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</div><div><span>Leydig cell testicular tumor</span></div></div>
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</a><h1 class="with-also" itemprop="name">Leydig cell testicular tumor</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>A Leydig cell tumor is a <a test="test" href="./001310.htm">tumor</a> of the testicle. It develops from Leydig cells. These are the cells in the testicles that release the male hormone, <a test="test" href="./003707.htm">testosterone</a>.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>The cause of this tumor is unknown. There are no known risk factors for this tumor. Unlike germ cell tumors of the testicles, this tumor does not seem to be linked to <a test="test" href="./000973.htm">undescended testes</a>.</p><p>Leydig cell tumors make up a very small number of all testicular tumors. They are most often found in men between 30 and 60 years of age. This tumor is not common in children before puberty, but it may cause <a test="test" href="./001168.htm">early puberty</a>.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>There may be no symptoms.</p><p>When symptoms do occur, they can include:</p><ul><li>Discomfort or pain in the testicle</li><li>Enlargement of a testicle or change in the way it feels</li><li>Excess growth of breast tissue (<a test="test" href="./003165.htm">gynecomastia</a>) -- however, this can occur normally in adolescent boys who do not have testicular cancer</li><li>Heaviness in the scrotum</li><li>Lump or swelling in either testicle</li><li>Pain in the lower abdomen or back</li><li>Not able to father children (infertility)</li></ul><p>Symptoms in other parts of the body, such as the lungs, abdomen, pelvis, back, or brain may also occur if the cancer has spread.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>A physical examination typically reveals a firm lump in one of the testicles. When your health care provider holds a flashlight up to your scrotum, the light does not pass through the lump. This test is called <a test="test" href="./003389.htm">transillumination</a>.</p><p>Other tests include:</p><ul><li>Blood tests for tumor markers: <a test="test" href="./003573.htm">alpha fetoprotein</a> (AFP), <a test="test" href="./003510.htm">human chorionic gonadotropin</a> (beta HCG), and <a test="test" href="./003499.htm">lactate dehydrogenase</a> (LDH)</li><li><a test="test" href="./003788.htm">CT scan of the chest</a>, <a test="test" href="./003789.htm">abdomen</a> and <a test="test" href="./007362.htm">pelvis</a> to check if the cancer has spread</li><li><a test="test" href="./003780.htm">Ultrasound of the scrotum</a></li></ul><p>An examination of the tissue is usually done after the entire testicle is surgically removed (orchiectomy).</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Treatment of a Leydig cell tumor depends on its stage.</p><ul><li>Stage I cancer has not spread beyond the testicle.</li><li>Stage II cancer has spread to lymph nodes in the abdomen.</li><li>Stage III cancer has spread beyond the lymph nodes (possibly as far as the liver, lungs, or brain).</li></ul><p>Surgery is done to remove the testicle (orchiectomy). Nearby lymph nodes may also be removed (lymphadenectomy).</p><p><a test="test" href="./002324.htm">Chemotherapy</a> may be used to treat this tumor. As Leydig cell tumors are rare, these treatments have not been studied as much as treatments for other, more common testicular cancers.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Joining a <a test="test" href="./002166.htm">support group</a> where members share common experiences and problems can often help ease the stress of illness.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>Testicular cancer is one of the most treatable and curable cancers. The outlook is worse if the tumor is not found early.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>The cancer may spread to other parts of the body. The most common sites include the:</p><ul><li>Abdomen</li><li>Lungs</li><li>Retroperitoneal area (the area near the kidneys behind the other organs in the belly area)</li><li>Spine </li></ul><p>Complications of surgery can include:</p><ul><li>Bleeding and infection</li><li><a test="test" href="./001191.htm">Infertility</a> (if both testicles are removed) </li></ul><p>If you are of childbearing age, ask your provider about methods to save your sperm for use at a later date.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Contact your provider if you have symptoms of testicular cancer.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>Performing <a test="test" href="./003909.htm">testicular self-examination (TSE)</a> each month may help detect testicular cancer at an early stage, before it spreads. Finding testicular cancer early is important for successful treatment and survival.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Tumor - Leydig cell; Testicular tumor - Leydig</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/1113t.jpg" alt="Male reproductive anatomy" title="Male reproductive anatomy" class="side-img"/><a href="../imagepages/1113.htm">Male reproductive anatomy</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Friedlander TW, Small E. Testicular cancer. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. <em>Abeloff's Clinical Oncology</em>. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 83.</p><p>National Cancer Institute website. Testicular cancer treatment (PDQ) – health professional version. <a href="https://www.cancer.gov/types/testicular/hp/testicular-treatment-pdq" target="_blank">www.cancer.gov/types/testicular/hp/testicular-treatment-pdq</a>. Updated March 15, 2024. Accessed July 9, 2024.</p><p>Stephenson AJ, Gilligan TD. Neoplasms of the testis. In: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. <em>Campbell-Walsh-Wein Urology</em>. 12th ed. Philadelphia, PA: Elsevier; 2021:chap 76.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 6/17/2024</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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