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</noscript></div><div class="main"><div id="ency_summary"><p>A vesicle is a small fluid-filled blister on the skin.</p></div><section><div class="section"><div class="section-header"><div class="section-title"><h2>Considerations</h2></div><div class="section-button"><button type="submit" aria-controls="section-1" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-1"><p>A vesicle is small. It may be as tiny as the top of a pin or up to 5 millimeters wide. A larger blister is called a bulla.</p><p>In many cases, vesicles break easily and release their fluid onto the skin. When this fluid dries, yellow crusts may remain on the skin surface.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Causes</h2></div><div class="section-button"><button type="submit" aria-controls="section-2" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-2"><p>Many diseases and conditions can cause vesicles. Common examples include:</p><ul><li>Allergic reactions to drugs</li><li>Atopic dermatitis (<a test="test" href="./000853.htm">eczema</a>)</li><li>Autoimmune disorders such as <a test="test" href="./000883.htm">bullous pemphigoid</a> or <a test="test" href="./000882.htm">pemphigus</a></li><li>Blistering skin diseases including <a test="test" href="./001208.htm">porphyria</a> cutanea tarda and <a test="test" href="./001480.htm">dermatitis herpetiformis</a></li><li><a test="test" href="./001592.htm">Chickenpox</a></li><li><a test="test" href="./000869.htm">Contact dermatitis</a> (may be caused by poison ivy)</li><li>Herpes simplex (cold sores, <a test="test" href="./000857.htm">genital herpes</a>)</li><li><a test="test" href="./000858.htm">Herpes zoster</a> (shingles)</li><li>Bacterial infections</li><li>Fungal infections</li><li>Burns</li><li>Friction</li><li>Treatment with cryotherapy (to treat a wart for example)</li></ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Home Care</h2></div><div class="section-button"><button type="submit" aria-controls="section-3" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-3"><p>It is best to have your health care provider examine any skin rashes, including vesicles.</p><p>Over-the-counter treatments are available for certain conditions that cause vesicles, including poison ivy and cold sores.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>When to Contact a Medical Professional</h2></div><div class="section-button"><button type="submit" aria-controls="section-4" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-4"><p>Call your provider if you have any unexplained blisters on your skin.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>What to Expect at Your Office Visit</h2></div><div class="section-button"><button type="submit" aria-controls="section-5" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-5"><p>Your provider will look at your skin. Some vesicles can be diagnosed simply by how they look. </p><p>In many cases, additional tests are needed. The fluid inside a blister may be sent to a lab for closer examination. In particularly difficult cases, a <a test="test" href="./003840.htm">skin biopsy</a> may be needed to make or confirm a diagnosis.</p><p>Treatment will depend on the cause of the vesicles.</p></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>Alternative Names</h2></div><div class="section-button"><button type="submit" aria-controls="section-Alt" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Alt"><p>Blisters</p></div></div></section><section><div class="section sec-mb"><div class="section-header"><div class="section-title"><h2>Images</h2></div><div class="section-button"><button type="submit" aria-controls="section-tnails" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/1531t.jpg" alt="Bullous pemphigoid - close-up of tense blisters" title="Bullous pemphigoid - close-up of tense blisters" class="side-img"/><a href="../imagepages/1531.htm">Bullous pemphigoid - close-up of tense blisters</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/2046t.jpg" alt="Chigger bite - close-up of blisters" title="Chigger bite - close-up of blisters" class="side-img"/><a href="../imagepages/2046.htm">Chigger bite - close-up of blisters</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/2157t.jpg" alt="Hand, foot, and mouth disease on the soles" title="Hand, foot, and mouth disease on the soles" class="side-img"/><a href="../imagepages/2157.htm">Hand, foot, and mouth disease on the soles</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/2161t.jpg" alt="Herpes simplex - close-up" title="Herpes simplex - close-up" class="side-img"/><a href="../imagepages/2161.htm">Herpes simplex - close-up</a></li>
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<li><img src="//medlineplus.gov/ency/images/ency/tnails/2163t.jpg" alt="Herpes zoster (shingles) - close-up of lesion" title="Herpes zoster (shingles) - close-up of lesion" class="side-img"/><a href="../imagepages/2163.htm">Herpes zoster (shingles) - close-up of lesion</a></li>
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||
<li><img src="//medlineplus.gov/ency/images/ency/tnails/2567t.jpg" alt="Poison ivy on the knee" title="Poison ivy on the knee" class="side-img"/><a href="../imagepages/2567.htm">Poison ivy on the knee</a></li>
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||
<li><img src="//medlineplus.gov/ency/images/ency/tnails/2568t.jpg" alt="Poison ivy on the leg" title="Poison ivy on the leg" class="side-img"/><a href="../imagepages/2568.htm">Poison ivy on the leg</a></li>
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</ul></div></div></section><section><div class="section"><div class="section-header"><div class="section-title"><h2>References</h2></div><div class="section-button"><button type="submit" aria-controls="section-Ref" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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</div></div><div class="section-body" id="section-Ref"><p>Dinulos JGH. Vesicular and bullous diseases. In: Dinulos JGH, ed. <em>Habif's Clinical Dermatology</em>. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 16.</p><p>Marks JG, Miller JJ. Vesicles and bullae. In: Marks JG, Miller JJ, eds. <em>Lookingbill and Marks' Principles of Dermatology</em>. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 10.</p></div></div></section>
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<section><div class="section"><div class="section-header"><div class="section-title"><h2>Review Date 6/7/2023</h2></div><div class="section-button"><button type="submit" aria-controls="section-version" role="button" title="Expand/Collapse section"><span class="icon icon-section-action">
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<div id="section-version" class="section-body"><p>Updated by: Elika Hoss, MD, Assistant Professor of Dermatology, Mayo Clinic, Scottsdale, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.</p>
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