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</div><div><span>Von Willebrand disease</span></div></div>
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<article><div id="d-article"><div class="page-info"><div class="page-title"><a name="start" id="start">
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</a><h1 class="with-also" itemprop="name">Von Willebrand disease</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Von Willebrand disease is the most common hereditary <a test="test" href="./001304.htm">bleeding disorder</a>.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Von Willebrand disease is caused by a deficiency or poor functioning of von Willebrand factor. Von Willebrand factor helps blood platelets clump together and stick to the blood vessel wall, which is necessary for normal blood clotting. There are several types of von Willebrand disease.</p><p>A family history of a bleeding disorder is the primary risk factor. </p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms may include:</p><ul><li>Abnormal menstrual bleeding</li><li><a test="test" href="./003062.htm">Bleeding of the gums</a></li><li><a test="test" href="./003235.htm">Bruising</a></li><li><a test="test" href="./003106.htm">Nosebleeds</a></li><li><a test="test" href="./003220.htm">Skin rash</a></li></ul><p><strong>Note:</strong> Most women with heavy or prolonged menstrual bleeding do not have von Willebrand disease.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>Von Willebrand disease may be hard to diagnose. Low von Willebrand factor levels and bleeding do not always mean you have von Willebrand disease.</p><p>Tests that may be done to diagnose this disease include:</p><ul><li><a test="test" href="./003656.htm">Bleeding time</a></li><li><a test="test" href="./003345.htm">Blood typing</a></li><li><a test="test" href="./003678.htm">Factor VIII level</a></li><li>Platelet function analysis</li><li><a test="test" href="./003647.htm">Platelet count</a></li><li>Ristocetin cofactor test</li><li>Von Willebrand factor specific tests </li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Treatment may include desmopressin (desamino-8-arginine vasopressin or DDAVP). It is a medicine to raise von Willebrand factor level and reduce the chances for bleeding. </p><p>However, DDAVP does not work for all types of von Willebrand disease. Tests should be done to determine what type of von Willebrand you have. If you are going to have surgery, your doctor may give you DDAVP before surgery to see if your von Willebrand factor levels increase.</p><p>The medicine Alphanate (antihemophilic factor) is approved to decrease bleeding in people with the disease who must have surgery or any other invasive procedure.</p><p>Blood plasma or certain factor VIII preparations may also be used to decrease bleeding.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Bleeding may decrease during pregnancy. Women who have this condition usually do not have excessive bleeding during childbirth.</p><p>This disease is passed down through families. <a test="test" href="../patientinstructions/000510.htm">Genetic counseling</a> may help prospective parents understand the risk for their children.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Bleeding may occur after surgery or when you have a tooth pulled. </p><p>Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) can make this condition worse. Do not take these medicines without first talking to your health care provider. </p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Contact your provider if bleeding occurs without reason.</p><p>If you have von Willebrand disease and are scheduled for surgery or are in an accident, be sure you or your family tell the providers about your condition.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Bleeding disorder - von Willebrand</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/19462t.jpg" alt="Blood clot formation" title="Blood clot formation" class="side-img"/><a href="../imagepages/19462.htm">Blood clot formation</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/9326t.jpg" alt="Blood clots" title="Blood clots" class="side-img"/><a href="../imagepages/9326.htm">Blood clots</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Branchford BR, Flood VH. Von Willebrand disease. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. <em>Nelson Textbook of Pediatrics</em>. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 526.</p><p>James P, Rawley O, Bowman M. Structure, biology, and genetics of von Willebrand factor. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. <em>Hematology: Basic Principles and Practice</em>. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 133.</p><p>Paola JD, O'Donnell JS. Von Willebrand disease and hemorrhagic abnormalities of platelet and vascular function. In: Goldman L, Cooney KA, eds. <em>Goldman-Cecil Medicine</em>. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 159.</p><p>Samuels P. Hematologic complications of pregnancy. In: Landon MB, Galan HL, Jauniaux ERM et al, eds. <em>Gabbe's Obstetrics: Normal and Problem Pregnancies</em>. 8th ed. Philadelphia, PA: Elsevier; 2021:chap 49.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 3/31/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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