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</div><div><span>Factor V deficiency</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Factor V deficiency</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Factor V deficiency is a <a test="test" href="./001304.htm">bleeding disorder</a> that is passed down through families. It affects the ability of the blood to clot.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade. It involves as many as 20 different special proteins called coagulation, or clotting, factors. You may have a higher chance of excess bleeding if one or more of these factors are missing or are not functioning like they should.</p><p>Factor V deficiency is caused by a lack of factor V. When certain blood clotting factors are low or missing, your blood does not clot properly. </p><p>Factor V deficiency is rare. It may be caused by: </p><ul><li>A variant factor V gene passed down through families (inherited)</li><li>An <a test="test" href="./002223.htm">antibody</a> that interferes with normal factor V function </li></ul><p>You can develop an antibody that interferes with factor V:</p><ul><li>After giving birth</li><li>After being treated with a certain type of fibrin glue</li><li>After surgery</li><li>With autoimmune diseases and certain cancers </li></ul><p>Sometimes the cause is unknown.</p><p>The disease is similar to <a test="test" href="./000537.htm">hemophilia</a>, except bleeding into joints is less common. In the inherited form of factor V deficiency, a family history of a bleeding disorder is a risk factor.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include:
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</p><ul><li><a test="test" href="./003235.htm">Bleeding into the skin</a></li><li><a test="test" href="./003062.htm">Bleeding of the gums</a></li><li>Excessive <a test="test" href="./003235.htm">bruising</a></li><li><a test="test" href="./003106.htm">Nosebleeds</a></li><li>Prolonged or excessive loss of blood with surgery or trauma</li><li>Umbilical stump bleeding </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Tests to detect factor V deficiency include:</p><ul><li><a test="test" href="./003675.htm">Factor V assay</a></li><li>Blood clotting tests, including <a test="test" href="./003653.htm">partial thromboplastin time</a> (PTT) and <a test="test" href="./003652.htm">prothrombin time</a> (PT)</li><li><a test="test" href="./003656.htm">Bleeding time</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>The outlook is good with diagnosis and proper treatment.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Severe bleeding (hemorrhage) could occur.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Go to the emergency room or call 911 or the local emergency number if you have an unexplained or prolonged loss of blood.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Parahemophilia; Owren disease; Bleeding disorder - factor V deficiency</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/19462t.jpg" alt="Blood clot formation" title="Blood clot formation" class="side-img"/><a href="../imagepages/19462.htm">Blood clot formation</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/9326t.jpg" alt="Blood clots" title="Blood clots" class="side-img"/><a href="../imagepages/9326.htm">Blood clots</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Gailani D, Benjamin FT, Wheeler AP. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. <em>Hematology: Basic Principles and Practice</em>. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 135.</p><p>Ragni MV. Coagulation factor deficiencies. In: Goldman L, Cooney KA, eds.<em> Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 160.</p><p>Samelson-Jones BJ, Branchford BR, Flood VH. Hereditary clotting factor deficiencies (bleeding disorders). In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. <em>Nelson Textbook of Pediatrics</em>. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 525.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 3/31/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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