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<h1>Matrix Combination Screening Scientific Capabilities</h1>
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Matrix combination screening lets NCATS scientists quickly analyze many possible drug combinations and find those with the most potential to help patients.
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<a href="/research/research-activities/matrix/capabilities" class="active active-trail first last active-trail is-active" data-drupal-link-system-path="node/27711">Matrix Screening Scientific Capabilities</a>
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<h2>The Matrix Combination Screening Platform</h2><p>The state-of-the-art high-throughput matrix combination screening platform relies on a robotics system, custom data analysis software and a web interface that shows data in a straightforward format that is easy to understand.</p><p>Thousands of combination pairs can be analyzed with this platform in a cost- and time-effective way, letting our scientists quickly narrow down a long list of drug pairs to identify the most effective drug combinations for follow-up and clinical studies.</p><p>The unbiased discovery of drug combinations through the matrix platform may reveal treatments that are more effective, delay onset of resistance and can be used at lower, less toxic doses.</p><h3>Matrix Screening Scientific Capabilities</h3><p>Our combination screening experts use an automated platform capable of screening thousands of drug combinations each week. Compound libraries include approved drugs, agents currently under clinical evaluation and high-value tool compounds. Researchers can apply combination screening to varied cell-based phenotypic assays ranging from simple viability assessments to more complex high-content studies. </p><p><br>The NCATS robotic combination screening platform takes advantage of an existing high-throughput screening foundation as well as several core enhancements: </p><ul><li>Mechanism interrogation plates library of pharmacologically defined small molecules for high-precision combination screening of known-mechanism compounds</li><li>Acoustic dispensing technology provided by EDC Biosystems</li><li>A custom web-based interface for data analysis and access to results</li></ul>
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