food and calories. At the same time, problems with choking and swallowing make it hard to eat enough. To help with feeding, a tube may be placed into the stomach. A dietitian who specializes in ALS can give advice on healthy eating.</p><p>Breathing devices include machines that are considered non-invasive (such as CPAP or BiPAP). Others require tube in the trachea (invasive ventilation).</p><p>Medicine for depression may be needed if a person with ALS is diagnosed with depression. They also should discuss their wishes regarding artificial ventilation with their families and providers.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-5"><p>Emotional support is vital in coping with the disorder, because mental functioning is not affected. <a test="test" href="./002189.htm">Groups</a> such as the ALS Association may be available to help people who are coping with the disorder.</p><p>Support for people who are caring for someone with ALS is also available, and may be very helpful.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-6"><p>Over time, people with ALS lose the ability to function and care for themselves. Death often occurs within 3 to 5 years of diagnosis. About 1 in 4 people survive for more than 5 years after diagnosis. Some people live much longer, but they typically need help breathing from a ventilator or other device.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Complications of ALS include:</p><ul><li>Breathing in food or fluid (<a test="test" href="./002216.htm">aspiration</a>)</li><li>Loss of ability to care for self</li><li>Lung failure</li><li><a test="test" href="./000145.htm">Pneumonia</a></li><li>Pressure sores</li><li>Weight loss</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</span></button></div><div class="sm-live-area hide-offscreen" aria-live="polite">
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</div></div><div class="section-body" id="section-8"><p>Contact your provider if:</p><ul><li>
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You have symptoms of ALS, particularly if you have a family history of the disorder
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</li><li>
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You or someone else has been diagnosed with ALS and symptoms get worse or new symptoms develop
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</li></ul><p>Increased difficulty swallowing, difficulty breathing, and episodes of <a test="test" href="./003069.htm">apnea</a> are symptoms that require immediate attention.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>You may want to see a <a test="test" href="../patientinstructions/000510.htm">genetic counselor</a> if you have a family history of ALS.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Lou Gehrig disease; ALS; Upper and lower motor neuron disease; Motor neuron disease</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Fearon C, Murray B, Mitsumoto H. Disorders of upper and lower motor neurons. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. <em>Bradley and Daroff's Neurology in Clinical Practice</em>. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 97.</p><p>Shaw PJ, Cudkowicz ME. Amyotrophic lateral sclerosis and other motor neuron diseases. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 387.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 6/13/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Joseph V. Campellone, MD, Department of Neurology, Cooper Medical School at Rowan University, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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