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</a><h1 class="with-also" itemprop="name">Anti-glomerular basement membrane disease</h1>
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</noscript></div><div class="main"><div id="ency_summary"><p>Anti-glomerular basement membrane disease (anti-GBM disease) is a rare disorder that can involve <a test="test" href="./000484.htm">quickly worsening kidney failure</a> and lung disease.</p><p>Some forms of the disease involve just the lungs or the kidneys. Anti-GBM disease used to be known as Goodpasture syndrome.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>Anti-GBM disease is an <a test="test" href="./000816.htm">autoimmune disorder</a>. It occurs when the immune system mistakenly attacks and destroys healthy body tissue. People with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomeruli) of the kidneys.</p><p>These substances are called antiglomerular basement membrane antibodies. The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. Antiglomerular basement membrane antibodies are <a test="test" href="./002223.htm">antibodies</a> against this membrane. They can damage the basement membrane, which can lead to kidney damage.</p><p>Sometimes, this disorder is triggered by a viral respiratory infection or by breathing in hydrocarbon solvents. In such cases, the immune system may attack organs or tissues because it mistakes them for these viruses or foreign chemicals.</p><p>The immune system's faulty response causes bleeding in the air sacs of the lungs and inflammation in the kidney's filtering units.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Symptoms</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Symptoms may occur very slowly over months or even years, but they often develop very quickly over days to weeks.</p><p>Loss of appetite, fatigue, and <a test="test" href="./003174.htm">weakness</a> are common early symptoms.</p><p>Lung symptoms may include:</p><ul><li>Coughing up blood</li><li>Dry <a test="test" href="./003072.htm">cough</a></li><li>Shortness of breath</li></ul><p>Kidney and other symptoms include:</p><ul><li><a test="test" href="./003138.htm">Bloody urine</a></li><li>Burning sensation when urinating</li><li><a test="test" href="./003117.htm">Nausea and vomiting</a></li><li><a test="test" href="./003244.htm">Pale skin</a></li><li>Swelling (edema) in any area of the body, especially in the legs</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Exams and Tests</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>A physical exam may reveal <a test="test" href="./000468.htm">high blood pressure</a> and signs of fluid overload. Your health care provider may hear abnormal heart and lung sounds when listening to the chest with a stethoscope.</p><p>Urinalysis results are often abnormal and show blood and protein in the urine. Abnormal red blood cells may be seen.</p><p>The following tests may also be done:</p><ul><li><a test="test" href="./003524.htm">Antiglomerular basement membrane test</a></li><li><a test="test" href="./003855.htm">Arterial blood gas</a></li><li><a test="test" href="./003474.htm">BUN
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</a></li><li><a test="test" href="./003804.htm">Chest x-ray</a></li><li><a test="test" href="./003475.htm">Creatinine</a> (serum)</li><li><a test="test" href="./003860.htm">Lung biopsy</a></li><li><a test="test" href="./003907.htm">Kidney biopsy</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Treatment</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>The main goal is to remove the harmful antibodies from the blood. Treatment may include:</p><ul><li>Plasmapheresis, which removes harmful antibodies to help reduce inflammation in the kidneys and lungs.</li><li>Corticosteroid medicines (such as prednisone) and other drugs, which suppress or quiet the immune system.</li><li>Medicines such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), which help control blood pressure.</li><li><a test="test" href="./007434.htm">Dialysis</a>, which may be done if kidney failure is severe and can no longer be treated by other means.</li><li>A <a test="test" href="./003005.htm">kidney transplant</a>, which may be done when your kidneys no longer function.</li></ul><p>You may be told to limit your intake of salt and fluids to control swelling. In some cases, a low-to-moderate protein diet may be recommended.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Support Groups</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>More information and support for people with anti-GBM disease and their families can be found at:</p><ul><li>National Institute of Diabetes and Digestive and Kidney Diseases -- <a class="extln" target="_blank" href="https://www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases/anti-gbm-goodpastures-disease">www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases/anti-gbm-goodpastures-disease</a></li><li>National Kidney Foundation -- <a class="extln" target="_blank" href="https://www.kidney.org/atoz/content/goodpasture">www.kidney.org/atoz/content/goodpasture</a></li><li>National Organization for Rare Disorders -- <a class="extln" target="_blank" href="https://rarediseases.org/rare-diseases/goodpasture-syndrome">rarediseases.org/rare-diseases/goodpasture-syndrome</a></li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Outlook (Prognosis)</h2></div><div class="section-button"><button type="submit" aria-controls="section-6" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-6"><p>An early diagnosis is very important. The outlook is much worse if the kidneys are already severely damaged when treatment begins. Lung damage can range from mild to severe.</p><p>Many people will need dialysis or a kidney transplant.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Possible Complications</h2></div><div class="section-button"><button type="submit" aria-controls="section-7" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-7"><p>Untreated, this condition can lead to any of the following:</p><ul><li><a test="test" href="./000471.htm">Chronic kidney disease</a></li><li><a test="test" href="./000500.htm">End-stage kidney disease</a></li><li>Lung failure</li><li><a test="test" href="./000484.htm">Rapidly progressive glomerulonephritis</a></li><li>Severe pulmonary hemorrhage (lung bleeding)</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-8" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-8"><p>Contact your provider for an appointment if you are producing less urine, or you have any other symptoms of anti-GBM disease.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Prevention</h2></div><div class="section-button"><button type="submit" aria-controls="section-9" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-9"><p>Never sniff glue or siphon gasoline with your mouth, which exposes the lungs to hydrocarbon solvents and can cause the disease.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Goodpasture syndrome; Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Pulmonary renal syndrome; Glomerulonephritis - pulmonary hemorrhage </p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/24353t.jpg" alt="Glomerulus and nephron" title="Glomerulus and nephron" class="side-img"/><a href="../imagepages/19932.htm">Glomerulus and nephron</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Phelps RG, Turner AN. Anti-glomerular basement membrane disease and Goodpasture disease. In: Johnson RJ, Floege J, Tonelli M, eds. <em>Comprehensive Clinical Nephrology</em>. 7th ed. Philadelphia, PA: Elsevier; 2024:chap 25.</p><p>Radhakrishnan J, Appel GB, D'Agati VD. Secondary glomerular disease. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. <em>Brenner and Rector's The Kidney</em>. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 32.</p><p>Schwarz MI, Matson S. Diffuse alveolar hemorrhage. In: Broaddus VC, Ernst JD, King TE, et al, eds. <em>Murray and Nadel's Textbook of Respiratory Medicine</em>. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 94.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 8/28/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. </p>
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