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<h1>National Clinical Cohort Collaborative (N3C)</h1>
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N3C translates health data into health solutions.
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</style><div class="contact-box"><h4>Contact</h4><p><a href="mailto:hythem.sidky@nih.gov">Hythem Sidky, Ph.D.</a></p><hr><p><a href="/sites/default/files/2024-06/NCATS-N3C-One-Pager-508.pdf">Read background on N3C</a> (PDF - 296KB)</p></div><p>N3C is a national resource of real-world data that researchers are using to speed medical research.</p><p>With stewardship from NCATS, more than 75 institutions worked together to build N3C. N3C systematically collects data derived from electronic health records from different institutions and harmonizes these data into data enclaves. The enclaves offer spaces for collaborative research. In addition, the enclaves can connect to other data sets, which creates a more complete picture of health outcomes.</p><p>Initially created in response to the COVID-19 pandemic, NCATS is piloting the use of the original N3C infrastructure for additional health conditions.</p><p>We know that the data in the enclaves represent people. As the steward of the data, we take the responsibility for keeping those data safe very seriously. We have taken a comprehensive approach to address the security of the N3C COVID Enclaves and protect patient privacy.</p>
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</style><ul class="usa-card-group"><li class="usa-card grid-col-4"><div class="featured usa-card__container"><div class="usa-card__header"><h3 class="title">Pilot Enclaves</h3></div><div class="usa-card__media usa-card__media--inset"><div class="usa-card__img"><img src="https://ncats.nih.gov/sites/default/files/2024-07/N3C_Pilot_Enclave_746x370.jpg" alt="Vials of blood"></div></div><div class="usa-card__body"><p>The N3C Pilot Enclaves leverage operational and governance aspects of the N3C COVID platform that are established already. The projects focus on using real-world clinical data to better understand chronic kidney disease and cancer.</p></div><div class="usa-card__footer"><button class="buttons btn-1 mt-4">
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<a href="/research/research-activities/n3c/covid-enclave">Learn About the N3C COVID Enclave</a>
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<h2 class="section-heading">N3C Impact</h2>
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<ul class="usa-card-group"><li class="usa-card usa-card--flag grid-col-12" style="margin-bottom:1em;"><div class="featured usa-card__container"><div class="usa-card__media usa-card__media--inset"><div class="usa-card__img"><img src="/sites/default/files/styles/media_library/public/image%20%281%29.png?itok=lSyaQGUP" alt="Patient speaks with a doctor" width="220" height="124"></div></div><div class="usa-card__body" style="padding-top:1.5rem;"><h3 class="title">N3C Data Identify Drugs That May Boost Risk of Post–COVID-19 Pulmonary Fibrosis</h3><p style="margin:.5rem 0;"><em>November 20, 2023</em></p><p style="margin:.5rem 0;">A new study used NCATS’ N3C database to see how more than 450,000 people without pulmonary fibrosis (PF) fared after they were hospitalized with COVID-19. Researchers looked at how common drugs linked to PF affected the risk of developing post–COVID-19 PF. Rituximab and chemotherapy drugs were tied to greater PF post-infection risk. In patients exposed to rituximab, PF incidence was 2.8 cases per 100 person-years, compared with 1.1 cases per 100 person-years in a control group. PF incidence among those exposed to chemotherapy was 2.2 cases per 100 person-years, compared with 1.3 cases among a control group. The heart drug amiodarone did not appear to boost risk.</p></div><div class="usa-card__footer"><p><a href="https://pubmed.ncbi.nlm.nih.gov/37564420/">Read Article</a></p></div></div></li><li class="usa-card grid-col-4"><div class="featured usa-card__container"><div class="usa-card__body"><h3 class="title">N3C Data Reveal COVID-19 Hospitalization Increases Risk of Heart Failure</h3><p style="margin:.5rem 0;"><em>October 25, 2022</em></p><p style="margin:.5rem 0;">Using data from more than half a million electronic health records in the N3C COVID Enclave, researchers found that a greater percentage of people who had been hospitalized with COVID-19 developed heart failure than people who had been hospitalized without COVID-19.</p></div><div class="usa-card__footer" style="margin:0;"><p><a href="/news-events/news/covid-19-hospitalization-may-increase-heart-failure-risk">Read Article</a></p></div></div></li><li class="usa-card grid-col-4"><div class="featured usa-card__container"><div class="usa-card__body"><h3 class="title">Scientists Identify Characteristics to Better Define Long COVID</h3><p style="margin:.5rem 0;"><em>June 10, 2022</em></p><p style="margin:.5rem 0;">To get a better understanding of long COVID and the individuals who are likely to have it, NIH-supported researchers used machine learning techniques to analyze an unprecedented collection of de-identified electronic health records in NCATS’ N3C COVID Enclave.</p></div><div class="usa-card__footer" style="margin:0;"><p><a href="/news-events/news/scientists-identify-characteristics-to-better-define-long-COVID">Read Article</a></p></div></div></li><li class="usa-card grid-col-4"><div class="featured usa-card__container"><div class="usa-card__body"><h3 class="title">N3C Study Ties Aspirin Use in Moderate COVID-19 to Lower Risk of Blood Clots and Death</h3><p style="margin:.5rem 0;"><em>March 24, 2022</em></p><p style="margin:.5rem 0;">Giving aspirin to people hospitalized with moderate COVID-19 may reduce their risks of blood clots in the lung and of death, according to a large study of patient information from the N3C COVID Enclave.</p></div><div class="usa-card__footer" style="margin:0;"><p><a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2790439">Read Article</a></p></div></div></li></ul><div class="two-buttons" style="display:block;margin:0 auto;width:34em;"><button class="buttons btn-1 mt-4" style="margin-right:.25em;">
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